Laboratory for Fluorescence Dynamics

A national research center for biomedical fluorescence spectroscopy at the University of California, Irvine

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The Laboratory for Fluorescence Dynamics' (LFD) database of publications contains more than 2400 journal articles, book chapters, conference proceedings, abstracts, patents, and theses by members of the LFD, and also selected publications of interest to the fluorescence community.
Electronic documents are not available publicly due to copyright restrictions. Reprints can be requested from the authors.

Recent LFD Publications

2022

  1. Yao Z, Brennan CK, Scipioni L, Chen H, Ng KK, Tedeschi G, Parag-Sharma K, Amelio AL, Gratton E, Digman MA, Prescher JA.
    Multiplexed bioluminescence microscopy via phasor analysis.
    Nat Methods. 2022; Online ahead of print.
  2. Tentori P, Signore G, Camposeo A, Carretta A, Ferri G, Pingue P, Luin S, Pozzi D, Gratton E, Beltram F, Caracciolo G, Cardarelli F.
    Fluorescence lifetime microscopy unveils the supramolecular organization of liposomal Doxorubicin.
    Nanoscale. 2022; Online ahead of print.
  3. Solano A, Lou J, Scipioni L, Gratton E, Hinde E.
    Radial pair correlation of molecular brightness fluctuations maps protein diffusion as a function of oligomeric state within live cell nuclear architecture.
    Biophys J. 2022; 121(11): 2152-2167.
  4. Fazel M, Jazani S, Scipioni L, Vallmitjana A, Gratton E, Digman MA, Pressé S.
    High resolution fluorescence lifetime maps from minimal photon counts.
    ACS Photonics. 2022; 2(3): 1015-1025.
  5. Vorontsova I, Vallmitjana A, Torrado B, Schilling TF, Hall JE, Gratton E, Malacrida L.
    In vivo macromolecular crowding is differentially modulated by aquaporin 0 in zebrafish lens: Insights from a nanoenvironment sensor and spectral imaging.
    Sci Adv. 2022; 8(7). PMCID: PMC8849302
  6. Torrado B, Malacrida L, Ranjit S.
    Linear combination properties of the phasor space in fluorescence imaging.
    Sensors. 2022; 22(3): 999. PMCID: PMC8840623
  7. Solano AN, Lou J, Scipioni L, Gratton E, Hinde E.
    Brightness correlation spectroscopy tracks transcription factor diffusion as a function of oligomeric state within live cell nuclear architecture.
    66th Annual Meeting of the Biophysical Society. San Francisco, California. February 19-23.
    Biophys J. 2022; 121(3, Suppl 1): 302a, 1460-Plat.
  8. Fazel M, Jazani S, LorenzoScipioni, Vallmitjana A, Gratton E, Digman MA, Pressé S.
    High resolution fluorescence lifetime maps from minimal photon counts.
    66th Annual Meeting of the Biophysical Society. San Francisco, California. February 19-23.
    Biophys J. 2022; 121(3, Suppl 1): 141a, 688-Pos.
  9. Torrado B, Dvornikov A, Gratton E.
    Using multi-channel detector for simultaneous hyperspectral and flim imaging in strongly scattering media.
    66th Annual Meeting of the Biophysical Society. San Francisco, California. February 19-23.
    Biophys J. 2022; 121(3, Suppl 1): 277a, 1342-Pos.
  10. Gratton E.
    Using phasors.
    66th Annual Meeting of the Biophysical Society. San Francisco, California. February 19-23.
    Biophys J. 2022; 121(3, Suppl 1): 411a, 1989-Pos.
  11. Hinde E, Lou J, Liang Z, Solano A, Scipioni L, Gratton E.
    The phasor approach to histone FLIM-FRET microscopy maps nuclear wide heterochromatin structure at the level of nucleosome proximity in a living cell.
    66th Annual Meeting of the Biophysical Society. San Francisco, California. February 19-23.
    Biophys J. 2022; 121(3, Suppl 1): 412a, 1997-Pos.
  12. Vallmitjana A, Vu TM, Gu J, La K, Flores J, Hedde PN, Zhao W, Gratton E.
    Spectral and lifetime multiplexing with combinatorial labeling.
    66th Annual Meeting of the Biophysical Society. San Francisco, California. February 19-23.
    Biophys J. 2022; 121(3, Suppl 1): 139a, 681-Pos.
  13. Scipioni L, Rossetta A, Tedeschi G, Anderson AJ, Gratton E.
    Phasor S-FLIM for the physiological profiling of living cells.
