Laboratory for Fluorescence Dynamics

A NIH research center for biomedical fluorescence spectroscopy at the University of California, Irvine

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The Laboratory for Fluorescence Dynamics' (LFD) database of publications contains more than 2200 journal articles, book chapters, conference proceedings, abstracts, patents, and theses by members of the LFD, and also selected publications of interest to the fluorescence community.
Electronic documents are not available publicly due to copyright restrictions. Reprints can be requested from the authors.

Recent LFD Publications

2019

  1. Hedde PN, Abram T, Vu T, Zhao W, Gratton E.
    Fluorescence lifetime detection with particle counting devices.
    Biomed Opt Express. 2019; 10(3): 1223-1233.
  2. Ou CY, Vu T, Grunwald JT, Toledano M, Zimak J, Toosky M, Shen B, Zell JA, Gratton E, Abram TJ, Zhao W.
    An ultrasensitive test for profiling circulating tumor DNA using integrated comprehensive droplet digital detection.
    Lab Chip. 2019; [Epub ahead of print].
  3. Begarani F, D'Autilia F, Signore G, Grosso AD, Cecchini M, Gratton E, Beltram F, Cardarelli F.
    Capturing metabolism-dependent solvent dynamics in the lumen of a trafficking lysosome.
    ACS Nano. 2019; [Epub ahead of print].
  4. Levi M, Gratton E.
    Visualizing the regulation of SLC34 proteins at the apical membrane.
    Pflugers Arch. 2019; [Epub ahead of print].

