Laboratory for Fluorescence Dynamics

A NIH research center for biomedical fluorescence spectroscopy at the University of California, Irvine

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The Laboratory for Fluorescence Dynamics' (LFD) database of publications contains more than 2200 journal articles, book chapters, conference proceedings, abstracts, patents, and theses by members of the LFD, and also selected publications of interest to the fluorescence community.
Electronic documents are not available publicly due to copyright restrictions. Reprints can be requested from the authors.

Recent LFD Publications

2021

  1. Gunther G, Malacrida L, Jameson DM, Gratton E, Sánchez SA.
    LAURDAN since Weber: The quest for visualizing membrane heterogeneity.
    Acc Chem Res. 2021; 54(4): 976-987.
  2. Gratton E.
    Single cell physiological characterization in living tissue.
    65th Annual Meeting of the Biophysical Society. Online. February 22-26.
    Biophys J. 2021; 120(3, Suppl 1): 180a, 875-Pos.
  3. Scipioni L, Rossetta A, Tedeschi G, Gratton E.
    Highly multiplexed determination of the cell state by phasor spectral FLIM.
    65th Annual Meeting of the Biophysical Society. Online. February 22-26.
    Biophys J. 2021; 120(3, Suppl 1): 356a-357a, 1721-Pos.
  4. Ranjit S, Henriksen K, Dvornikov A, Delsante M, Rosenberg A, Levi M, Gratton E.
    Quantification of chronic renal parenchymal injury using phasor approach to autofluorescence lifetime imaging.
    65th Annual Meeting of the Biophysical Society. Online. February 22-26.
    Biophys J. 2021; 120(3, Suppl 1): 357a, 1725-Pos.
  5. Malacrida LS, Kamaid A, Gratton E, Hedde PN.
    Hyperspectral imaging in a single plane illumination microscope by spectral phasor analysis with sine-cosine transmission filters.
    65th Annual Meeting of the Biophysical Society. Online. February 22-26.
    Biophys J. 2021; 120(3, Suppl 1): 358a, 1727-Pos.
  6. Vallmitjana A, Torrado B, Gratton E.
    Automatic image segmentation based on phasor space clustering.
    65th Annual Meeting of the Biophysical Society. Online. February 22-26.
    Biophys J. 2021; 120(3, Suppl 1): 360a, 1739-Pos.
  7. Cinco R, Dragan M, Gratton E, Welch H, Timpson P, Dai X, Digman MA.
    Spatiotemporal dynamics of RAC1 signaling during wound healing in Forster resonance energy transfer biosensor mice.
    65th Annual Meeting of the Biophysical Society. Online. February 22-26.
    Biophys J. 2021; 120(3, Suppl 1): 105a, 506-Plat.
  8. Torrado B, Dvornikov A, Gratton E.
    Hyperspectral analysis of fluorescence images in scattering media using optical filters.
    65th Annual Meeting of the Biophysical Society. Online. February 22-26.
    Biophys J. 2021; 120(3, Suppl 1): 106a, 509-Plat.
  9. Ranjit S, Lanzanò L, Libby AE, Gratton E, Levi M.
    Advances in fluorescence microscopy techniques to study kidney function.
    Nat Rev Nephrol. 2021; 17(2): 128-144.
  10. Sameni S, Zhang R, Digman MA.
    The phasor FLIM method reveals a link between a change in energy metabolism and mHtt protein spread in healthy mammalian cells when co-cultured with Huntington diseased cells.
    Methods Appl Fluoresc. 2021; 9(1), 015005.

