Gregorio Weber - Curriculum Vitae

Date of Birth

July 4, 1916; Buenos Aires, Argentina

U. S. Resident - 1962, U. S. Citizen - 1971.

Training

Societies

Awards

  1. British Council Scholar, 1944-1947
  2. Beit Memorial Fellow, 1948-1951
  3. American Academy of Arts and Sciences, Elected Fellow, 1968
  4. 1st National Lecturer of the Biophysical Society, 1969
  5. Guggenheim Foundation Fellow, 1970
  6. Corresponding Member of the National Academy of Exact Sciences of Argentina, 1971
  7. NATO Lecturer in Europe, 1975
  8. National Academy of Sciences (U.S.), Elected Member, 1975
  9. Rumford Premium of American Academy of Arts and Sciences, 1979
  10. ISCO Award for excellence in Biochemical Instrumentation, 1983
  11. First recipient of Repligen Award for the Chemistry of Biological Processes of the American Chemical Society, 1986
  12. First recipient of the International Jablonski Award for Fluorescence - 1996

Academic Appointments

University of Illinois

University of Buenos Aires

University of California at Los Angeles

Harvard University

University of Washington

Stanford University

Brandeis University

Sheffield University

Institute of Physiology of the University of Buenos Aires

Publications

  1. Weber, G. (1948) The quenching of fluorescence in liquids by complex formation. Determination of the mean life of the complex. Trans Faraday Soc. 44, 185-189.
  2. Weber, G. (1950) Fluorescence of riboflavin and flavin-adenine dinucleotide. Biochem. J. 47, 114-121.
  3. Weber, G. (1952) Polarization of the fluorescence of macormolecules. I. Theory and experimental method. Biochem. J. 51, 145-155.
  4. Weber, G. (1952) Polarization of the fluorescence of macromolecules. II. Fluorescent conjugates of ovalbumin and bovine serum albumin. Biochem. J. 51, 155-167.
  5. Weber, G. (1953) Polarization of the fluorescence of labeled protein molecules. Faraday Soc. Discussions 13, 33-39.
  6. Weber, G. (1953) Rotational Brownian motion and polarization of the fluorescence of solutions. Adv. Protein Chemistry 8, 415-459.
  7. Weber, G. (1954) Dependence of the polarization of the fluorescence on the concentration. Trans. Faraday Soc. 50, 552-555.
  8. Weber, G. and Laurence, D.J.R. (1954) Fluorescent indicators of adsorption in aqueous solution and on the solid phase. Biochem J. 56, xxxi.
  9. Whittam, R., Bartley, W., and Weber, G. (1955) The kinetics of the exchange of the phosphate groups of adenosine triphosphate during oxidative phosphorylation. Biochem. J. 59, 590-599.
  10. Weber, G. (1955) Enzyme action at a distance. An examination of its kinetics and physical possibilities. Faraday Soc. Discussions 20, 156-161.
  11. Weber, G. (1956) Photoelectric method for the measurement of the polarization of the fluorescence of solutions. J. Opt. Soc. Amer. 46, 962-970.
  12. Weber, G. and Teale, F.W.J. (1957) Determination of the absolute quantum yield of fluorescent solutions. Trans. Faraday Soc. 53, 646-655.
  13. Weber, G. and Teale, F.W.J. (1957) Ultraviolet fluorescence of aromatic amino acids. Biochem. J. 65, 476-482.
  14. Weber, G. (1957) Intramolecular transfer of electronic energy in dihydrodiphosphopyridine nucleotide. Nature (London) 180, 1409.
  15. Weber, G. and Teale, F.W.J. (1958) Fluorescence excitation spectrum of organic compounds in solution. Trans. Faraday Soc. 54, 640-648.
  16. Weber, G. (1958) Transfert d'energie dans la dihydro-diphosphopyridine nucleotide. J. Chim. Physique 55, 878-886.
  17. Weber, G. and Teale, F.W.J. (1959) Electronic energy transfer in heme proteins. Faraday Soc. Discussions 27, 134-141.
  18. Teale, F.W.J. and Weber, G. (1959) Ultraviolet fluorescence of proteins. Biochem. J. 72, 15.
  19. Weber, G. and Tea1e, F.W.J. (1959) Polarization of the ultraviolet fluorescence and electronic energy transfer in proteins. Biochem. J. 72, 15.
  20. Porter, G. and Weber, G. (1959) Energy transfer with special reference to biological systems. Nature 184, 688-709.
  21. Weber, G. (1960) Fluorescence polarization spectrum and electronic energy transfer in tyrosine, tryptophan and related compounds. Biochem. J. 75, 335-345.
