Laboratory for Fluorescence Dynamics

A NIH research center for biomedical fluorescence spectroscopy at the University of California, Irvine

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The Laboratory for Fluorescence Dynamics' (LFD) database of publications contains more than 2200 journal articles, book chapters, conference proceedings, abstracts, patents, and theses by members of the LFD, and also selected publications of interest to the fluorescence community.
Electronic documents are not available publicly due to copyright restrictions. Reprints can be requested from the authors.

Recent LFD Publications

2019

  1. Dvornikov A, Malacrida L, Gratton E.
    The DIVER microscope for imaging in scattering media.
    Methods Protoc. 2019; 2(2): 53.
  2. Ranjit S, Malacrida L, Stakic M, Gratton E.
    Determination of the metabolic index using the fluorescence lifetime of free and bound NADH in the phasor approach.
    J Biophotonics. 2019; [Epub ahead of print].
  3. Levi M, Gratton E, Forster IC, Hernando N, Wagner CA, Biber J, Sorribas V, Murer H.
    Mechanisms of phosphate transport.
    Nat Rev Nephrol. 2019; [Epub ahead of print].
  4. Polyzos AA, Lee DY, Datta R, Hauser M, Budworth H, Holt A, Mihalik S, Goldschmidt P, Frankel K, Trego K, Bennett MJ, Vockley J, Xu K, Gratton E, McMurray CT.
    Metabolic reprogramming in astrocytes distinguishes region-specific neuronal susceptibility in Huntington mice.
    Cell Metab. 2019; 29(6): 1258-1273.
  5. Rodriguez-Agudo D, Malacrida L, Kakiyama G, Sparrer T, Fortes C, Maceyka M, Sublerh MA, Windle JJ, Gratton E, Pandak WM, Gil G.
    StarD5: an ER stress protein regulates plasma membrane and intracellular cholesterol homeostasis.
    J Lipid Res. 2019; 60(6): 1087-1098. PMCID: PMC6547630
  6. Chen H, Ma N, Kagawa K, Kawahito S, Digman M, Gratton E.
    Widefield multifrequency fluorescence lifetime imaging using a two-tap complementary metal-oxide semiconductor camera with lateral electric field charge modulators.
    J Biophotonics. 2019; 12(5), e201800223.
  7. Planes N, Digman MA, Vanderheyden PPML, Gratton E, Caballero-George C.
    Number and brightness analysis to study spatio-temporal distribution of the angiotensin II AT1 and the endothelin-1 ETA receptors: Influence of ligand binding.
    Biochim Biophys Acta Gen Subj. 2019; 1863(5): 917-924.
  8. Levi M, Gratton E.
    Visualizing the regulation of SLC34 proteins at the apical membrane.
    Pflugers Arch. 2019; 471(4): 533-542. PMCID: PMC6436987
  9. Lou J, Scipioni L, Wright BK, Bartolec TK, Zhang J, Masamsetti VP, Gaus K, Gratton E, Cesare AJ, Hinde E.
    Phasor histone FLIM-FRET microscopy quantifies spatiotemporal rearrangement of chromatin architecture during the DNA damage response.
    Proc Natl Acad Sci USA. 2019; [Epub ahead of print]. PMCID: PMC6462080
  10. Lees AV, Gratton E.
    3D orbital tracking under STED microscopy.
    63rd Annual Meeting of the Biophysical Society. Baltimore, Maryland. March 2–6, 2019.
    Biophys J. 2019; 116(3, Suppl 1): 440a, 2174-Pos.
  11. Gratton E, Rossetta A, Chen H.
    A new faster Flimbox with higher harmonic content and multi detector input.
    63rd Annual Meeting of the Biophysical Society. Baltimore, Maryland. March 2–6, 2019.
    Biophys J. 2019; 116(3, Suppl 1): 441a, 2179-Pos.
  12. Tedeschi G, Scipioni L, Trinh A, Lee KA, Malacrida LS, Digman MA, Gratton E.
    Characterization of the metabolic state and molecular crowding in breast cancer spheroids.
    63rd Annual Meeting of the Biophysical Society. Baltimore, Maryland. March 2–6, 2019.
    Biophys J. 2019; 116(3, Suppl 1): 421a, 2080-Pos.
  13. Leemans SW, Gratton E.
    Adaptive optics in strongly scattering samples.
    63rd Annual Meeting of the Biophysical Society. Baltimore, Maryland. March 2–6, 2019.
    Biophys J. 2019; 116(3, Suppl 1): 441a, 2181-Pos.
  14. Malacrida LS, Scipioni L, Gratton E.
    In vivo chromatin compaction changes as detected by water dipolar relaxations: the molecular crowding role revealed by the ACDAN fluorescence.
    63rd Annual Meeting of the Biophysical Society. Baltimore, Maryland. March 2–6, 2019.
    Biophys J. 2019; 116(3, Suppl 1): 70a, 355-Pos.
  15. Hedde PN, Staaf E, Singh SB, Johansson S, Gratton E.
    Dynamics of activating and inhibitory receptors in Murine Natural Killer cells revealed by 2D pair correlation function analysis.
    63rd Annual Meeting of the Biophysical Society. Baltimore, Maryland. March 2–6, 2019.
