Enrico Gratton

Curriculum Vitae

Current Address
University of California, Irvine Department of Biomedical Engineering 3210 Natural Sciences II Irvine, CA 92697-2715, USA	Telephone: 949/824-2674 Laboratory: 949/824-3264 Telefax: 949/824-1727 E-Mail: egratton22@yahoo.com with copy to lfd@uci.edu

Education

Doctorate degree: Physics, University of Rome (1969)
Thesis: "The acid denaturation of DNA" (Advisor: Professor Mario Ageno).

Employment:

2006-present: Professor, Department of Biomedical Engineering, UCI

2006-present: Emeritus Professor, Department of Physics, Univ. of Illinois, Urbana-Champaign (UIUC)

1986-present: Principal Investigator and Director, Laboratory for Fluorescence Dynamics

1989-2006: Professor, Departments of Physics and Biophysics, UIUC

1984-1989: Associate Professor, Department of Physics, UIUC

1978-1984: Assistant Professor, Department of Physics, UIUC

1976-1978: Research Associate, Biochemistry Department (advisor: Gregorio Weber), UIUC

1971-1977: Researcher, SNAM PROGETTI, Monterotondo, Italy

1970: Fellowship, Instituto Superiore di Sanita Rome (advisor: Prof. Mario Ageno)

Research Areas:

            Protein Aggregation

            Membrane interactions

            Migration of cells

            Tracking moving particles

            Analyzing collagen formation and deformation

            Noninvasive optical technology methods for studying breast cancer

            Fluorescence microscopy

            Image correlation spectroscopy

            Membran protein-lipid interactions

Consulting Activities:

            2006-current: Abbott, Illinois

2007 – 2009:  Allergan, Inc. Irvine, CA

            2006:  Pacific Biosciences, Menlo Park, CA

Recent Honors & Awards:

• Awarded the “Gregorio Weber Award for Excellence in Fluorescence Theory and Application,” Biological Fluorescence Subgroup, at the Biophysical Society, February 2005. 

• Awarded Membership of Academia Nacional De Ciencias, Argentina 2012

• Avanti Polar Award 2019

• AIMBE Fellow, 2019

• Program Advisory Committee of the University of Illinois at Urbana-Champaign, 8/11/2005.

• 2003: Listed on "Incomplete List of Teachers Ranked as Excellent by their Students," for Spring Semester, Physics 101: General Physics.

• 1991-1992: Associate in the Center for Advanced Study

• 1987-1988: University of Illinois, Xerox Award for Faculty Research, April 1988.

Professional Activities

• 2004: Program Committee Member, Optical Society of American Topical Meeting: Optical Techniques in Neuroscience, April 2004.
• 2003: Chair, Biological Fluorescence Subgroup of the Biophysical Society Meeting, San Antonios, March 2003.
• 2002: Chair, Biological Fluorescence Subgroup of the Biophysical Society Meeting, San Francisco, February 2002.
• 2000: Program Committee, Optical Imaging Workshop, "From Bench to Bedside." Natcher Center, National Institutes of Health, Bethesda, MD, September 7-8, 2000.
• 1986-present: Organizer, International Weber Symposium on Innovative Fluorescence Methodologies in Biochemistry and Medicine.
• 1986-present: Globals Unlimited© Author of the kernel of the commercialized software package (analyzes frequency and time domain fluorescence data).

Science Advisory Committee Memberships

• Scientific Advisory Board (Fachbeirat), the Max Planck Institute for Biophysical Chemistry, 2004-2010.
• CNR, Institute of Biology, Genoa, Italy, 2001-2012.
• Cellular and Molecular Biology Group, National Flow Cytometry Resource, Los Alamos National Laboratory, Los Alamos, NM, 1990-2000.
• The Sincrotrone Trieste, Trieste, Italy, 1990-2000.
• National Institutes of Health, Division of Research Grant Advisory Committee, Bethesda, MD, 1997.
• Biomedical Magnetic Resonance Research and Technology Resource (NIH), Urbana, IL, 1996-2002.

Society Memberships

• Biophysical Society
• American Physical Society
• Optical Society of America

Editorial Boards:

Biophysical Journal, 2003-2009

Journal of Fluorescence, 1992-97

Comments On Molecular and Cellular Biophysics, 1995-96.

Administrative Services to the University (Departmental)

• Bobone Award Comm UIUC.
• Ph.D. Qualifying Exam UIUC and UCI
• Liaison to Medical Scholars Program UIUC
• Grad. Student Academic Advisor UIUC and UCI
• Molecular Biophysics Seminars (UIUC)

Service to the International Community

• The Maria Pia Gratton International Travel Fellowship

Scientific Journals and Manuscripts Reviews

• Analytical Biochemistry
• Biochemistry
• Biochimica et Biophysica Acta
• Biophysical Journal
• Journal of Biochemical and Biophysical Methods
• Journal of Physical Chemistry
• Photochemistry and Photobiology
• Nature Biotechnology
• Nature Methods
• PlosONE

Grants Reviews

• Department of Energy
• National Institutes of Health
• National Science Foundation
• Petroleum Research Fund
• The Wellcome Trust
• University of Illinois
• University of Missouri
• W. M. Keck Foundation

Courses Taught

University of California, Irvine

Winter 2006

BME 297 – PhD Dissertation Research

Spring 2006

BME 297 – PhD Dissertation Research

Fall 2006

BME 297 – PhD Dissertation Research

Winter 2007

BME 195/295 – Spectroscopy& Imag Bio System (undergraduate& graduate)

BME 297 – PhD Dissertation Research

BME 299 – Individual Research

Spring 2007

BME 170 – Biomedical Engineering Lab (undergraduate)

BME 297 – PhD Dissertation Research

Fall 2007

BME 195/295 – Bio-Spectroscopy (undergraduate & graduate)

BME 297 – PhD Dissertation Research

BME 299 – Individual Research

Winter 2008

BME 297 – PhD Dissertation Research

BME 299 – Individual Research

Spring 2008

BME 170 – Biomedical Engineering Lab (undergraduate)

BME 299 – Individual Research

Fall 2008 2019

BME 138/238 – Bio-Spectroscopy (undergraduate & graduate)

BME 299 – Individual Research

University Service

APAC Committee at UCI School of Engineering (2012-2017)

Departmental Committees (Biomedical Engineering

Faculty Awards Committee, Chair (2007-2009) 

Faculty Recruitment Committee, Assistant - Associate Positions, Chair (2007-2008)

Retreat Planning Committee, member (2008-2010)        

Classroom Teaching Assignments (UIUC)

• 1996-97: Physics 450
• 1997-98: Physics 450 (Frauenfelder Notes)
• Spring 1998 : Physics 102
• Fall 1999: Physics 101
• Fall 2000: Physics 301
• Fall 2001: Physics 101
• Spring 2003: Physics 101; Listed on "Incomplete List of Teachers Ranked as Excellent by their Students."
• Fall 2003: Physics 398OS
• Spring 2004: Physics 450
• Fall 2004: Physics 598OS
• Fall 2005: Physics 102 Discussion
• August 2005: Awarded the "6th Annual MSPAC Outstanding Advisor Award" by the Medical Scholars Program Advisory Committee of the University of Illinois at Urbana-Champaign

Teaching/Advising/Supervising:

Graduate Students:

Graduation Date:

1.   Simon Leemans (2019)

Past graduate students (Year Degree was Completed), present status, if known:

1. Ottavia Golfetto (2011)

2. Chi-Li Chiu (2012) , Imaris.

3. Kaveh Azartash (2010)

4. Giulia Ossato (2010), Leica (Germany)

5. Peter Fwu

6. Cosimo Arnesano(2010) Zeiss US

7. Ylenia Santoro(2010 Masimo (CA)

8. Shanshan Xu(2010)

9. Francesco Cutrale(2010) USC

10. Molly Rosso (2009)

11. Ryan Colyer (Ph.D., 2008), currently at UCLA, Los Angeles, CA

12. Claudia Lee (Ph.D., 2007), currently at UVP Inc., Upland, CA

13. Shwayta Kukreti (Ph.D., 2007), currently in Medical Scholars Program, University of Illinois at Urbana-Champaign

14. Kandice Tanner (Ph.D., 2006), currently at Univ. of California, Berkeley

15. Anna Celli (2006), currently at Veterans Affairs Medical Center, UCSF

16. D. Eckhoff (Ph.D., 2006), currently at Webster University, St. Louis, MO

17. Chiara Polzonetti (M.S., 2006)

18. Abdel Tahari (2005), currently finishing Medical Scholars Program, UIUC*

19. Natalia Machado (M.S., 2005)

20. Jee-Hyun Choi (Ph.D., 2003), currently at Samsung Advanced Institute of Technology, South Korea

21. John Eid (Ph.D., 2003), currently at Rowland Institute at Harvard, Cambridge, MA

22. Osman Akcakir (Ph.D., 2002), currently at Molecular Biology Consortium, Chicago, IL

23. L. Adelina Paunescu (Ph.D., 2001), currently at MIT, Cambridge, MA

24. Timothy Ragan (Ph.D., 2001), currently at MIT, Cambridge, MA

25. Claudia Casavola (2000-Italian doctorate), currently in Italy

26. Matthia Filiaci (Ph.D., 2000), currently at Rutter Associates, NY

27. Yan Chen (Ph.D., 1999), currently at University of Minnesota

28. Albert Cerussi (Ph.D., 1999), currently at Beckman Institute, CA

29. Scott Walker * (Ph.D., 1998; M.D., 2001), currently at University of Colorado Health Sciences Center

30. Chen-Yuan Dong (Ph.D., 1997), currently at National Taiwan University, Republic of China

31. J. Maier* (Ph.D., 1997), currently at Chemimage Corp, PA

32. Todd French (Ph.D., 1996), currently at Molecular Devices, Inc., Sunnyvale, CA

33. Keith Berland (Ph.D., 1995), currently at Emory University, GA

34. Jenny Carrero (Ph.D., 1994), currently at Unilever, NY

35. Joshua Fishkin (Ph.D., 1994), currently at Boeing, Los Angeles, CA

36. Brett Feddersen (Ph.D., 1993), currently at Frasca, Champaign, IL

37. Norberto Silva (Ph.D., 1993), currently at Mayo Clinic, Rochester, NY

38. J. L. Vittitow (Ph.D., 1990)

39. David W. Piston (Ph.D., 1989), currently at Washington Univerity, StLuis MO

40. S. L. Lin (Ph.D., 1988)

41. Jose R. Alcala (Ph.D., 1987), deceased

42. M. K. Limkeman (Ph.D., 1984), currently at Milwaukee GE Medical Center, WI

43. C. J. Hardy (Ph.D., 1983), currently at Medical Center Schenckdidy, NY

*Medical Scholars Program

Research Associates (Post-doctorate):

At UCI

1. Michelle Digman

2. Luca Lanzano

3. Ilaria Altamore

4. Francesco Cardarelli

5. Laura Estrada

6. Chiara Stringari

7. Leonel Malacrida

8. Per Niklas Hedde

9. Suman Ranjit

10. Lorenzo Scipioni

11. Chris Heylman

12. Ylenia Santoro

13. Bo Chen (2009-2010)

14. Kandice Tanner (2007-2008), currently at Univ. of California, Berkeley

15. Enrico D'Amico (2002-2007), currently at Univ. of California, Irvine

16. Michelle Digman (2003-2008), currently at Univ. of California, Irvine

17. Christian Hellriegel (2006-2008), currently at Zeiss

18. Jay Unruh (2006-2008), currently at Stowers Institute for Medical Research, Kansas City, MO

19. Alexander Vallmitjana Lees

20. Paolo Annibale

21. Andrea Anzalone

22. Margaux Bouzin

23. Luca Dalbosco

24. Oliver Holub

25. Elizabeth Hinde

At UIUC

1. Nicholas Barry (1997-2003), currently at Univ. of Colorado, Health Sciences Ctr, Denver

2. Joseph M. Beechem (1987-89), currently at Molecular Probes, Oregon
3. Luis A. Bagatolli (1997-00), currently at University of Southern Denmark
4. Christof Buehler (1996-98), currently at Paul Schrerrer Institute, Switzerland
5. Mateo Calderon-Arnulphi (2002-05), currently at University of Illinois at Chicago
6. Yan Chen (1998-00), currently at University of Minnesota
7. Andrea De Oliveira (2003-2006), currently at Universida de Federal do Rio de Janeiro, Brazil
8. Svante Eriksson (1992-93)
9. Sergio Fantini (1993-96), currently at Tufts University, Massachusetts
10. Mari A. Franceschini (1993-99), currently at Massachusetts General Hospital
11. Katerina Kis-Petikova (1999-2001), currently at Institute of Biophysics & Radiation Biology, Budapest, Hungary
12. Valeria Levi (2003-2006), currently at University of Buenos Aires, Argentina
13. Jochen Müller (1997-00), currently at University of Minnesota
14. Gina Perez (2002), currently at Vanderbilt University Medical Center
15. Qiaoqiao Ruan (2003-2004), currently at Abbott Labs, Illinois
16. Cathy A. Royer (1988-91), currently at CNRS, France
17. Larissa P. Safonova (2000-2003), currently in Russia
18. Parijat, Sengupta (2004-), currently at SUNY Stony Brook, NY
19. Peter T. C. So (1992-96), currently at Massachusetts Institute of Technology
20. Allain Sillen (1999-2002)
21. Martin Wolf (1998-2001)
22. Ursula Wolf (1999-2001)
23. Weiming Yu (1997-2000), currently at Indiana University

Visiting Scholars (more than 6 months):

1. Paul Wiseman (2007-2008)

2. Andre M. O. Gomes (2003)

3. Wooseok Ko (2004)

Research Technicians:

1. Viera Crosignani

2. Elizabeth Hinde

3. Claudia Magaudda

4. Milka Stakic

5. Ben Pruess (2008)

6. Jennifer Sasaki (2007-present)

7. Christine M. Larson (1991-1997)

8. Ruth M. Rusch (1987-1990)

Visiting Scholars (more than 6 months)

1.      Paul Wiseman (2007-2008), currently at McGill University, Montreal, QC, Canada

Extramural Support:

Since joining UCI, I brought support grants for about $28M, from NIH and Keck foundation

Publications

A complete list of publication and citations including 2019- can be found at https://scholar.google.com/citations?hl=en&user=Pb-ZWXEAAAAJ

Book Chapters:

B-1 di Rienzo C, Gratton E, Beltram F, Cardarelli F.Super-Resolution in a standard microscope: from fast fluorescence imaging to molecular diffusion laws in live cells.Super-Resolution Imaging in Biomedicine. By A Diaspro and MAMJ van Zandvoort (Editors). CRC Press, pp. 19-43, 2016. ISBN: 9781482244342

B-2 Gratton E.Measurements of fluorescence decay time by the frequency domain method.Perspectives on Fluorescence: A Tribute to Gregorio Weber (Springer Series on Fluorescence). By DM Jameson (Editors). Springer Berlin Heidelberg, 2016.

B-3 Cardarelli F, Gratton E.Spatiotemporal fluorescence correlation spectroscopy of inert tracers: a journey within cells, one molecule at a time.Perspectives on Fluorescence: A Tribute to Gregorio Weber (Springer Series on Fluorescence). By DM Jameson (Editors). Springer Berlin Heidelberg, 2016.

B-4 Gratton E, Digman MA.Laurdan identifies different lipid membranes in eukaryotic cells.Cell Membrane Nanodomains: From Biochemistry to Nanoscopy. By A Cambi and DS Lidke (Editors). CRC Press, pp. 283-304, 2014. ISBN: 9781482209891

B-5 Golfetto O, Hinde E, Gratton E.The Laurdan spectral phasor method to explore membrane micro-heterogeneity and lipid domains in live cells.Methods in Membrane Lipids (Methods in Molecular Biology, Vol. 1232). By DM Owen (Editors). Springer New York, pp. 273-290, 2014. ISBN: 9781493917518

B-6 Digman MA, Gratton E.The phasor approach to fluorescence lifetime imaging: exploiting phasor linear properties.Fluorescence Lifetime Spectroscopy and Imaging: Principles and Applications in Biomedical Diagnostics. By L Marcu, PMW French, and DS Elson (Editors). CRC Press, pp. 235-248, 2014. ISBN: 9781439861677

B-7 Gratton E, Stakic M, Digman MA.Raster image correlation spectroscopy and number and brightness analysis.Fluorescence Fluctuation Spectroscopy (FFS) Part A (Methods in Enzymology, Vol. 518). By SY Tetin (Editors). Academic Press, pp. 121-144, 2013. ISBN: 9780123884220

B-8 Levi V, Gratton E.Three-dimensional particle tracking in a laser scanning fluorescence microscope.Single-particle tracking and single molecule energy transfer. By C Bräuchle, DC Lamb, and J Michaelis (Editors). Wiley VCH, pp. 3-24, 2010. ISBN: 9783527322961

B-9 Gratton E, Toronov VY, Wolf U, Wolf M.Detection of brain activity by near-infrared light.Biomedical Optical Imaging. By JG Fujimoto and D Farkas (Editors). Oxford University Press, pp. 378-395, 2009. ISBN: 9780195150445

B-10 Sánchez SA, Tricerri MA, Gunther G, Gratton E. Laurdan generalized polarization: from cuvette to microscope.Modern Research and Educational Topics in Microscopy. Vol. 3: Applications in Physical/Chemical Sciences (Microscopy Book Series, Vol. 3). By A Méndez-Vilas and J Díaz (Editors). Formatex Research Center, Badajoz, Spain, pp. 1007-1014, 2007. ISBN: 9788461194209

B-11 Celli A, Lee CY, Gratton E. Fluorescence microscopy to study pressure between lipids in giant unilamellar vesicles.Methods in Membrane Lipids (Methods in Molecular Biology, Vol. 400). By AM Dopico (Editors). Humana Press, pp. 333-340, 2007. ISBN: 9781588296627

B-12 Digman MA, Gratton E.The RICS method: measurement of fast dynamics in cells with the laser scanning microscope.Image Analysis in Medical Microscopy and Pathology. By HS Wu and AJ Einstein (Editors). Research Signpost, Kerala, India, pp. 207-224, 2007. ISBN: 8130801167

B-13 Gratton E, vandeVen MJ.Laser sources for confocal microscopy.The Handbook of Biological Confocal Microscopy (Third Edition). By JB Pawley (Editors). Springer-Verlag New York, pp. 80-125, 2006. ISBN: 9780387259215

B-14 Gratton E, Breusegem SY, Barry NP, Ruan Q, Eid JS.Fluctuation correlation spectroscopy in cells: determination of molecular aggregation.Biophotonics: Optical Science and Engineering for the 21st Century (Vol. XVIII). By X Shen and R van Wijk (Editors). Springer Verlag, pp. 1-14, 2006. ISBN: 9780387249957

B-15 Gratton E, Fantini S.Reflectance and transmittance spectroscopy.Laser and Current Optical Techniques in Biology (Comprehensive Series in Photochemical & Photobiological Sciences). By G Palumbo and R Pratesi (Editors). Royal Society of Chemistry, pp. 211-258, 2005. ISBN: 9780854043217

B-16 Palumbo G, Pratesi R, Gratton E, Fantini S, Häder DP, Jori G.Reflectance and transmittance spectroscopy.Lasers and Current Optical Techniques in Biology (Comprehensive Series in Photochemical & Photobiological Sciences). By G Palumbo and R Pratesi (Editors). Royal Society of Chemistry, pp. 213-247, 2004. ISBN: 9780854043217

B-17 Dong CY, French TE, So PTC, Buehler C, Berland KM, Gratton E.Fluorescence-lifetime imaging techniques for microscopy.Digital Microscopy. A second edition of "Video Microscopy" (Methods in Cell Biology, Vol. 72). By G Sluder and DE Wolf (Editors). Academic Press, pp. 431-464, 2003. ISBN: 9780125641692

B-18 Beechem JM, Gratton E, Ameloot M, Knutson JR, Brand L.The global analysis of fluorescence intensity and anisotropy decay data: second-generation theory and programs.Topics in Fluorescence Spectroscopy: "Principles" (Vol. 2). By JR Lakowicz (Editors). Springer US, pp. 241-305, 2003. ISBN: 9780306438752

B-19 Müller JD, Chen Y, Gratton E.Fluorescence correlation spectroscopy.Biophotonics, Part B (Methods in Enzymology, Vol. 361). By G Marriott and I Parker (Editors). Academic Press, pp. 69-92, 2003. ISBN: 9780121822644

B-20 Bagatolli LA, Sánchez SA, Hazlett TL, Gratton E.Giant vesicles, Laurdan, and two-photon fluorescence microscopy: evidence of lipid lateral separation in bilayers.Biophotonics, Part A (Methods in Enzymology, Vol. 360). By G Marriott and I Parker (Editors). Academic Press, pp. 481-500, 2003. ISBN: 9780121822637

B-21 Learmonth RP, Gratton E.Assessment of membrane fluidity in individual yeast cells by Laurdan Generalized Polarization and multi-photon scanning fluorescence microscopy.Fluorescence Spectroscopy, Imaging and Probes (Vol. 2). By R Kraayenhof, AJWG Visser, and HC Gerritsen (Editors). Springer-Verlag Berlin, Heidelberg, New York, pp. 241-252, 2002. ISBN: 9783540427681

B-22 Dong CY, Buehler C, So PTC, French T, Gratton E.Biological applications of time-resolved, pump-probe fluorescence microscopy and spectroscopy in the frequency domain.Methods In Cellular Imaging (Methods in Physiology Series, Vol. IV). By A Periasamy (Editors). Springer New York, pp. 324-340, 2001. ISBN: 9780195139365