2018

  1. Scipioni L, Lanzanò L, Diaspro A, Gratton E.
    Comprehensive correlation analysis for super-resolution dynamic fingerprinting of cellular compartments using the Zeiss Airyscan detector.
    Nat Commun. 2018; 9(1), 5120. PMCID: PMC6269422
  2. Malacrida L, Gratton E.
    LAURDAN fluorescence and phasor plots reveal the effects of a H2O2 bolus in NIH-3T3 fibroblast membranes dynamics and hydration.
    Free Radic Biol Med. 2018; 128: 144-156. PMCID: PMC6175669
  3. Chen H, Ma N, Kagawa K, Kawahito S, Digman M, Gratton E.
    Widefield multi-frequency fluorescence lifetime imaging using a two-tap CMOS camera with lateral electric field charge modulators.
    J Biophotonics. 2018; [Epub ahead of print], e201800223.
  4. Ranjit S, Malacrida L, Gratton E.
    Differences between FLIM phasor analyses for data collected with the Becker and Hickl SPC830 card and with the FLIMbox card.
    Microsc Res Tech. 2018; 81(9): 980-989. PMCID: PMC6240382
  5. Ranjit S, Malacrida L, Jameson DM, Gratton E.
    Fit-free analysis of fluorescence lifetime imaging data using the phasor approach.
    Nat. Protoc. 2018; 13(9): 1979-2004.
  6. Hellenkamp B, Schmid S, Doroshenko O, Opanasyuk O, Kühnemuth R, Adariani SR, Ambrose B, Aznauryan M, Barth A, Birkedal V, Bowen ME, Chen H, Cordes T, Eilert T, Fijen C, Gebhardt C, Götz M, Gouridis G, Gratton E, Ha T, Hao P, Hanke CA, Hartmann A, Hendrix J, Hildebrandt LL, Hirschfeld V, Hohlbein J, Hua B, Hübner CG, Kallis E, Kapanidis AN, Kim JY, Krainer G, Lamb DC, Lee NK, Lemke EA, Levesque B, Levitus M, McCann JJ, Naredi-Rainer N, Nettels D, Ngo T, Qiu R, Robb NC, Röcker C, Sanabria H, Schlierf M, Schröder T, Schuler B, Seidel H, Streit L, Thurn J, Tinnefeld P, Tyagi S, Vandenberk N, Vera AM, Weninger KR, Wünsch B, Yanez-Orozco IS, Michaelis J, Seidel CAM, Craggs TD, Hugel T.
    Precision and accuracy of single-molecule FRET measurements-a multi-laboratory benchmark study.
    Nat Methods. 2018; 15(9): 669-676. PMCID: PMC6121742
  7. Pedrote MM, de Oliveira GAP, Felix AL, Mota MF, de Marques MA, Soares IN, Iqbal A, Norberto DR, Gomes AMO, Gratton E, Cino EA, Silva JL.
    Aggregation-primed molten globule conformers of the p53 core domain provide potential tools for studying p53C aggregation in cancer.
    J Biol Chem. 2018; 293(29): 11374-11387. PMCID: PMC6065177
  8. Murata MM.
    Analyses of the cellular signaling responses to DNA damage and DNA repair factor recruitment using fluorescence lifetimes and fluctuations.
    PhD in Biomedical Engineering, University of California, Irvine, 2018.
    Advisor: Michelle A Digman
  9. Dvornikov A, Gratton E.
    Hyperspectral imaging in highly scattering media by the spectral phasor approach using two filters.
    Biomed Opt Express. 2018; 9(8): 3503-3511. PMCID: PMC6191637
  10. Kim SM, Nguyen TT, Ravi A, Kubiniok P, Finicle BT, Jayashankar V, Malacrida L, Hou J, Robertson J, Gao D, Chernoff J, Digman MA, Potma EO, Tromberg BJ, Thibault P, Edinger AL.
    PTEN deficiency and AMPK activation promote nutrient scavenging and anabolism in prostate cancer cells.
    Cancer Discov. 2018; 8(7): 866-883. PMCID: PMC6030497
  11. Hadraba D, Lopot F, Paesen R, Ameloot M, Jelen K, Digman MA.
    Mechanical testing of connective tissue from nano to macro.
    19th Annual UC Systemwide Bioengineering Symposium. Riverside, CA. June 21-23, 2018.
    UCR BIEN Symposium Complete ABSTRACT Book. 2018; 1: 108.
  12. Trinh AL, Chen H, Chen Y, Hu Y, Li Z, Siegel ER, Linskey ME, Wang PH, Zhou YH, Digman MA.
    Distinguishing stem-like tumor-initiating cells in malignant glioma by phasor fluorescence lifetime imaging.
    19th Annual UC Systemwide Bioengineering Symposium. Riverside, CA. June 21-23, 2018.
    UCR BIEN Symposium Complete ABSTRACT Book. 2018; 1: 113.
  13. Rahim MK, Gratton E, Haun JB.
    Transforming FLIM into a high-content molecular analysis platform.
    19th Annual UC Systemwide Bioengineering Symposium. Riverside, CA. June 21-23, 2018.
    UCR BIEN Symposium Complete ABSTRACT Book. 2018; 1: 69.
  14. Mah EJ.
    Nanoscale changes for macroscale results: modulation of cancer metabolism and adhesion by the substrate.
    PhD in Chemical and Biochemical Engineering, University of California, Irvine, 2018.
    Advisor: Michelle A Digman
  15. Davey RJ, Digman MA, Gratton E, Moens PDJ.
    Quantitative image mean squared displacement (iMSD) analysis of the dynamics of Profilin 1 at the membrane of live cells.
    Methods. 2018; 140-141: 119-125. PMCID: PMC5995621
  16. Malacrida L, Rao E, Gratton E.
    Comparison between iMSD and 2D-pCF analysis for molecular motion studies on in vivo cells: the case of the epidermal growth factor receptor.
    Methods. 2018; 140-141: 74-84. PMCID: PMC5999564
  17. Lee DH, Li X, Ma N, Digman MA, Lee AP.
    Rapid and label-free identification of single leukemia cells from blood in a high-density microfluidic trapping array by fluorescence lifetime imaging microscopy.
    Lab Chip. 2018; 18(9): 1349-1358.
  18. Sameni S.
    Multiphoton imaging and phasor approach to identify new biomarkers in Huntington Disease.
    PhD in Biomedical Engineering, University of California, Irvine, 2018.
    Advisor: Michelle A Digman
  19. Gratton E.
    Spectroscopic signatures of cells metabolism and extracellular species using phasor-FLIM (Conference Presentation).
    BiOS 2018. Part of SPIE Photonics West. San Francisco, California, January 27 - February 1, 2018.
    Multiphoton Microscopy in the Biomedical Sciences XVIII (Vol. 10498). 1049803, 2018.
  20. Kobylkevich BM, Sarkar A, Carlberg BR, Huang L, Ranjit S, Graham DM, Messerli MA.
    Reversing the direction of galvanotaxis with controlled increases in boundary layer viscosity.
    Phys Biol. 2018; 15(3): 036005. PMCID: PMC5970543
  21. Staaf E, Hedde PN, Singh SB, Piguet J, Gratton E, Johansson S.
    Educated natural killer cells show dynamic movement of the activating receptor NKp46 and confinement of the inhibitory receptor Ly49A.
    Sci Signal. 2018; 11(517), eaai9200. PMCID: PMC5925740
  22. Leemans SW, Dvornikov A, Gratton E.
    Adaptive optics in deep tissue microscopy.
    62nd Annual Meeting of the Biophysical Society. San Francisco, California. February 17–21, 2018.
    Biophys J. 2018; 114(3, Suppl 1): 533a, 2638-Pos.
  23. Scipioni L, Diaspro A, Lanzanò L, Gratton E.
    AiryScan comprehensive superresolution correlation analysis.
    62nd Annual Meeting of the Biophysical Society. San Francisco, California. February 17–21, 2018.
    Biophys J. 2018; 114(3, Suppl 1): 533a, 2641-Pos.
  24. Malacrida LS, Hedde PN, Ranjit S, Cardarelli F, Gratton E.
    Elucidating invisible barriers and obstacles to molecular diffusion in live cells by the spatial pair-correlation function: a connectivity view of the cell.
    62nd Annual Meeting of the Biophysical Society. San Francisco, California. February 17–21, 2018.
    Biophys J. 2018; 114(3, Suppl 1): 166a, 835-Pos.
  25. Torrado B, Malacrida L, Badano JL, Irigoín F, Gratton E.
    Intracellular transport characterization of the transcription factor Gli2 by fluorescence correlation spectroscopy approaches.
    62nd Annual Meeting of the Biophysical Society. San Francisco, California. February 17–21, 2018.
    Biophys J. 2018; 114(3, Suppl 1): 630a, 3123-Pos.
  26. Ranjit S, Dvornikov A, Levi M, Gratton E.
    Multicomponent analysis of phasor plot to decipher changes in metabolic trajectory of biological systems.
    62nd Annual Meeting of the Biophysical Society. San Francisco, California. February 17–21, 2018.
    Biophys J. 2018; 114(3, Suppl 1): 167a, 843-Pos.
  27. Digman MA, Palomba F, Kong X, Yokomori K, Gratton E.
    Pair correlation analysis of Ku dynamics upon DNA damage.
    62nd Annual Meeting of the Biophysical Society. San Francisco, California. February 17–21, 2018.
    Biophys J. 2018; 114(3, Suppl 1): 351a, 1740-Pos.
  28. Hedde PN, Malacrida L, Ahrar S, Siryaporn A, Gratton E.
    SideSPIM - a flexible multipurpose platform for light sheet microscopy.
    62nd Annual Meeting of the Biophysical Society. San Francisco, California. February 17–21, 2018.
    Biophys J. 2018; 114(3, Suppl 1): 187a, 945-Plat.