Laboratory for Fluorescence Dynamics

A national research center for biomedical fluorescence spectroscopy at the University of California, Irvine

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The Laboratory for Fluorescence Dynamics' (LFD) database of publications contains more than 2400 journal articles, book chapters, conference proceedings, abstracts, patents, and theses by members of the LFD, and also selected publications of interest to the fluorescence community.
Electronic documents are not available publicly due to copyright restrictions. Reprints can be requested from the authors.

Recent LFD Publications

2023

  1. Sohrabi A, Lefebvre AEYT, Harrison MJ, Condro MC, Sanazzaro TM, Safarians G, Solomon I, Bastola S, Kordbacheh S, Toh N, Kornblum HI, Digman MA, Seidlits SK.
    Microenvironmental stiffness induces metabolic reprogramming in glioblastoma.
    Cell Rep. 2023; 42(10), 113175.
  2. Kettmayer C, Gratton E, Estrada LC.
    Comparison of MSD analysis from single particle tracking with MSD from images. Getting the best of both worlds.
    Methods Appl Fluoresc. 2023; 12(1), 015001.
  3. Philipp N, Gratton E, Estrada L.
    Measuring protein-membrane interaction through radial fluorescence correlation in 2 dimension.
    Methods Appl Fluoresc. 2023; Online ahead of print.
  4. Tharp K, Park S, Timblin G, Richards A, Twells N, Riley N, Peltan E, Shon J, Stevenson E, Tsui K, Palomba F, Lefebvre A, Soens R, Ayad, N, Hoeve-Scott JT, Healy K, Digman M, Dillin A, Bertozzi C, Swaney D, Mahal L, Cantor J, Paszek M, Weaver VM, Twells N.
    The microenvironment dictates glycocalyx construction and immune surveillance.
    Res Sq. 2023; Preprint. PMCID: PMC10462183
  5. Agustinus AS, Al-Rawi D, Dameracharla B, Raviram R, Jones BSCL, Stransky S, Scipioni L, Luebeck J, di Bona M, Norkunaite D, Myers RM, Duran M, Choi S, Weigelt B, Yomtoubian S, McPherson A, Toufektchan E, Keuper K, Mischel PS, Mittal V, Shah SP, Maciejowski J, Storchova Z, Gratton E, Ly P, Landau D, Bakhoum MF, Koche RP, Sidoli S, Bafna V, David Y, Bakhoum SF.
    Epigenetic dysregulation from chromosomal transit in micronuclei.
    Nature. 2023; 619(7968): 176-183. PMCID: PMC10322720
  6. Fazel M, Vallmitjana A, Scipioni L, Gratton E, Digman MA, Pressé S.
    Fluorescence lifetime: Beating the IRF and interpulse window.
    Biophys J. 2023; 122(4): 672-683. PMCID: PMC9989884
  7. Lopez KL, Palomba F, Digman MA.
    Fluorescent single particle tracking enables high sensitivity viscometry measurements of micro-volume samples.
    67th Annual Meeting of the Biophysical Society. San Diego, California. February 18-22.
    Biophys J. 2023; 122(3, Suppl 1): 140a, 683-Pos.
  8. Tedeschi G, Zhu S, Aleghe G, Aleman E, Finch T, Ly C, Morenkov P, Scipioni L, Digman MA, Gratton E.
    Investigation of breast cancer metabolic plasticity in the tumor microenvironment by single-cell organelle phenotyping.
    67th Annual Meeting of the Biophysical Society. San Diego, California. February 18-22.
    Biophys J. 2023; 122(3, Suppl 1): 132a, 642-Pos.
  9. Zhu S, Digman MA, Thompson J, Campos-Chillon F.
    IVF bovine oocyte classification and selection.
    67th Annual Meeting of the Biophysical Society. San Diego, California. February 18-22.
    Biophys J. 2023; 122(3, Suppl 1): 415a, 2017-Pos.
  10. Huang Y, Zhuang M, Digman MA.
    Metabolic profiling of transferred mitochondria using FLIM intensity based image segmentation (FIBIS).
    67th Annual Meeting of the Biophysical Society. San Diego, California. February 18-22.
    Biophys J. 2023; 122(3, Suppl 1): 129a, 626-Pos.
  11. Torrado B, Vallmitjana A, Dvornikov A, Gratton E.
    Simultaneous FLIM, harmonic generation and hyperspectral imaging using a 4-channel detector.
    67th Annual Meeting of the Biophysical Society. San Diego, California. February 18-22.
    Biophys J. 2023; 122(3, Suppl 1): 129a, 1358-Pos.
  12. Scipioni L, Tedeschi G, Atwood S, Digman MA, Gratton E.
    Spatiotemporal single-cell phenotyping in living 3D skin organoids.
    67th Annual Meeting of the Biophysical Society. San Diego, California. February 18-22.
    Biophys J. 2023; 122(3, Suppl 1): 129a, 628-Pos.