B-23 Parasassi T, Bagatolli LA, Gratton E, Levi M, Ursini F, Yu W, Zajicek HK.Two-photon excitation microscopy for image spectroscopy and biochemistry of tissues, cells, organelles and lipid vesicles under physiological conditions.Confocal and Two-Photon Microscopy: Foundations, Applications and Advances. By A Diaspro (Editors). John Wiley & Sons, New York, pp. 469-482, 2001. ISBN: 9780471409205

B-24 Chen Y, Müller JD, Eid JS, Gratton E.  Two-photon fluorescence fluctuation spectroscopy. New Trends in Fluorescence Spectroscopy:Applications to Chemical and Life Sciences (Springer Series on Fluorescence). By B Valeur and JC Brochon (Editors). pp. 277-296, 2001. ISBN: 9783540677796

B-25 Müller JD, Chen Y, Gratton E.Photon counting histogram statistics.Fluorescence Correlation Spectroscopy. Theory and Applications (Springer Series in Chemical Physics, Vol. 65). By R Riegler and EL Elson (Editors). Springer-Verlag, Berlin, pp. 410-437, 2001. ISBN: 9783540674337

B-26 Yu W, Mantulin WW, Gratton E.Fluorescence lifetime imaging: new microscopy technologies.Emerging Tools for Single-Cell Analysis (Advances in Optical Measurement Technologies). By G Durack and JP Robinson (Editors). Wiley-Liss, pp. 139-173, 2000. ISBN: 9780471315759

B-27 Dong CY, Kim KH, Buehler C, Hsu L, Kim H, So PTC, Masters BR, Gratton E, Kochevar IE.Probing deep-tissue structures by two-photon fluorescence microscopy.Emerging Tools for Single-Cell Analysis (Advances in Optical Measurement Technologies). By G Durack and JP Robinson (Editors). Wiley-Liss, Inc, pp. 221-237, 2000. ISBN: 9780471315759

B-28 Masters BR, So PTC, Gratton E.Multiphoton excitation microscopy and spectroscopy of cells, tissues, and human skin in vivo.Fluorescent and Luminescent Probes for Biological Activity: A Practical Guide to Technology for Quantitative Real-Time Analysis (Second Edition) (Biological Techniques Series). By WT Mason (Editors). Academic Press, pp. 414-432, 1999. ISBN: 9780124778306

B-29 Masters BR, So PTC, Kim KH, Buehler C, Gratton E.Multiphoton excitation microscopy, confocal microscopy, and spectroscopy of living cells and tissues; functional metabolic imaging of human skin in vivo.Confocal Microscopy (Methods in Enzymology, Vol. 307). By JN Abelson, MI Simon, and PM Conn (Editors). Academic Press, pp. 513-36, 1999. ISBN: 0121822087

B-30 French TE, So PTC, Dong CY, Berland KM, Gratton E.Fluorescence lifetime imaging techniques for microscopy.Video Microscopy (Methods in Cell Biology, Vol. 56). By G Sluder and DE Wolf (Editors). Academic Press, pp. 277-304, 1998. ISBN: 9780126491609

B-31 Masters BR, So PTC, Gratton E.Multiphoton excitation microscopy of in vivo human skin. Functional and morphological optical biopsy based on three-dimensional imaging, lifetime measurements and fluorescence spectroscopy.Advances in Optical Biopsy and Optical Mammography (Annals of the New York Academy of Sciences, Vol. 838). pp. 58-67, 1998. ISBN: 9781573311267

B-32 So PTC, Dong CY, Berland KM, French TE, Gratton E.Time-resolved stimulated-emission and transient-absorption microscopy and spectroscopy.Nonlinear and Two-Photon-Induced Fluorescence (Topics in Fluorescence Spectroscopy, Vol. 5). By JR Lakowicz (Editors). Plenum Press, New York, pp. 427-469, 1997. ISBN: 9780306455537

B-33 Gratton G, Fabiani M, Corballis PM, Gratton E.Noninvasive detection of fast signals from the cortex using frequency-domain optical methods.Imaging Brain Structure and Function: Emerging Technologies in the Neurosciences (Annals of the New York Academy of Sciences, Vol. 820). By DS Lester, CC Felder, and EN Lewis (Editors). pp. 286-298, 1997. ISBN: 9781573310697

B-34 So PTC, French TE, Yu W, Berland KM, Dong CY, Gratton E.Two-photon fluorescence microscopy: time-resolved and intensity imaging.Fluorescence Imaging Spectroscopy and Microscopy (Chemical Analysis: A Series of Monographs on Analytical Chemistry and Its Applications. Vol. 137). By XF Wang and B Herman (Editors). John Wiley & Sons, pp. 351-374, 1996. ISBN: 9780471015277

B-35 Gratton E, vandeVen MJ.Laser sources for confocal microscopy.The Handbook of Biological Confocal Microscopy (Second Edition). By JB Pawley (Editors). Springer-Verlag New York, pp. 69-97, 1995. ISBN: 0306448262

B-36 vandeVen MJ, Gratton E.Time-resolved fluorescence lifetime imaging.Optical Microscopy: Emerging Methods and Applications. By B Herman and JJ Lemasters (Editors). Academic Press, pp. 373-402, 1992. ISBN: 9780123420602

B-37 Ferreira ST, Gratton E. Enzyme activity in reverse micelles: roles of diffusion and extent of hydration.iomolecules in Organic Solvents. By A Gómez-Puyou (Editors). CRC Press, pp. 189-202, 1992. ISBN: 9780849348235

B-38 Gratton E, Alcala JR, Barbieri BB.Frequency-domain fluorometry.Luminescence Techniques in Chemical and Biochemical Analysis (Luminescence Spectroscopy, Vol. 12). By WRG Baeyens, D de Keukeleire, and K Korkidis (Editors). CRC Press, pp. 47-72, 1990. ISBN: 9780824783693

B-39 Gratton E, vandeVen MJ Laser sources for confocal microscopy.The Handbook of Biological Confocal Microscopy. By JB Pawley (Editors). Springer-Verlag New York, pp. 47-59, 1989. ISBN: 0306448262 Gratton E, Silva N Jr, Ferreira ST.Fluorescence of tryptophan and protein dynamics.Biological and Artificial Intelligence Systems. By E Clementi and S Chin (Editors). ESCOM Science Publishers, Leiden, The Netherlands, pp. 49-55, 1988. ISBN: 9789072199027

B-40 Careri G, Gratton E. The statistical time correlation approach to enzyme action: the role of hydration.The Fluctuating Enzyme (Nonequilibrium Problems in the Physical Sciences & Biology). By GR Welch (Editors). John Wiley & Sons, New York, pp. 227-262, 1986. ISBN: 9780471888703

B-41 Frauenfelder H, Gratton E. Biomembranes Part O: Protons and Water: Structure and Translocation (Methods in Enzymology, Vol. 127). Academic Press, pp. 207-216, 1986. ISBN: 0121820270

B-42 Gratton, E. and R. Lopez-Delgado. Remarks on a novel method for fluorescence lifetime measurements. In Time Resolved Fluorescence Spectroscopy in Biochemistry and Biology (R. B. Cundall and R. E. Dale, Eds.) NATO ASIS, Ser. A. Vol. 69A, Plenum Press, NY, pp. 109-114 (1983).

B-43 Jameson, D. and E. Gratton. Analysis of heterogeneous emissions by multifrequency phase and modulation fluorometry. In New Directions in Molecular Luminescence. ASTM-STP 822 (D. Eastwood, Ed.) (American Society of Testing and Materials), pp. 67-81 (1983).

B-44 Gratton, E., J. R. Alcala and G. Marriott. Rotational motions of tryptophan and tyrosine residues in proteins. In Structure and Dynamics of Nucleic Acids, Proteins, and Membranes (E. Clementi and S. Chin, Eds.) 149-151 (1986).

B-45 Lentz, B. R., S. W. Burgess and E. Gratton. Concentration dependence of DPHpPC fluorescence lifetime: Photophysics and utility for monitoring membrane fusion. In Molecular Mechanisms of Membrane Fusion (S. Ohki, D. Doyle, T. D. Flanagan, S. W. Hue and E. Mayhew, Eds.) Plenum Pub. Corp. (1988).

B-46 Gratton, E., J. R. Alcala and F. G. Prendergast. Protein dynamics: Fluorescence lifetime distributions. In Fluorescent Biomolecules, pp. 17-32 (D. M. Jameson and G. Reinhart, Eds.) Plenum Press (1989).

B-47 Gratton, E. and M. J. vandeVen. Laser sources for confocal microscopy. In The Handbook of Biological Confocal Microscopy (J. Pawley, Ed.) Ch. 5, pp. 53-67. Plenum Press, Proc. EMSA 47th Annual Mtg., San Antonio, TX (1990).

B-48 Beechem, J. M., E. Gratton, M. Ameloot, J. R. Knutson and L. Brand. The global analysis of fluorescence intensity and anisotropy decay data: Second generation theory and programs. In Topics in Fluorescence Spectroscopy, II "Principles." (J. R. Lakowicz, Ed.) Ch. 5, pp. 241-305 (1991).

B-49 Parasassi, T., M. Di Stefano, G. Ravagnan, O. Sapora and E. Gratton. Membrane aging during cell growth ascertained by Laurdan generalized polarization. In Experimental Cell Research 202, Academic Press, 432-439 (1992).

B-50 Ferreira, S. T. and E. Gratton. Enzyme activity in reverse micelles: Roles of diffusion and extent of hydration. In Biomolecules in Organic Solvents, CRC Meeting, Ch. 8, pp. 189-201 (1992).

B-51 Reinhart, G., E. Gratton and W. Mantulin. Dissociation of large oligomeric proteins by high hydrostatic pressure: dynamic light scattering studies. NATO ASI Series Volume "High Pressure Chemistry, Biochemistry and Materials Sciences." (R. Winter, Ed.), 619-626 (1993).

B-52 vandeVen, M. and E. Gratton. Time-resolved fluorescence lifetime imaging. In Optical Microscopy: Emerging Methods and Applications, Academic Press, Ch. 14, 373-402 (1993).

Journal Articles:

Published:

J-1 Gratton, E. (1971). Method for the automatic correction of scattering in absorption spectra by using the integrating sphere. Biopolymers, 10(12), 2629–2634. https://doi.org/10.1002/bip.360101225

J-2 Dore, E., Frontali, C., & Gratton, E. (1972). Physico‐chemical description of a condensed form of DNA. Biopolymers, 11(2), 443–459. https://doi.org/10.1002/bip.1972.360110210

J-3 Dore, E., Frontali, C., & Gratton, E. (1972). The Role of ions in the acid melting of DNA. Biopolymers, 11(10), 2033–2041. https://doi.org/10.1002/bip.1972.360111004

J-4 Dore, E., Frontali, C., & Gratton, E. (1973). The effect of temperature on acid condensation of DNA. Biopolymers, 12(5), 1171–1176. https://doi.org/10.1002/bip.1973.360120519

J-5 Cancellieri, A., Frontali, C., & Gratton, E. (1974). Dispersion effect on turbidimetric size measurement. Biopolymers, 13(4), 735–743. https://doi.org/10.1002/bip.1974.360130408

J-6 Careri, G., Fasella, P., Gratton, E., & Jencks, W. P. (1975). Statistical time events in enzymes: A physical assessmen. Critical Reviews in Biochemistry and Molecular Biology, 3(2), 141–164. https://doi.org/10.3109/10409237509102555

J-7 Careri, G., & Gratton, E. (1977). Onsager coupling in enzymes. BioSystems, 8(4), 185–186. https://doi.org/10.1016/0303-2647(77)90037-5

J-8 Careri, G., De Angelis, L., Gratton, E., & Messana, C. (1977). Magnetic susceptibility of lysozyme. Physics Letters A, 60(5), 490–491. https://doi.org/10.1016/0375-9601(77)90065-2

J-9 Ascoli, F., Gratton, E., Riva, F., Fasella, P., & Brunori, M. (1978). Infrared stretching frequencies of CO in carbomonoxy-hemoglobin from trout. BBA - Protein Structure, 533(2), 534–537. https://doi.org/10.1016/0005-2795(78)90400-2

J-10 Gratton, E., & Delgado, R. L. (1979). Use of synchrotron radiation for the measurement of fluorescence lifetimes with subpicosecond resolution. Review of Scientific Instruments, 50(6), 789–790. https://doi.org/10.1063/1.1135928

J-11 Frontali, C., Dore, E., Ferrauto, A., Gratton, E., Bettini, A., Pozzan, M. R., & Valdevit, E. (1979). An absolute method for the determination of the persistence length of native DNA from electron micrographs. Biopolymers, 18(6), 1353–1373. https://doi.org/10.1002/bip.1979.360180604

J-12 Careri, G., Fasella, P., & Gratton, E. (1979). Enzyme dynamics: the statistical physics approach. Annual Review of Biophysics and Bioengineering, 8, 69–97. https://doi.org/10.1146/annurev.bb.08.060179.000441

J-13 Careri, G., Giansanti, A., Gratton, E., & Snamprogetti. (1979). Lysozyme film hydration events: An IR and gravimetric study. Biopolymers, 18(5), 1187–1203. https://doi.org/10.1002/bip.1979.360180512

J-14 Gratton, E., & Lopez-Delgado, R. (1980). Measuring fluorescence decay times by phase-shift and modulation techniques using the high harmonic content of pulsed light sources. Il Nuovo Cimento B Series 11, 56(1), 110–124. https://doi.org/10.1007/BF02738361

J-15 Careri, G., Gratton, E., Yang, P.-H., & Rupley, J. A. (1980). Correlation of IR spectroscopic, heat capacity, diamagnetic susceptibility and enzymatic measurements on lysozyme powder. Nature, 284(5756), 572–573. https://doi.org/10.1038/284572a0

J-16 Careri, G., Giansanti, A., & Gratton, E. (1981). Molecular aspects of the hydration process in a globular protein. International Journal of Quantum Chemistry, 19(6), 1133–1135. https://doi.org/10.1002/qua.560190622

J-17 Rupley, J. A., Gratton, E., & Careri, G. (1983). Water and globular proteins. Trends in Biochemical Sciences, 8(1), 18–22. https://doi.org/10.1016/0968-0004(83)90063-4

J-18 Gavish, B., Gratton, E., Hardy, C. J., & St. Denis, A. (1983). Differential sound velocity apparatus for the investigation of protein solutions. Review of Scientific Instruments, 54(12), 1756–1760. https://doi.org/10.1063/1.1137327

J-19 Jameson, D. M., & Gratton, E. (1983). ANALYSIS OF HETEROGENEOUS EMISSIONS BY MULTIFREQUENCY PHASE AND MODULATION FLUOROMETRY. In ASTM Special Technical Publication (pp. 67–81). Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0020937680&partnerID=40&md5=9ccfcf4df0723446defbba514a6414d3

J-20 Gavish, B., Gratton, E., & Hardy, C. J. (1983). Adiabatic compressibility of globular proteins. Proceedings of the National Academy of Sciences of the United States of America, 80(3), 750–754. https://doi.org/10.1073/pnas.80.3.750

J-21 Gratton, E., & Limkeman, M. (1983). Microprocessor-controlled photon-counting spectrofluorometer. Review of Scientific Instruments, 54(3), 294–299. https://doi.org/10.1063/1.1137386

J-22 Careri, G., Buontempo, U., Carta, F., Gratton, E.,& Scott, A. C. (1983). Infrared absorption in acetanilide by solitons. Physical Review Letters, 51(4), 304–307. https://doi.org/10.1103/PhysRevLett.51.304

J-23 Gratton, E., & Limkeman, M. (1983). A continuously variable frequency cross-correlation phase fluorometer with picosecond resolution. Biophysical Journal, 44(3), 315–324. https://doi.org/10.1016/S0006-3495(83)84305-7

J-24 Jameson, D. M., Gratton, E., Weber, G., & Alpert, B. (1984). Oxygen distribution and migration within Mbdes Fe and Hbdes Fe. Multifrequency phase and modulation fluorometry study. Biophysical Journal, 45(4), 795–803. https://doi.org/10.1016/S0006-3495(84)84224-1

J-25 Gratton, E., Jameson, D. M., & Hall, R. D. (1984). Multifrequency phase and modulation fluorometry. Annual Review of Biophysics and Bioengineering, 13, 105–124. https://doi.org/10.1146/annurev.bb.13.060184.000541

J-26 Parasassi, T., Conti, F., & Gratton, E. (1984). Study of Heterogeneous Emission of Parinaric Acid Isomers Using Multifrequency Phase Fluorometry. Biochemistry, 23(23), 5660–5664. https://doi.org/10.1021/bi00318a042

J-27 Gratton, E., Limkeman, M., Lakowicz, J. R., Maliwal, B. P., Cherek, H., & Laczko, G. (1984). Resolution of mixtures of fluorophores using variable-frequency phase and modulation data. Biophysical Journal, 46(4), 479–486. https://doi.org/10.1016/S0006-3495(84)84044-8

J-28 Gratton, E., Jameson, D. M., Weber, G., & Alpert, B. (1984). A model of dynamic quenching of fluorescence in globular proteins. Biophysical Journal, 45(4), 789–794. https://doi.org/10.1016/S0006-3495(84)84223-X

J-29 Gratton, E., Jameson, D. M., Rosato, N., & Weber, G. (1984). Multifrequency cross-correlation phase fluorometer using synchrotron radiation. Review of Scientific Instruments, 55(4), 486–494. https://doi.org/10.1063/1.1137777

J-30 Lakowicz, J. R., Cherek, H., Laczko, G., & Gratton, E. (1984). Time-resolved fluorescence emission spectra of labeled phospholipid vesicles, as observed using multi-frequency phase-modulation fluorometry. BBA - Biomembranes, 777(2), 183–193. https://doi.org/10.1016/0005-2736(84)90419-X

J-31 Lakowicz, J. R., Gratton, E., Cherek, H., Maliwal, B. P., & Laczko, G. (1984). Determination of time-resolved fluorescence emission spectra and anisotropies of a fluorophore-protein complex using frequency-domain phase-modulation fluorometry. Journal of Biological Chemistry, 259(17), 10967–10972. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0021130930&partnerID=40&md5=9e6a2f425b04d5a213b8e7b1e77b45d8

J-32 Marque, J., Eisenstein, L., Gratton, E., Sturtevant, J. M., & Hardy, C. J. (1984). Thermodynamic properties of purple membrane. Biophysical Journal, 46(5), 567–572. https://doi.org/10.1016/S0006-3495(84)84055-2

J-33 Parasassi, T., Conti, F., Glaser, M., & Gratton, E. (1984). Detection of phospholipid phase separation. A multifrequency phase fluorimetry study of 1,6-diphenyl-1,3,5-hexatriene fluorescence. Journal of Biological Chemistry, 259(22), 14011–14017. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0021717208&partnerID=40&md5=38afc74c1479a3f4631954050bab1a9b

J-34 Careri, G., Buontempo, U., Galluzzi, F., Scott, A. C., Gratton, E., & Shyamsunder, E. (1984). Spectroscopic evidence for Davydov-like solitons in acetanilide. Physical Review B, 30(8), 4689–4702. https://doi.org/10.1103/PhysRevB.30.4689

J-35 Lakowicz, J. R., Cherek, H., Maliwal, B., & Gratton, E. (1984). Frequency-domain phase-modulation fluorometry: Resolution of complex decays of fluorescence intensity and anisotropy. Journal of Luminescence, 31–32(PART 2), 699–702. https://doi.org/10.1016/0022-2313(84)90100-5

J-36 Lakowicz, J. R., Laczko, G., Cherek, H., Gratton, E.,& Limkeman, M. (1984). Analysis of fluorescence decay kinetics from variable-frequency phase shift and modulation data. Biophysical Journal, 46(4), 463–477. https://doi.org/10.1016/S0006-3495(84)84043-6

J-37 Jameson, D. M., Gratton, E., & Hall, R. D. (1984). The measurement and analysis of heterogeneous emissions by multifrequency phase and modulation fluorometry. Applied Spectroscopy Reviews, 20(1), 55–106. https://doi.org/10.1080/05704928408081716

J-38 Conti, F., Parasassi, T., Rosato, N., Sapora, O., & Gratton, E. (1984). Fluorescence studies using synchrotron radiation on normal and differentiated cells labeled with parinaric acids. BBA - Molecular Cell Research, 805(1), 117–122. https://doi.org/10.1016/0167-4889(84)90043-0

J-39 Lakowicz, J. R., Cherek, H., Maliwal, B. P., & Gratton, E. (1985). Time-Resolved Fluorescence Anisotropics of Diphenylhexatriene and Perylene in Solvents and Lipid Bilayers Obtained from Multifrequency Phase-Modulation Fluorometry. Biochemistry, 24(2), 376–383. https://doi.org/10.1021/bi00323a021

J-40 Scott, A. C., Gratton, E., Shyamsunder, E., & Careri, G. (1985). Ir overtone spectrum of the vibrational soliton in crystalline acetanilide. Physical Review B, 32(8), 5551–5553. https://doi.org/10.1103/PhysRevB.32.5551

J-41 Alcala, J. R., & Gratton, E. (1985). A Multifrequency Prase Fluorometer Using the Harmonic Content of a Mode-Locked Laser. Instrumentation Science & Technology, 14(3–4), 225–250. https://doi.org/10.1080/10739148508543579

