Laboratory for Fluorescence Dynamics

A NIH research center for biomedical fluorescence spectroscopy at the University of California, Irvine

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The Laboratory for Fluorescence Dynamics' (LFD) database of publications contains more than 2200 journal articles, book chapters, conference proceedings, abstracts, patents, and theses by members of the LFD, and also selected publications of interest to the fluorescence community.
Electronic documents are not available publicly due to copyright restrictions. Reprints can be requested from the authors.

Recent LFD Publications

2020

  1. Ranjit S, Henriksen K, Dvornikov A, Delsante M, Rosenberg A, Levi M, Gratton E.
    Phasor approach to autofluorescence lifetime imaging FLIM can be a qantitative biomarker of chronic renal Parenchymal injury.
    Kidney Int. 2020; Online ahead of print.
  2. Chen YC, Sood C, Marin M, Aaron J, Gratton E, Salaita K, Melikyan GB.
    Super-resolution fluorescence imaging reveals that Serine incorporator protein 5 inhibits human immunodeficiency virus fusion by disrupting envelope glycoprotein clusters.
    ACS Nano. 2020; Online ahead of print.
  3. Cervantes M, Forné I, Ranjit S, Gratton E, Imhof A, Sassone-Corsi P.
    BMAL1 associates with NOP58 in the nucleolus and contributes to pre-rRNA processing.
    iScience. 2020; 23(6), 101151.
  4. Vallmitjana A, Dvornikov A, Torrado B, Jameson DM, Ranjit S, Gratton E.
    Resolution of 4 components in the same pixel in FLIM images using the phasor approach.
    Methods Appl Fluoresc. 2020; 8(3), 035001.
  5. Sameni S, Zhang R, Digman MA.
    The phasor FLIM method reveals a link between a change in energy metabolism and mHtt protein spread in healthy mammalian cells when co-cultured with Huntington diseased cells.
    Methods Appl Fluoresc. 2020; [Epub ahead of print].
  6. Pascua SM, McGahey GE, Ma N, Wang JJ, Digman MA.
    Caffeine and Cisplatin effectively targets the metabolism of a triple-negative breast cancer cell line assessed via Phasor-FLIM.
    Int J Mol Sci. 2020; 21(7), E2443. PMCID: PMC7177700
  7. Haensel D, Jin S, Sun P, Cinco R, Dragan M, Nguyen Q, Cang Z, Gong Y, Vu R, MacLean AL, Kessenbrock K, Gratton E, Nie Q, Dai X.
    Defining epidermal basal cell states during skin homeostasis and wound healing using single-cell transcriptomics.
    Cell Rep. 2020; 30(11): 3932-3947.e6. PMCID: PMC7218802
  8. Liang Z, Lou J, Scipioni L, Gratton E, Hinde E.
    Quantifying nuclear wide chromatin compaction by phasor analysis of histone Förster resonance energy transfer (FRET) in frequency domain fluorescence lifetime imaging microscopy (FLIM) data.
    Data Brief. 2020; 30, 105401. PMCID: PMC7152662
  9. Perinbam K, Kannan JVCA, Digman MA, Siryaporn A.
    A shift in central metabolism accompanies virulence activation in Pseudomonas aeruginosa.
    mBio. 2020; 11(2), e02730-18. PMCID: PMC7064766
  10. Davis RT, Blake K, Ma D, Gabra MBI, Hernandez GA, Phung AT, Yang Y, Maurer D, Lefebvre AEYT, Alshetaiwi H, Xiao Z, Liu J, Locasale JW, Digman MA, Mjolsness E, Kong M, Werb Z, Lawson DA.
    Transcriptional diversity and bioenergetic shift in human breast cancer metastasis revealed by single-cell RNA sequencing.
    Nat Cell Biol. 2020; 22(3): 310-320.
  11. Titlow J, Robertson F, Järvelin A, Ish-Horowicz D, Smith C, Gratton E, Davis I.
    Syncrip/hnRNP Q is required for activity-induced Msp300/Nesprin-1 expression and new synapse formation.
    J Cell Biol. 2020; 219(3), e201903135. PMCID: PMC7055005
  12. Tetreau G, Banneville AS, Andreeva EA, Brewster AS, Hunter MS, Sierra RG, Teulon JM, Young ID, Burke N, Grünewald TA, Beaudouin J, Snigireva I, Fernandez-Luna MT, Burt A, Park HW, Signor L, Bafna JA, Sadir R, Fenel D, Boeri-Erba E, Bacia M, Zala N, Laporte F, Després L, Weik M, Boutet S, Rosenthal M, Coquelle N, Burghammer M, Cascio D, Sawaya MR, Winterhalter M, Gratton E, Gutsche I, Federici B, Pellequer JL, Sauter NK, Colletier JP.
    Serial femtosecond crystallography on in vivo-grown crystals drives elucidation of mosquitocidal Cyt1Aa bioactivation cascade.
    Nat Commun. 2020; 11(1): 1153. PMCID: PMC7052140
