I am a PhD student in biomedical engineering. I
attended Rice University in
Houston, Texas, where I earned a Bachelor of Science in Electrical
and Computer Engineering in 2003. From 2003 to 2004 I worked as a
lab technician in Neal Waxham's lab
at the University of Texas
Health Science Center at Houston where I studied focal volume
characterization for fluorescence correlation spectroscopy. In 2004,
I entered the bioengineering graduate program at the University of
Illinois at Urbana-Champaign and joined the Laboratory for Fluorescence
Dynamics with Enrico
Gratton as my advisor. I earned a Master of Science degree from
UIUC before moving with the lab to the University of California at
Irvine where I am continuing my PhD research.
Currently I am developing a novel technique that will
serve as the basis for a surgical instrument that measures blood
flow in exposed blood vessels. Surgeons
measure blood flow during surgery, especially neurosurgery, to avoid
life-threatening complications. My technique, near-infrared
spatial-temporal image correlation spectroscopy (NIR-STICS) draws on
near-infrared spectroscopy (NIRS) and spatial-temporal image
correlation spectroscopy (STICS) to provide a quantitative map of
fluid velocity in arterioles over an area. NIR-STICS is non-invasive within
the context of surgery and has the potential to be adapted into
existing surgical microscopes.
Publications
- "Spatio-temporal image correlation spectroscopy measurements of flow demonstrated in microfluidic channels." M. Rossow, W. Mantulin, and E. Gratton. J. Biomed Opt. Vol. 14, No. 2 (Mar.-Apr., 2009).
- "Peak two-photon molecular brightness of fluorophoes is a robust measure of quantum efficiency and photostability." V. Iyer, M. Rossow, M. N. Waxham. J. Opt. Soc. Am. B. 23 7 (2006).
- "Focal volume characterization using multiphoton fluorescence correlation spectroscopy (MP-FCS)." V. Iyer, M. Rossow, and M. N. Waxham. Proc. of SPIE. 5323, 146 (2004).
- "Single-cycle terahertz electromagnetic pulses: a new test bed for physical seismic modeling." T. D. Dorney, M. Rossow, W. W. Symes, and D. M. Mittleman, Geophysics, Vol. 68, No. 1 (Jan.-Feb., 2003).
Abstracts and Posters
- "Embryonic zebrafish (danio reio) as a model for the investigation of blood flow measurements using scanning laser image correlation (SLIC)." A. East, M. Rossow, W. Matulin, and E. Gratton. 34th Annual West Coast Biological Sciences Undergraduate Research Conference, San Diego, California 2009.
"Line scanning flow measurements." M. Rossow, W. Mantulin, and E. Gratton. 53rd Annual Meeting of the Biophysical Society, Boston, Massachusetts, 2009.
- "An optical tool to investigate cerebral aneurysms." M. Rossow, W. Mantulin, and E. Gratton. Society of Women Engineers (SWE) National Conference, Baltimore, Maryland, 2008. (Collegiate Poster Competition winner.)
- "Spatial temporal image correlation spectroscopy (STICS) for flow analysis with application for blood flow mapping." M. Rossow, W. Mantulin, and E. Gratton. Third IUPAP International Conference on Women in Physics, Seoul, S. Korea, 2008.
- "Spatial temporal image correlation spectroscopy for detailed flow analysis." M. Rossow, W. Mantulin, and E. Gratton. Biomedical Engineering Society (BMES) annual meeting, St. Louis, Missouri, 2008.
- "Spatial temporal image correlation spectroscopy (STICS) for blood flow mapping." M. Rossow, W. Mantulin, and E. Gratton. Engineering the Life Sciences — UCI Engineering Symposium, Irvine, California, 2008.
- "Blood flow mapping through spatial temporal image correlation." M. Rossow, W. Mantulin, and E. Gratton. 52nd Annual Meeting of the Biophysical Society, Long Beach, California, 2008. Biophys J Supplement, 1691-Pos/B667, 2008.
- "A new way to measure blood flow." M. Rossow, W. Mantulin, and E. Gratton. Society of Women Engineers (SWE) National Conference, Nashville, Tennessee, 2007. (Collegiate Poster Competition finalist.)
- "Spatial temporal image correlation spectroscopy analysis for fluid velocity measurement." M. Rossow, W. Mantulin, and E. Gratton. Biomedical Engineering Society (BMES) annual meeting, Los Angeles, California, 2007.
- "Flow measurement using correlation analysis of optical signals." M. Rossow, W. Mantulin, and E. Gratton. Network for Translational Research: Optical Imaging (NTROI) Retreat, Irvine, California, 2007.
- "An optical technique for fluid velocity measurement applicable to intra-operative blood flow." M. Rossow, W. Mantulin, and E. Gratton. 51st Annual Meeting of the Biophysical Society, Baltimore, Maryland, 2007. Biophys J Supplement: 332a, 1565-Pos/B618, 2007.
- "Blood flow measurements and clot detection with near-infrared spectroscopy." M. Rossow, R. Gatto, E. D'Amico, W. Mantulin, and E. Gratton. OSA Biomedical Topical Meeting (BIO), Fort Lauderdale, Florida, March 18-23, 2006. Biomedical Optics (Technical Digest). Optical Society of America, paper ME72, 2006.
- "Intra-operative blood flow measurement with near-infrared spectroscopy using a camera based detection system." M. Rossow, E. D'Amico, R. Gatto, F. Charbel, W. Mantulin, and E. Gratton. Biomedical Engineering Society (BMES) annual meeting, Chicago, Illinois, 2006.
- "Characterization and optimization of multiphoton excitation (MPE) instrumentation using fluorescence correlation spectroscopy." V. Iyer, M. Rossow, P. Saggau, and M. N. Waxham. Biophs. J. 86: 607A, 2004.
Professional Activities
- Supervised an undergraduate researcher, Fall 2007 — present
- President, ZotSpeak Toastmasters Club, Founder's District club #9524 (July 2008 — December 2008)
- Judge, Orange County Science Fair (Spring 2007, Spring 2008)
- Co-chair, UCI Engineering Graduate Student Council (Fall 2007)
- Mentor to undergraduate engineering student (Fall 2005)
- Member Biomedical Engineering Society, Society of Women Engineers, Biophysical Society and Sigma Xi
Technical Skills
- Matlab
- Python
- Iron CAD
- clean room and microfabrication procedures including photolithography
Certificates and Awards
- Winner, Society of Women Engineers national student poster competition 2008.
- Finalist, Society of Women Engineers national student poster competition 2007.
- Scholarship recipient, Spring 2007. Society of Women Engineers Orange County Section
- Medical Device Management Certificate Program. August 28-31, 2007. North Orange County Community College
- 1st LFD Workshop in Advanced Fluorescence Imaging and Dynamics certificate of completion. October 20-23, 2006. Laboratory for Fluorescence Dynamics, University of California, Irvine