J-42 Mugnier, J., Valeur, B., & Gratton, E. (1985). Rate of intramolecular electronic energy transfer in coumarin bichromophoric molecules. An investigation by multifrequency phase-modulation fluorometry. Chemical Physics Letters, 119(2–3), 217–222. https://doi.org/10.1016/0009-2614(85)80063-4

J-43 Alcala, J. R., Gratton, E., & Jameson, D. M. (1985). A multifrequency phase fluorometer using the harmonic content of a mode-locked laser. Analytical Instrumentation, 14(3–4), 225–250. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022129680&partnerID=40&md5=3bc5e867d974a5024bb753d91e695b5b

J-44 Gratton, E., & Jameson, D. M. (1985). New Approach to Phase and Modulation Resolved Spectra. Analytical Chemistry, 57(8), 1694–1697. https://doi.org/10.1021/ac00285a041

J-45 Lakowicz, J. R., Maliwal, B. P., & Gratton, E. (1985). RECENT DEVELOPMENTS IN FREQUENCY-DOMAIN FLUOROMETRY. Analytical Instrumentation, 14(3–4), 193–223. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022127156&partnerID=40&md5=ae8d9276ad9c0bfb248b51c683d2289e

J-46 Gratton, E., Alcala, J. R., & Marriott, G. (1986). Rotations of tryptophan residues in proteins. Biochemical Society Transactions, 14(5), 835–838. https://doi.org/10.1042/bst0140835

J-47 Parasassi, T., Conti, F., & Gratton, E. (1986). Fluorophores in a polar medium: time dependence of emission spectra detected by multifrequency phase and modulation fluorometry. Cellular and Molecular Biology, 32(1), 99–102. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022574570&partnerID=40&md5=c623e5100a79aaf1c2df150f248859e3

J-48 Frauenfelder, H., & Gratton, E. (1986). [14] Protein Dynamics and Hydration. Methods in Enzymology, 127(C), 207–216. https://doi.org/10.1016/0076-6879(86)27017-2

J-49 Parasassi, T., Conti, F., & Gratton, E. (1986). Time-resolved fluorescence emission spectra of Laurdan in phospholipid vesicles by multifrequency phase and modulation fluorometry. Cellular and Molecular Biology, 32(1), 103–108. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022647019&partnerID=40&md5=3af1dca9b981a2dcc9c5a0672bc00564

J-50 Parasassi, T., Conti, F., Gratton, E., & Sapora, O. (1987). Membranes modification of differentiating proerythroblasts. Variation of 1,6-diphenyl-1,3,5-hexatriene lifetime distributions by multifrequency phase and modulation fluorimetry. BBA - Biomembranes, 898(2), 196–201. https://doi.org/10.1016/0005-2736(87)90038-1

J-51 Fiorini, R. M., Valentino, M., Gratton, E., Bertoli, E., & Curatola, G. (1987). Erythrocyte membrane heterogeneity studied using 1,6 - diphenyl - 1,3,5- hexatriene fluorescence lifetime distribution. Biochemical and Biophysical Research Communications, 147(1), 460–466. https://doi.org/10.1016/S0006-291X(87)80143-2

J-52 Fiorini, R., Valentino, M., Wang, S., Glaser, M., & Gratton, E. (1987). Fluorescence Lifetime Distributions of 1,6-Diphenyl-1,3,5-hexatriene in Phospholipid Vesicles. Biochemistry, 26(13), 3864–3870. https://doi.org/10.1021/bi00387a019

J-53 Schroeder, F., Barenholz, Y., Gratton, E., & Thompson, T. E. (1987). A Fluorescence Study of Dehydroergosterol in Phosphatidylcholine Bilayer Vesicles. Biochemistry, 26(9), 2441–2448. https://doi.org/10.1021/bi00383a007

J-54 Rosato, N., Finazzi-Agro, A., Gratton, E., Stefanini, S., & Chiancone, E. (1987). Time-resolved fluorescence of apoferritin and its subunits. The Journal of Biological Chemistry, 262(30), 14487–14491. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023665169&partnerID=40&md5=31e785235adb5ad759bcc0b21e7e6026

J-55 Eccleston, J. F., Gratton, E., & Jameson, D. M. (1987). Interaction of a Fluorescent Analogue of GDP with Elongation Factor Tu: Steady-State and Time-Resolved Fluorescence Studies. Biochemistry, 26(13), 3902–3907. https://doi.org/10.1021/bi00387a024

J-56 Jameson, D. M., Gratton, E., & Eccleston, J. F. (1987). Intrinsic Fluorescence of Elongation Factor Tu in Its Complexes with GDP and Elongation Factor Ts. Biochemistry, 26(13), 3894–3901. https://doi.org/10.1021/bi00387a023

J-57 Bismuto, E., Jameson, D. M., & Gratton, E. (1987). Dipolar Relaxations in Glycerol: A Dynamic Fluorescence Study of 4-2′-(Dimethylamino)-6′-naphthoylcyclohexanecarboxylic Acid (DANCA). Journal of the American Chemical Society, 109(8), 2354–2357. https://doi.org/10.1021/ja00242a019

J-58 Alcala, J. R., Gratton, E., & Prendergast, F. G. (1987). Interpretation of fluorescence decays in proteins using continuous lifetime distributions. Biophysical Journal, 51(6), 925–936. https://doi.org/10.1016/S0006-3495(87)83420-3

J-59 Bismuto, E., Irace, G., Colonna, G., Jameson, D. M.,& Gratton, E. (1987). Dynamic aspects of the heme-binding site in phylogenetically distant myoglobins. Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular, 913(2), 150–154. https://doi.org/10.1016/0167-4838(87)90324-4

J-60 Alcala, J. R., Gratton, E., & Prendergast, F. G. (1987). Resolvability of fluorescence lifetime distributions using phase fluorometry. Biophysical Journal, 51(4), 587–596. https://doi.org/10.1016/S0006-3495(87)83383-0

J-61 Gratton, E., & Barbieri, B. (1987). MOLECULAR DYNAMICS STUDIES USING FREQUENCY-DOMAIN FLUOROMETRY. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 743, pp. 104–109). Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023593828&partnerID=40&md5=ce8c12d4f4b65db600933a5bed4e22b9

J-62 Alcala, J. R., Gratton, E., & Prendergast, F. G. (1987). Fluorescence lifetime distributions in proteins. Biophysical Journal, 51(4), 597–604. https://doi.org/10.1016/S0006-3495(87)83384-2

J-63 Thompson, R. B., & Gratton, E. (1988). Phase Fluorometric Method for Determination of Standard Lifetimes. Analytical Chemistry, 60(7), 670–674. https://doi.org/10.1021/ac00158a014

J-64 Beechem, J. M., & Gratton, E. (1988). Fluorescence spectroscopy data analysis environment: A second generation global analysis program. Proceedings of SPIE - The International Society for Optical Engineering, 909, 70–81. https://doi.org/10.1117/12.945370

J-65 Barbieri, B. F., De Piccoli, F., & Gratton, E. (1988). Resolution of overlapping spectra using frequency-domain fluorometry. Proceedings of SPIE - The International Society for Optical Engineering, 909, 366–369. https://doi.org/10.1117/12.945415

J-66 Fiorini, R. M., Valentino, M., Glaser, M., Gratton, E.,& Curatola, G. (1988). Fluorescence lifetime distributions of 1,6-diphenyl-1,3,5-hexatriene reveal the effect of cholesterol on the microheterogeneity of erythrocyte membrane. BBA - Biomembranes, 939(3), 485–492. https://doi.org/10.1016/0005-2736(88)90095-8

J-67 Valentino, M., Governa, M., Gratton, E., Fiorini, R., Curatola, G., & Bertoli, E. (1988). Increased membrane heterogeneity in stimulated human granulocytes. FEBS Letters, 234(2), 451–454. https://doi.org/10.1016/0014-5793(88)80136-4

J-68 Bismuto, E., Gratton, E., & Irace, G. (1988). Effect of Unfolding on the Tryptophanyl Fluorescence Lifetime Distribution in Apomyoglobin. Biochemistry, 27(6), 2132–2136. https://doi.org/10.1021/bi00406a047

J-69 Careri, G., Gratton, E., & Shyamsunder, E. (1988). Fine structure of the amide i band in acetanilide. Physical Review A, 37(10), 4048–4051. https://doi.org/10.1103/PhysRevA.37.4048

J-70 Schroeder, F., Nemecz, G., Gratton, E., Barenholz, Y.,& Thompson, T. E. (1988). Fluorescence properties of cholestatrienol in phosphatidylcholine bilayer vesicles. Biophysical Chemistry, 32(1), 57–72. https://doi.org/10.1016/0301-4622(88)85034-8

J-71 Piston, D. W., Marriott, G., Radivoyevich, T., Clegg, R. M., Jovin, T. M., & Gratton, E. (1989). Wide-band acousto-optic light modulator for frequency domain fluorometry and phosphorimetry. Review of Scientific Instruments, 60(8), 2596–2600. https://doi.org/10.1063/1.1140677

J-72 Fiorini, R., Gratton, E., & Curatola, G. (1989). Effect of cholesterol on membrane microheterogeneity: a study using 1,6-diphenyl-1,3,5-hexatriene fluorescence lifetime distributions. Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism, 1006(2), 198–202. https://doi.org/10.1016/0005-2760(89)90196-3

J-73 Bismuto, E., Irace, G., & Gratton, E. (1989). Multiple Conformational States in Myoglobin Revealed by Frequency Domain Fluorometry. Biochemistry, 28(4), 1508–1512. https://doi.org/10.1021/bi00430a013

J-74 Barcellona, M. L., Gardiel, G., & Gratton, E. (1989). Polydeoxynucleotides/DAPI interactions: A fluorescence study by multifrequency phase fluorometry. Italian Journal of Biochemistry, 38(1), 51A–52A. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0024594342&partnerID=40&md5=2bd037744b73e37034ddcf97fb1dee99

J-75 Piston, D. W., & Gratton, E. (1989). Orientational exchange approach to fluorescence anisotropy decay. Biophysical Journal, 56(6), 1083–1091. https://doi.org/10.1016/S0006-3495(89)82756-0

J-76 Wratten, M. L., Gratton, E., van de Ven, M., & Sevanian, A. (1989). DPH lifetime distributions in vesicles containing phospholipid hydroperoxides. Biochemical and Biophysical Research Communications, 164(1), 169–175. https://doi.org/10.1016/0006-291X(89)91698-7

J-77 Piston, D. W., Bilash, T., & Gratton, E. (1989). Compartmental analysis approach to fluorescence anisotropy: Perylene in viscous solvents. Journal of Physical Chemistry®, 93(10), 3963–3967. https://doi.org/10.1021/j100347a019

J-78 Feddersen, B. A., Piston, D. W., & Gratton, E. (1989). Digital parallel acquisition in frequency domain fluorimetry. Review of Scientific Instruments, 60(9), 2929–2936. https://doi.org/10.1063/1.1140629

J-79 Barbieri, B., De Piccoli, F., & Gratton, E. (1989). Synthesizers’ phase noise in frequency-domain fluorometry. Review of Scientific Instruments, 60(10), 3201–3206. https://doi.org/10.1063/1.1140552

J-80 Barcellona, M. L., & Gratton, E. (1989). Fluorescence lifetime distributions of DNA-4′,6-diamidino-2-phenylindole complex. BBA - General Subjects, 993(2–3), 174–178. https://doi.org/10.1016/0304-4165(89)90160-8

J-81 Barcellona, M. L., Cardiel, G., & Gratton, E. (1990). Time-resolved fluorescence of DAPI in solution and bound to polydeoxynucleotides. Biochemical and Biophysical Research Communications, 170(1), 270–280. https://doi.org/10.1016/0006-291X(90)91270-3

J-82 VanderMeulen, D. L., Nealon, D. G., Gratton, E., & Jameson, D. M. (1990). Excitation wavelength dependent fluorescence anisotropy of eosin-myosin adducts. Evidence for anisotropic rotations. Biophysical Chemistry, 36(2), 177–184. https://doi.org/10.1016/0301-4622(90)85021-W

J-83 Rosato, N., Mei, G., Gratton, E., Bannister, J. V, Bannister, W. H., & Finazzi-Agrò, A. (1990). A time-resolved fluorescence study of human copper-zinc superoxide dismutase. Biophysical Chemistry, 36(1), 41–46. https://doi.org/10.1016/0301-4622(90)85005-Q

J-84 Govindjee, van de Ven, M., Preston, C., Seibert, M.,& Gratton, E. (1990). Chlorophyll a fluorescence lifetime distributions in open and closed Photosystem II reaction center preparations. BBA - Bioenergetics, 1015(2), 173–179. https://doi.org/10.1016/0005-2728(90)90017-X

J-85 Zolese, G., Gratton, E., & Curatola, G. (1990). Phosphatidic acid affects structural organization of phosphatidylcholine liposomes. A study of 1,6-diphenyl-1,3,5-hexatriene (DPH) and 1-(4-trimethylammonium-phenyl)-6-phenyl,1,3,5-hexatriene (TMA-DPH) fluorescence decay using distributional analysis. Chemistry and Physics of Lipids, 55(1), 29–39. https://doi.org/10.1016/0009-3084(90)90146-I

J-86 Parasassi, T., De Stasio, G., d’Ubaldo, A., & Gratton, E. (1990). Phase fluctuation in phospholipid membranes revealed by Laurdan fluorescence. Biophysical Journal, 57(6), 1179–1186. https://doi.org/10.1016/S0006-3495(90)82637-0

J-87 Pin, S., Royer, C. A., Gratton, E., Pin, S., Alpert, B., & Weber, G. (1990). Subunit Interactions in Hemoglobin Probed by Fluorescence and High-Pressure Techniques. Biochemistry, 29(39), 9194–9202. https://doi.org/10.1021/bi00491a013

J-88 Gratton, E., Feddersen, B., & van de Ven, M. (1990). Parallel acquisition of fluorescence decay using array detectors. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 1204 pt 1, pp. 21–25). Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-17944392675&partnerID=40&md5=d6eceddfe60822e323ddae8232e4e070

J-89 Barcellona, M. L., Cardiel, G., & Gratton, E. (1990). Dapi fluorescence decay process: A global analytical approach proves a ground-state heterogeneity with interconversion. Italian Journal of Biochemistry, 39(3), 179A–181A. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025152778&partnerID=40&md5=e0bc8d734a2b6488e9af30f3c64b9fd9

J-90 Parasassi, T., Stasio, G. D., Miccheli, A., Bruno, F., Conti, F., & Gratton, E. (1990). Abscisic acid-induced microheterogeneity in phospholipid vesicle. A fluorescence study. Biophysical Chemistry, 35(1), 65–73. https://doi.org/10.1016/0301-4622(90)80061-B

J-91 Rosato, N., Gratton, E., Mei, G., & Finazzi-Agrò, A. (1990). Fluorescence lifetime distributions in human superoxide dismutase. Effect of temperature and denaturation. Biophysical Journal, 58(4), 817–822. https://doi.org/10.1016/S0006-3495(90)82427-9

J-92 Barbieri, B., De Piccoli, F., van deVen, M., & Gratton, E. (1990). What determines the uncertainty of phase and modulation measurements in frequency domain fluorometry? In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 1204 pt 1, pp. 158–170). Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025677009&partnerID=40&md5=e03fa62a575ffbd159d0247801187a86

J-93 Barcellona, M. L., & Gratton, E. (1990). The fluorescence properties of a DNA probe - 4′-6-Diamidino-2-phenylindole (DAPI). European Biophysics Journal, 17(6), 315–323. https://doi.org/10.1007/BF00258380

J-94 Rosato, N., Gratton, E., Mei, G., Savini, I., & Finazzi Agrò, A. (1990). Dynamic fluorescence in copper proteins Selected examples. Biology of Metals, 3(2), 133–136. https://doi.org/10.1007/BF01179522

J-95 Ferreira, S., & Gratton, E. (1990). Hydration and protein substates: Fluorescence of proteins in reverse micelles. Journal of Molecular Liquids, 45(3–4), 253–272. https://doi.org/10.1016/0167-7322(90)80034-H

J-96 Parasassi, T., De Stasio, G., Rusch, R. M., & Gratton, E. (1991). A photophysical model for diphenylhexatriene fluorescence decay in solvents and in phospholipid vesicles. Biophysical Journal, 59(2), 466–475. https://doi.org/10.1016/S0006-3495(91)82240-8

J-97 Axelsen, P. H., Prendergast, F. G., & Gratton, E. (1991). Experimentally Verifying Molecular Dynamics Simulations through Fluorescence Anisotropy Measurements. Biochemistry, 30(5), 1173–1179. https://doi.org/10.1021/bi00219a002

J-98 Reinhart, G. D., Marzola, P., Jameson, D. M., & Gratton, E. (1991). A method for on-line background subtraction in frequency domain fluorometry. Journal of Fluorescence, 1(3), 153–162. https://doi.org/10.1007/BF00865362

J-99 Wang, S., Beechem, J. M., Gratton, E., & Glaser, M. (1991). Orientational Distribution of 1,6-Diphenyl-1,3,5-hexatriene in Phospholipid Vesicles As Determined by Global Analysis of Frequency Domain Fluorimetry Data. Biochemistry, 30(22), 5565–5572. https://doi.org/10.1021/bi00236a032

J-100 Fishkin, J., Gratton, E., vandeVen, M. J., & Mantulin, W. W. (1991). Diffusion of intensity modulated near-infrared light in turbid media. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 1431, pp. 122–135). Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025868058&partnerID=40&md5=1bc21624480d44b56cbe719ff0e86a97

J-101 Marzola, P., & Gratton, E. (1991). Hydration and protein dynamics: Frequency domain fluorescence spectroscopy on proteins in reverse micelles. Journal of Physical Chemistry, 95(23), 9488–9495. https://doi.org/10.1021/j100176a083

J-102 Arduini, A., vande Ven, M. J., Shohet, S. B., Mancinelli, G., & Gratton, E. (1991). Measurement and analysis of triplet-state lifetimes by multifrequency cross-correlation phase and modulation phosphorimetry. Analytical Biochemistry, 195(2), 327–329. https://doi.org/10.1016/0003-2697(91)90338-T

J-103 Di Iorio, E. E., Hiltpold, U. R., Filipovic, D., Winterhalter, K. H., Gratton, E., Vitrano, E., … Cordone, L. (1991). Protein dynamics. Comparative investigation on heme-proteins with different physiological roles. Biophysical Journal, 59(3), 742–754. https://doi.org/10.1016/S0006-3495(91)82287-1

J-104 Barcellona, M. L., & Gratton, E. (1991). A molecular approach to 4′,6-diamidine-2-phenylindole (DAPI) photophysical behaviour at different pH values. Biophysical Chemistry, 40(3), 223–229. https://doi.org/10.1016/0301-4622(91)80022-J

J-105 Fishkin, J. B., Feddersen, B. A., & Gratton, E. (1991). Experimental study of the diffraction of photon density waves by an absorbing edge in highly scattering media. In IEEE MTT-S International Microwave Symposium Digest (Vol. 2, pp. 917–920). Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026366864&partnerID=40&md5=503883f4f686ff702ea9f0a44b642d81

J-106 Parasassi, T., De Stasio, G., Ravagnan, G., Rusch, R. M., & Gratton, E. (1991). Quantitation of lipid phases in phospholipid vesicles by the generalized polarization of Laurdan fluorescence. Biophysical Journal, 60(1), 179–189. https://doi.org/10.1016/S0006-3495(91)82041-0

J-107 Feddersen, B. A., Piston, D. W., & Gratton, E. (1991). Reply to "Comment on “Digital parallel acquisition in frequency domain fluorometry” " [Rev. Sci. Instrum. 60, 2929 (1989)]. Review of Scientific Instruments, 62(6), 1674. https://doi.org/10.1063/1.1142408

J-108 Chance, B., Leigh, J. S., & Gratton, E. (1991). New image [5]. Nature, 349(6311), 660. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026089685&partnerID=40&md5=3b48eaa692bcb4fe3ca96f5d65b1ba2f

J-109 Parasassi, T., & Gratton, E. (1992). Packing of phospholipid vesicles studied by oxygen quenching of Laurdan fluorescence. Journal of Fluorescence, 2(3), 167–174. https://doi.org/10.1007/BF00866931

J-110 French, T., Gratton, E., & Maier, J. (1992). Frequency-domain imaging of thick tissues using a CCD. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 1640, pp. 254–261). Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026477543&partnerID=40&md5=2d83ec7fdbc2616ca0a223f3c8c67e79

J-111 Mei, G., Rosato, N., Savini, I., Finazzi-Agrd, A., Silva, N., Rusch, R., & Gratton, E. (1992). Denaturation of Human Cu/Zn Superoxide Dismutase by Guanidine Hydrochloride : A Dynamic Fluorescence Study1-. Biochemistry, 31(32), 7224–7230. https://doi.org/10.1021/bi00147a003

J-112 Bucci, E., Gryczynski, Z., Gratton, E., & Tenenholz, T. (1992). Heme-tryptophan relationships in hemoglobin explored by frequency-domain time-resolved fluorescence at 10-GHz resolution. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 1640, pp. 784–791). Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026491384&partnerID=40&md5=be13f3959c755dd6feced87c639a5af4

J-113 der Meer, B. W., Raymer, M. A., Wagoner, S. L., Hackney, R. L., Beechem, J. M., & Gratton, E. (1992). Models for fluorescence energy transfer between moving donors and acceptors. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 1640, pp. 220–229). Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026487416&partnerID=40&md5=81b5a581231d5c10d405b907ff9759e9

