Laboratory for Fluorescence Dynamics

A NIH research center for biomedical fluorescence spectroscopy at the University of California, Irvine

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Publications

The Laboratory for Fluorescence Dynamics' (LFD) database of publications contains more than 2200 journal articles, book chapters, conference proceedings, abstracts, patents, and theses by members of the LFD, and also selected publications of interest to the fluorescence community.
Electronic documents are not available publicly due to copyright restrictions. Reprints can be requested from the authors.

Recent LFD Publications

2018

  1. Malacrida L, Gratton E.
    LAURDAN fluorescence and phasor plots reveal the effects of a H2O2 bolus in NIH-3T3 fibroblast membranes dynamics and hydration.
    Free Radic Biol Med. 2018; [Epub ahead of print].
  2. Pedrote MM, de Oliveira GAP, Felix AL, Mota MF, de Marques MA, Soares IN, Iqbal A, Norberto DR, Gomes AMO, Gratton E, Cino EA, Silva JL.
    Aggregation-primed molten globule conformers of the p53 core domain provide potential tools for studying p53C aggregation in cancer.
    J Biol Chem. 2018; [Epub ahead of print].
  3. Davey RJ, Digman MA, Gratton E, Moens PDJ.
    Quantitative image mean squared displacement (iMSD) analysis of the dynamics of Profilin 1 at the membrane of live cells.
    Methods. 2018; 140-141: 119-125. PMCID: PMC5995621
  4. Malacrida L, Rao E, Gratton E.
    Comparison between iMSD and 2D-pCF analysis for molecular motion studies on in vivo cells: the case of the epidermal growth factor receptor.
    Methods. 2018; 140-141: 74-84. PMCID: PMC5999564
  5. Lee DH, Li X, Ma N, Digman MA, Lee AP.
    Rapid and label-free identification of single leukemia cells from blood in a high-density microfluidic trapping array by fluorescence lifetime imaging microscopy.
    Lab Chip. 2018; 18(9): 1349-1358.
  6. Kim SM, Nguyen TT, Ravi A, Kubiniok P, Finicle BT, Jayashankar V, Malacrida L, Hou J, Robertson J, Gao D, Chernoff J, Digman MA, Potma EO, Tromberg BJ, Thibault P, Edinger AL.
    PTEN deficiency and AMPK activation promote nutrient scavenging and anabolism in prostate cancer cells.
    Cancer Discov. 2018; [Epub ahead of print].
  7. Gratton E.
    Spectroscopic signatures of cells metabolism and extracellular species using phasor-FLIM (Conference Presentation).
    BiOS 2018. Part of SPIE Photonics West. San Francisco, California, January 27 - February 1, 2018.
    Multiphoton Microscopy in the Biomedical Sciences XVIII (Vol. 10498). 1049803, 2018.
  8. Kobylkevich BM, Sarkar A, Carlberg BR, Huang L, Ranjit S, Graham DM, Messerli MA.
    Reversing the direction of galvanotaxis with controlled increases in boundary layer viscosity.
    Phys Biol. 2018; 15(3): 036005. PMCID: PMC5970543
  9. Staaf E, Hedde PN, Singh SB, Piguet J, Gratton E, Johansson S.
    Educated natural killer cells show dynamic movement of the activating receptor NKp46 and confinement of the inhibitory receptor Ly49A.
    Sci Signal. 2018; 11(517), eaai9200. PMCID: PMC5925740
  10. Leemans SW, Dvornikov A, Gratton E.
    Adaptive optics in deep tissue microscopy.
    62nd Annual Meeting of the Biophysical Society. San Francisco, California. February 17–21, 2018.
    Biophys J. 2018; 114(3, Suppl 1): 533a, 2638-Pos.
  11. Scipioni L, Diaspro A, Lanzanò L, Gratton E.
    AiryScan comprehensive superresolution correlation analysis.
    62nd Annual Meeting of the Biophysical Society. San Francisco, California. February 17–21, 2018.
    Biophys J. 2018; 114(3, Suppl 1): 533a, 2641-Pos.
  12. Malacrida LS, Hedde PN, Ranjit S, Cardarelli F, Gratton E.
    Elucidating invisible barriers and obstacles to molecular diffusion in live cells by the spatial pair-correlation function: a connectivity view of the cell.
    62nd Annual Meeting of the Biophysical Society. San Francisco, California. February 17–21, 2018.
    Biophys J. 2018; 114(3, Suppl 1): 166a, 835-Pos.
  13. Torrado B, Malacrida L, Badano JL, Irigoín F, Gratton E.
    Intracellular transport characterization of the transcription factor Gli2 by fluorescence correlation spectroscopy approaches.
    62nd Annual Meeting of the Biophysical Society. San Francisco, California. February 17–21, 2018.
    Biophys J. 2018; 114(3, Suppl 1): 630a, 3123-Pos.
  14. Ranjit S, Dvornikov A, Levi M, Gratton E.
    Multicomponent analysis of phasor plot to decipher changes in metabolic trajectory of biological systems.
    62nd Annual Meeting of the Biophysical Society. San Francisco, California. February 17–21, 2018.
    Biophys J. 2018; 114(3, Suppl 1): 167a, 843-Pos.
  15. Digman MA, Palomba F, Kong X, Yokomori K, Gratton E.
    Pair correlation analysis of Ku dynamics upon DNA damage.
    62nd Annual Meeting of the Biophysical Society. San Francisco, California. February 17–21, 2018.
    Biophys J. 2018; 114(3, Suppl 1): 351a, 1740-Pos.
  16. Hedde PN, Malacrida L, Ahrar S, Siryaporn A, Gratton E.
    SideSPIM - a flexible multipurpose platform for light sheet microscopy.
    62nd Annual Meeting of the Biophysical Society. San Francisco, California. February 17–21, 2018.
    Biophys J. 2018; 114(3, Suppl 1): 187a, 945-Plat.
  17. Cinco R, Hedde PN, Digman MA, Gratton E.
    Spatial characterization of NADH concentration and diffusion in cells and tissue.
    62nd Annual Meeting of the Biophysical Society. San Francisco, California. February 17–21, 2018.
    Biophys J. 2018; 114(3, Suppl 1): 335a, 1662-Pos.
  18. Gratton E, Dvornikov A.
    Spectral resolution in fluorescence microscopy in strongly scattering media.
    62nd Annual Meeting of the Biophysical Society. San Francisco, California. February 17–21, 2018.
    Biophys J. 2018; 114(3, Suppl 1): 166a, 838-Pos.
  19. Murata MM, Kong X, Yokomori K, Digman MA.
    Fluorescence lifetime of NADH reveals PARP-dependent increase of oxidative phosphorylation critical for cell survival.
    62nd Annual Meeting of the Biophysical Society. San Francisco, California. February 17–21, 2018.
    Biophys J. 2018; 114(3, Suppl 1): 83a, 425-Pos.
  20. Mah EJ, Yee AF, Digman MA.
    Metabolism modulation of cancer cells on varying substrate stiffnesses.
    62nd Annual Meeting of the Biophysical Society. San Francisco, California. February 17–21, 2018.
    Biophys J. 2018; 114(3, Suppl 1): 19a, 101-Plat.
  21. Sameni S.
    Laurdan imaging and spectral phasor analysis reveals increased membrane fluidity in Huntington disease.
    62nd Annual Meeting of the Biophysical Society. San Francisco, California. February 17–21, 2018.
    Biophys J. 2018; 114(3, Suppl 1): 177a, 891-Pos.
  22. Kong L, Murata MM, Digman MA.
    Absence of REV3L promotes p53-regulated cancer cell metabolism in cisplatin-treated lung carcinoma cells.
    Biochem Biophys Res Commun. 2018; 496(1): 199-204.
  23. Cutrale F, Gratton E.
    Apparatus and method for an inclined single plane imaging microscope box (iSPIM box).
    Patent US9874736B2, 23 Jan 2018.
  24. Mäntylä E, Chacko JV, Aho V, Parrish CR, Shahin V, Kann M, Digman MA, Gratton E, Vihinen-Ranta M.
    Viral highway to nucleus exposed by image correlation analyses.
    Sci Rep. 2018; 8(1): 1152. PMCID: PMC5773500
  25. Sameni S, Malacrida L, Tan Z, Digman MA.
    Alteration in fluidity of cell plasma membrane in Huntington disease revealed by spectral phasor Analysis.
    Sci Rep. 2018; 8(1): 734. PMCID: PMC5768877
  26. Wang XX, Wang D, Luo Y, Myakala K, Dobrinskikh E, Rosenberg AZ, Levi J, Kopp JB, Field A, Hill A, Lucia S, Qiu L, Jiang T, Peng Y, Orlicky D, Garcia G, Herman-Edelstein M, D’Agati V, Henriksen K, Adorini L, Pruzanski M, Xie C, Krausz KW, Gonzalez FJ, Ranjit S, Dvornikov A, Gratton E, Levi M.
    FXR/TGR5 dual agonist prevents progression of nephropathy in diabetes and obesity.
    J Am Soc Nephrol. 2018; 29(1). PMCID: PMC5748904
  27. Malacrida L, Hedde PN, Ranjit S, Cardarelli F, Gratton E.
    Visualization of barriers and obstacles to molecular diffusion in live cells by spatial pair-cross-correlation in two dimensions.
    Biomed Opt Express. 2018; 9(1): 303-321. PMCID: PMC5772584