  22. Weber, G. (1960) Fluorescence-polarization spectrum and electronic energy transfer in proteins. Biochem. J. 75, 345-352.
  23. Weber, G. (1960) Fluorescence parameters and photosynthesis. In Comparative Biochemistry of Photoreactive Systems, M.B. Allen (ed.), Academic Press, Inc., New York, p. 395.
  24. Weber, G. (1961) Excited states of proteins. In Light and Life, W.D. McElroy and Bently Glass (eds.), Johns Hopkins Press, Baltimore, p. 82-106.
  25. Weber, G. (1960) Enumeration of components in complex systems by fluorescence spectrophotometry. Nature 190, 27-29.
  26. Rosenheck, K. and Weber, G. (1961) pH dependence of the fluorescence yield of tyrosine copolymers. Biochem. J. 79, 29.
  27. Weber, G. (1961) Tyrosine fluorescence in the albumins. Biochem. J. 79, 29.
  28. Weber, G. (1962) Nature of the configurational changes of bovine serum albumin in acid. Biochem. J. 84, 74.
  29. Hastings, J.W. and Weber, G. (1963) Total quantum flux of isotropic sources. J. Opt. Soc. Am. 53, 1410-1415.
  30. Weber, G. and Young, L.B. (1964) Fragmentation of bovine serum albumin by pepsin. I. The origin of the acid expansion of the albumin molecule. J. Biol. Chem. 239, 1415-1423.
  31. Weber, G. and Young, L.B. (1964) Fragmentation of bovine serum albumin by pepsin. II. Isolation, amino acid composition and physical properties of the fragments. J. Bio. Chem. 239, 1424-1431.
  32. Weber, G. and Rosenheck, K. (1964) Proton-transfer effects in the quenching of fluorescence of tyrosine copolymers. Biopolymers, Symposia I, p. 333-341.
  33. Weber, G. (1965) Polarization of the fluorescence of solutions subjected to an electric field. J. Chem. Phys. 43, 521-524.
  34. Weber, G. and Anderson, S. R. (1965) Multiplicity of binding. Range of validity and practical test of Adair's equation. Biochemistry 4, 1942-1947.
  35. Anderson, S. R. and Weber, G. (1965) Multiplicity of binding by lactate dehydrogenases. Biochemistry 4, 1948-1957.
  36. Weber, G. and Teale, F.W.J. (1965) Interaction of proteins with radiation. In The Proteins, Vol. III, 2nd edition, Hans Neurath (ed.) Academic Press, New York, pp. 445-521.
  37. Weber, G. (1965) The binding of small molecules to proteins. In Molecular Biophysics, B. Pullman and M. Weissbluth (eds.), Academic Press, New York, pp. 369-396.
  38. Hastings, J.W. and Weber, G. (1965) A low intensity permanent liquid light standard activated by radioactivity. Photochem. and Photobiol. 4, 1049-1050.
  39. Weber, G. (1966) Polarization of the fluorescence of solutions In Fluorescence and Phosphorescence Analysis, D.M. Hercules (ed.), Inter-science Publishers, New York, pp. 217-240.
  40. Brewer, J. and Weber, G. (1966) The effect of magnesium on some physical properties of yeast enolase. J. Biol. Chem. 241, 2550-2557.
  41. Weber, G. and Bablouzian, B. (1966) Construction and performance of a fluorescence polarization spectrophotometer. J. Biol. Chem. 241, 2558-2561.
  42. Daniel, E. and Weber, G. (1966) Cooperative binding by bovine serum albumin. I. The binding of 1-anilino-8-naphthalenesulfonate. Fluorimetric titrations. Biochemistry 5, 1893-1899.
  43. Weber, G. and Daniel, E. (1966) Cooperative effects in binding by bovine serum albumin. II. The binding of 1-anilino-8-naphthalene-sulfonate. Polarization of the ligand fluorescence and quenching of the protein fluorescence. Biochemistry 5, 1900-1907.
  44. Weber, G. (1966) Intramolecular complexes of flavin. In Flavins and Flavoproteins, E.C. Slater (ed.), Elsevier Publishing Co., Amsterdam, pp. 15-21.
  45. Anderson, S.R. and Weber, G. (1966) The reversible acid dissociation and hybridization of lactic dehydrogenase. Arch. Biochem. and Biophys. 116, 207-223.
  46. Hemmerich, P., Massey, V. and Weber, G. (1967) Photo-induced benzyl-substitution of flavins by phenylacetate, a possible model for flavoprotein catalysis. Nature 213, 728-730.
  47. Wahl, P. and Weber, G. (1967) Fluorescence depolarization of rabbit Gamma globulin conjugates. J. Mol. Biol. 30, 371-382.
  48. Knopp, J. and Weber, G. (1967) Fluorescence depolarization measurements in pyrene butyric-bovine serum albumin conjugates. J. Biol. Chem. 242, 1353-1354.