    Biophys J. 2019; 116(3, Suppl 1): 280a, 1380-Pos.
  16. Dvornikov A, Gratton E.
    Hyperspectral imaging in scattering media using two filters.
    63rd Annual Meeting of the Biophysical Society. Baltimore, Maryland. March 2–6, 2019.
    Biophys J. 2019; 116(3, Suppl 1): 441a, 2178-Pos.
  17. Begarani F, D'Autilia F, Signore G, Gratton E, Beltram F, Cardarelli F.
    Capturing metabolism-dependent solvent polarity fluctuations in a trafficking Lysosome.
    63rd Annual Meeting of the Biophysical Society. Baltimore, Maryland. March 2–6, 2019.
    Biophys J. 2019; 116(3, Suppl 1): 307a, 1516-Plat.
  18. Scipioni L, Lanzanò L, Diaspro A, Gratton E.
    Airyscan CCA provides structural and dynamics fingerprinting of subcellular compartments in living cells.
    63rd Annual Meeting of the Biophysical Society. Baltimore, Maryland. March 2–6, 2019.
    Biophys J. 2019; 116(3, Suppl 1): 282a, 1389-Pos.
  19. Ranjit S, Malacrida LS, Gratton E.
    The fluorescence lifetime of bound NADH: clues from the phasor plots.
    63rd Annual Meeting of the Biophysical Society. Baltimore, Maryland. March 2–6, 2019.
    Biophys J. 2019; 116(3, Suppl 1): 565a, 2804-Pos.
  20. Chen H, Ma N, Kagawa K, Kawahito S, Digman MA, Gratton E.
    Widefield multi-frequency fluorescence lifetime imaging using a two-tap CMOS camera with lateral electric field charge modulators.
    63rd Annual Meeting of the Biophysical Society. Baltimore, Maryland. March 2–6, 2019.
    Biophys J. 2019; 116(3, Suppl 1): 567a, 2812-Pos.
  21. Cinco R, Hedde PN, Malacrida L, Digman MA, Gratton E.
    Multi-modal fluorescence characterization of cell cycle progression and cytokinesis.
    63rd Annual Meeting of the Biophysical Society. Baltimore, Maryland. March 2–6, 2019.
    Biophys J. 2019; 116(3, Suppl 1): 24a, 125-Plat.
  22. Digman MA, Lefebvre AEYT, Adame FA, Fong E.
    The phasor FLIM analysis monitors metabolic changes at the leading edge in response to Rac photo-activation and mitochondrial transport in MDA MB231 cells.
    63rd Annual Meeting of the Biophysical Society. Baltimore, Maryland. March 2–6, 2019.
    Biophys J. 2019; 116(3, Suppl 1): 442a, 2185-Pos.
  23. Lefebvre AEYT, Adame FA, Digman MA.
    A non-invasive metabolic investigation of breast cancer invasion.
    63rd Annual Meeting of the Biophysical Society. Baltimore, Maryland. March 2–6, 2019.
    Biophys J. 2019; 116(3, Suppl 1): 550a, 2727-Pos.
  24. Ou CY, Vu T, Grunwald JT, Toledano M, Zimak J, Toosky M, Shen B, Zell JA, Gratton E, Abram TJ, Zhao W.
    An ultrasensitive test for profiling circulating tumor DNA using integrated comprehensive droplet digital detection.
    Lab Chip. 2019; 19(6): 993-1005. PMCID: PMC6559803
  25. Stringari C, Gratton E, Digman MA, Donovan P.
    Phasor method to fluorescence lifetime microscopy to discriminate metabolic state of cells in living tissue.
    Patent US10222335B2, 05 Mar 2019.
  26. Begarani F, D'Autilia F, Signore G, Grosso AD, Cecchini M, Gratton E, Beltram F, Cardarelli F.
    Capturing metabolism-dependent solvent dynamics in the lumen of a trafficking lysosome.
    ACS Nano. 2019; 13(2): 1670-1682.
  27. Hedde PN, Abram T, Vu T, Zhao W, Gratton E.
    Fluorescence lifetime detection with particle counting devices.
    Biomed Opt Express. 2019; 10(3): 1223-1233. PMCID: PMC6420272
  28. Dong Y, Digman MA, Brewer GJ.
    Age- and AD-related redox state of NADH in subcellular compartments by fluorescence lifetime imaging microscopy.
    Geroscience. 2019; 41(1): 51-67. PMCID: PMC6423217
  29. Ma N, Kamalakshakurup G, Aghaamoo M, Lee AP, Digman MA.
    Label-Free Metabolic Classification of Single Cells in Droplets Using the Phasor Approach to Fluorescence Lifetime Imaging Microscopy.
    Cytometry A. 2019; 95(1): 93-100.

2018

  1. Mah EJ, Lefebvre AEYT, McGahey GE, Yee AF, Digman MA.
    Collagen density modulates triple-negative breast cancer cell metabolism through adhesion-mediated contractility.
    Sci Rep. 2018; 8(1), 17094. PMCID: PMC6244401
  2. Scipioni L, Lanzanò L, Diaspro A, Gratton E.
    Comprehensive correlation analysis for super-resolution dynamic fingerprinting of cellular compartments using the Zeiss Airyscan detector.
    Nat Commun. 2018; 9(1), 5120. PMCID: PMC6269422
  3. Malacrida L, Gratton E.
    LAURDAN fluorescence and phasor plots reveal the effects of a H2O2 bolus in NIH-3T3 fibroblast membranes dynamics and hydration.
    Free Radic Biol Med. 2018; 128: 144-156. PMCID: PMC6175669