J-114 Berland, K., Gratton, E., & vandeVen, M. J. (1992). Laser heterodyning detector for frequency-domain ultrafast spectroscopy. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 1640, pp. 370–378). Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026455405&partnerID=40&md5=ccf7c84c5660c99a52ae9e417ab4f2f6

J-115 Parasassi, T., Di Stefano, M., Ravagnan, G., Sapora, O., & Gratton, E. (1992). Membrane aging during cell growth ascertained by laurdan generalized polarization. Experimental Cell Research, 202(2), 432–439. https://doi.org/10.1016/0014-4827(92)90096-Q

J-116 Parasassi, T., Ravagnan, G., Sapora, O., & Gratton, E. (1992). Membrane oxidative damage induced by ionizing radiation detected by diphenylhexatriene fluorescence lifetime distributions. International Journal of Radiation Biology, 61(6), 791–796. https://doi.org/10.1080/09553009214551661

J-117 Gratton, E., Silva, N., Mei, G., Rosato, N., Savini, I., & Finazzi‐Agro, A. (1992). Fluorescence lifetime distribution of folded and unfolded proteins. International Journal of Quantum Chemistry, 42(5), 1479–1489. https://doi.org/10.1002/qua.560420522

J-118 vandeVen, M. J., Barbieri, B. F., Gratton, E., & Maier, J. (1992). Analysis of noise sources in frequency-domain fluorometry. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 1640, pp. 332–341). Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026477542&partnerID=40&md5=160d2fab761e5c8d99cfebdc964d9ef5

J-119 Fishkin, J. B., & Gratton, E. (1992). Diffraction of intensity-modulated light in strongly scattering media in the presence of a “semi-infinite” absorbing or reflecting plane bounded by a straight edge. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 1640, pp. 362–367). Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026455553&partnerID=40&md5=407ae0f8211787c19a16bfc74dadd77a

J-120 Clegg, R. M., Feddersen, B., Gratton, E., & Jovin, T. M. (1992). Time-resolved imaging fluorescence microscopy. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 1640, pp. 448–460). Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026455552&partnerID=40&md5=2adc1ef77f37f6fb74eab545563dea4b

J-121 Parasassi, T., Loiero, M., Raimondi, M., Ravagnan, G.,& Gratton, E. (1993). Absence of lipid gel-phase domains in seven mammalian cell lines and in four primary cell types. BBA - Biomembranes, 1153(2), 143–154. https://doi.org/10.1016/0005-2736(93)90399-K

J-122 Parasassi, T., Ravagnan, G., Rusch, R. M., & Gratton, E. (1993). MODULATION AND DYNAMICS OF PHASE PROPERTIES IN PHOSPHOLIPID MIXTURES DETECTED BY LAURDAN FLUORESCENCE. Photochemistry and Photobiology, 57(3), 403–410. https://doi.org/10.1111/j.1751-1097.1993.tb02309.x

J-123 BISMUTO, E., GRATTON, E., SIRANGELO, I., & IRACE, G. (1993). Structure and dynamics of the acidic compact state of apomyoglobin by frequency‐domain fluorometry. European Journal of Biochemistry, 218(1), 213–219. https://doi.org/10.1111/j.1432-1033.1993.tb18367.x

J-124 Zolese, G., Staffolani, R., Mazzanti, L., & Gratton, E. (1993). Effect of divalent cations on Na+,K+-ATPase obtained from human placenta. FEBS Letters, 323(1–2), 11–14. https://doi.org/10.1016/0014-5793(93)81437-5

J-125 van der Meer, B. W., Raymer, M. A., Wagoner, S. L., Hackney, R. L., Beechem, J. M., & Gratton, E. (1993). Designing matrix models for fluorescence energy transfer between moving donors and acceptors. Biophysical Journal, 64(4), 1243–1263. https://doi.org/10.1016/S0006-3495(93)81490-5

J-126 Gratton, E., Mantulin, W. W., vandeVen, M. J., Fishkin, J. B., Maris, M. B., & Chance, B. (1993). A novel approach to laser tomography. Bioimaging, 1(1), 40–46. https://doi.org/10.1002/1361-6374(199303)1:1<40::AID-BIO7>3.3.CO;2-M

J-127 Gratton, E. (1993). TECHNIQUES C. Frequency domain. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 10311, p. 483). https://doi.org/10.1117/12.2283773

J-128 Maier, J. S., & Gratton, E. (1993). Frequency-domain methods in optical tomography: detection of localized absorbers and a backscattering reconstruction scheme. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 1888, pp. 440–451). Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027737604&partnerID=40&md5=0657d21cc5787f73f85a5a23847a1458

J-129 Silva Jr., N., Gratton, E., Mei, G., Rosato, N., Rusch, R., & Finazzi-Agrò, A. (1993). Molten globule monomers in human superoxide dismutase. Biophysical Chemistry, 48(2), 171–182. https://doi.org/10.1016/0301-4622(93)85008-6

J-130 Fiorini, R., Curatola, G., Kantar, A., Glorgi, P. L.,& Gratton, E. (1993). USE OF LAURDAN FLUORESCENCE IN STUDYING PLASMA MEMBRANE ORGANIZATION OF POLYMORPHONUCLEAR LEUKOCYTES DURING THE RESPIRATORY BURST. Photochemistry and Photobiology, 57(3), 438–441. https://doi.org/10.1111/j.1751-1097.1993.tb02315.x

J-131 Gratton, E., & Maier, J. (1993). Frequency- domain measurements of photon migration in highly scattering media. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 10311, pp. 534–544). https://doi.org/10.1117/12.2283776

J-132 Mantulin, W. W., Fishkin, J. B., So, P. T., Gratton, E., & Maier, J. S. (1993). Quantitative diffusive wave spectroscopy in tissues. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 1888, pp. 420–427). Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027764773&partnerID=40&md5=040ab98d7cbab3e2cefcc5206b2bab78

J-133 Mantulin, W. W., French, T., & Gratton, E. (1993). Optical imaging in the frequency domain. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 1892, pp. 158–166). Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027746648&partnerID=40&md5=f227e3d7bf13edbe60ab350c7cbfff2f

J-134 Levi, M., Wilson, P. V, Cooper, O. J., & Gratton, E. (1993). LIPID PHASES IN RENAL BRUSH BORDER MEMBRANES REVEALED BY LAURDAN FLUORESCENCE. Photochemistry and Photobiology, 57(3), 420–425. https://doi.org/10.1111/j.1751-1097.1993.tb02312.x

J-135 Fishkin, J. B., & Gratton, E. (1993). Propagation of photon-density waves in strongly scattering media containing an absorbing semi-infinite plane bounded by a straight edge. Journal of the Optical Society of America A: Optics and Image Science, and Vision, 10(1), 127–140. https://doi.org/10.1364/JOSAA.10.000127

J-136 Covindjee, de Ven, M., Cao, J., Roye, C., & Gratton, E. (1993). MULTIFREQUENCY CROSS‐CORRELATION PHASE FLUOROMETRY OF CHLOROPHYLL a FLUORESCENCE IN THYLAKOID AND PSII‐ENRICHED MEMBRANES. Photochemistry and Photobiology, 58(3), 438–445. https://doi.org/10.1111/j.1751-1097.1993.tb09587.x

J-137 Bismuto, E., Sirangelo, I., Gratton, E., & Irace, G. (1993). Conformational dynamics of native, compact and fully unfolded states of proteins detected by frequency domain fluorometry. Studies in Organic Chemistry, 47(C), 197–204. https://doi.org/10.1016/B978-0-444-89372-7.50026-9

J-138 Fantini Maria, S., Gratton, E., Franceschini, A., Fishkin, J. B., & Barbieri, B. (1994). Quantitative determination of the absorption spectra of chromophores in strongly scattering media: A light-emitting-diode based technique. Applied Optics, 33(22), 5204–5214. https://doi.org/10.1364/AO.33.005204

J-139 Brunet, J. E., Vargas, V., Gratton, E., & Jameson, D. M. (1994). Hydrodynamics of horseradish peroxidase revealed by global analysis of multiple fluorescence probes. Biophysical Journal, 66(2), 446–453. https://doi.org/10.1016/S0006-3495(94)80796-9

J-140 Parasassi, T., Di Stefano, M., Loiero, M., Ravagnan, G., & Gratton, E. (1994). Cholesterol modifies water concentration and dynamics in phospholipid bilayers: a fluorescence study using Laurdan probe. Biophysical Journal, 66(3), 763–768. https://doi.org/10.1016/S0006-3495(94)80852-5

J-141 Ferreira, S. T., Stella, L., & Gratton, E. (1994). Conformational dynamics of bovine Cu, Zn superoxide dismutase revealed by time-resolved fluorescence spectroscopy of the single tyrosine residue. Biophysical Journal, 66(4), 1185–1196. https://doi.org/10.1016/S0006-3495(94)80901-4

J-142 Fantini, S., Franceschini, M. A., & Gratton, E. (1994). Semi-infinite-geometry boundary problem for light migration in highly scattering media: A frequency-domain study in the diffusion approximation. Journal of the Optical Society of America B: Optical Physics, 11(10), 2128–2138. https://doi.org/10.1364/JOSAB.11.002128

J-143 Parasassi, T., Di Stefano, M., Loiero, M., Ravagnan, G., & Gratton, E. (1994). Influence of cholesterol on phospholipid bilayers phase domains as detected by Laurdan fluorescence. Biophysical Journal, 66(1), 120–132. https://doi.org/10.1016/S0006-3495(94)80763-5

J-144 Maier, J. S., Walker, S. A., Fantini, S., Franceschini, M. A., & Gratton, E. (1994). Possible correlation between blood glucose concentration and the reduced scattering coefficient of tissues in the near infrared. Optics Letters, 19(24), 2062–2064. https://doi.org/10.1364/OL.19.002062

J-145 Parasassi, T., Giusti, A. M., Gratton, E., Monaco, E., Raimondi, M., Ravagnan, G., & Sapora, O. (1994). Evidence for an increase in water concentration in bilayers after oxidative damage of phospholipids induced by ionizing radiation. International Journal of Radiation Biology, 65(3), 329–334. https://doi.org/10.1080/09553009414550391

J-146 Kantar, A., Giorgi, P. L., Gratton, E., & Fiorini, R. (1994). Probing the interaction of PAF with human platelet membrane using the fluorescent probe laurdan. Platelets, 5(3), 145–148. https://doi.org/10.3109/09537109409005527

J-147 Gratton, E., So, P., & French, T. (1994). Fluorescence lifetime-resolved two-photon microscope. In Proceedings - Annual Meeting, Microscopy Society of America (pp. 154–155). Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028747921&partnerID=40&md5=2f73ccd1e946b40668f9e4d715bbd814

J-148 GRATTON, G., MAIER, J. S., FABIANI, M., MANTULIN, W. W., & GRATTON, E. (1994). Feasibility of intracranial near‐infrared optical scanning. Psychophysiology, 31(2), 211–215. https://doi.org/10.1111/j.1469-8986.1994.tb01043.x

J-149 Maris, M., Gratton, E., Maier, J., Mantulin, W., & Chance, B. (1994). Functional near‐infrared imaging of deoxygenated hemoglobin during exercise of the finger extensor muscles using the frequency‐domain technique. Bioimaging, 2(4), 174–183. https://doi.org/10.1002/1361-6374(199412)2:4<174::AID-BIO2>3.3.CO;2-H

J-150 Maris, M., Gratton, E., Maier, J., Mantulin, W., & Chance, B. (1994). Functional near-infrared imaging of deoxygenated hemoglobin during exercise of the finger extensor muscles using the frequency-domain technique. Bioimaging, 2(4), 174–183. https://doi.org/10.1002/1361-6374(199412)2:4<174::AID-BIO2>3.0.CO;2-Q

J-151 Ferreira, S. T., & Gratton, E. (1994). Anisotropic Rotational Diffusion of the Adenine Moiety in 1, N6-Ethenoadenosine Triphosphate in Viscous Solvents Investigated by Time-Resolved Fluorescence Spectroscopy. Journal of the American Chemical Society, 116(13), 5791–5795. https://doi.org/10.1021/ja00092a033

J-152 Carrero, J., Jameson, D. M., & Gratton, E. (1995). Oxygen penetration and diffusion into myoglobin revealed by quenching of zincprotoporphyrin IX fluorescence. Biophysical Chemistry, 54(2), 143–154. https://doi.org/10.1016/0301-4622(94)00133-5

J-153 Gratton, G., Fabiani, M., Friedman, D., Franceschini, M. A., Fantini, S., Corballis, P., & Gratton, E. (1995). Rapid changes of optical parameters in the human brain during a tapping task. Journal of Cognitive Neuroscience, 7(4), 446–456. https://doi.org/10.1162/jocn.1995.7.4.446

J-154 Ferrari, M., De Blasi, R. A., Fantini, S., Franceschini, M.-A., Barbieri, B. B., Quaresima, V., & Gratton, E. (1995). Cerebral and muscle oxygen saturation measurement by a frequency-domain near-infrared spectroscopic technique. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 2389, pp. 868–874). https://doi.org/10.1117/12.209950

J-155 Dong, C. Y., So, P. T., French, T., & Gratton, E. (1995). Fluorescence lifetime imaging by asynchronous pump-probe microscopy. Biophysical Journal, 69(6), 2234–2242. https://doi.org/10.1016/S0006-3495(95)80148-7

J-156 Fishkin, J. B., So, P. T. C., Cerussi, A. E., Fantini, S., Franceschini, M. A., & Gratton, E. (1995). Frequency-domain method for measuring spectral properties in multiple-scattering media: Methemoglobin absorption spectrum in a tissuelike phantom. Applied Optics, 34(7), 1143–1155. https://doi.org/10.1364/AO.34.001143

J-157 De Blasi, R. A., Fantini, S., Franceschini, M. A., Ferrari, M., & Gratton, E. (1995). Cerebral and muscle oxygen saturation measurement by frequency-domain near-infra-red spectrometer. Medical& amp; Biological Engineering &amp; Computing, 33(2), 228–230. https://doi.org/10.1007/BF02523048

J-158 Gratton, E., & Parasassi, T. (1995). Fluorescence lifetime distributions in membrane systems. Journal of Fluorescence, 5(1), 51–57. https://doi.org/10.1007/BF00718782

J-159 Fantini, S., Franceschini, M.-A., Walker, S. A., Maier, J. S., & Gratton, E. (1995). Photon path distributions in turbid media: Applications for imaging. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 2389, pp. 340–349). https://doi.org/10.1117/12.209984

J-160 Franceschini, M.-A., Fantini, S., Walker, S. A., Maier, J. S., Mantulin, W. W., & Gratton, E. (1995). Multichannel optical instrument for near-infrared imaging of tissue. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 2389, pp. 264–273). https://doi.org/10.1117/12.209975

J-161 Parasassi, T., Giusti, A. M., Raimondi, M., Ravagnan, G., Sapora, O., & Gratton, E. (1995). Cholesterol protects the phospholipid bilayer from oxidative damage. Free Radical Biology and Medicine, 19(4), 511–516. https://doi.org/10.1016/0891-5849(95)00038-Y

J-162 Walker, S. A., Cerussi, A. E., & Gratton, E. (1995). Back-projection image reconstruction using photon density waves in tissues. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 2389, pp. 350–357). https://doi.org/10.1117/12.209985

J-163 Berland, K. M., So, P. T., & Gratton, E. (1995). Two-photon fluorescence correlation spectroscopy: method and application to the intracellular environment. Biophysical Journal, 68(2), 694–701. https://doi.org/10.1016/S0006-3495(95)80230-4

J-164 So, P. T. C., French, T., Yu, W. M., Berland, K. M., Dong, C. Y., & Gratton, E. (1995). Time-resolved fluorescence microscopy using two-photon excitation. Bioimaging, 3(2), 49–63. https://doi.org/10.1002/1361-6374(199506)3:2<49::AID-BIO1>3.0.CO;2-E

J-165 Parasassi, T., Giusti, A. M., Raimondi, M., & Gratton, E. (1995). Abrupt modifications of phospholipid bilayer properties at critical cholesterol concentrations. Biophysical Journal, 68(5), 1895–1902. https://doi.org/10.1016/S0006-3495(95)80367-X

J-166 So, P. T. C., French, T., Yu, W. M., Berland, K. M., Dong, C. Y., & Gratton, E. (1995). Time‐resolved fluorescence microscopy using two‐photon excitation. Bioimaging, 3(2), 49–63. https://doi.org/10.1002/1361-6374(199506)3:2<49::AID-BIO1>3.3.CO;2-5

J-167 Parasassi, T., & Gratton, E. (1995). Membrane lipid domains and dynamics as detected by Laurdan fluorescence. Journal of Fluorescence, 5(1), 59–69. https://doi.org/10.1007/BF00718783

J-168 Gratton, E., Dong, C. Y., & So, P. T. (1996). Fluorescence lifetime microscopy: a stimulated emission approach. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 2678, pp. 98–109). Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0029774829&partnerID=40&md5=7043d316ae9f591d66c759f5c1de34b7

J-169 Barcellona, M. L., & Gratton, E. (1996). Fluorescence anisotropy of DNA/DAPI complex: Torsional dynamics and geometry of the complex. Biophysical Journal, 70(5), 2341–2351. https://doi.org/10.1016/S0006-3495(96)79800-4

J-170 Barcellona, M. L., & Gratton, E. (1996). Torsional dynamics and orientation of DNA-DAPI complexes. Biochemistry, 35(1), 321–333. https://doi.org/10.1021/bi951027b

J-171 König, K., So, P. T. C., Mantulin, W. W., Tromberg, B. J., & Gratton, E. (1996). Two-photon excited lifetime imaging of autofluorescence in cells during UVA and NIR photostress. Journal of Microscopy, 183(3), 197–204. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0029843925&partnerID=40&md5=29cfa0587e3eb58432f013733dfc7b97

J-172 Fishkin, J. B., Fantini, S., vandeVen, M. J., & Gratton, E. (1996). Gigahertz photon density waves in a turbid medium: Theory and experiments. Physical Review E - Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics, 53(3), 2307–2319. https://doi.org/10.1103/PhysRevE.53.2307

J-173 Koenig, K., So, P. T., Mantulin, W. W., & Gratton, E. (1996). Cell damage in two-photon microscopes. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 2926, pp. 172–176). Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030367640&partnerID=40&md5=47ba1421b932be5a67d9537e73a36760

J-174 Barcellona, M. L., & Gratton, E. (1996). Anisotropy decay and dynamics of DNA/DAPI complex. Italian Journal of Biochemistry, 45(3), 173–174. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-1542611618&partnerID=40&md5=01378be7d6c7aee272d9904e2ce3a477

J-175 So, P. T. C., French, T., Yu, W. M., Berland, K. M., Dong, C. Y., & Gratton, E. (1996). Two-photon fluorescence microscopy: Time-resolved and intensity imaging. Chemical Analysis, 137, 351–374. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0343989593&partnerID=40&md5=83f591ac0abb65b48748cfcfe7640092

J-176 Fantini, S., Franceschini, M. A., Gaida, G., Gratton, E., Jess, H., Mantulin, W. W., … Kaschke, M. (1996). Frequency-domain optical mammography: Edge effect corrections. Medical Physics, 23(1), 149–157. https://doi.org/10.1118/1.597696

J-177 Bismuto, E., Sirangelo, I., Irace, G., & Gratton, E. (1996). Pressure-induced perturbation of apomyoglobin structure: Fluorescence studies on native and acidic compact forms. Biochemistry, 35(4), 1173–1178. https://doi.org/10.1021/bi951163g

J-178 Parasassi, T., Gratton, E., Tang, D., der Meer, B. W.,& Chen, S.-Y. S. (1996). Comments on 1,6-diphenyl-1,3,5-hexatriene fluorescence decrease at critical cholesterol concentration in phospholipid membranes. Biophysical Journal, 70(3), 1560–1561. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030032811&partnerID=40&md5=dc2ea61ab44d72fa16f14c43c0785da6

J-179 Bismuto, E., Irace, G., Sirangelo, I., & Gratton, E. (1996). Pressure-induced perturbation of ANS-apomyoglobin complex: Frequency domain fluorescence studies on native and acidic compact states. Protein Science, 5(1), 121–126. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030031755&partnerID=40&md5=583f0134f0809390fb5c4ad4036cd40b

J-180 Gratton, E., Mantulin, W. W., Weber, G., Royer, C. A., Jameson, D. M., Reininger, R., & Hansen, R. W. C. (1996). Fluorescence dynamics of biological systems using synchrotron radiation (invited). Review of Scientific Instruments, 67(9), 3363. https://doi.org/10.1063/1.1147351

J-181 Berland, K. M., So, P. T. C., Chen, Y., Mantulin, W. W., & Gratton, E. (1996). Scanning two-photon fluctuation correlation spectroscopy: Particle counting measurements for detection of molecular aggregation. Biophysical Journal, 71(1), 410–420. https://doi.org/10.1016/S0006-3495(96)79242-1

J-182 Barshtein, G., Yedgar, S., Bergelson, L., & Gratton, E. (1996). Human Red Blood Cell Shape and Volume are Changed by Physiological levels of Hydrostatic Pressure. Journal of Basic and Clinical Physiology and Pharmacology, 7(4), 321–330. https://doi.org/10.1515/JBCPP.1996.7.4.321