    66th Annual Meeting of the Biophysical Society. San Francisco, California. February 19-23.
    Biophys J. 2022; 121(3, Suppl 1): 411a, 1990-Pos.
  14. Jones B, Torrado B, Rosenberg A, Gratton E, Levi M, Ranjit S.
    Determination of cardiac fibrosis using picrosirius red fluorescence.
    66th Annual Meeting of the Biophysical Society. San Francisco, California. February 19-23.
    Biophys J. 2022; 121(3, Suppl 1): 279a, 1349-Pos.
  15. Palomba F, Scipioni L, Truong T, Stukenberg TP, Jiang H, Gratton E, Digman MA.
    Fluorescence methods for the biophysical characterization of protein phase separated condensates.
    66th Annual Meeting of the Biophysical Society. San Francisco, California. February 19-23.
    Biophys J. 2022; 121(3, Suppl 1): 280a, 1353-Pos.
  16. Zaccheo K, Benítez-Mata AB, Digman MA, Barbee KA.
    Investigating the effects of alcohols and cholesterol manipulations on bovine aortic endothelial cell membrane properties using phasor analysis of laurdan fluorescence lifetime microscopy and spectral imaging.
    66th Annual Meeting of the Biophysical Society. San Francisco, California. February 19-23.
    Biophys J. 2022; 121(3, Suppl 1): 366a, 1777-Pos.
  17. Benítez-Mata AB, Palomba F, Scipioni L, Digman MA.
    Analysis of membrane fluidity disturbances by mutant huntingtin in different membranal compartments using phasor analysis of local ICS and spectral phasor analysis.
    66th Annual Meeting of the Biophysical Society. San Francisco, California. February 19-23.
    Biophys J. 2022; 121(3, Suppl 1): 138a, 676-Pos.
  18. Huang Y, Fang T, Wei J, Mena JEM, Lakey PSJ, Kleinman MT, Shiraiwa M, Digman MA.
    Phasor approach FLIM as an indicator for NADPH oxidase during exposure to secondary organic aerosols.
    66th Annual Meeting of the Biophysical Society. San Francisco, California. February 19-23.
    Biophys J. 2022; 121(3, Suppl 1): 415a, 2012-Pos.
  19. Tedeschi G, Scipioni L, Palomba F, Digman MA.
    Multiparametric fluorescence imaging approaches to investigate metabolic signature, lipid droplets, and collagen remodeling in breast cancer spheroids.
    66th Annual Meeting of the Biophysical Society. San Francisco, California. February 19-23.
    Biophys J. 2022; 121(3, Suppl 1): 409a, 1980-Pos.
  20. Zhu S, Scipioni L, Digman MA.
    Phasor unmixing to reveal organelle organization and cellular response.
    66th Annual Meeting of the Biophysical Society. San Francisco, California. February 19-23.
    Biophys J. 2022; 121(3, Suppl 1): 278a, 1346-Pos.
  21. Lopez KL, Tedeschi G, Palomba F, Digman MA.
    Metabolic fingerprinting of HUVEC cells during phenotypic shifts using fluorescence lifetime image microscopy (FLIM).
    66th Annual Meeting of the Biophysical Society. San Francisco, California. February 19-23.
    Biophys J. 2022; 121(3, Suppl 1): 404a, 1954-Pos.
  22. Brennan CK, Yao Z, Scipioni L, Chen H, Ng K, Tedeschi G, Digman MA, Prescher JA.
    Multiplexed bioluminescence microscopy via phasor analysis.
    66th Annual Meeting of the Biophysical Society. San Francisco, California. February 19-23.
    Biophys J. 2022; 121(3, Suppl 1): 142a, 695-Pos.
  23. Palomba F, Digman MA, Luo X, Lee A.
    NADH autofluorescence phasor FLIM for the metabolic characterization of T cell and leukemia cell in a droplet.
    66th Annual Meeting of the Biophysical Society. San Francisco, California. February 19-23.
    Biophys J. 2022; 121(3, Suppl 1): 359a, 1733-Pos.
  24. Digman MA.
    Metabolic imaging using the phasor approach to FLIM and tracking phenotypic change of mitochondria in cancer cells with Mitometer.
    Single Molecule Spectroscopy and Superresolution Imaging XV. San Francisco, California. January 22-27, 2022.
  25. Vu T, Vallmitjana A, Gu J, La K, Xu Q, Flores J, Zimak J, Shiu J, Hosohama L, Wu J, Douglas C, Waterman ML, Ganesan A, Hedde PN, Gratton E, Zhao W.
    Spatial transcriptomics using combinatorial fluorescence spectral and lifetime encoding, imaging and analysis.
    Nat Commun. 2022; 13(1), 169. PMCID: PMC8748653