2022

  1. Fang T, Huang YK, Wei J, Mena JEM, Lakey PSJ, Kleinman MT, Digman MA, Shiraiwa M.
    Superoxide release by macrophages through NADPH oxidase activation dominating chemistry by isoprene secondary organic aerosols and quinones to cause oxidative damage on membranes.
    Environ Sci Technol. 2022; 56(23): 17029-17038. PMCID: PMC9730850
  2. Halbrook CJ, Thurston G, Boyer S, Anaraki C, Jiménez JA, McCarthy A, Steele NG, Kerk SA, Hong HS, Lin L, Law FV, Felton C, Scipioni L, Sajjakulnukit P, Andren A, Beutel AK, Singh R, Nelson BS, van Bergh FD, Krall AS, Mullen PJ, Zhang L, Batra S, Morton JP, Stanger BZ, Christofk HR, Digman MA, Beard DA, Viale A, Zhang J, Crawford HC, di Magliano MP, Jorgensen C, Lyssiotis CA.
    Differential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic adenocarcinoma cells.
    Nat Cancer. 2022; 3(11): 1386-1403. PMCID: PMC9701142
  3. Wang XX, Xie C, Libby AE, Ranjit S, Levi J, Myakala K, Bhasin K, Jones BA, Orlicky DJ, Takahashi S, Dvornikov A, Kleiner DE, Hewitt SM, Adorini L, Kopp JB, Krausz KW, Rosenberg A, McManaman JL, Robertson CE, Ir D, Frank DN, Luo Y, Gonzalez FJ, Gratton E, Levi M.
    The role of FXR and TGR5 in reversing and preventing progression of Western diet-induced hepatic steatosis, inflammation, and fibrosis in mice.
    J Biol Chem. 2022; 298(11), 102530. PMCID: PMC9638804
  4. Benítez-Mata B, Palomba F, Tan Z, Thompson L, Digman M.
    Changes in membrane fluidity of the expanded mutant Huntingtin protein with the Phasor-FLIM approach signatures of Laurdan.
    XLV Mexican Conference on Biomedical Engineering. Puerto Vallarta, México. October 6-8, 2022.
    XLV Mexican Conference on Biomedical Engineering. CNIB 2022 (IFMBE Proceedings, Vol. 86). Springer, Cham, pp. 403-413, 2023. ISBN: 9783031182556
  5. Rahim MK, Zhao J, Patel HV, Lagouros HA, Kota R, Fernandez I, Gratton E, Haun JB.
    Phasor analysis of fluorescence lifetime enables quantitative multiplexed molecular imaging of three probes.
    Anal Chem. 2022; 94(41): 14185-14194.
  6. Guaglianone G, Torrado B, Lin YF, Watkins MC, Wysocki VH, Gratton E, Nowick JS.
    Elucidating the oligomerization and cellular interactions of a trimer derived from Aβ through fluorescence and mass spectrometric studies.
    ACS Chem Neurosci. 2022; 13(16): 2473-2482. PMCID: PMC9389591
  7. Chun SK, Fortin BM, Fellows RC, Habowski AN, Verlande A, Song WA, Mahieu AL, Lefebvre AEYT, Sterrenberg JN, Velez LM, Digman MA, Edwards RA, Pannunzio NR, Seldin MM, Waterman ML, Masri S.
    Disruption of the circadian clock drives Apc loss of heterozygosity to accelerate colorectal cancer.
    Sci Adv. 2022; 8(32), eabo2389. PMCID: PMC9365282
  8. Sallaberry I, Luszczak A, Philipp N, Navarro GSC, Gabriel MV, Gratton E, Gamarnik AV, Estrada LC.
    Author Correction: In vivo pair correlation microscopy reveals dengue virus capsid protein nucleocytoplasmic bidirectional movement in mammalian infected cells.
    Sci Rep. 2022; 12(1): 11343. PMCID: PMC9256625
  9. Yao Z, Brennan CK, Scipioni L, Chen H, Ng KK, Tedeschi G, Parag-Sharma K, Amelio AL, Gratton E, Digman MA, Prescher JA.