J-183 Yu, W., So, P. T. C., French, T., & Gratton, E. (1996). Fluorescence generalized polarization of cell membranes: A two-photon scanning microscopy approach. Biophysical Journal, 70(2 I), 626–636. https://doi.org/10.1016/S0006-3495(96)79646-7

J-184 Berberan-Santos, M. N., Canceill, J., Gratton, E., Jullien, L., Lehn, J.-M., So, P., … Valeur, B. (1996). Multichromophoric cyclodextrins. 3. Investigation of dynamics of energy hopping by frequency-domain fluorometry. Journal of Physical Chemistry, 100(1), 15–20. https://doi.org/10.1021/jp951598d

J-185 Koenig, K., So, P. T., Mantulin, W. W., Gratton, E., Krasieva, T., Berns, M. W., & Tromberg, B. J. (1996). Two-photon excited cellular autofluorescence induced by cw and femtosecond NIR microradiation. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 2628, pp. 12–19). Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0029751476&partnerID=40&md5=108e0d89ffa581ec471320c5b8563fd3

J-186 Gratton, E., So, P., French, T., & Yu, W. (1996). A two-photon lifetime resolved fluorescence microscope. Scanning, 18(2), 56. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0029918241&partnerID=40&md5=e4e3795a374c6973f0eb2e9b2494eba3

J-187 Zolese, G., Giambanco, I., Curatola, G., Staffolani, R., Gratton, E., & Donato, R. (1996). Time-resolved fluoresence of S-100a protein: Effect of Ca2+, Mg2+ and unilamellar vesicles of egg phosphatidylcholine. Cell Calcium, 20(6), 465–474. https://doi.org/10.1016/S0143-4160(96)90088-3

J-188 Barshtein, G., Bergelson, L., Dagan, A., Gratton, E.,& Yedgar, S. (1997). Membrane lipid order of human red blood cells is altered by physiological levels of hydrostatic pressure. American Journal of Physiology - Heart and Circulatory Physiology, 272(1 41-1), H538–H543. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031014186&partnerID=40&md5=a339db227d54dc835edd745e7b9de5a1

J-189 Maier, J. S., Cerussi, A. E., Fantini, S., & Gratton, E. (1997). Experimental recovery of absorption, scattering and fluorescence parameters in highly-scattering media from a single frequency measurement. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 2979, pp. 6–13). https://doi.org/10.1117/12.280223

J-190 König, K., So, P. T. C., Mantulin, W. W., & Gratton, E. (1997). Cellular response to near-infrared femtosecond laser pulses in two-photon microscopes. Optics Letters, 22(2), 135–136. https://doi.org/10.1364/OL.22.000135

J-191 Franceschini, M. A., Moesta, K. T., Fantini, S., Gaida, G., Gratton, E., Jess, H., … Kaschke, M. (1997). Frequency-domain techniques enhance optical mammography: Initial clinical results. Proceedings of the National Academy of Sciences of the United States of America, 94(12), 6468–6473. https://doi.org/10.1073/pnas.94.12.6468

J-192 Cerussi, A. E., Maier, J. S., Fantini, S., Franceschini, M. A., Mantulin, W. W., & Gratton, E. (1997). Experimental verification of a theory for the time-resolved fluorescence spectroscopy of thick tissues. Applied Optics, 36(1), 116–124. https://doi.org/10.1364/AO.36.000116

J-193 Walker, S. A., Fantini, S., & Gratton, E. (1997). Effect of index of refraction mismatch on the recovery of optical properties of cylindrical inhomogeneities in an infinite turbid medium. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 2979, pp. 219–225). https://doi.org/10.1117/12.280248

J-194 Parasassi, T., Gratton, E., Yu, W. M., Wilson, P.,& Levi, M. (1997). Two-photon fluorescence microscopy of laurdan generalized polarization domains in model and natural membranes. Biophysical Journal, 72(6), 2413–2429. https://doi.org/10.1016/S0006-3495(97)78887-8

J-195 Walker, S. A., Fantini, S., & Gratton, E. (1997). Image reconstruction by backprojection from frequency-domain optical measurements in highly scattering media. Applied Optics, 36(1), 170–179. https://doi.org/10.1364/AO.36.000170

J-196 Bernsdorff, C., Wolf, A., Winter, R., & Gratton, E. (1997). Effect of hydrostatic pressure on water penetration and rotational dynamics in phospholipid-cholesterol bilayers. Biophysical Journal, 72(3), 1264–1277. https://doi.org/10.1016/S0006-3495(97)78773-3

J-197 So, P. T. C., Ragan, T., Gratton, E., Carerro, J.,& Voss, E. (1997). Two-photon single particle tracking in 3D. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 2983, pp. 45–56). https://doi.org/10.1117/12.274323

J-198 König, K., Liang, H., Kimel, S., Svaasand, L. O., Tromberg, B. J., Krasieva, T. B., … Gratton, E. (1997). Cell damage in UVA and CW/femtosecond NIR microscopes. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 2983, pp. 37–44). https://doi.org/10.1117/12.274337

J-199 Gratton, G., Fabiani, M., Corballis, P. M., Hood, D. C., Goodman-Wood, M. R., Hirsch, J., … Gratton, E. (1997). Fast and localized event-related optical signals(EROS) in the human occipital cortex: Comparisons with the visual evoked potential and fMRI. NeuroImage, 6(3), 168–180. https://doi.org/10.1006/nimg.1997.0298

J-200 Fantini, S., Franceschini, M. A., & Gratton, E. (1997). Effect of spatially distributed light sources on the frequency-domain solution to the diffusion equation. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 2979, pp. 509–514). https://doi.org/10.1117/12.280285

J-201 Dong, C. Y., So, P. T. C., Buehler, C., & Gratton, E. (1997). Spatial resolution in scanning pump-probe fluorescence microscopy. Optik (Jena), 106(1), 7–14. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031193194&partnerID=40&md5=d204110e7b8bd51c799cbc526cac46f0

J-202 Barshtein, G., Bergelson, L. E. V, Dagan, A., Gratton, E., & Yedgar, S. (1997). Membrane lipid order of human red blood cells is altered by physiological levels of hydrostatic pressure. American Journal of Physiology - Heart and Circulatory Physiology, 41(1), H538–H543. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-33750681713&partnerID=40&md5=b868dccc92c892b86b51c47ff4039012

J-203 Masters, B. R., So, P. T. C., & Gratton, E. (1997). Multiphoton excitation fluorescence microscopy and spectroscopy of in vivo human skin. Biophysical Journal, 72(6), 2405–2412. https://doi.org/10.1016/S0006-3495(97)78886-6

J-204 French, T., So, P. T. C., Weaver Jr., D. J., Coelho-Sampaio, T., Gratton, E., Voss Jr., E. W., & Carrero, J. (1997). Two-photon fluorescence lifetime imaging microscopy of macrophage-mediated antigen processing. Journal of Microscopy, 185(3), 339–353. https://doi.org/10.1046/j.1365-2818.1997.d01-632.x

J-205 Fantini, S., Moesta, K. T., Franceschini, M. A., Jess, H., Erdl, H., Gratton, E., … Kaschke, M. (1997). Instrumentation and clinical applications in frequency-domain optical mammography. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Vol. 6, pp. 2741–2744). Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031294635&partnerID=40&md5=304df816a2b867650f1bb76a6cfe1736

J-206 Franceschini, M. A., Fantini, S., Cerussi, A., Barbieri, B., Chance, B., & Gratton, E. (1997). Quantitative spectroscopic determination of hemoglobin concentration and saturation in a turbid medium: Analysis of the effect of water absorption. Journal of Biomedical Optics, 2(2), 147–153. https://doi.org/10.1117/12.262145

J-207 Cerussi, A. E., Fantini, S., Maier, J. S., Mantulin, W. W., & Gratton, E. (1997). Chromophore detection by fluorescence spectroscopy in tissue-like phantoms. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 2979, pp. 139–150). https://doi.org/10.1117/12.280240

J-208 Fantini, S., Franceschini, M. A., & Gratton, E. (1997). Effective source term in the diffusion equation for photon transport in turbid media. Applied Optics, 36(1), 156–163. https://doi.org/10.1364/AO.36.000156

J-209 Gratton, G., Fabiani, M., Corballis, P. M., & Gratton, E. (1997). Noninvasive detection of fast signals from the cortex using frequency-domain optical methods. Annals of the New York Academy of Sciences, 820, 286–299. https://doi.org/10.1111/j.1749-6632.1997.tb46202.x

J-210 Barshtein, G., Bergelson, L., Dagan, A., Gratton, E.,& Yedgar, S. (1997). Membrane lipid order of human red blood cells is altered by physiological levels of hydrostatic pressure. American Journal of Physiology, 272(1 PART 2), H485–H492. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-33745408581&partnerID=40&md5=11b3127157da02fc326afbee8e4dd4bb

J-211 Quaresima, V., Franceschini, M. A., Fantini, S., Gratton, E., & Ferrari, M. (1997). Difference in leg muscles oxygenation during treadmill exercise by a new near infrared frequency-domain oximeter. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 3194, pp. 116–120). https://doi.org/10.1117/12.301042

J-212 Gratton, E., Fantini, S., Franceschini, M. A., Gratton, G., & Fabiani, M. (1997). Measurements of scattering and absorption changes in muscle and brain. Philosophical Transactions of the Royal Society B: Biological Sciences, 352(1354), 727–735. https://doi.org/10.1098/rstb.1997.0055

J-213 Fantini, S., Franceschini, M. A., & Gratton, E. (1997). Effective source term in the diffusion equation for photon transport in turbid media. Applied Optics, 36(1), 10–20. https://doi.org/10.1364/AO.36.000156

J-214 Franceschini, M. A., Fantini, S., Palumbo, R., Pasqualini, L., Vaudo, G., Franceschini, E., … Mannarino, E. (1997). Quantitative near-infrared spectroscopy on patients with peripheral vascular disease. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 3194, pp. 112–115). https://doi.org/10.1117/12.301041

J-215 Franceschini, M. A., Wallace, D., Barbieri, B., Fantini, S., Mantulin, W. W., Pratesi, S., … Gratton, E. (1997). Optical study of the skeletal muscle during exercise with a second generation frequency-domain tissue oximeter. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 2979, pp. 807–814). https://doi.org/10.1117/12.280229

J-216 French, T., So, P. T. C., Dong, C. Y., Berland, K. M.,& Gratton, E. (1998). Fluorescence lifetime imaging techniques for microscopy. Methods in Cell Biology, (56), 277–304. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031612173&partnerID=40&md5=71db2536df84b99253c218212f96d7c8

J-217 Walker, S. A., Boas, D. A., & Gratton, E. (1998). Photon density waves scattered from cylindrical inhomogeneities: Theory and experiments. Applied Optics, 37(10), 1935–1944. https://doi.org/10.1364/AO.37.001935

J-218 Kim, K. H., So, P. T. C., Kochevar, I. E., Masters, B. R., & Gratton, E. (1998). Two-photon fluorescence and confocal reflected light imaging of thick tissue structures. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 3260, pp. 46–57). https://doi.org/10.1117/12.307081

J-219 Franceschini, M. A., Fantini, S., Paunescu, L. A., Maier, J. S., & Gratton, E. (1998). Influence of a superficial layer in the quantitative spectroscopic study of strongly scattering media. Applied Optics, 37(31), 7447–7458. https://doi.org/10.1364/AO.37.007447

J-220 Masters, B. R., So, P. T. C., & Gratton, E. (1998). Optical biopsy of in vivo human skin: Multi-photon excitation microscopy. Lasers in Medical Science, 13(3), 196–203. https://doi.org/10.1007/s101030050074

J-221 Di Venere, A., Mei, G., Gilardi, G., Rosato, N., De Matteis, F., McKay, R., … Finazzi Agrò, A. (1998). Resolution of the heterogeneous fluorescence in multi-tryptophan proteins: Ascorbate oxidase. European Journal of Biochemistry, 257(2), 337–343. https://doi.org/10.1046/j.1432-1327.1998.2570337.x

J-222 So, P. T., König, K., Berland, K., Dong, C. Y., French, T., Bühler, C., … Gratton, E. (1998). New time-resolved techniques in two-photon microscopy. Cellular and Molecular Biology (Noisy-Le-Grand, France), 44(5), 771–793. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032109768&partnerID=40&md5=87e87838c3d52ed4a30a8a5b271528ff

J-223 Krasnowska, E. K., Gratton, E., & Parasassi, T. (1998). Prodan as a membrane surface fluorescence probe: Partitioning between water and phospholipid phases. Biophysical Journal, 74(4), 1984–1993. https://doi.org/10.1016/S0006-3495(98)77905-6

J-224 Chance, B., Cope, M., Gratton, E., Ramanujam, N., & Tromberg, B. (1998). Phase measurement of light absorption and scatter in human tissue. Review of Scientific Instruments, 69(10), 3457–3481. https://doi.org/10.1063/1.1149123

J-225 Parasassi, T., Krasnowska, E. K., Bagatolli, L., & Gratton, E. (1998). Laurdan and Prodan as Polarity-Sensitive Fluorescent Membrane Probes. Journal of Fluorescence, 8(4), 365–373. https://doi.org/10.1023/A:1020528716621

J-226 Bagatolli, L. A., Gratton, E., & Fidelio, G. D. (1998). Water dynamics in glycosphingolipid aggregates studied by LAURDAN fluorescence. Biophysical Journal, 75(1), 331–341. https://doi.org/10.1016/S0006-3495(98)77517-4

J-227 So, P. T. C., Duggap, K., Berland, K. M., & Gratton, E. (1998). Generating an intracellular diffusion map by two-photon fluorescence correlation spectroscopy. In Materials Research Society Symposium - Proceedings (Vol. 489, pp. 187–192). Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032321056&partnerID=40&md5=e034fff1f968c200024c13f58815de19

J-228 Toronov, V., Filiaci, M., Fantini, S., & Gratton, E. (1998). Photon-density wave correlation spectroscopy detects large-scale fluctuations in turbid media. Physical Review E - Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics, 58(2), 2288–2297. https://doi.org/10.1103/PhysRevE.58.2288

J-229 Masters, B. R., So, P. T. C., & Gratton, E. (1998). Multiphoton excitation microscopy of in vivo human skin: Functional and morphological optical biopsy based on three-dimensional imaging, lifetime measurements and fluorescence spectroscopy. Annals of the New York Academy of Sciences, 838, 58–67. https://doi.org/10.1111/j.1749-6632.1998.tb08187.x

J-230 Casavola, C., Paunescu, L. A., Fantini, S., Franceschini, M. A., Lugarà, P. M., & Gratton, E. (1999). Application of near-infrared tissue oxymetry to the diagnosis of peripheral vascular disease. Clinical Hemorheology and Microcirculation, 21(3–4), 389–393. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033501580&partnerID=40&md5=c970d5ca2e8eb48a2c3d819908cd0bff

J-231 Paunescu, L. A., Casavola, C., Franceschini, M. A., Fantini, S., Winter, L., Kim, J., … Gratton, E. (1999). Calf muscle blood flow and oxygen consumption measured with near-infrared spectroscopy during venous occlusion. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 3597, pp. 317–323). Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033344843&partnerID=40&md5=a44d19142a63e7ee3687162517d6243c

J-232 Stankovic, M. R., Maulik, D., Rosenfeld, W., Stubblefield, P. G., Kofinas, A. D., Drexler, S., … Fantini, S. (1999). Real-time optical imaging of experimental brain ischemia and hemorrhage in neonatal piglets. Journal of Perinatal Medicine, 27(4), 279–286. https://doi.org/10.1515/JPM.1999.039

J-233 Casavola, C., Paunescu, L. A., Franceschini, M. A., Fantini, S., Winter, L., Kim, J., … Gratton, E. (1999). Near-infrared spectroscopy and the tilting table protocol: a novel method to study the blood flow and the oxygen consumption in tissues. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 3597, pp. 685–692). Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033318048&partnerID=40&md5=83c0fb7af86109ba5a5d7651a36d2374

J-234 Toronov, V., Filiaci, M., Franceschini, M. A., Fantini, S., & Gratton, E. (1999). Photon-density-wave fluctuation-correlation-spectroscopy: study of coherence in the brain and muscles. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 3597, pp. 244–251). Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033311658&partnerID=40&md5=391f464c7e1bdff0cadde00a83dd4fcf

J-235 Stankovic, M. R., Hueber, D. M., Maulik, D., Stubblefield, P. G., Rosenfeld, W., Gratton, E., … Fantini, S. (1999). Real - time optical imaging and spectroscopy of brain ischemia and hemorrhage. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 3597, pp. 676–684). Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033339027&partnerID=40&md5=80f957685a4bb8f7763bba57ded3350b

J-236 Parasassi, T., Gratton, E., Zajicek, H., Levi, M.,& Yu, W. (1999). Detecting membrane lipid microdomains by two-photon fluorescence microscopy. IEEE Engineering in Medicine and Biology Magazine, 18(5), 92–99. https://doi.org/10.1109/51.790991

J-237 Toronov, V., Filiaci, M., Franceschini, M., Fantini, S., & Gratton, E. (1999). Exploring tissue dynamics by photon-density-wave fluctuation correlation spectroscopy. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 3726, pp. 555–559). Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032662191&partnerID=40&md5=be6570dbc0f6cd93f9c7e06551919754

J-238 Nayfeh, M., Akcakir, O., Therrien, J., Yamani, Z., Barry, N., Yu, W., & Gratton, E. (1999). Highly nonlinear photoluminescence threshold in porous silicon. Applied Physics Letters, 75(26), 4112–4114. https://doi.org/10.1063/1.125553

J-239 Fantini, S., Hueber, D., Franceschini, M. A., Gratton, E., Rosenfeld, W., Stubblefield, P. G., … Stankovic, M. R. (1999). Non-invasive optical monitoring of the newborn piglet brain using continuous-wave and frequency-domain spectroscopy. Physics in Medicine and Biology, 44(6), 1543–1563. https://doi.org/10.1088/0031-9155/44/6/308

J-240 Chen, Y., Müller, J. D., Berland, K. M., & Gratton, E. (1999). Fluorescence fluctuation spectroscopy. Methods: A Companion to Methods in Enzymology, 19(2), 234–252. https://doi.org/10.1006/meth.1999.0854

J-241 Bagatolli, L. A., Parasassi, T., Fidelio, G. D., & Gratton, E. (1999). A model for the interaction of 6-lauroyl-2-(N,N-dimethylamino)naphthalene with lipid environments: Implications for spectral properties. Photochemistry and Photobiology, 70(4), 557–564. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033212099&partnerID=40&md5=ca66eaa305cb5c064e32996772a2cb59

J-242 Franceschini, M. A., Gratton, E., Hueber, D., & Fantini, S. (1999). Near-infrared absorption and scattering spectra of tissues in vivo. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 3597, pp. 526–531). Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033356482&partnerID=40&md5=761f55c36e927b8d7842a74d2a80f5f6

J-243 Bagatolli, L. A., & Gratton, E. (1999). Two-photon fluorescence microscopy observation of shape changes at the phase transition in phospholipid giant unilamellar vesicles. Biophysical Journal, 77(4), 2090–2101. https://doi.org/10.1016/S0006-3495(99)77050-5

J-244 Fantini, S., Franceschini, M. A., Gratton, E., Hueber, D., Rosenfeld, W., Maulik, D., … Stankovic, M. R. (1999). Non-invasive optical mapping of the piglet brain in real time. Optics Express, 4(8), 308–314. https://doi.org/10.1364/OE.4.000308

J-245 Lasagna, M., Gratton, E., Jameson, D. M., & Brunet, J. E. (1999). Apohorseradish peroxidase unfolding and refolding: Intrinsic tryptophan fluorescence studies. Biophysical Journal, 76(1 I), 443–450. https://doi.org/10.1016/S0006-3495(99)77211-5

J-246 Masters, B. R., So, P. T. C., Kim, K. H., Buehler, C.,& Gratton, E. (1999). Multiphoton excitation microscopy, confocal microscopy, and spectroscopy of living cells and tissues; functional metabolic imaging of human skin in vivo. Methods in Enzymology, 307, 513–536. https://doi.org/10.1016/S0076-6879(99)07031-7

J-247 Cerussi, A. E., Gratton, E., & Fantini, S. (1999). Fluorescence lifetime spectroscopy in multiple-scattering environments: An application to biotechnology. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 3600, pp. 171–181). Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032683949&partnerID=40&md5=8206146fdf92d6fb0f60dabe7f1539db

J-248 Buehler, C., Dong, C.-Y., So, P. T. C., French, T. E.,& Gratton, E. (1999). Frequency-domain pump-probe microscopic imaging using intensity modulated laser diodes. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 3603, pp. 262–271). Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032690985&partnerID=40&md5=1f93ee5326dac18aca9f52a5b191c3e3

J-249 Chen, Y., Müller, J. D., So, P. T. C., & Gratton, E. (1999). The photon counting histogram in fluorescence fluctuation spectroscopy. Biophysical Journal, 77(1), 553–567. https://doi.org/10.1016/S0006-3495(99)76912-2

J-250 Franceschini, M. A., Gratton, E., & Fantini, S. (1999). Noninvasive optical method of measuring tissue and arterial saturation: An application to absolute pulse oximetry of the brain. Optics Letters, 24(12), 829–831. https://doi.org/10.1364/OL.24.000829

J-251 Wolf, M., Wolf, U., Toronov, V., Paunescu, L. A., Michalos, A., Franceschini, M. A., … Gratton, E. (2000). Fast cerebral functional signals in the 100 ms range detected by frequency-domain near-infrared spectroscopy. NeuroImage, 11(5 PART II). Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-4243588896&partnerID=40&md5=4da60a5abd82841f04ad32703686c71d

