Laboratory for Fluorescence Dynamics

A NIH research center for biomedical fluorescence spectroscopy at the University of California, Irvine

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Publications

The Laboratory for Fluorescence Dynamics' (LFD) database of publications contains more than 2100 journal articles, book chapters, conference proceedings, abstracts, patents, and theses by members of the LFD, and also selected publications of interest to the fluorescence community.
Electronic documents are not available publicly due to copyright restrictions. Reprints can be requested from the authors.

Recent LFD Publications

2017

  1. Bohórquez-Hernández A, Gratton E, Pacheco J, Asanov A, Vaca L.
    Cholesterol modulates the cellular localization of Orai1 channels and its disposition among membrane domains.
    Biochim Biophys Acta. 2017; [Epub ahead of print].
  2. Malacrida L, Jameson DM, Gratton E.
    A multidimensional phasor approach reveals LAURDAN photophysics in NIH-3T3 cell membranes.
    Sci Rep. 2017; 7(1): 9215. PMCID: PMC5569084
  3. Liu L, Zhang SX, Liao W, Farhoodi HP, Wong CW, Chen CC, Ségaliny AI, Chacko JV, Nguyen LP, Lu M, Polovin G, Pone EJ, Downing TL, Lawson DA, Digman MA, Zhao W.
    Mechanoresponsive stem cells to target cancer metastases through biophysical cues.
    Sci Transl Med. 2017; 9(400), aan2966.
  4. Stortz M, Presman DM, Bruno L, Annibale P, Dansey MV, Burton G, Gratton E, Pecci A, Levi V.
    Mapping the dynamics of the Glucocorticoid Receptor within the nuclear landscape.
    Sci Rep. 2017; 7(1), 6219. PMCID: PMC5524710
  5. Herrington KA, Trinh AL, Dang C, O’Shaughnessy E, Hahn KM, Gratton E, Digman MA, Sütterlin C.
    Spatial analysis of Cdc42 activity reveals a role for plasma membrane-associated Cdc42 in centrosome regulation.
    Mol Biol Cell. 2017; 28(15): 2135-2145. PMCID: PMC5509425
  6. Bhattacharjee A, Datta R, Gratton E, Hochbaum AI.
    Metabolic fingerprinting of bacteria by fluorescence lifetime imaging microscopy.
    Sci Rep. 2017; 7(1), 3743. PMCID: PMC5473825
  7. Ranjit S, Dvornikov A, Dobrinskikh E, Wang X, Luo Y, Levi M, Gratton E.
    Measuring the effect of a Western diet on liver tissue architecture by FLIM autofluorescence and harmonic generation microscopy.
    Biomed Opt Express. 2017; 8(7): 3143-3154. PMCID: PMC5508820
  8. Ceccarelli A, di Venere A, Nicolai E, de Luca A, Rosato N, Gratton E, Mei G, Caccuri AM.
    New insight into the interaction of TRAF2 C-terminal domain with lipid raft microdomains.
    Biochim Biophys Acta. 2017; 1862(9): 813-822. PMCID: PMC5562040
  9. Liang EI, Mah EJ, Yee AF, Digman MA.
    Correlation of focal adhesion assembly and disassembly with cell migration on nanotopography.
    Integr Biol (Camb). 2017; 9(2): 145-155. PMCID: PMC5399776
  10. Hinde E, Pandzic E, Yang Z, Ng I, Bogoyevitch M, Jans D, Gratton E, Gaus K.
    Tracking oligomeric transcription factor dynamics by pair correlation of molecular brightness (pCOMB).
    61st Annual Meeting of the Biophysical Society. New Orleans, Louisiana. February 11–15, 2017.
    Biophys J. 2017; 112(3, Suppl 1): 20a.
  11. Lanzanò L, di Bona M, Scipioni L, Sarmento MJ, Gratton E, Vicidomini G, Diaspro A.
    Heterogeneity of the nuclear environment investigated by superresolution microscopy and fluorescence correlation spectroscopy.
    61st Annual Meeting of the Biophysical Society. New Orleans, Louisiana. February 11–15, 2017.
    Biophys J. 2017; 112(3, Suppl 1): 142a.
  12. Hedde PN, Malacrida L, Gratton E.
    Selective plane illumination microscopy in the conventional inverted microscope geometry.
    61st Annual Meeting of the Biophysical Society. New Orleans, Louisiana. February 11–15, 2017.
    Biophys J. 2017; 112(3, Suppl 1): 145a.
  13. Digman MA, Rottschäfer L, Gratton E, Hedde PN.
    Fluorescence diffusion tensor maps of p53 activation acquired with SPIM.
    61st Annual Meeting of the Biophysical Society. New Orleans, Louisiana. February 11–15, 2017.
    Biophys J. 2017; 112(3, Suppl 1): 148a.
  14. Ranjit S, Aguilar-Arnal L, Stringari C, Sassone-Corsi P, Gratton E.
    Spatial dynamics of SIRT1 relates to metabolic transitions in the cell nucleus.
    61st Annual Meeting of the Biophysical Society. New Orleans, Louisiana. February 11–15, 2017.
    Biophys J. 2017; 112(3, Suppl 1): 149a.
  15. Cardarelli F, Gratton E, Beltram F, di Rienzo C.
    Spatiotemporal fluctuation analysis: a powerful tool for the future nanoscopy of dynamic molecular processes.
    61st Annual Meeting of the Biophysical Society. New Orleans, Louisiana. February 11–15, 2017.
    Biophys J. 2017; 112(3, Suppl 1): 149a.
  16. Datta R, Bhattacharjee A, Hochbaum A, Gratton E.
    FLIM phasor fingerprint of bacterial metabolic state.
    61st Annual Meeting of the Biophysical Society. New Orleans, Louisiana. February 11–15, 2017.
    Biophys J. 2017; 112(3, Suppl 1): 186a.
  17. Malacrida LS, Ranjit S, Gratton E.
    Water activity inside the nucleus: some clues using ACDAN fluorescence and its implications in the chromatin supramolecular organization.
    61st Annual Meeting of the Biophysical Society. New Orleans, Louisiana. February 11–15, 2017.
    Biophys J. 2017; 112(3, Suppl 1): 218a.
  18. Bouzin M, Heylman C, Zhao W, Gratton E.
    Particle counting by confocal microscopy: increasing the dynamic range via multiple-slits fluorescence detection.
    61st Annual Meeting of the Biophysical Society. New Orleans, Louisiana. February 11–15, 2017.
    Biophys J. 2017; 112(3, Suppl 1): 295a.
  19. Digiacomo L, Marchini C, Digman MA, Gratton E, Caracciolo G.
    Intracellular dynamics of nanoparticles probed by an image-derived mean square displacement approach.
    61st Annual Meeting of the Biophysical Society. New Orleans, Louisiana. February 11–15, 2017.
    Biophys J. 2017; 112(3, Suppl 1): 296a.
  20. Gratton E, Ma N, Digman MA, Malacrida L.
    Of absolute concentrations of NADH in cells using the Phasor FLIM method.
    61st Annual Meeting of the Biophysical Society. New Orleans, Louisiana. February 11–15, 2017.
    Biophys J. 2017; 112(3, Suppl 1): 581a.
  21. Chacko JV Digman M.
    NADH auto fluorescence reveals new metabolic signatures in yeast and mammalian cells.
    61st Annual Meeting of the Biophysical Society. New Orleans, Louisiana. February 11–15, 2017.
    Biophys J. 2017; 112(3, Suppl 1): 282a.
  22. Sameni S Digman MA.
    Metabolic Shifts in Huntington Disease Revealed by Fluorescence Lifetime Imaging Microscopy.
    61st Annual Meeting of the Biophysical Society. New Orleans, Louisiana. February 11–15, 2017.
    Biophys J. 2017; 112(3, Suppl 1): 584a.
  23. de Vega GB, Ceballos JA, Anzalone A, Digman MA, Gratton E.
    A laser-scanning confocal microscopy study of carrageenan in red algae from seaweed farms near the Caribbean entrance of the Panama Canal.
    J Appl Phycol. 2017; 29(1): 495-508.
  24. Romero-López M, Trinh AL, Sobrino A, Hatch MMS, Keating MT, Fimbres C, Lewis DE, Gershon PD, Botvinick EL, Digman MA, Lowengrub JS, Hughes CCW.
    Recapitulating the human tumor microenvironment: Colon tumor-derived extracellular matrix promotes angiogenesis and tumor cell growth.
    Biomaterials. 2017; 116: 118-129. PMCID: PMC5226635