  49. Weber, G. (1968) Energy transfer methods in the study of ligand-protein interactions. In Molecular Associations in Biology, B. Pullman (ed.), Academic Press, New York, pp. 419-515.
  50. Brewer, J.M. and Weber, G. (1968) The reversible dissociation of yeast enolase. Proc. Natl. Acad. Sci. USA 59, 216-223.
  51. Weber, G. and Anderson, S.R. (1969) The effects of energy transfer and rotational diffusion upon the fluorescence polarization of macromolecules. Biochemistry 8, 361-371.
  52. Anderson, S.R. and Weber, G. (1969) Fluorescence polarization of the complexes of 1-anilino-8-naphthalene sulfonate with bovine serum albumin. Evidence for preferential orientation of the ligand. Biochemistry 8, 3371-3775.
  53. Spencer, R.D., Vaughan, W. and Weber, G. (1969) Dependence of fluorescence lifetime upon the emission and absorption spectra. In Molecular Luminescence, E.C. Lim (ed.), Benjamin, New York, pp. 609-629.
  54. Spencer, R.D. and Weber, G. (1969) Measurement of subnanosecond fluorescence lifetimes with a cross-correlation phase fluorometer. Ann. N. Y. Acad. Sci. 158, 361-376.
  55. Knopp, A. and Weber, G. (1969) Fluorescence polarization of pyrene-butyric-bovine serum albumin and pyrenebutyric-human macroglobulin conjugates. J. Biol. Chem. 244, 6309-6315.
  56. Rawitch, A.B., Hudson, E.N. and Weber, G. (1969) The rotational diffusion of thyroglobulin. J. Biol. Chem. 244, 6543-6547.
  57. Rosen, C.G. and Weber, G. (1969) Dimer formation from 1-anilino-8-naphthalene sulfonate catalyzed by bovine serum albumin - A new fluorescent molecule with exceptional binding properties. Biochemistry 8, 3915-3920.
  58. Weber, G. (1969) Fluorescence methods in kinetic studies. In Methods in Enzymology, Vol. XVI, pp. 380-393.
  59. Vaughan, W.M. and Weber, G. (1970) Oxygen quenching pyrenebutyric acid fluorescence in water. A dynamic probe of the microenvironment. Biochemistry 9, 464-473.
  60. Scott, G.T., Spencer, R.D., Leonard, N. and Weber, G. (1970) Emission properties of NADH. Studies of fluorescence lifetimes and quantum efficiencies of NADH, AcPyADH, and simplified synthetic models. J. Amer. Chem. Soc. 92, 687-695.
  61. Spencer, R. D. and Weber, G. (1970) Influence of Brownian rotations and energy transfer upon the measurements of fluorescence lifetime. J. Chem. Phys. 52, 1654-1663.
  62. Weber, G. and Shinitzky, M. (1970) Failure of energy transfer between identical aromatic molecules on excitation at the long wave edge of the absorption spectrum. Proc. Natl. Acad. Sci. USA 65, 823-830.
  63. Weber, G. (1970) Fluorescence methods in the study of protein conformation. In Spectroscopic approaches to biomolecular conformation, D.W. Urry (ed.), American Medical Association, Chicago, IL, pp. 23-31.
  64. Jonas, A. and Weber, G. (1970) Partial modification of bovine serum albumin with dicarboxylic anhydrides. Physical properties of modified species. Biochemistry 9, 4729-4735.
  65. Jonas, A. and Weber, G. (1970) Limited digestion of citraconylated bovine serum albumin with a-chymotrypsin. Biochemistry 9, 5092-5099.
  66. Anderson, S.R., Brunori, M. and Weber, G. (1970) Fluorescence studies of aplysia and sperm whale apomyoglobins. Biochemistry 9, 4723-4729.
  67. Weber, G. (1970) Molecular complexes of biological interest. Proceedings of the Fourth International Congress on Pharmacology (July 14-18, 1969), Vol. III, 180-191.
  68. Weber, G. (1970) The binding of small ligands by proteins. In Hormonal Steroids. Proceedings of the Third International Congress, Hamburg, September 1970, p. 58-65.
  69. Jonas, A. and Weber, G. (1971) Presence of arginine residues at the strong, hydrophobic anion binding sites of bovine serum albumin. Biochemistry 10, 1335-1339.
  70. Jonas, A. and Weber, G. (1971) Strong binding of hydrophobic anions by bovine serum albumin peptides covalently linked to lysozyme. Biochemistry 10, 4492-4495.
  71. Weber, G. (1971) Theory of fluorescence depolarization by anisotropic Brownian rotations. J. Chem. Physics 55, 2399-2407.
  72. Shinitzky, M., Dianoux, A.C., Gitler, C., and Weber, G. (1971) Microviscosity and order in the hydrocarbon region of micelles and membranes determined with fluorescent probes. I. Synthetic micelles. Biochemistry 10, 2106-2113.