J-252 Bagatolli, L. A., & Gratton, E. (2000). Two photon fluorescence microscopy of coexisting lipid domains in giant unilamellar vesicles of binary phospholipid mixtures. Biophysical Journal, 78(1), 290–305. https://doi.org/10.1016/S0006-3495(00)76592-1

J-253 Eid, J. S., Müller, J. D., & Gratton, E. (2000). Data acquisition card for fluctuation correlation spectroscopy allowing full access to the detected photon sequence. Review of Scientific Instruments, 71(2 I), 361–368. https://doi.org/10.1063/1.1150208

J-254 Nayfeh, M. H., Akcakir, O., Belomoin, G., Barry, N., Therrien, J., & Gratton, E. (2000). Second harmonic generation in microcrystallite films of ultrasmall Si nanoparticles. Applied Physics Letters, 77(25), 4086–4088. https://doi.org/10.1063/1.1334945

J-255 Parasassi, T., Yu, W., Durbin, D., Kuriashkina, L., Gratton, E., Maeda, N., & Ursini, F. (2000). Two-photon microscopy of aorta fibers shows proteolysis induced by LDL hydroperoxides. Free Radical Biology and Medicine, 28(11), 1589–1597. https://doi.org/10.1016/S0891-5849(00)00275-6

J-256 Bagatolli, L., Gratton, E., Khan, T. K., & Chong, P. L.-G. (2000). Two-photon fluorescence microscopy studies of bipolar tetraether giant liposomes from thermoacidophilic archaebacteria Sulfolobus acidocaldarius. Biophysical Journal, 79(1), 416–425. https://doi.org/10.1016/S0006-3495(00)76303-X

J-257 Akcakir, O., Therrien, J., Belomoin, G., Barry, N., Muller, J. D., Gratton, E., & Nayfeh, M. (2000). Detection of luminescent single ultrasmall silicon nanoparticles using fluctuation correlation spectroscopy. Applied Physics Letters, 76(14), 1857–1859. https://doi.org/10.1063/1.126191

J-258 Sukhishvili, S. A., Chen, Y., Müller, J. D., Gratton, E., Schweizer, K. S., & Granick, S. (2000). Material science: Diffusion of a polymer “pancake.” Nature, 406(6792), 146. https://doi.org/10.1038/35018166

J-259 Frolov, A., Petrescu, A., Atshaves, B. P., So, P. T. C., Gratton, E., Serrero, G., & Schroeder, F. (2000). High density lipoprotein-mediated cholesterol uptake and targeting to lipid droplets in intact L-cell fibroblasts. A single- and multiphoton fluorescence approach. Journal of Biological Chemistry, 275(17), 12769–12780. https://doi.org/10.1074/jbc.275.17.12769

J-260 Zolese, G., Falcioni, G., Bertoli, E., Galeazzi, R., Wozniak, M., Wypych, Z., … Ambrosini, A. (2000). Steady-state and time resolved fluorescence of albumins interacting with N-oleylethanolamine, a component of the endogenous N-acylethanolamines. Proteins: Structure, Function and Genetics, 40(1), 39–48. https://doi.org/10.1002/(SICI)1097-0134(20000701)40:1<39::AID-PROT60>3.0.CO;2-N

J-261 Buehler, C., Dong, C.-Y., So, P. T. C., French, T.,& Gratton, E. (2000). Time-resolved polarization imaging by pump-probe (stimulated emission) fluorescence microscopy. Biophysical Journal, 79(1), 536–549. https://doi.org/10.1016/S0006-3495(00)76315-6

J-262 Toronov, V., Franceschini, M. A., Filiaci, M., Fantini, S., Wolf, M., Michalos, A., & Gratton, E. (2000). Near-infrared study of fluctuations in cerebral hemodynamics during rest and motor stimulation: Temporal analysis and spatial mapping. Medical Physics, 27(4), 801–815. https://doi.org/10.1118/1.598943

J-263 Chen, Y., Müller, J. D., Tetin, S. Y., Tyner, J. D.,& Gratton, E. (2000). Probing ligand protein binding equilibria with fluorescence fluctuation spectroscopy. Biophysical Journal, 79(2), 1074–1084. https://doi.org/10.1016/S0006-3495(00)76361-2

J-264 Dong, C. Y., Huang, H., Sutin, J., Kwon, H. S., Cragg, G., Gilbert, R., … So, P. T. C. (2000). Magnetic tweezers microscope for cellular manipulation. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 3921, pp. 176–185). Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033740299&partnerID=40&md5=d18d08879f753c1ea42ed914d4ca28f5

J-265 Bagatolli, L. A., Parasassi, T., & Gratton, E. (2000). Giant phospholipid vesicles: Comparison among the whole lipid sample characteristics using different preparation methods - A two photon fluorescence microscopy study. Chemistry and Physics of Lipids, 105(2), 135–147. https://doi.org/10.1016/S0009-3084(00)00118-3

J-266 Toronov, V., Fantini, S., Franceschini, M. A., Filiaci, M., Wolf, M., & Gratton, E. (2000). Temporal analysis of fluctuations in cerebral hemodynamics revealed by near-infrared spectroscopy. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4001, pp. 224–227). Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033727943&partnerID=40&md5=1f265b1967a1f91c311c7249506e253d

J-267 Casavola, C., Paunescu, L. A., Fantini, S., & Gratton, E. (2000). Blood flow and oxygen consumption with near-infrared spectroscopy and venous occlusion: Spatial maps and the effect of time and pressure of inflation. Journal of Biomedical Optics, 5(3), 269–276. https://doi.org/10.1117/1.429995

J-268 Bettati, S., Benci, S., Campanini, B., Raboni, S., Chirico, G., Beretta, S., … Mozzarelli, A. (2000). Role of pyridoxal 5′-phosphate in the structural stabilization of O-acetylserine sulfhydrylase. Journal of Biological Chemistry, 275(51), 40244–40251. https://doi.org/10.1074/jbc.M007015200

J-269 Muller, J. D., Chen, Y., & Gratton, E. (2000). Resolving heterogeneity on the single molecular level with the photon- counting histogram. Biophysical Journal, 78(1), 474–486. https://doi.org/10.1016/S0006-3495(00)76610-0

J-270 Arcangeli, C., Yu, W., Cannistraro, S., & Gratton, E. (2000). Two-photon autofluorescence microscopy and spectroscopy of Antarctic fungus: New approach for studying effects of UV-B irradiation. Biopolymers - Biospectroscopy Section, 57(4), 218–225. https://doi.org/10.1002/1097-0282(2000)57:4<218::AID-BIP3>3.0.CO;2-G

J-271 Stankovic, M. R., Maulik, D., Rosenfeld, W., Stubblefield, P. G., Kofinas, A. D., Gratton, E., … Hueber, D. M. (2000). Role of Frequency Domain Optical Spectroscopy in the Detection of Neonatal Brain Hemorrhage—A Newborn Piglet Study. Journal of Maternal-Fetal Medicine, 9(2), 142–149. https://doi.org/10.3109/14767050009053440

J-272 Fantini, S., & Gratton, E. (2000). Fluorescence photon-density waves in optically diffusive media. Optics Communications, 173(1–6), 73–79. https://doi.org/10.1016/S0030-4018(99)00648-3

J-273 Franceschini, M. A., Toronov, V., Filiaci, M. E., Gratton, E., & Fantini, S. (2000). On-line optical imaging of the human brain with 160-ms temporal resolution. Optics Express, 6(3), 49–57. https://doi.org/10.1364/OE.6.000049

J-274 Bagatolli, L. A., & Gratton, E. (2000). A correlation between lipid domain shape and binary phospholipid mixture composition in free standing bilayers: A two-photon fluorescence microscopy study. Biophysical Journal, 79(1), 434–447. https://doi.org/10.1016/S0006-3495(00)76305-3

J-275 Gratton, E., Barry, N. P., Beretta, S., & Celli, A. (2001). Multiphoton fluorescence microscopy. Methods, 25(1), 103–110. https://doi.org/10.1006/meth.2001.1219

J-276 Toronov, V., Webb, A., Choi, J. H., Wolf, M., & Gratton, E. (2001). Simultaneous assessment of human brain functional hemodynamics by magnetic resonance and near-infrared imaging. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4320, pp. 861–867). https://doi.org/10.1117/12.430911

J-277 Ragan, T., So, P. T., Kwon, H.-S., & Gratton, E. (2001). 3D particle tracking on the two-photon microscope. Proceedings of SPIE - The International Society for Optical Engineering, 4262, 247–258. https://doi.org/10.1117/12.424560

J-278 Chirico, G., Bettati, S., Mozzarelli, A., Chen, Y., Müller, J. D., & Gratton, E. (2001). Molecular heterogeneity of O-acetylserine sulfhydrylase by two-photon excited fluorescence fluctuation spectroscopy. Biophysical Journal, 80(4), 1973–1985. https://doi.org/10.1016/S0006-3495(01)76167-X

J-279 Krasnowska, E. K., Bagatolli, L. A., Gratton, E., & Parasassi, T. (2001). Surface properties of cholesterol-containing membranes detected by Prodan fluorescence. Biochimica et Biophysica Acta - Biomembranes, 1511(2), 330–340. https://doi.org/10.1016/S0005-2736(01)00286-3

J-280 Barcellona, M. L., Chen, Y., Müller̈, J. D., & Gratton, E. (2001). 4′,6-Diamidino-2-phenylindole (DAPI) interacts with rare structures of GC polymers. European Biophysics Journal, 30(2), 98–109. https://doi.org/10.1007/s002490000129

J-281 Nayfeh, M. H., Barry, N., Therrien, J., Akcakir, O., Gratton, E., & Belomoin, G. (2001). Stimulated blue emission in reconstituted films of ultrasmall silicon nanoparticles. Applied Physics Letters, 78(8), 1131–1133. https://doi.org/10.1063/1.1347398

J-282 Margeat, E., Poujol, N., Boulahtouf, A., Chen, Y., Müller, J. D., Gratton, E., … Royer, C. A. (2001). The human estrogen receptor α dimer binds a single SRC-1 coactivator molecule with an affinity dictated by agonist structure. Journal of Molecular Biology, 306(3), 433–442. https://doi.org/10.1006/jmbi.2000.4418

J-283 Dietrich, C., Bagatolli, L. A., Volovyk, Z. N., Thompson, N. L., Levi, M., Jacobson, K., & Gratton, E. (2001). Lipid rafts reconstituted in model membranes. Biophysical Journal, 80(3), 1417–1428. https://doi.org/10.1016/S0006-3495(01)76114-0

J-284 Paunescu, L. A., Michalos, A., Choi, J. H., Wolf, U., Wolf, M., & Gratton, E. (2001). In vitro correlation between reduced scattering coefficient and hemoglobin concentration of human blood determined by near-infrared spectroscopy. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4250, pp. 319–326). https://doi.org/10.1117/12.434505

J-285 Toronov, V., Webb, A., Choi, J. H., Wolf, M., Michalos, A., Gratton, E., & Hueber, D. (2001). Investigation of human brain hemodynamics by simultaneous near-infrared spectroscopy and functional magnetic resonance imaging. Medical Physics, 28(4), 521–527. https://doi.org/10.1118/1.1354627

J-286 Toronov, V., Webb, A., Choi, J. H., Wolf, M., Gratton, E., & Hueber, D. (2001). Simultaneous functional magnetic resonance and near-infrared imaging of adult human brain. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4250, pp. 380–382). https://doi.org/10.1117/12.434517

J-287 Müller, J. D., Chen, Y., & Gratton, E. (2001). Photon counting histogram statistics. Springer Series in Chemical Physics, 65, 410–437. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0035777503&partnerID=40&md5=3d9b5a4c8e89d01e5aacc618925aeb3d

J-288 Sanchez, S. A., Chen, Y., Müller, J. D., Gratton, E.,& Hazlett, T. L. (2001). Solution and interface aggregation states of Crotalus atrox venom phospholipase A2 by two-photon excitation fluorescence correlation spectroscopy. Biochemistry, 40(23), 6903–6911. https://doi.org/10.1021/bi001599i

J-289 Bismuto, E., Gratton, E., & Lamb, D. C. (2001). Dynamics of ANS binding to tuna apomyoglobin measured with fluorescence correlation spectroscopy. Biophysical Journal, 81(6), 3510–3521. https://doi.org/10.1016/S0006-3495(01)75982-6

J-290 Van Rompaey, E., Chen, Y., Müller, J. D., Gratton, E., Van Craenenbroeck, E., Engelborghs, Y., … Demeester, J. (2001). Fluorescence fluctuation analysis for the study of interactions between oligonucleotides and polycationic polymers. Biological Chemistry, 382(3), 379–386. https://doi.org/10.1515/BC.2001.046

J-291 Dong, C.-Y., Buehler, C., So, P. T. C., French, T.,& Gratton, E. (2001). Implementation of intensity-modulated laser diodes in time-resolved, pump-probe fluorescence microscopy. Applied Optics, 40(7), 1109–1115. https://doi.org/10.1364/AO.40.001109

J-292 Nayfeh, M. H., Therrien, J., Belomoin, G., Akcakir, O., Barry, N., & Gratton, E. (2001). Stimulated blue emission and second harmonic generation from films of ultrasmall Si nanoparticles. Materials Research Society Symposium - Proceedings, 638, F951–F9512. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0035558351&partnerID=40&md5=fef4733940e4db3930780a43753a3879

J-293 Bagatolli, L. A., & Gratton, E. (2001). Direct observation of lipid domains in free-standing bilayers using two-photon excitation fluorescence microscopy. Journal of Fluorescence, 11(3), 141–160. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0000138260&partnerID=40&md5=9cfbaf7370b086a7a68a88461fe17b7a

J-294 Toronov, V., Webb, A., Choi, J. H., Wolf, M., Safonova, L., Wolf, U., & Gratton, E. (2001). Study of local cerebral hemodynamics by frequency-domain near-infrared spectroscopy and correlation with simultaneously acquired functional magnetic resonance imaging. Optics Express, 9(8), 417–427. https://doi.org/10.1364/OE.9.000417

J-295 Sanchez, S. A., Bagatolli, L. A., Gratton, E., & Hazlett, T. L. (2002). A two-photon view of an enzyme at work: Crotalus atrox venom PLA<inf>2</inf> interaction with single-lipid and mixed-lipid giant unilamellar vesicles. Biophysical Journal, 82(4), 2232–2243. https://doi.org/10.1016/S0006-3495(02)75569-0

J-296 Gratton, E. (2002). Near-infrared detection of correlated activity in the brain. In Pacific Rim Conference on Lasers and Electro-Optics, CLEO - Technical Digest (p. 368). Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0036458965&partnerID=40&md5=64f93bed74f43f730efb7058bf8ec3e1

J-297 Barry, N. P., Hanson, K. M., Gratton, E., Clegg, R. M., Behne, M. J., & Mauro, T. M. (2002). Applications of ultrafast lasers to two-photon fluorescence and lifetime imaging. Proceedings of SPIE - The International Society for Optical Engineering, 4633, 50–61. https://doi.org/10.1117/12.461387

J-298 Tricerri, M. A., Sanchez, S. A., Arnulphi, C., Durbin, D. M., Gratton, E., & Jonas, A. (2002). Interaction of apolipoprotein A-I in three different conformations with palmitoyl oleoyl phosphatidylcholine vesicles. Journal of Lipid Research, 43(2), 187–197. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0036192245&partnerID=40&md5=26e06c2e4dc3b9024f4df57f2d326133

J-299 Sukhishvili, S. A., Chen, Y., Müller, J. D., Gratton, E., Schweizer, K. S., & Granick, S. (2002). Surface diffusion of poly(ethylene glycol). Macromolecules, 35(5), 1776–1784. https://doi.org/10.1021/ma0113529

J-300 Chen, Y., Müller, J. D., Ruan, Q., & Gratton, E. (2002). Molecular brightness characterization of EGFP in vivo by fluorescence fluctuation spectroscopy. Biophysical Journal, 82(1), 133–144. https://doi.org/10.1016/S0006-3495(02)75380-0

J-301 Toronov, V., Webb, A., Walker, S., Gupta, R., Choi, J. H., Gratton, E., & Hueber, D. (2002). Study of the FMRI blood oxygen level dependent effect by near-infrared spectroscopy. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 5068, pp. 222–226). Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-1342289445&partnerID=40&md5=48a84a355299a7d4551fb5797de1fcbe

J-302 Patel, R. C., Kumar, U., Lamb, D. C., Eid, J. S., Rocheville, M., Grant, M., … Patel, Y. C. (2002). Ligand binding to somatostatin receptors induces receptor-specific oligomer formation in live cells. Proceedings of the National Academy of Sciences of the United States of America, 99(5), 3294–3299. https://doi.org/10.1073/pnas.042705099

J-303 Fahsel, S., Pospiech, E.-M., Zein, M., Hazlet, T. L., Gratton, E., & Winter, R. (2002). Modulation of concentration fluctuations in phase-separated lipid membranes by polypeptide insertion. Biophysical Journal, 83(1), 334–344. https://doi.org/10.1016/S0006-3495(02)75173-4

J-304 Morren, G., Wolf, M., Lemmerling, P., Wolf, U., Choi, J. H., Gratton, E., … van Huffel, S. (2002). Extraction of fast neuronal changes from multichannel, functional near infrared spectroscopy signals using independent component analysis. Proceedings of SPIE - The International Society for Optical Engineering, 4623(1), 68–76. https://doi.org/10.1117/12.469474

J-305 Wolf, M., Wolf, U., Toronov, V., Michalos, A., Paunescu, L. A., Choi, J. H., & Gratton, E. (2002). Different time evolution of oxyhemoglobin and deoxyhemoglobin concentration changes in the visual and motor cortices during functional stimulation: A near-infrared spectroscopy study. NeuroImage, 16(3 I), 704–712. https://doi.org/10.1006/nimg.2002.1128

J-306 Toronov, V., Webb, A., Choi, J. H., Wolf, M., Safonova, L., Wolf, U., & Gratton, E. (2002). Functional cerebral activation detected by frequency-domain near-infrared spectroscopy. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4707, pp. 92–96). https://doi.org/10.1117/12.475639

J-307 Behne, M. J., Meyer, J. W., Hanson, K. M., Barry, N. P., Murata, S., Crumrine, D., … Mauro, T. M. (2002). NHE1 regulates the stratum corneum permeability barrier homeostasis: Microenvironment acidification assessed with fluorescence lifetime imaging. Journal of Biological Chemistry, 277(49), 47399–47406. https://doi.org/10.1074/jbc.M204759200

J-308 Hanson, K. M., Behne, M. J., Barry, N. P., Mauro, T. M., Gratton, E., & Clegg, R. M. (2002). Two-photon fluorescence lifetime imaging of the skin stratum corneum pH gradient. Biophysical Journal, 83(3), 1682–1690. https://doi.org/10.1016/S0006-3495(02)73936-2

J-309 Best, K. B., Ohran, A. J., Hawes, A. C., Hazlett, T. L., Gratton, E., Judd, A. M., & Bell, J. D. (2002). Relationship between erythrocyte membrane phase properties and susceptibility to secretory phospholipase A2. Biochemistry, 41(47), 13982–13988. https://doi.org/10.1021/bi026796r

J-310 Wolf, M., Wolf, U., Choi, J. H., Gupta, R., Safonova, L. P., Paunescu, L. A., … Gratton, E. (2002). Functional frequency-domain near-infrared spectroscopy detects fast neuronal signal in the motor cortex. NeuroImage, 17(4), 1868–1875. https://doi.org/10.1006/nimg.2002.1261

J-311 Bettati, S., Campanini, B., Vaccari, S., Mozzarelli, A., Schianchi, G., Hazlett, T. L., … Benci, S. (2002). Unfolding of pyridoxal 5′-phosphate-dependent O-acetylserine sulfhydrylase probed by time-resolved tryptophan fluorescence. Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology, 1596(1), 47–54. https://doi.org/10.1016/S0167-4838(01)00316-8

J-312 Ruan, Q., Chen, Y., Gratton, E., Glaser, M., & Mantulin, W. W. (2002). Cellular characterization of adenylate kinase and its isoform: Two-photon excitation fluorescence imaging and fluorescence correlation spectroscopy. Biophysical Journal, 83(6), 3177–3187. https://doi.org/10.1016/S0006-3495(02)75320-4

J-313 Wolf, U., Wolf, M., Choi, J. H., Levi, M., Choudhury, D., Hull, S., … Gratton, E. (2003). Localized irregularities in hemoglobin flow and oxygenation in calf muscle in patients with peripheral vascular disease detected with near-infrared spectrophotometry. Journal of Vascular Surgery, 37(5), 1017–1026. https://doi.org/10.1067/mva.2003.214

J-314 Müller, J. D., Chen, Y., & Gratton, E. (2003). Fluorescence correlation spectroscopy. Methods in Enzymology, 361, 69–92. https://doi.org/10.1016/S0076-6879(03)61006-2

J-315 Wolf, M., Franceschini, M. A., Paunescu, L. A., Toronov, V., Michalos, A., Wolf, U., … Fantini, S. (2003). Absolute frequency-domain pulse oximetry of the brain: Methodology and measurements. Advances in Experimental Medicine and Biology, 530, 61–73. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0242362088&partnerID=40&md5=f2441adaaa01510856b2251d8d56247e