  13. Takahashi S, Luo Y, Ranjit S, Xie C, Libby AE, Orlicky DJ, Dvornikov A, Wang XX, Myakala K, Jones BA, Bhasin K, Wang D, McManaman JL, Krausz KW, Gratton E, Ir D, Robertson CE, Frank DN, Gonzalez FJ, Levi M.
    Bile acid sequestration reverses liver injury and prevents progression of NASH in western diet-fed mice.
    J Biol Chem. 2020; [Epub ahead of print]. PMCID: PMC7135973
  14. Abram TJ, Cherukury H, Ou CY, Vu T, Toledano M, Li Y, Grunwald JT, Toosky MN, Tifrea DF, Slepenkin A, Chong J, Kong L, Pozo DVD, La KT, Labanieh L, Zimak J, Shen B, Huang SS, Gratton E, Peterson EM, Zhao W.
    Rapid bacterial detection and antibiotic susceptibility testing in whole blood using one-step, high throughput blood digital PCR.
    Lab Chip. 2020; 20(3): 477-489. PMCID: PMC7250044
  15. Palomba F, Scipioni L, Gratton E, Digman MA.
    Water dynamics of a model protein phase separation via fluorescence lifetime and spectral analysis of ACDAN.
    64th Annual Meeting of the Biophysical Society. San Diego, California. February 15-19, 2020.
    Biophys J. 2020; 118(3, Suppl 1): 308a, 1509-Pos.
  16. Torrado B, Scipioni L, Gratton E, Badano JL, Malacrida LS, Irigoín F.
    Primary cilium submicron organization and dynamics.
    64th Annual Meeting of the Biophysical Society. San Diego, California. February 15-19, 2020.
    Biophys J. 2020; 118(3, Suppl 1): 437a, 2144-Pos.
  17. Hedde PN, Staaf E, Singh SB, Johansson S, Gratton E.
    Pair correlation analysis reveals barriers to natural killer cell receptor motion at the synapse.
    64th Annual Meeting of the Biophysical Society. San Diego, California. February 15-19, 2020.
    Biophys J. 2020; 118(3, Suppl 1): 246a, 1211-Pos.
  18. Oneto M, Scipioni L, Sarmento M, Cainero I, Cerutti E, Pelicci S, Furia L, Pelicci PG, Dellino GI, Bianchini P, Faretta M, Gratton E, Diaspro A, Lanzano L.
    Nanoscale distribution of nuclear sites analyzed by superresolution STED image cross-correlation spectroscopy.
    64th Annual Meeting of the Biophysical Society. San Diego, California. February 15-19, 2020.
    Biophys J. 2020; 118(3, Suppl 1): 20a, 93-Plat.
  19. Hsu C, Gratton E, Anders R, Rosenberg A, Levi M, Ranjit S.
    Image correlation microscopy approach to study collagen accumulation for distinguishing recurrence in liver cancer patients.
    64th Annual Meeting of the Biophysical Society. San Diego, California. February 15-19, 2020.
    Biophys J. 2020; 118(3, Suppl 1): 309a-310a, 1514-Pos.
  20. Vallmitjana A, Vorontsova I, Torrado B, Schilling TF, Hall JE, Gratton E, Malacrida LS.
    Measuring the spatial distribution of dipolar relaxation in live Zebrafish eye lenses during development.
    64th Annual Meeting of the Biophysical Society. San Diego, California. February 15-19, 2020.
    Biophys J. 2020; 118(3, Suppl 1): 308a, 1508-Pos.
  21. Tedeschi G, Scipioni L, Abbott G, Digman MA.
    Dynamic characterization of KCNQ1 and its regulatory subunits revealed by fluorescence fluctuation techniques.
    64th Annual Meeting of the Biophysical Society. San Diego, California. February 15-19, 2020.
    Biophys J. 2020; 118(3, Suppl 1): 262a, 1285-Pos.
  22. Lefebvre AEYT, Adame FA, Liu M, Digman MA.
    Non-destructively analyzing the metabolic dysregulation of Invasive cancer cells on an intracellular scale.
    64th Annual Meeting of the Biophysical Society. San Diego, California. February 15-19, 2020.
    Biophys J. 2020; 118(3, Suppl 1): 307a, 1505-Pos.
  23. Sameni S, Zhang R, Digman MA.
    Number and molecular brightness analysis reveals Htt25Q protein aggregation upon the uptake of Htt97Q aggregates.
    Biochem Biophys Res Commun. 2020; 522(1): 133-137.
  24. Pedrote MM, Motta MF, Ferretti GDS, Norberto DR, Spohr TCLS, Lima FRS, Gratton E, Silva JL, de Oliveira GAP.
    Oncogenic gain of function in Glioblastoma is linked to mutant p53 Amyloid oligomers.
    iScience. 2020; 23(2), 100820. PMCID: PMC6976948
  25. Castro-Castillo V, Gajardo J, Sandoval-Altamirano C, Gratton E, Sanchez S, Malacrida L, Gunther G.
    CAPRYDAA, an anthracene dye analog to LAURDAN: a comparative study using cuvette and microscopy.
    J Mater Chem B. 2020; 8(1). PMCID: PMC7029800