  73. Weber, G., Borris, D., DeRobertis, E., Barrantes, F.J., LaTorre, J.L. and Carlin, M.C.L. (1971) The use of a cholinergic fluorescent probe for the study of the receptor proteolipid. Molecular Pharmacology 7, 530-537.
  74. Weber, G. (1972) Ligand binding and internal equilibria in proteins. Biochemistry 11, 862.
  75. Belford, G.C., Belford, R.L. and Weber, G. (1972) Dynamics of fluorescence polarization in macromolecules. Proc. Natl. Acad. Sci. USA 69, 1392-1393.
  76. Secrist, J.A., III, Barrio, J.R., Leonard, N.J. and Weber, G. (1972) Fluorescent modifications of adenosine containing coenzymes. Biological activities and spectroscopic properties. Biochemistry 11, 3499-3506.
  77. Weber, G. (1972) Addition of chemical and osmotic free energies through negative interaction of protein bound ligands. Proc. Natl. Acad. Sci. USA 69, 3000-3003.
  78. Spencer, R.D. and Weber, G. (1972) Thermodynamics and kinetics of the intramolecular complex in flavin adenine dinucleotide. In Structure and Function of Oxidation Reduction Enzymes, A. Akeson and A. Ehrenberg (eds.), Pergamon, Oxford-New York, pp. 393-399.
  79. Weber, G. (1972) Uses of Fluorescence in biophysics: Some recent developments. Ann. Rev. Biophys. Bioeng. 1, 553-570.
  80. Rawitch, A.B. and Weber, G. (1972) The reversible association of lysozyme and thyroglobulin. J. Biol. Chem. 247, 680-685.
  81. Cogan, U., Shinitzky, M., Weber, G. and Nishida, T. (1973) Microviscosity and order in the hydrocarbon region of phospholipid and phospholipid-cholesterol dispersions determined with fluorescent probes. Biochemistry 12, 521.
  82. Hudson, E.N. and Weber, G. (1973) Synthesis and characterization of two fluorescent sulfhydryl reagents. Biochemistry 12, 4154-4161.
  83. Lakowicz, J.R. and Weber, G. (1973) Quenching of fluorescence by oxygen. A probe for structural fluctuations in macromolecules. Biochemistry 12, 4161-4170.
  84. Lakowicz, J.R. and Weber, G. (1973) Quenching of protein fluorescence by oxygen. Detection of structural fluctuations in proteins in the nanosecond time scale. Biochemistry 12, 4171-4179.
  85. Barrio, J.R., Tolman, G.L., Leonard, N.J., Spencer, R.D. and Weber, G. (1973) Flavin 1, N6-ethenoadenine dinucleotide: Dynamic and static quenching of fluorescence. Proc. Natl. Acad. Sci. USA 70, 941-943.
  86. Chien, Y. and Weber, G. (1973) Kinetic and binding effects of 1, N6-ethenoadenosine triphosphate to aspartate transcarbamylase. Biochem. Biophys. Res. Comm. 50, 538-543.
  87. Weber, G. and Lakowicz, J.R. (1973) Subnanosecond solvent relaxation studies by oxygen quenching of fluorescence. Chem. Phys. Lett. 22, 419-423.
  88. Weber, G. (1973) Polarized fluorescence. In Fluorescence Techniques in Cell Biology, A.A. Thaer and M. Sternetz (eds.), Springer-Verlag, pp. 5-13.
  89. Weber, G. (1974) Addition of chemical and osmotic energies by ligand protein interactions. Ann. N. Y. Acad. Sci. 227, 486-496.
  90. Weber, G., Tanaka, F., Okamoto, B.Y. and Drickamer, H.G. (1974) The effect of pressure on the molecular complex of isoalloxazine and adenine. Proc. Natl. Acad. Sci. USA 71, 1264-1266.
  91. Spencer, R.D., Weber, G., Tolman, G.L., Barrio, J.R. and Leonard, N.J. (1974) Species responsible for the fluorescence of 1, N6-ethenoadenosine. Eur. J. Biochem. 45, 425-429.
  92. Weber, G. (1975) Ligand interactions in globular proteins. In Protein Ligand Interactions, H. Sund (ed.), de Gruyter and Co., Berlin, pp. 16-26.
  93. Weber, G. (1975) Energetics of ligand binding to proteins. Adv. Prot. Chem. 29, 1-83.
  94. Weber, G. and Mitchell, G.W. (1975) Demonstration of anisotropic molecular rotations by differential polarized phase fluorometry. In Excited States of Biological Molecules, J.B. Birks (ed.), Wiley, pp. 72-76.
  95. Weber, G. (1975) What we have learnt about proteins from the study of their photo-excited states. In Excited States of Biological Molecules, J. B. Birks (ed.), Wiley, pp. 363-374.
  96. Kolb, D.A. and Weber, G. (1975) Cooperativity of binding of anilinonaphthalenesulfonate to serum albumin induced by a second ligand. Biochemistry 14, 4476-4481.