J-316 Toronov, V., D’Amico, E., Hueber, D., Gratton, E., Barbieri, B., & Webb, A. (2003). Optimization of the signal-to-noise ratio of frequency-domain instrumentation for near-infrared spectro-imaging of the human brain. Optics Express, 11(21), 2717–2729. https://doi.org/10.1364/OE.11.002717

J-317 Wolf, M., Wolf, U., Choi, J. H., Gupta, R., Safonova, L. P., Paunescu, L. A., … Gratton, E. (2003). Detection of the fast neuronal signal on the motor cortex using functional frequency domain near infrared spectroscopy. Advances in Experimental Medicine and Biology, 510, 193–197. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0037228199&partnerID=40&md5=9c7a74eac5b3b51844a569ba28df0601

J-318 Gratton, E., Breusegem, S., Sutin, J., Ruan, Q., & Barry, N. (2003). Fluorescence lifetime imaging for the two-photon microscope: Time-domain and frequency-domain methods. Journal of Biomedical Optics, 8(3), 381–390. https://doi.org/10.1117/1.1586704

J-319 Levi, V., Ruan, Q., Kis-Petikova, K., & Gratton, E. (2003). Scanning FCS, a novel method for three-dimensional particle tracking. Biochemical Society Transactions, 31(5), 997–1000. https://doi.org/10.1042/bst0310997

J-320 Toronov, V., Walker, S., Gupta, R., Choi, J. H., Gratton, E., Hueber, D., & Webb, A. (2003). The roles of changes in deoxyhemoglobin concentration and regional cerebral blood volume in the fMRI BOLD signal. NeuroImage, 19(4), 1521–1531. https://doi.org/10.1016/S1053-8119(03)00152-6

J-321 Dong, C. Y., French, T., So, P. T. C., Buehler, C., Berland, K. M., & Gratton, E. (2003). Fluorescence-lifetime imaging techniques for microscopy. Methods in Cell Biology, 2003(72), 431–464. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-1442330794&partnerID=40&md5=a433a2a9fcb0ab91a26da0e56a95a1d0

J-322 Behne, M. J., Barry, N. P., Hanson, K. M., Aronchik, I., Clegg, R. W., Gratton, E., … Mauro, T. M. (2003). Neonatal development of the stratum corneum pH gradient: Localization and mechanisms leading to emergence of optimal barrier function. Journal of Investigative Dermatology, 120(6), 998–1006. https://doi.org/10.1046/j.1523-1747.2003.12262.x

J-323 Müller, J. D., & Gratton, E. (2003). High-pressure fluorescence correlation spectroscopy. Biophysical Journal, 85(4), 2711–2719. https://doi.org/10.1016/S0006-3495(03)74694-3

J-324 Bagatolli, L. A., Sanchez, S. A., Hazlett, T., & Gratton, E. (2003). Giant vesicles, laurdan, and two-photon fluorescence microscopy: Evidence of lipid lateral separation in bilayers. Methods in Enzymology, 360, 481–500. https://doi.org/10.1016/S0076-6879(03)60124-2

J-325 Zamai, M., VandeVen, M., Farao, M., Gratton, E., Ghiglieri, A., Castelli, M. G., … Caiolfa, V. R. (2003). Camptothecin poly[N-(2-hydroxypropyl) methacrylamide] copolymers in antitopoisomerase-I tumor therapy: Intratumor release and antitumor efficacy. Molecular Cancer Therapeutics, 2(1), 29–40. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0141857672&partnerID=40&md5=16f0f5ffe59b87b3008e374dc48705ef

J-326 Safonova, L. P., Michalos, A., Wolf, U., Choi, J. H., Wolf, M., Mantulin, W. W., … Gratton, E. (2003). Diminished cerebral circulatory autoregulation in obstructive sleep apnea investigated by near-infrared spectroscopy. Sleep Research Online, 5(4), 123–132. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-3242795092&partnerID=40&md5=2636ffc9d89cfbef3751cddef6dfdc9e

J-327 Gaus, K., Gratton, E., Kable, E. P. W., Jones, A. S., Gelissen, I., Kritharides, L., & Jessup, W. (2003). Visualizing lipid structure and raft domains in living cells with two-photon microscopy. Proceedings of the National Academy of Sciences of the United States of America, 100(26), 15554–15559. https://doi.org/10.1073/pnas.2534386100

J-328 Wolf, U., Wolf, M., Choi, J. H., Paunescu, L. A., Safonova, L. P., Michalos, A., & Gratton, E. (2003). Mapping of hemodynamics on the human calf with near infrared spectroscopy and the influence of the adipose tissue thickness. Advances in Experimental Medicine and Biology, 510, 225–230. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-0037225676&partnerID=40&md5=f7d73df2a9dc35a8421bccc05e0b1a91

J-329 Wolf, M., Wolf, U., Choi, J. H., Toronov, V., Paunescu, L. A., Michalos, A., & Gratton, E. (2003). Fast cerebral functional signal in the 100-ms range detected in the visual cortex by frequency-domain near-infrared spectrophotometry. Psychophysiology, 40(4), 521–528. https://doi.org/10.1111/1469-8986.00054

J-330 Toronov, V., DíAmico, E., Hueber, D., Gratton, E., Webb, A., & Barbieri, B. (2004). Optimization of the frequency-domain instrument for the near-infrared spectro-imaging of the human brain. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 5, pp. 378–383). https://doi.org/10.1117/12.530254

J-331 Czeslik, C., Jackler, G., Hazlett, T., Gratton, E., Steitz, R., Wittemann, A., & Ballauff, M. (2004). Salt-induced protein resistance of polyelectrolyte brushes studied using fluorescence correlation spectroscopy and neutron reflectometry. Physical Chemistry Chemical Physics, 6(24), 5557–5563. https://doi.org/10.1039/b410805a

J-332 Kis-Petikova, K., & Gratton, E. (2004). Distance Measurement by Circular Scanning of the Excitation Beam in the Two-Photon Microscope. Microscopy Research and Technique, 63(1), 34–49. https://doi.org/10.1002/jemt.10417

J-333 Choi, J., Wolf, M., Toronov, V., Wolf, U., Polzonetti, C., Hueber, D., … Gratton, E. (2004). Noninvasive determination of the optical properties of adult brain: Near-infrared spectroscopy approach. Journal of Biomedical Optics, 9(1), 221–229. https://doi.org/10.1117/1.1628242

J-334 Inoue, M., Digman, M. A., Cheng, M., Breusegem, S. Y., Halaihel, N., Sorribas, V., … Levi, M. (2004). Partitioning of NaP<inf>i</inf> cotransporter in cholesterol-, sphingomyelin-, and glycosphingolipid-enriched membrane domains modulates NaP<inf>i</inf> protein diffusion, clustering, and activity. Journal of Biological Chemistry, 279(47), 49160–49171. https://doi.org/10.1074/jbc.M408942200

J-335 Janosch, S., Nicolini, C., Ludolph, B., Peters, C., Völkert, M., Hazlet, T. L., … Winter, R. (2004). Partitioning of dual-lipidated peptides into membrane microdomains: Lipid sorting vs peptide aggregation. Journal of the American Chemical Society, 126(24), 7496–7503. https://doi.org/10.1021/ja049922i

J-336 Morren, G., Wolf., M., Lemmerling, P., Wolf, U., Choi, J. H., Gratton, E., … Van Huffel, S. (2004). Detection of fast neuronal signals in the motor cortex from functional near infrared spectroscopy measurements using independent component analysis. Medical and Biological Engineering and Computing, 42(1), 92–99. https://doi.org/10.1007/BF02351016

J-337 Ruan, Q., Cheng, M. A., Levi, M., Gratton, E., & Mantulin, W. W. (2004). Spatial-temporal studies of membrane dynamics: Scanning fluorescence correlation spectroscopy (SFCS). Biophysical Journal, 87(2), 1260–1267. https://doi.org/10.1529/biophysj.103.036483

J-338 Barcellona, M. L., Gammon, S., Hazlett, T., Digman, M. A., & Gratton, E. (2004). Polarized fluorescence correlation spectroscopy of DNA-DAPI complexes. Microscopy Research and Technique, 65(4–5), 205–217. https://doi.org/10.1002/jemt.20121

J-339 Rao, S., Sutin, J., Clegg, R., Gratton, E., Nayfeh, M. H., Habbal, S., … Martin, R. M. (2004). Excited states of tetrahedral single-core Si<inf>29</inf> nanoparticles. Physical Review B - Condensed Matter and Materials Physics, 69(20), 205317–205319. https://doi.org/10.1103/PhysRevB.69.205319

J-340 Toronov, V., Franceschini, M. A., Fantini, S., Webb, A.,& Gratton, E. (2004). Study of complex hemodynamic fluctuations in the human brain by simultaneous near-infrared spectro-imaging and functional magnetic resonance imaging. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 5330, pp. 22–28). https://doi.org/10.1117/12.532950

J-341 Czeslik, C., Jansen, R., Ballauff, M., Wittemann, A., Royer, C. A., Gratton, E., & Hazlett, T. (2004). Mechanism of protein binding to spherical polyelectrolyte brushes studied in situ using two-photon excitation fluorescence fluctuation spectroscopy. Physical Review E - Statistical, Nonlinear, and Soft Matter Physics, 69(2 1), 21401–21409. https://doi.org/10.1103/PhysRevE.69.021401

J-342 Toronov, V., D’Amico, E., Hueber, D., Gratton, E., Barbieri, B., & Webb, A. (2004). Optimization of the phase and modulation depth signal-to-noise ratio for near-infrared spectroscopy of the biological tissue. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 5, pp. 281–284). https://doi.org/10.1117/12.578960

J-343 Safonova, L. P., Michalos, A., Wolf, U., Wolf, M., Hueber, D. M., Choi, J. H., … Gratton, E. (2004). Age-correlated changes in cerebral hemodynamics assessed by near-infrared spectroscopy. Archives of Gerontology and Geriatrics, 39(3), 207–225. https://doi.org/10.1016/j.archger.2004.03.007

J-344 Masters, B. R., So, P. T. C., Buehler, C., Barry, N., Sutin, J. D., Mantulin, W. W., & Gratton, E. (2004). Mitigating thermal mechanical damage potential during two-photon dermal imaging. Journal of Biomedical Optics, 9(6), 1265–1270. https://doi.org/10.1117/1.1806135

J-345 Behne, M. J., Barry, N. P., Moll, I., Gratton, E.,& Mauro, T. M. (2004). Fluorescence Lifetime to image epidermal ionic concentrations. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 5, pp. 37–44). https://doi.org/10.1117/12.545928

J-346 Choi, J. H., Wolf, M., Toronov, V., Michalos, A., & Gratton, E. (2004). Spatio-temporal analysis of the cerebral spontaneous oscillation. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 5330, pp. 29–37). https://doi.org/10.1117/12.548202

J-347 Digman, M. A., Brown, C. M., Sengupta, P., Wiseman, P. W., Horwitz, A. R., & Gratton, E. (2005). Measuring fast dynamics in solutions and cells with a laser scanning microscope. Biophysical Journal, 89(2), 1317–1327. https://doi.org/10.1529/biophysj.105.062836

J-348 Sánchez, S. A., & Gratton, E. (2005). Lipid-protein interactions revealed by two-photon microscopy and fluorescence correlation spectroscopy. Accounts of Chemical Research, 38(6), 469–477. https://doi.org/10.1021/ar040026l

J-349 Digman, M. A., Sengupta, P., Wiseman, P. W., Brown, C. M., Horwitz, A. R., & Gratton, E. (2005). Fluctuation correlation spectroscopy with a laser-scanning microscope: Exploiting the hidden time structure. Biophysical Journal, 88(5), L33–L36. https://doi.org/10.1529/biophysj.105.061788

J-350 Levi, V., Ruan, Q., & Gratton, E. (2005). 3-D particle tracking in a two-photon microscope: Application to the study of molecular dynamics in cells. Biophysical Journal, 88(4), 2919–2928. https://doi.org/10.1529/biophysj.104.044230

J-351 Tricerri, M. A., Toledo, J. D., Sanchez, S. A., Hazlett, T. L., Gratton, E., Jonas, A., & Garda, H. A. (2005). Visualization and analysis of apolipoprotein A-I interaction with binary phospholipid bilayers. Journal of Lipid Research, 46(4), 669–678. https://doi.org/10.1194/jlr.M400340-JLR200

J-352 Eckhoff, D. A., Sutin, J. D. B., Clegg, R. M., Gratton, E., Rogozhina, E. V, & Braun, P. V. (2005). Optical characterization of ultrasmall Si nanoparticles prepared through electrochemical dispersion of bulk Si. Journal of Physical Chemistry B, 109(42), 19786–19797. https://doi.org/10.1021/jp052214e

J-353 Ko, W. S., Darwish, N., Gratton, E., & Kim, S. H. (2005). Development of the scanning system to detect the concentration of oxy- and deoxy-hemoglobin by tracking the head. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 5686, pp. 588–595). https://doi.org/10.1117/12.590755

J-354 Levi, V., Ruan, Q., Plutz, M., Belmont, A. S., & Gratton, E. (2005). Chromatin dynamics in interphase cells revealed by tracking in a two-photon excitation microscope. Biophysical Journal, 89(6), 4275–4285. https://doi.org/10.1529/biophysj.105.066670

J-355 Tanner, K., D’Amico, E., Kaczmarowski, A., Kukreti, S., Malpeli, J., Mantulin, W. W., & Gratton, E. (2005). Spectrally resolved neurophotonics: A case report of hemodynamics and vascular components in the mammalian brain. Journal of Biomedical Optics, 10(6). https://doi.org/10.1117/1.2137291

J-356 Arnulphi, C., Sánchez, S. A., Tricerri, M. A., Gratton, E., & Jonas, A. (2005). Interaction of human apolipoprotein A-I with model membranes exhibiting lipid domains. Biophysical Journal, 89(1), 285–295. https://doi.org/10.1529/biophysj.104.047480

J-357 Gokhale, N. A., Abraham, A., Digman, M. A., Gratton, E., & Cho, W. (2005). Phosphoinositide specificity of and mechanism of lipid domain formation by annexin A2-p11 heterotetramer. Journal of Biological Chemistry, 280(52), 42831–42840. https://doi.org/10.1074/jbc.M508129200

J-358 Gratton, E., Toronov, V., Wolf, U., Wolf, M., & Webb, A. (2005). Measurement of brain activity by near-infrared light. Journal of Biomedical Optics, 10(1). https://doi.org/10.1117/1.1854673

J-359 Gratton, E., Toronov, V., Wolf, U., Wolf, M., & Webb, A. (2005). Measurement of brain activity by near-infrared light. Journal of Biomedical Optics, 10(1), 1–13. https://doi.org/10.1117/1.1854673

J-360 Levi, V., Gelfand, V. I., Serpinskaya, A. S., & Gratton, E. (2006). Melanosomes transported by myosin-V in xenopus melanophores perform slow 35 nm steps. Biophysical Journal, 90(1), L07–L09. https://doi.org/10.1529/biophysj.105.075556

J-361 Hanson, K. M., Gratton, E., & Bardeen, C. J. (2006). Sunscreen enhancement of UV-induced reactive oxygen species in the skin. Free Radical Biology and Medicine, 41(8), 1205–1212. https://doi.org/10.1016/j.freeradbiomed.2006.06.011

J-362 Tanner, K., Beitel, E., D’Amico, E., Mantulin, W. W.,& Gratton, E. (2006). Effects of vasodilation on intrinsic optical signals in the mammalian brain: A phantom study. Journal of Biomedical Optics, 11(6). https://doi.org/10.1117/1.2398920

J-363 Machado, N. G., Pearlman, A., & Gratton, E. (2006). Near-infrared spectroscopy and the swallowing event. In Optics InfoBase Conference Papers. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899135938&partnerID=40&md5=362dbabe861d5001a3bc7294067c67d8

J-364 Simonson, P., D’Amico, E., & Gratton, E. (2006). Modulation of an optical needle’s reflectivity alters the average photon path through scattering media. Journal of Biomedical Optics, 11(1). https://doi.org/10.1117/1.2168167

J-365 Rogozhina, E. V, Eckhoff, D. A., Gratton, E., & Braun, P. V. (2006). Carboxyl functionalization of ultrasmall luminescent silicon nanoparticles through thermal hydrosilylation. Journal of Materials Chemistry, 16(15), 1421–1430. https://doi.org/10.1039/b509868h

J-366 Gratton, E., Tanner, K., Beitel, E., D’Amico, E., & Mantulin, W. W. (2006). Effects of vasodilation on intrinsic optical signals. In Optics InfoBase Conference Papers. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899156177&partnerID=40&md5=579d5ca67acfde7ea7a36b45d6f682f0

J-367 Gratton, E., & Van De Ven, M. J. (2006). Laser sources for confocal microscopy. Handbook of Biological Confocal Microscopy: Third Edition. https://doi.org/10.1007/978-0-387-45524-2_5

J-368 Gatto, R., D’Amico, E., Mantulin, W., Gratton, E.,& Charbel, F. (2006). Optical microprobe for blood clot detection. In Optics InfoBase Conference Papers. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899132670&partnerID=40&md5=e61a095e217723c87800c6e37290110b

J-369 Rossow, M. J., Gatto, R., D’Amico, E., Mantulin, W. W.,& Gratton, E. (2006). Blood flow measurements and clot detection with nearinfrared spectroscopy. In Optics InfoBase Conference Papers. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899133332&partnerID=40&md5=65bbc806ac6e68419ab27f015190f4f7

J-370 Nicolini, C., Celli, A., Gratton, E., & Winter, R. (2006). Pressure tuning of the morphology of heterogeneous lipid vesicles: A two-photon-excitation fluorescence microscopy study. Biophysical Journal, 91(8), 2936–2942. https://doi.org/10.1529/biophysj.106.088716

J-371 Eckhoff, D. A., Stuart, J. N., Sutin, J. D. B., Sweedler, J. V, & Gratton, E. (2006). Capillary electrophoresis of ultrasmall carboxylate functionalized silicon nanoparticles. Journal of Chemical Physics, 125(8). https://doi.org/10.1063/1.2345366

J-372 Nicolini, C., Baranski, J., Schlummer, S., Palomo, J., Lumbierres-Burgues, M., Kahms, M., … Winter, R. (2006). Visualizing association of N-Ras in lipid microdomains: Influence of domain structure and interfacial adsorption. Journal of the American Chemical Society, 128(1), 192–201. https://doi.org/10.1021/ja055779x

J-373 Simonson, P. D., D’Amico, E., & Gratton, E. (2006). Proposal and proof of principle for a novel optical biopsy needle: Modulating an optical needle’s reflectivity alters the average photon path in scattering media. In Optics InfoBase Conference Papers. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899152567&partnerID=40&md5=31cac1e03d3a27055f99a6aaf635c332

J-374 Tanner, K., D’Amico, E., Kukreti, S., Mantulin, W. W., Gratton, E., Kaczmarowski, A., & Malpeli, J. (2006). Spectrally resolved neurophotonics: The optical BOLD effect and vascular components in the mammalian brain. In Optics InfoBase Conference Papers. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899130547&partnerID=40&md5=fa3f83e4f67ecd6b0955a7197bc2acf5

J-375 Levi, V., Serpinskaya, A. S., Gratton, E., & Gelfand, V. (2006). Organelle transport along microtubules in Xenopus melanophores: Evidence for cooperation between multiple motors. Biophysical Journal, 90(1), 318–327. https://doi.org/10.1529/biophysj.105.067843

J-376 Ragan, T., Huang, H., So, P., & Gratton, E. (2006). 3D Particle tracking on a two-photon microscope. Journal of Fluorescence, 16(3), 325–336. https://doi.org/10.1007/s10895-005-0040-1

J-377 Boens, N., Qin, W., Basarić, N., Hofkens, J., Ameloot, M., Pouget, J., … Miura, A. (2007). Fluorescence lifetime standards for time and frequency domain fluorescence spectroscopy. Analytical Chemistry, 79(5), 2137–2149. https://doi.org/10.1021/ac062160k

J-378 Caiolfa, V. R., Zamai, M., Malengo, G., Andolfo, A., Madsen, C. D., Sutin, J., … Sidenius, N. (2007). Monomer-dimer dynamics and distribution of GPI-anchored uPAR are determined by cell surface protein assemblies. Journal of Cell Biology, 179(5), 1067–1082. https://doi.org/10.1083/jcb.200702151

J-379 Celli, A., Lee, C. Y. C., & Gratton, E. (2007). Fluorescence microscopy to study pressure between lipids in giant unilamellar vesicles. Methods in Molecular Biology, 400, 333–339. https://doi.org/10.1385/1-59745-519-9:333

J-380 Calderon-Arnulphi, M., Alaraj, A., Amin-Hanjani, S., Mantulin, W. W., Polzonetti, C. M., Gratton, E., & Charbel, F. T. (2007). Detection of cerebral ischemia in neurovascular surgery using quantitative frequency-domain near-infrared spectroscopy. Journal of Neurosurgery, 106(2), 283–290. https://doi.org/10.3171/jns.2007.106.2.283

J-381 Azartash, K., & Gratton, E. (2007). Measuring the cell-induced deformation of collagen matrix detected with digital holographic microscopy. In Proceedings of the 2nd Frontiers in Biomedical Devices Conference 2007 (pp. 123–124). https://doi.org/10.1115/BioMed2007-38064