    Multiplexed bioluminescence microscopy via phasor analysis.
    Nat Methods. 2022; 19(7): 893-898.
  10. Tentori P, Signore G, Camposeo A, Carretta A, Ferri G, Pingue P, Luin S, Pozzi D, Gratton E, Beltram F, Caracciolo G, Cardarelli F.
    Fluorescence lifetime microscopy unveils the supramolecular organization of liposomal Doxorubicin.
    Nanoscale. 2022; 14(25): 8901-8905.
  11. Solano A, Lou J, Scipioni L, Gratton E, Hinde E.
    Radial pair correlation of molecular brightness fluctuations maps protein diffusion as a function of oligomeric state within live cell nuclear architecture.
    Biophys J. 2022; 121(11): 2152-2167.
  12. Morris MA, Vallmitjana A, Grein F, Schneider T, Arts M, Jones CR, Nguyen BT, Hashemian MH, Malek M, Gratton E, Nowick JS.
    Visualizing the mode of action and supramolecular assembly of teixobactin analogues in Bacillus subtilis.
    Chem Sci. 2022; 13(26): 7747-7754. PMCID: PMC9258396
  13. Fazel M, Jazani S, Scipioni L, Vallmitjana A, Gratton E, Digman MA, Pressé S.
    High resolution fluorescence lifetime maps from minimal photon counts.
    ACS Photonics. 2022; 9(3): 1015-1025. PMCID: PMC9278809
  14. Vorontsova I, Vallmitjana A, Torrado B, Schilling TF, Hall JE, Gratton E, Malacrida L.
    In vivo macromolecular crowding is differentially modulated by aquaporin 0 in zebrafish lens: Insights from a nanoenvironment sensor and spectral imaging.
    Sci Adv. 2022; 8(7). PMCID: PMC8849302
  15. Torrado B, Malacrida L, Ranjit S.
    Linear combination properties of the phasor space in fluorescence imaging.
    Sensors. 2022; 22(3), 999. PMCID: PMC8840623
  16. Solano AN, Lou J, Scipioni L, Gratton E, Hinde E.
    Brightness correlation spectroscopy tracks transcription factor diffusion as a function of oligomeric state within live cell nuclear architecture.
    66th Annual Meeting of the Biophysical Society. San Francisco, California. February 19-23.
    Biophys J. 2022; 121(3, Suppl 1): 302a, 1460-Plat.
  17. Fazel M, Jazani S, LorenzoScipioni, Vallmitjana A, Gratton E, Digman MA, Pressé S.
    High resolution fluorescence lifetime maps from minimal photon counts.
    66th Annual Meeting of the Biophysical Society. San Francisco, California. February 19-23.
    Biophys J. 2022; 121(3, Suppl 1): 141a, 688-Pos.
  18. Torrado B, Dvornikov A, Gratton E.
    Using multi-channel detector for simultaneous hyperspectral and flim imaging in strongly scattering media.
    66th Annual Meeting of the Biophysical Society. San Francisco, California. February 19-23.
    Biophys J. 2022; 121(3, Suppl 1): 277a, 1342-Pos.
  19. Gratton E.
    Using phasors.
    66th Annual Meeting of the Biophysical Society. San Francisco, California. February 19-23.
    Biophys J. 2022; 121(3, Suppl 1): 411a, 1989-Pos.
  20. Hinde E, Lou J, Liang Z, Solano A, Scipioni L, Gratton E.
    The phasor approach to histone FLIM-FRET microscopy maps nuclear wide heterochromatin structure at the level of nucleosome proximity in a living cell.
    66th Annual Meeting of the Biophysical Society. San Francisco, California. February 19-23.
    Biophys J. 2022; 121(3, Suppl 1): 412a, 1997-Pos.