  97. Kolb, D.A. and Weber, G. (1975) Quantitative demonstration of the reciprocity of ligand effects in the ternary complex of chicken heart lactate dehydrogenase with nicotinamide adenine dinucleotide and oxalate. Biochemistry 14, 4471-4475.
  98. Schuldiner, S., Spencer, R.D., Weber, G., Weil, R. and Kaback, H.R. (1975) Lifetime and rotational relaxation time of dansylgalactoside bound to the LAC carrier protein. J. Biol. Chem. 250, 8893-8896.
  99. Li, T.M., Hook, J.W., III, Drickamer, H.G. and Weber, G. (1976) Effects of pressure upon the fluorescence of the riboflavin binding protein and its flavin mononucleotide complex. Biochemistry 15, 3205-3211.
  100. Jameson, D.M., Spencer, R.D. and Weber, G. (1976) Construction and performance of a scanning, photon-counting spectrofluorometer. Rev. Sci. Instrum. 47, 1034-1038.
  101. Weber, G., Helgerson, S.L., Cramer, W.A. and Mitchell, G. W. (1976) Changes in rotational motion of a cell-bound fluorophore caused by Colicin E1: A study of fluorescence polarization and differential polarized phase fluorometry. Biochemistry 15, 4429-4432.
  102. Weber, G. (1976) Practical applications and philosophy of optical spectroscopic probes. In Horizons in Biochemistry and Biophysics 2, Addison Wesley, Reading, Mass., pp. 163-198.
  103. Li, T.J., Hook, J.W., III, Drickamer, H.G. and Weber, G. (1976) Plurality of pressure-denatured forms in lysozyme and chymotrypsinogen. Biochemistry 15, 5571-5580.
  104. Valeur, B. and Weber, G. (1977) Anisotropic rotations in 1-naphthylamine. Existence of a red-edge transition moment normal to the ring plane. Chem. Phys. Lett. 45, 140-144.
  105. Weber, G. (1977) Theory of differential phase fluorometry: Detection of anisotropic molecular rotations. J. Chem. Phys. 66, 4081-4091.
  106. Mantulin, W.W. and Weber, G. (1977) Rotational anisotropy and solvent-fluorophore bonds: An investigation by differential polarized phase fluorometry. J. Chem. Phys. 66, 4092-4099.
  107. Valeur, B. and Weber, G. (1977) Resolution of the fluorescence excitation spectrum of indole into the 1La and 1Lb excitations bands. Photochem. Photobiol. 25, 441-444.
  108. Visser, A.J.W.G., Li, T.M., Drickamer, H.G. and Weber, G. (1977) Volume changes in the formation of internal complexes of flavinyltryptophan peptides. Biochemistry 16, 4883-4886.
  109. Visser, A.J.W.G., Li, T.M., Drickamer, H.G. and Weber, G. (1977) Effect of pressure upon the fluorescence of various flavodoxins. Biochemistry 16, 4879-4882.
  110. Mustacich, R.V. and Weber, G. (1978) Ligand-promoted transfer of proteins between phases: spontaneous and electrically helped. Proc. Natl. Acad. Sci. USA 75, 779-783.
  111. Jameson, D.M., Weber, G., Spencer, R.D. and Mitchell, G. (1978) Fluorescence polarization: Measurements with a photon-counting photometer. Rev. Sci. Instrum. 49, 510-514.
  112. Chryssomallis, G.S., Drickamer, H.G. and Weber, G. (1978) The measurement of fluorescence polarization at high pressure. J. Appl. Phys. 49, 3084-3987.
  113. Farris, F.J., Weber, G., Chiang, Chian C. and Paul, Iain C. (1978) Preparation, crystalline structure and optical properties of the fluorescent probe, 4-4-bis-1-phenylamino-8-naphthalene sulfonate. J. Amer. Chem. Soc. 100, 4469-4474.
  114. Valeur, B. and Weber, G. (1978) A new red-edge effect in aromatic molecules: Anomaly of apparent rotation revealed by fluorescence polarization. J. Chem. Phys. 69, 2393-2400.
  115. Weber, G. (1978) Limited rotational motion: Recognition by differential phase fluorometry. Acta Physica Polonica A54, 859-865.
  116. Weber, G. (1978) Energetic advantage of ion countertransport in chemiosmotic conversion. In Frontiers of Biological Energetics, Academic Press, Vol. 1, pp. 12-18.
  117. Weber, G. and Farris, F. J. (1979) Synthesis and spectral properties of a hydrophobic fluorescent probe: 2-dimethylamino-6-propionylnaphthalene. Biochemistry 18, 3075-3078.
  118. Torgerson, P.M., Drickamer, H.G. and Weber, G. (1979) Inclusion complexes of poly-b-cyclodextrin: A model for the effect of high pressure upon protein-ligand complexes, Biochemistry 18, 3079-3083.
  119. Mustacich, R.V. and Weber, G. (1980) Ligand-induced transfer of proteins between phases: dependence upon the strength of ion pair interactions. Biochemistry 19, 990-995.