2021

  1. Sallaberry I, Luszczak A, Philipp N, Navarro GSC, Gabriel MV, Gratton E, Gamarnik AV, Estrada LC.
    In vivo pair correlation microscopy reveals dengue virus capsid protein nucleocytoplasmic bidirectional movement in mammalian infected cells.
    Sci Rep. 2021; 11(1), 24415. PMCID: PMC8709865
  2. Ma D, Hernandez GA, Lefebvre AEYT, Alshetaiwi H, Blake K, Dave KR, Rauf M, Williams JW, Davis RT, Evans KT, Longworth A, Masoud MYG, Lee R, Edwards RA, Digman MA, Kessenbrock K, Lawson DA.
    Patient-derived xenograft culture-transplant system for investigation of human breast cancer metastasis.
    Commun Biol. 2021; 4(1): 1268. PMCID: PMC8571269
  3. Gabriel MV, Sallaberry I, Navarro GSC, Gratton E, Gamarnik AV, Estrada LC.
    Dengue virus capsid-protein dynamics in live infected cells studied by pair correlation analysis.
    Dengue Virus (Methods in Molecular Biology, Vol. 2409). By R Mohana-Borges (Editors). Humana, New York, NY, pp. 99-117, 2022.
  4. Nicolai E, Pieri M, Gratton E, Motolese G, Bernardini S.
    Bacterial infection diagnosis and antibiotic prescription in 3 h as an answer to antibiotic resistance: the case of urinary tract infections.
    Antibiotics (Basel). 2021; 10(10): 1168. PMCID: PMC8532666
  5. Shi B, Li W, Song Y, Wang Z, Ju R, Ulman A, Hu J, Palomba F, Zhao Y, Le JP, Jarrard W, Dimoff D, Digman MA, Gratton E, Zang C, Jiang H.
    UTX condensation underlies its tumour-suppressive activity.
    Nature. 2021; 597(7878): 726-731. PMCID: PMC9008583
  6. Lefebvre AEYT.
    The phenotypic investigation of mitochondria in cancer.
    PhD in Biomedical Engineering, University of California, Irvine, 2021.
    Advisor: Digman, Michelle
  7. Lefebvre AEYT, Ma D, Kessenbrock K, Lawson DA, Digman MA.
    Automated segmentation and tracking of mitochondria in live-cell time-lapse images.
    Nat Methods. 2021; 18(9): 1091-1102.