2017

  1. Gach JS, Bouzin M, Wong MP, Chromikova V, Gorlani A, Yu KT, Sharma B, Gratton E, Forthal DN.
    Human Immunodeficiency Virus type-1 (HIV-1) evades antibody-dependent phagocytosis.
    PLoS Pathog. 2017; 13(12), e1006793. PMCID: PMC5760106
  2. Trinh AL, Chen H, Chen Y, Hu Y, Li Z, Siegel ER, Linskey ME, Wang PH, Digman MA, Zhou YH.
    Tracking functional tumor cell subpopulations of malignant glioma by phasor fluorescence lifetime imaging microscopy of NADH.
    Cancers (Basel). 2017; 9(12), E168. PMCID: PMC5742816
  3. Bohórquez-Hernández A, Gratton E, Pacheco J, Asanov A, Vaca L.
    Cholesterol modulates the cellular localization of Orai1 channels and its disposition among membrane domains.
    Biochim Biophys Acta. 2017; 1862(12): 1481-1490. PMCID: PMC5902182
  4. Digiacomo L, Cardarelli F, Pozzi D, Palchetti S, Digman MA, Gratton E, Capriotti AL, Mahmoudi M, Caracciolo G.
    An apolipoprotein-enriched biomolecular corona switches the cellular uptake mechanism and trafficking pathway of lipid nanoparticles.
    Nanoscale. 2017; 9(44): 17254-17262. PMCID: PMC5700750
  5. Gratton E, D'Amico E.
    System and method for digital parallel frequency fluorometry.
    Patent EP2529152B1, 15 Nov 2017.