  120. Torgerson, P.M., Drickamer, H.G. and Weber, G. (1980) Effect of hydrostatic pressure upon ethidium bromide association with transfer ribonucleic acid. Biochemistry 19, 3957-3960.
  121. Lakowicz, J.R. and Weber, G. (1980) Nanosecond segmental mobilities of tryptophan residues in proteins observed by lifetime-resolved fluorescence anisotropies. Biophys. J. 10, 591-601.
  122. Weber, G. (1980) The effects of high-pressure upon proteins and other biomolecules. In New Horizons in Biological Chemistry, T. Ozawa (ed.), JSSP, Tokyo, pp. 237-245.
  123. Paladini, A.A. and Weber, G. (1981) Absolute measurements of fluorescence polarization at high pressures. Rev. Sci. Instrum. 52, 419-427.
  124. Weber, G. (1981) Resolution of the fluorescence lifetimes in a heterogeneous system by phase and modulation measurements. J. Phys. Chem. 85, 949-953.
  125. Jameson, D.M. and Weber, G. (1981) Resolution of the pH-dependent heterogeneous fluorescence decay of tryptophan by phase and modulation measurements. J. Phys. Chem. 85, 953-958.
  126. Macgregor, R. B. and Weber, G. (1981) Fluorophores in polar media: Spectral effects of the Langevin distribution of electrostatic interactions. Annals of the N.Y. Acad. Sci. 366, 140-150.
  127. Chryssomallis, G.S., Torgerson, P.M., Drickamer, H. G. and Weber, G. (1981) Effect of hydrostatic pressure on lysozyme and chymotrypsinogen detected by fluorescence polarization. Biochemistry 20, 3955-3959.
  128. Paladini, A.A. and Weber, G. (1981) Pressure-induced reversible dissociation of enolase. Biochemistry 20, 2587-2593.
  129. Chryssomallis, P.M., Torgerson, P.M., Drickamer, H.G. and Weber, G. (1981) Effect of hydrostatic pressure on lysozyme and chymotrypsinogen detected by fluorescence polarization. Biochemistry 20, 3955-3959.
  130. Xu, G.-J. and Weber, G. (1982) Dynamics and time-averaged chemical potential of proteins: Importance in oligomer association. Proc. Natl. Acad. Sci. USA 79, 5268-5271.
  131. Kasprzak, A. and Weber, G. (1982) Fluorescence depolarization and rotational modes of tyrosine in bovine pancreatic trypsin inhibitor. Biochemistry 21, 5924-5927.
  132. Weber, G. (1982) Asymmetric ligand binding by hemoglobin. Nature 300, 603-607.
  133. Weber, G. and Drickamer, H.G. (1983) The effect of high pressure upon proteins and other biomolecules. Quart. Rev. Biophys. 16, 89-112.
  134. Weber, G. (1983) Stability of oligomeric proteins and its bearing on their association equilibria (A Reply). Proc. Natl. Acad. Sci. USA 80, 5303-5304.
  135. Weber, G. (1983) "Old and new developments in fluorescence spectroscopy." In Time-Resolved Fluorescence Spectroscopy in Biochemistry and Biology, R.B. Cundall and R.E. Dale (eds.), Plenum, pp.1-20.
  136. Younis, H. M., Weber, G. and Boyer, John S. (1983) Activity and conformational changes in chloroplast coupling factor induced by ion binding: Formation of a magnesium enzyme phosphate complex. Biochemistry 22, 2505-2512.
  137. Chong, P. L.G. and Weber, G. (1983) Pressure dependence of 1,6-diphenyl-1,3,5-hexatriene fluorescence in single-component phosphatidylcholine liposomes. Biochemistry 22, 5544-5550.
  138. Gratton, E., Jameson, D.M., Rosato, N., and Weber, G. (1984) A Multifrequency Cross-Correlation Phase Fluorometer Using Synchrotron Radiation.  Rev. Sci. Instrum. 55,486-494.
  139. Gratton, E., Jameson, D.M., Weber, G. and Alpert, B. (1984) A model for the dynamic quenching of fluorescence in globular proteins. Biophys. J. 45, 789-794.
  140. Jameson, D.M., Gratton, E., Weber, G. and Alpert, B. (1984) Oxygen distribution and migration in myoglobin (Des Fe) and hemoglobin (Des Fe). Biophys. J. 45, 795-803.
  141. Weber, G. (1984) Order of free-energy couplings between ligand binding and protein subunit association in hemoglobin. Proc. Natl. Acad. Sci. USA 81, 7098-7102.
  142. Weber, G., Scarlata, S. and Rholam, M. (1984) Thermal coefficient of the frictional resistance to rotation in simple fluorophores determined by fluorescence polarization. Biochemistry 23, 6785-6788.
  143. Scarlata, S., Rholam, M. and Weber, G. (1984) Frictional resistance to local rotations in aromatic fluorophores in some small peptides. Biochemistry 23, 6789-6792.