2020

  1. Greco CM, Cervantes M, Fustin JM, Ito K, Ceglia N, Samad M, Shi J, Koronowski KB, Forne I, Ranjit S, Gaucher J, Kinouchi K, Kojima R, Gratton E, Li W, Baldi P, Imhof A, Okamura H, Sassone-Corsi P.
    S-adenosyl-l-homocysteine hydrolase links methionine metabolism to the circadian clock and chromatin remodeling.
    Sci Adv. 2020; 6(51), eabc5629. PMCID: PMC7744083
  2. Gratton E, Dvornikov A.
    System and method for hyperspectral imaging in highly scattering media by the spectral phasor approach using two filters.
    Patent US20200378830A1, 03 Dec 2020.
  3. Vallmitjana A, Torrado B, Dvornikov A, Ranjit S, Gratton E.
    Blind resolution of lifetime components in individual pixels of fluorescence lifetime images using the phasor approach.
    J Phys Chem B. 2020; 124(45): 10126-10137.
  4. Makaremi S, Rose M, Ranjit S, Digman MA, Bowdish DME, Moran-Mirabal JM.
    Lateral diffusion of CD14 and TLR2 in macrophage plasma membrane assessed by raster image correlation spectroscopy and single particle tracking.
    Sci Rep. 2020; 10(1): 19375. PMCID: PMC7652837
  5. Ranjit S, Henriksen K, Dvornikov A, Delsante M, Rosenberg A, Levi M, Gratton E.
    Phasor approach to autofluorescence lifetime imaging FLIM can be a qantitative biomarker of chronic renal Parenchymal injury.
    Kidney Int. 2020; 98(5): 1341-1346. PMCID: PMC7606347
  6. Chen YC, Sood C, Marin M, Aaron J, Gratton E, Salaita K, Melikyan GB.
    Super-resolution fluorescence imaging reveals that Serine incorporator protein 5 inhibits human immunodeficiency virus fusion by disrupting envelope glycoprotein clusters.
    ACS Nano. 2020; 14(9): 10929-10943.
  7. Hedde PN, Abram TJ, Jain A, Nakajima R, de Assis RR, Pearce T, Jasinskas A, Toosky MN, Khan S, Felgner PL, Gratton E, Zhao W.
    A modular microarray imaging system for highly specific COVID-19 antibody testing.
    Lab Chip. 2020; 20(18): 3302-3309. PMCID: PMC7263497
  8. Harris CR, Millman KJ, van der Walt SJ, Gommers R, Virtanen P, Cournapeau D, Wieser E, Taylor J, Berg S, Smith NJ, Kern R, Picus M, Hoyer S, van Kerkwijk MH, Brett M, Haldane A, Río JFd, Wiebe M, Peterson P, Gérard-Marchant P, Sheppard K, Reddy T, Weckesser W, Abbasi H, Gohlke C, Oliphant TE.
    Array programming with NumPy.
    Nature. 2020; 585(7825): 357-362. PMCID: PMC7759461
  9. Palczewska G, Boguslawski J, Stremplewsk P, Kornaszewski L, Zhang J, Dong Z, Liang XX, Gratton E, Vogel A, Wojtkowski M, Palczewski K.
    Noninvasive two-photon optical biopsy of retinal fluorophores.
    Proc Natl Acad Sci USA. 2020; 117(36): 22532-22543. PMCID: PMC7486747
  10. Li W, Hu J, Sh B, Palomba F, Digman MA, Gratton E, Jiang H.
    Biophysical properties of AKAP95 protein condensates regulate splicing and tumorigenesis.
    Nat Cell Biol. 2020; 22(8): 960-972. PMCID: PMC7425812
  11. Hedde PN, Bouzin M, Abram TJ, Chen X, Toosky MN, Vu T, Li Y, Zhao W, Gratton E.
    Rapid isolation of rare targets from large fluid volumes.
    Sci Rep. 2020; 10(1), 12458. PMCID: PMC7385493
  12. Nguyen DG.
    Fluorescence lifetime imaging microscopy and LAURDAN spectral imaging for dynamically investigating osteoclast differentiation.
    PhD in Biomedical Engineering, University of California, Irvine, 2020.
    Advisor: Michelle A Digman
  13. Leemans SW.
    Fluorescence based adaptive optics and multidimensional fluorescence microscopy.
    PhD in Biomedical Engineering, University of California, Irvine, 2020.
    Advisor: Enrico Gratton
  14. Cervantes M, Forné I, Ranjit S, Gratton E, Imhof A, Sassone-Corsi P.
    BMAL1 associates with NOP58 in the nucleolus and contributes to pre-rRNA processing.
    iScience. 2020; 23(6), 101151. PMCID: PMC7256328
  15. Vallmitjana A, Dvornikov A, Torrado B, Jameson DM, Ranjit S, Gratton E.
    Resolution of 4 components in the same pixel in FLIM images using the phasor approach.
    Methods Appl Fluoresc. 2020; 8(3), 035001.
  16. Takahashi S, Luo Y, Ranjit S, Xie C, Libby AE, Orlicky DJ, Dvornikov A, Wang XX, Myakala K, Jones BA, Bhasin K, Wang D, McManaman JL, Krausz KW, Gratton E, Ir D, Robertson CE, Frank DN, Gonzalez FJ, Levi M.
    Bile acid sequestration reverses liver injury and prevents progression of NASH in western diet-fed mice.
    J Biol Chem. 2020; 295(14): 4733-4747. PMCID: PMC7135973
  17. Planes N, Vanderheyden PPML, Gratton E, Caballero-George C.
    Image mean square displacement to study the lateral mobility of Angiotensin II type 1 and Endothelin 1 type A receptors on living cells.
    Microsc Res Tech. 2020; 83(4): 381-392.
  18. Pascua SM, McGahey GE, Ma N, Wang JJ, Digman MA.
    Caffeine and Cisplatin effectively targets the metabolism of a triple-negative breast cancer cell line assessed via Phasor-FLIM.
    Int J Mol Sci. 2020; 21(7), E2443. PMCID: PMC7177700
  19. Haensel D, Jin S, Sun P, Cinco R, Dragan M, Nguyen Q, Cang Z, Gong Y, Vu R, MacLean AL, Kessenbrock K, Gratton E, Nie Q, Dai X.
    Defining epidermal basal cell states during skin homeostasis and wound healing using single-cell transcriptomics.
    Cell Rep. 2020; 30(11): 3932-3947.e6. PMCID: PMC7218802
  20. Liang Z, Lou J, Scipioni L, Gratton E, Hinde E.
    Quantifying nuclear wide chromatin compaction by phasor analysis of histone Förster resonance energy transfer (FRET) in frequency domain fluorescence lifetime imaging microscopy (FLIM) data.
    Data Brief. 2020; 30, 105401. PMCID: PMC7152662
  21. Perinbam K, Chacko JV, Kannan A, Digman MA, Siryaporn A.
    A shift in central metabolism accompanies virulence activation in Pseudomonas aeruginosa.
    mBio. 2020; 11(2), e02730-18. PMCID: PMC7064766
  22. Davis RT, Blake K, Ma D, Gabra MBI, Hernandez GA, Phung AT, Yang Y, Maurer D, Lefebvre AEYT, Alshetaiwi H, Xiao Z, Liu J, Locasale JW, Digman MA, Mjolsness E, Kong M, Werb Z, Lawson DA.
    Transcriptional diversity and bioenergetic shift in human breast cancer metastasis revealed by single-cell RNA sequencing.
    Nat Cell Biol. 2020; 22(3): 310-320.