2019

  1. Hedde PN, Staaf E, Singh SB, Johansson S, Gratton E.
    Pair correlation analysis maps the dynamic two-dimensional organization of natural killer cell receptors at the synapse.
    ACS Nano. 2019; 13(2): 14274-14282.
  2. Planes N, Vanderheyden PPML, Gratton E, Caballero-George C.
    Image mean square displacement to study the lateral mobility of Angiotensin II type 1 and Endothelin 1 type A receptors on living cells.
    Microsc Res Tech. 2019; [Epub ahead of print].
  3. Sitiwin E, Madigan MC, Gratton E, Cherepanoff S, Conway RM, Whan R, Macmillan A.
    Shedding light on melanins within in situ human eye melanocytes using 2-photon microscopy profiling techniques.
    Sci Rep. 2019; 9(1), 18585. PMCID: PMC6901595
  4. Vorontsova I, Vallmitjana A, Nakazawa Y, Torrado B, Schilling TF, Hall JE, Gratton E, Malacrida L.
    Aquaporin 0a is required for water homeostasis in the zebrafish lens in vivo.
    6th International Conference on the Lens. Kailua Kona, Hawaii. December 8-13, 2019. 2019; ICL 2019 Meeting Program: 23.
  5. Oneto M, Scipioni L, Sarmento MJ, Cainero I, Pelicci S, Furia L, Pelicci PG, Dellino GI, Bianchini P, Faretta M, Gratton E, Diaspro A, Lanzanò L.
    Nanoscale distribution of nuclear sites by super-resolved image cross-correlation spectroscopy.
    Biophys J. 2019; 117(11): 2054-2065. PMCID: PMC6895719
  6. Ranjit S, Datta R, Dvornikov AS, Gratton E.
    Multicomponent analysis of phasor plot in a single pixel to calculate changes of metabolic trajectory in biological systems.
    J Phys Chem A. 2019; 123(45): 9865-9873.
  7. Ranjit S, Malacrida L, Stakic M, Gratton E.
    Determination of the metabolic index using the fluorescence lifetime of free and bound NADH in the phasor approach.
    J Biophotonics. 2019; 12(11), e201900156. PMCID: PMC6842045