  144. Rholam, M. Scarlata, S. and Weber, G. (1984) Frictional resistance to the local rotations of fluorophores in proteins. Biochemistry 23, 6793-6796.
  145. Macgregor, R. B. and Weber, G. (1986) Estimation of the polarity of the protein interior by optical spectroscopy. Nature 319, 70-72.
  146. King, L. and Weber, G. (1986) Conformational drift of lactate dehydrogenase. Biophys. J. 49, 72-73.
  147. Weber, G. (1986) Phenomenological description of the association of protein subunits subjected to conformational drift. Effects of dilution and of hydrostatic pressure. Biochemistry 25, 3626-3631.
  148. King, L. and Weber, G. (1986) Conformational drift of dissociated lactate dehydrogenase. Biochemistry 25, 3632-3636.
  149. King, L. and Weber, G. (1986) Conformational drift and cryoinactivation of lactate dehydrogenase. Biochemistry 25, 3637-3640.
  150. Weber, G. (1986) "Solution spectroscopy and image spectroscopy." In Application of Fluorescence in the Biomedical Sciences (D. Lansing Taylor and others, Eds.). A. R. Liss, New York, pp. 601-615.
  151. Silva, J.L., Miles, E.W. and Weber, G. (1986) Pressure dissociation and conformational drift of the 2 subunit of tryptophan synthase. Biochemistry 25, 5781-5786.
  152. Royer, C.A., Weber, G., Daly, T.J. and Matthews, K.S. (1986) Dissociation of the lactose repressor protein tetramer by high hydrostatic pressure. Biochemistry 25, 8308-8315.
  153. Verjoski-Almeida, S., Kurtenbach, E., Amorim, A.F. and Weber, G. (1986) Pressure-induced dissociation of solubilized sarcoplasmic reticulum ATPase. J. Biol. Chem. 261, 9872-9878.
  154. Weber, G. (1987) Free energy couplings between ligand binding and subunit association in hemoglobin are of first order. Biochemistry 26, 331-332.
  155. Paladini, A.A., Silva, J.L. and Weber, G. (1987) Slab gel electrophoresis of oligomeric proteins under high hydrostatic pressure. Anal. Biochem. 161, 358-364.
  156. Weber, G. (1987) Dissociation of oligomeric proteins by hydrostatic pressure. In High Pressure Chemistry and Biochemistry, R. Van Eldik and J. Jonas (eds.), D. Riedel, Dordrecht, pp. 401-420.
  157. Morrison, L.E. and Weber, G. (1987) Biological membrane modeling with a liquid/liquid interface. Biophys. J. 52, 367-379.
  158. Weber, G. (1987) Abrupt transitions in physics and biophysics: van der Waals revisited. Proc. Natl. Acad. Sci. USA 84, 7359-7362.
  159. Ruan, K. and Weber, G. (1988) Dissociation of yeast hexokinase by hydrostatic pressure. Biochemistry 27, 3295-3301.
  160. Silva, J.L. and Weber, G. (1988) Pressure-induced dissociation of Brome Mosaic virus. J. Mol. Biol. 199, 149-159.
  161. Ruan, K. and Weber, G. (1989) Hysteresis and conformational drift of pressure-dissociated glyceraldehydephosphate dehydrogenase. Biochemistry 28, 2144-2153.
  162. Weber, G. (1989) Perrin revisited: Parametric theory of the motional depolarization of fluorescence. J. Phys. Chem. 93, 6069-6973.
  163. Weber, G. (1989) Dynamics of oligomeric proteins. J. Mol. Liquids 42, 255-268.
  164. Weber, G. (1989) From solution spectroscopy to image spectroscopy. In Cell Structure and Function by Microspectrofluorometry, Elli Kohen (Ed.), Academic Press, Inc., New York, p. 71-85.
  165. Weber, G. (1990) Whither Biophysics? Annu. Rev. Biophys. Biophys. Chem. 19, 1-6.
  166. Erijman, L. and Weber, G. (1991) Oligomeric protein associations: Transition from stochastic to deterministic equilibrium. Biochemistry 30, 1595-1599.
  167. Weber, G. (1991) Pressure and low temperature stability of oligomeric enzymes. In New Trends in Biological Chemistry, (Ozawa T., Ed.). JSSP Tokyo/Springer/ Berlin, pp. 225-238.
  168. Silva, J.L., Luan, P., Glaser, M., Voss, E.W. and Weber, G. (1992) Effects of hydrostatic pressure on a membrane-enveloped virus: High immunogenicity of the pressure-inactivated Virus. Journal of Virology 66, 2111-2117.
  169. Weber, G. (1992) Protein Interactions. Chapman and Hall, New York.
  170. Weber, G. (1991) Functional significance of the free volume inside proteins: A conjecture. In Retrospect and Prospect of Protein Research, (Li Z.-P., Lu Z.-X and Zhang Y.-S., Eds). World Scientific, Hong-Kong and London, pp. 221-225.