2016

  1. Porcaro F, Miao Y, Kota R, Haun JB, Polzonetti G, Battocchio C, Gratton E.
    Fluctuation spectroscopy analysis of glucose capped gold nanoparticles.
    Langmuir. 2016; 32(50): 13409-13417. PMCID: PMC5470844
  2. Chen CC, Liu L, Ma F, Wong CW, Guo XE, Chacko JV, Farhoodi HP, Zhang SX, Zimak J, Ségaliny A, Riazifar M, Pham V, Digman MA, Pone EJ, Zhao W.
    Elucidation of exosome migration across the blood-brain barrier model in vitro.
    Cell Mol Bioeng. 2016; 9(4): 509-529. PMCID: PMC5382965
  3. Malacrida L, Astrada S, Briva A, Bollati-Fogolín M, Gratton E, Bagatolli LA.
    Spectral Phasor analysis of LAURDAN fluorescence in live A549 lung cells to study the hydration and time evolution of intracellular lamellar body-like structures.
    Biochim Biophys Acta. 2016; 1858(11): 2625-2635. PMCID: PMC5045802
  4. Ranjit S, Dobrinskikh E, Montford J, Dvornikov A, Lehman A, Orlicky DJ, Nemenoff R, Gratton E, Levi M, Furgeson S.
    Label-free fluorescence lifetime and second harmonic generation imaging microscopy improves quantification of experimental renal fibrosis.
    Kidney Int. 2016; 90(5): 1123-1128. PMCID: PMC5473685
  5. Aguilar-Arnal L, Ranjit S, Stringari C, Orozco-Solis R, Gratton E.
    Spatial dynamics of SIRT1 and the subnuclear distribution of NADH species.
    Proc Natl Acad Sci USA. 2016; 113(45): 12715-12720. PMCID: PMC5111721
  6. di Rienzo C, Gratton E, Beltram F, Cardarelli F.
    Super-Resolution in a standard microscope: from fast fluorescence imaging to molecular diffusion laws in live cells.
    Super-Resolution Imaging in Biomedicine. By A Diaspro and MAMJ van Zandvoort (Editors). CRC Press, pp. 19-43, 2016. ISBN: 9781482244342
  7. Sameni S, Syed A, Marsh JL, Digman MA.
    The phasor-FLIM fingerprints reveal shifts from OXPHOS to enhanced glycolysis in Huntington Disease.
    Sci Rep. 2016; 6: 34755. PMCID: PMC5054433
  8. Cinco R, Digman MA, Gratton E, Luderer U.
    Spatial characterization of bioenergetics and metabolism of primordial to preovulatory follicles in whole ex vivo murine ovary.
    Biol Reprod. 2016; 95(6): 129. PMCID: PMC5315427