  171. Foguel, D., Chaloub, R.M., Silva, J.L., Crofts, A.R. and Weber, G. (1992) Pressure and low-temperature effects on the fluorescence emission spectra and lifetimes of the photosynthetic components of the cyanobacteria. Biophys. J. 63, 1613-1622.
  172. Erijman, L. and Weber, G. (1993) Use of sensitized fluorescence for the study of the exchange of subunits in protein aggregates. Photochem. Photobiol.57, 411-415.
  173. Ruan, K.-C. and Weber, G. (1993) Physical heterogeneity of muscle glycogen phosphorylase revealed by hydrostatic pressure dissociation. Biochemistry 32, 6295-6301.
  174. Erijman, L., Lorimer, G.H. and Weber, G. (1993) Reversible dissociation and conformational stability of dimeric ribulose phosphate carboxylase. Biochemistry 32, 5187-5195.
  175. Weber, G.(1993) Bioenergetics at the end of the XX century: A personal perspective. Brazilian J. Med. Biol. Res. 26, 425-437.
  176. Weber, G. (1993) Thermodynamics of the association and the pressure dissociation of oligomeric proteins. J. Phys. Chem. 97, 7108-7115.
  177. Da Paoian, A.T., Oliveira, A.C., Gaspar, L.P., Silva J.L. and Weber, G. (1993) Reversible pressure dissociation of R17 bacteriophage. The physical individuality of the virus particles. J. Mol. Biol. 231, 999-1008.
  178. Silva, J.L. and Weber, G. (1993) Pressure stability of proteins. Annu. Rev. Phys. Chem. 44, 89-113.
  179. Weber G (1993) Pressure dissociation of the smaller oligomers: Dimers and tetramers. In: High Pressure Chemistry, Biochemistry and Material Science (R. Winter and J. Jonas, Eds.). NATO ASI Ser C, Vol. 401, Kulwer, Dordrecht, pp. 471-487.
  180. Weber G (1993) Relations of bond energies and entropies with volume, pressure and temperature in protein aggregates. In: High Pressure Chemistry, Biochemistry and Material Science, (R. Winter and J. Jonas, Eds.). NATO ASI Ser C Vol 401, Kulwer, Dordrecht, pp. 489-509.
  181. Erijman, L., Paladini A.A., Lorimer, G.H. and Weber G. (1993) Plurality of protein conformations of Ribulose 1,5-bisphosphate carboxylase/oxygenase monomers probed by high pressure electrophoresis. J. Biol. Chem. 268, 25914-25919.
  182. Weber G. (1993) Thermodynamics of the association and the pressure dissociation of oligomeric proteins. J. Phys. Chem. 97, 71108-7115.
  183. Paladini, A.A., Weber, G. and Erijman, L. (1994) Analysis of dissociation and unfolding of oligomeric proteins using a flat bed gel electrophoresis at high pressure. Anal.. Biochem. 218, 364-369.
  184. Weber, G. (1995) Van't Hoff revisited: Enthalpy of association of protein subunits. J. Phys. Chem. 99, 1052-1059.
  185. Juriekwicz, E., Villas-Boas, M., Silva, J.L., Weber, G., Hunsmann, G., and Clegg, R.M. (1995) Inactivation of simian immunodeficiency virus by hydrostatic pressure. Proc. Natl. Acad. Sci. USA 92, 6935-6937.
  186. Foguel D. and Weber G. (1995) Pressure-induced dissociation and denaturation of allophycocyanin at subzero temperatures. J.Biol.Chem. 270, 28759-28766.
  187. Gratton, E., Mantulin, W.W., Weber, G., Royer, C.A., Jameson, D.M., Reininger, R. and Hansen, R.W.C. (1996) Fluorescence Dynamics of Biological Systems Using Synchrotron Radiation  Rev. Sci. Instrum. 67,1-7. "
  188. Weber G., Da Poian A. and Silva J.L.(1996) Concentration dependence of the subunit association of oligomers and viruses and the modification of the latter by urea binding. Biophys J. 70, 167-173.
  189. Ehrhardt, M.R., Erijman, L., Weber, G. And Wand, A.J. (1996) Molecular recognition by calmodulin: pressure-induced reorganization of a novel calmodulin-peptide complex. Biochemistry 35, 1599-1605.
  190. Weber, G. (1996) Persistent confusion of total entropy and chemical system entropy in chemical thermodynamics. Proc Natl Acad Sci U S A. 93, 7452-7453.
  191. Weber, G. (1997) Fluorescence in biophysics: accomplishments and deficiencies. Methods Enzymol. 278, 1-15.
  192. Weber, G. (1998) Fluorescence, bifurcations, protein folding and the second law of thermodynamics. Comm. Mol. Cell. Biophys. 9, 167-177.
  193. Weber, G. (1998) Thermodynamic concepts in protein condensation. Comm. Mol. Cell. Biophys. 9. 201-218.

Gregorio Weber - A Fluorescent Lifetime