J-382 Levi, V., & Gratton, E. (2007). Exploring dynamics in living cells by tracking single particles. Cell Biochemistry and Biophysics, 48(1), 1–15. https://doi.org/10.1007/s12013-007-0010-0

J-383 Sanchez, S. A., Tricerri, M. A., & Gratton, E. (2007). Interaction of high density lipoprotein particles with membranes containing cholesterol. Journal of Lipid Research, 48(8), 1689–1700. https://doi.org/10.1194/jlr.M600457-JLR200

J-384 Olopade, C. O., Mensah, E., Gupta, R., Huo, D., Picchietti, D. L., Gratton, E., & Michalos, A. (2007). Noninvasive determination of brain tissue oxygenation during sleep in obstructive sleep apnea: A near-infrared spectroscopic approach. Sleep, 30(12), 1747–1755. https://doi.org/10.1093/sleep/30.12.1747

J-385 Gatto, R., Hoffman, W., Paisansathan, C., Mantulin, W., Gratton, E., & Charbel, F. T. (2007). Effect of age on brain oxygenation regulation during changes in position. Journal of Neuroscience Methods, 164(2), 308–311. https://doi.org/10.1016/j.jneumeth.2007.04.020

J-386 Wolf, U., Wolf, M., Choi, J. H., Paunescu, L. A., Michalos, A., & Gratton, E. (2007). Regional Differences of Hemodynamics and Oxygenation in the Human Calf Muscle Detected with Near-Infrared Spectrophotometry. Journal of Vascular and Interventional Radiology, 18(9), 1094–1101. https://doi.org/10.1016/j.jvir.2007.06.004

J-387 Levi, V., & Gratton, E. (2008). Chromatin dynamics during interphase explored by single-particle tracking. Chromosome Research, 16(3), 439–449. https://doi.org/10.1007/s10577-008-1240-8

J-388 Celli, A., Beretta, S., & Gratton, E. (2008). Phase fluctuations on the micron-submicron scale in GUVs composed of a binary lipid mixture. Biophysical Journal, 94(1), 104–116. https://doi.org/10.1529/biophysj.107.105353

J-389 Brown, C. M., Dalal, R. B., Hebert, B., Digman, M. A., Horwitz, A. R., & Gratton, E. (2008). Raster image correlation spectroscopy (RICS) for measuring fast protein dynamics and concentrations with a commercial laser scanning confocal microscope. Journal of Microscopy, 229(1), 78–91. https://doi.org/10.1111/j.1365-2818.2007.01871.x

J-390 Kukreti, S., Cerussi, A., Tromberg, B., & Gratton, E. (2008). Intrinsic near-infrared spectroscopic markers of breast tumors. Disease Markers, 25(6), 281–290. https://doi.org/10.1155/2008/651308

J-391 Dalal, R. B., Digman, M. A., Horwitz, A. F., Vetri, V.,& Gratton, E. (2008). Determination of particle number and brightness using a laser scanning confocal microscope operating in the analog mode. Microscopy Research and Technique, 71(1), 69–81. https://doi.org/10.1002/jemt.20526

J-392 Fiorini, R., Ragni, L., Ambrosi, S., Littarru, G. P., Gratton, E., & Hazlett, T. (2008). Fluorescence studies of the interactions of ubiquinol-10 with liposomes. Photochemistry and Photobiology, 84(1), 209–214. https://doi.org/10.1111/j.1751-1097.2007.00221.x

J-393 Kwok, S., Lee, C., Sánchez, S. A., Hazlett, T. L., Gratton, E., & Hayashi, Y. (2008). Erratum to “Genetically encoded probe for fluorescence lifetime imaging of CaMKII activity” [Biochem. Biophys. Res. Commun. 369 (2008) 519-525] (DOI:10.1016/j.bbrc.2008.02.070). Biochemical and Biophysical Research Communications, 373(1), 179. https://doi.org/10.1016/j.bbrc.2008.05.109

J-394 Digman, M. A., Caiolfa, V. R., Zamai, M., & Gratton, E. (2008). The phasor approach to fluorescence lifetime imaging analysis. Biophysical Journal, 94(2), L14–L16. https://doi.org/10.1529/biophysj.107.120154

J-395 Malengo, G., Andolfo, A., Sidenius, N., Gratton, E., Zamai, M., & Caiolfa, V. R. (2008). Fluorescence correlation spectroscopy and photon counting histogram on membrane proteins: Functional dynamics of the glycosylphosphatidylinositol- anchored urokinase plasminogen activator receptor. Journal of Biomedical Optics, 13(3). https://doi.org/10.1117/1.2940570

J-396 García-Marcos, A., Sánchez, S. A., Parada, P., Eid, J., Jameson, D. M., Remacha, M., … Ballesta, J. P. G. (2008). Yeast ribosomal stalk heterogeneity in vivo shown by two-photon FCS and molecular brightness analysis. Biophysical Journal, 94(7), 2884–2890. https://doi.org/10.1529/biophysj.107.121822

J-397 Gratton, E. (2008). Digital frequency-domain FLIM. In Optics InfoBase Conference Papers. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-84898629923&partnerID=40&md5=d0dddec64bc8fb1c2cd2cdb50bda2246

J-398 Colyer, R. A., Lee, C., & Gratton, E. (2008). A novel fluorescence lifetime imaging system that optimizes photon efficiency. Microscopy Research and Technique, 71(3), 201–213. https://doi.org/10.1002/jemt.20540

J-399 Kwok, S., Lee, C., Sánchez, S. A., Hazlett, T. L., Gratton, E., & Hayashi, Y. (2008). Genetically encoded probe for fluorescence lifetime imaging of CaMKII activity. Biochemical and Biophysical Research Communications, 369(2), 519–525. https://doi.org/10.1016/j.bbrc.2008.02.070

J-400 Barreiro, O., Zamai, M., Yáñez-Mó, M., Tejera, E., López-Romero, P., Monk, P. N., … Sánchez-Madrid, F. (2008). Endothelial adhesion receptors are recruited to adherent leukocytes by inclusion in preformed tetraspanin nanoplatforms. Journal of Cell Biology, 183(3), 527–542. https://doi.org/10.1083/jcb.200805076

J-401 Digman, M. A., Brown, C. M., Horwitz, A. R., Mantulin, W. W., & Gratton, E. (2008). Erratum: Paxillin dynamics measured during adhesion assembly and disassembly by correlation (Biophysical Journal (2008) 94 (2819-2831)). Biophysical Journal, 94(11), 4577. https://doi.org/10.1529/biophysj.108.0900177

J-402 Digman, M. A., Brown, C. M., Horwitz, A. R., Mantulin, W. W., & Gratton, E. (2008). Paxillin dynamics measured during adhesion assembly and disassembly by correlation spectroscopy. Biophysical Journal, 94(7), 2819–2831. https://doi.org/10.1529/biophysj.107.104984

J-403 Digman, M. A., Dalal, R., Horwitz, A. F., & Gratton, E. (2008). Mapping the number of molecules and brightness in the laser scanning microscope. Biophysical Journal, 94(6), 2320–2332. https://doi.org/10.1529/biophysj.107.114645

J-404 Unruh, J. R., & Gratton, E. (2008). Analysis of molecular concentration and brightness from fluorescence fluctuation data with an electron multiplied CCD camera. Biophysical Journal, 95(11), 5385–5398. https://doi.org/10.1529/biophysj.108.130310

J-405 Raub, C. B., Unruh, J., Suresh, V., Krasieva, T., Lindmo, T., Gratton, E., … George, S. C. (2008). Image correlation spectroscopy of multiphoton images correlates with collagen mechanical properties. Biophysical Journal, 94(6), 2361–2373. https://doi.org/10.1529/biophysj.107.120006

J-406 Sanabria, H., Digman, M. A., Gratton, E., & Waxham, M. N. (2008). Spatial diffusivity and availability of intracellular calmodulin. Biophysical Journal, 95(12), 6002–6015. https://doi.org/10.1529/biophysj.108.138974

J-407 Katayama, Y., Burkacky, O., Meyer, M., Bräuchle, C., Gratton, E., & Lamb, D. C. (2009). Real-time nanomicroscopy via three-dimensional singleparticle tracking. ChemPhysChem, 10(14), 2458–2464. https://doi.org/10.1002/cphc.200900436

J-408 Caracciolo, G., Caminiti, R., Digman, M. A., Gratton, E., & Sanchez, S. (2009). Efficient escape from endosomes determines the superior efficiency of multicomponent lipoplexes. Journal of Physical Chemistry B, 113(15), 4995–4997. https://doi.org/10.1021/jp811423r

J-409 Gielen, E., Smisdom, N., Vandeven, M., De Clercq, B., Gratton, E., Digman, M., … Ameloot, M. (2009). Measuring diffusion of lipid-like probes in artificial and natural membranes by raster image correlation spectroscopy (rics): Use of a commercial laser-Scanning microscope with analog detection. Langmuir, 25(9), 5209–5218. https://doi.org/10.1021/la8040538

J-410 Cerussi, A., Tanamai, W., Chung, S., Hsiang, D., Kukreti, S., Mehta, R., … Tromberg, B. (2009). TU‐E‐303A‐02: Breast Cancer Applications of Optical Imaging Biomarkers Measured with Diffuse Optical Spectroscopic Imaging. Medical Physics, 36(6), 2746–2747. https://doi.org/10.1118/1.3182423

J-411 Gratton, E., & Digman, M. (2009). One photon up, one photon down. Nature Biotechnology, 27(2), 147–148. https://doi.org/10.1038/nbt0209-147

J-412 Digman, M. A., Wiseman, P. W., Choi, C., Horwitz, A. R., & Gratton, E. (2009). Stoichiometry of molecular complexes at adhesions in living cells. Proceedings of the National Academy of Sciences of the United States of America, 106(7), 2170–2175. https://doi.org/10.1073/pnas.0806036106

J-413 Rossow, M., Mantulin, W. W., & Gratton, E. (2009). Spatiotemporal image correlation spectroscopy measurements of flow demonstrated in microfluidic channels. Journal of Biomedical Optics, 14(2). https://doi.org/10.1117/1.3088203

J-414 Digman, M. A., & Gratton, E. (2009). Imaging barriers to diffusion by pair correlation functions. Biophysical Journal, 97(2), 665–673. https://doi.org/10.1016/j.bpj.2009.04.048

J-415 Hellriegel, C., & Gratton, E. (2009). Real-time multi-parameter spectroscopy and localization in three-dimensional single-particle tracking. Journal of the Royal Society Interface, 6(SUPPL. 1), S3–S14. https://doi.org/10.1098/rsif.2008.0313.focus

J-416 Krishnan, K., Holub, O., Gratton, E., Clayton, A. H. A., Cody, S., & Moens, P. D. J. (2009). Profilin interaction with phosphatidylinositol (4,5)-bisphosphate destabilizes the membrane of giant unilamellar vesicles. Biophysical Journal, 96(12), 5112–5121. https://doi.org/10.1016/j.bpj.2009.03.034

J-417 Levi, V., & Gratton, E. (2009). Three-Dimensional Particle Tracking in a Laser Scanning Fluorescence Microscope. Single Particle Tracking and Single Molecule Energy Transfer. https://doi.org/10.1002/9783527628360.ch1

J-418 Digman, M. A., & Gratton, E. (2009). Analysis of diffusion and binding in cells using the RIGS approach. Microscopy Research and Technique, 72(4), 323–332. https://doi.org/10.1002/jemt.20655

J-419 Digman, M. A., Wiseman, P. W., Horwitz, A. R., & Gratton, E. (2009). Detecting protein complexes in living cells from laser scanning confocal image sequences by the cross correlation raster image spectroscopy method. Biophysical Journal, 96(2), 707–716. https://doi.org/10.1016/j.bpj.2008.09.051

J-420 Tanner, K., Ferris, D. R., Lanzano, L., Mandefro, B., Mantulin, W. W., Gardiner, D. M., … Gratton, E. (2009). Coherent movement of cell layers during wound healing by image correlation spectroscopy. Biophysical Journal, 97(7), 2098–2106. https://doi.org/10.1016/j.bpj.2009.06.052

J-421 Toro, C., Sanchez, S. A., Zanocco, A., Lemp, E., Gratton, E., & Gunther, G. (2009). Solubilization of lipid bilayers by myristyl sucrose ester: effect of cholesterol and phospholipid head group size. Chemistry and Physics of Lipids, 157(2), 104–112. https://doi.org/10.1016/j.chemphyslip.2008.11.004

J-422 Digman, M. A., & Gratton, E. (2009). Fluorescence correlation spectroscopy and fluorescence cross-correlation spectroscopy. Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 1(2), 273–282. https://doi.org/10.1002/wsbm.5

J-423 Cardarelli, F., & Gratton, E. (2010). In vivo imaging of single-molecule translocation through nuclear pore complexes by pair correlation functions. PLoS ONE, 5(5). https://doi.org/10.1371/journal.pone.0010475

J-424 Hinde, E., Cardarelli, F., Digman, M. A., & Gratton, E. (2010). In vivo pair correlation analysis of EGFP intranuclear diffusion reveals DNA-dependent molecular flow. Proceedings of the National Academy of Sciences of the United States of America, 107(38), 16560–16565. https://doi.org/10.1073/pnas.1006731107

J-425 Kim, S. A., Sanabria, H., Digman, M. A., Gratton, E., Schwille, P., Zipfel, W. R., & Waxham, M. N. (2010). Quantifying translational mobility in neurons: Comparison between current optical techniques. Journal of Neuroscience, 30(49), 16409–16416. https://doi.org/10.1523/JNEUROSCI.3063-10.2010

J-426 Ossato, G., Digman, M. A., Aiken, C., Lukacsovich, T., Marsh, J. L., & Gratton, E. (2010). A two-step path to inclusion formation of huntingtin peptides revealed by number and brightness analysis. Biophysical Journal, 98(12), 3078–3085. https://doi.org/10.1016/j.bpj.2010.02.058

J-427 Azartash, K., Shy, C.-J. N., Flynn, K., Jester, J. V,& Gratton, E. (2010). Non-invasive in vivo measurement of the tear film using spatial autocorrelation in a live mammal model. Biomedical Optics Express, 1(4), 1127–1137. https://doi.org/10.1364/BOE.1.001127

J-428 Yoon, Y., Tong, J., Lee, P. J., Albanese, A., Bhardwaj, N., Källberg, M., … Cho, W. (2010). Molecular basis of the potent membrane-remodeling activity of the epsin 1 N-terminal homology domain. Journal of Biological Chemistry, 285(1), 531–540. https://doi.org/10.1074/jbc.M109.068015

J-429 Rossow, M. J., Sasaki, J. M., Digman, M. A., & Gratton, E. (2010). Raster image correlation spectroscopy in live cells. Nature Protocols, 5(11), 1761–1774. https://doi.org/10.1038/nprot.2010.122

J-430 Kukreti, S., Cerussi, A. E., Tanamai, W., Hsiang, D., Tromberg, B. J., & Gratton, E. (2010). Characterization of metabolic differences between benign and malignant tumors: High-spectral-resolution diffuse optical spectroscopy. Radiology, 254(1), 277–284. https://doi.org/10.1148/radiol.09082134

J-431 Celli, A., Sanchez, S., Behne, M., Hazlett, T., Gratton, E., & Mauro, T. (2010). The epidermal Ca2+ gradient: Measurement using the phasor representation of fluorescent lifetime imaging. Biophysical Journal, 98(5), 911–921. https://doi.org/10.1016/j.bpj.2009.10.055

J-432 Sánchez, S. A., Tricerri, M. A., Ossato, G., & Gratton, E. (2010). Lipid packing determines protein-membrane interactions: Challenges for apolipoprotein A-I and high density lipoproteins. Biochimica et Biophysica Acta - Biomembranes, 1798(7), 1399–1408. https://doi.org/10.1016/j.bbamem.2010.03.019

J-433 Rossow, M. J., Mantulin, W. W., & Gratton, E. (2010). Scanning laser image correlation for measurement of flow. Journal of Biomedical Optics, 15(2). https://doi.org/10.1117/1.3365946

J-434 Fu, C.-C., Ossato, G., Long, M., Digman, M. A., Gopinathan, A., Lee, L. P., … Khine, M. (2010). Bimetallic nanopetals for thousand-fold fluorescence enhancements. Applied Physics Letters, 97(20). https://doi.org/10.1063/1.3495773

J-435 Celli, A., & Gratton, E. (2010). Dynamics of lipid domain formation: Fluctuation analysis. Biochimica et Biophysica Acta - Biomembranes, 1798(7), 1368–1376. https://doi.org/10.1016/j.bbamem.2009.12.002

J-436 Choi, C. K., Zareno, J., Digman, M. A., Gratton, E.,& Horwitz, A. R. (2011). Cross-correlated fluctuation analysis reveals phosphorylation-regulated paxillin-fak complexes in nascent adhesions. Biophysical Journal, 100(3), 583–592. https://doi.org/10.1016/j.bpj.2010.12.3719

J-437 Sanchez, S. A., Gunther, G., Tricerri, M. A., & Gratton, E. (2011). Methyl-β-cyclodextrins preferentially remove cholesterol from the liquid disordered phase in giant unilamellar vesicles. Journal of Membrane Biology, 241(1), 1–10. https://doi.org/10.1007/s00232-011-9348-8

J-438 Sanchez, S., Bakás, L., Gratton, E., & Herlax, V. (2011). Alpha hemolysin induces an increase of erythrocytes calcium: A FLIM 2-Photon Phasor analysis approach. PLoS ONE, 6(6). https://doi.org/10.1371/journal.pone.0021127

J-439 Choi, C. K., Zareno, J., Digman, M. A., Gratton, E.,& Horwitz, A. R. (2011). Erratum: Cross-correlated fluctuation analysis reveals phosphorylation- regulated paxillin-FAK complexes in nascent adhesions (Biophysical Journal (2011) 100 (583-592)). Biophysical Journal, 101(2), 517. https://doi.org/10.1016/j.bpj.2011.06.036

J-440 Azartash, K., Kwan, J., Paugh, J. R., Nguyen, A. L., Jester, J. V, & Gratton, E. (2011). Pre-corneal tear film thickness in humans measured with a novel technique. Molecular Vision, 17, 756–767. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-79955606515&partnerID=40&md5=496b7d0dbc3b27f50bfbc84b6f24fe18

J-441 Leproux, A., Cerussi, A. E., Tanamai, W., Durkin, A. F., Compton, M., Gratton, E., & Tromberg, B. J. (2011). Impact of contralateral and ipsilateral reference tissue selection on self-referencing differential spectroscopy for breast cancer detection. Journal of Biomedical Optics, 16(11). https://doi.org/10.1117/1.3652711

J-442 Behne, M. J., Sanchez, S., Barry, N. P., Kirschner, N., Meyer, W., Mauro, T. M., … Gratton, E. (2011). Major translocation of calcium upon epidermal barrier insult: Imaging and quantification via FLIM/Fourier vector analysis. Archives of Dermatological Research, 303(2), 103–115. https://doi.org/10.1007/s00403-010-1113-9

J-443 Ross, J. A., Digman, M. A., Wang, L., Gratton, E., Albanesi, J. P., & Jameson, D. M. (2011). Oligomerization state of dynamin 2 in cell membranes using TIRF and number and brightness analysis. Biophysical Journal, 100(3), L15–L17. https://doi.org/10.1016/j.bpj.2010.12.3703

J-444 Stringari, C., Cinquin, A., Cinquin, O., Digman, M. A., Donovan, P. J., & Gratton, E. (2011). Phasor approach to fluorescence lifetime microscopy distinguishes different metabolic states of germ cells in a live tissue. Proceedings of the National Academy of Sciences of the United States of America, 108(33), 13582–13587. https://doi.org/10.1073/pnas.1108161108

J-445 Lanzano, L., Digman, M. A., Fwu, P., Giral, H., Levi, M., & Gratton, E. (2011). Nanometer-scale imaging by the modulation tracking method. Journal of Biophotonics, 4(6), 415–424. https://doi.org/10.1002/jbio.201100002

J-446 Moens, P. D. J., Gratton, E., & Salvemini, I. L. (2011). Fluorescence correlation spectroscopy, raster image correlation spectroscopy, and number and brightness on a commercial confocal laser scanning microscope with analog detectors (Nikon C1). Microscopy Research and Technique, 74(4), 377–388. https://doi.org/10.1002/jemt.20919

J-447 Vetri, V., Ossato, G., Militello, V., Digman, M. A., Leone, M., & Gratton, E. (2011). Fluctuation methods to study protein aggregation in live cells: Concanavalin a oligomers formation. Biophysical Journal, 100(3), 774–783. https://doi.org/10.1016/j.bpj.2010.11.089

J-448 Sanchez, S. A., Gratton, E., Zanocco, A. L., Lemp, E.,& Gunther, G. (2011). Sucrose monoester micelles size determined by fluorescence correlation spectroscopy (FCS). PLoS ONE, 6(12). https://doi.org/10.1371/journal.pone.0029278

J-449 Santoro, Y., Leproux, A., Cerussi, A., Tromberg, B.,& Gratton, E. (2011). Breast cancer spatial heterogeneity in near-infrared spectra and the prediction of neoadjuvant chemotherapy response. Journal of Biomedical Optics, 16(9). https://doi.org/10.1117/1.3638135

J-450 Chen, B., Estrada, L. C., Hellriegel, C., & Gratton, E. (2011). Nanometer-scale optical imaging of collagen fibers using gold nanoparticles. Biomedical Optics Express, 2(3), 511–519. https://doi.org/10.1364/BOE.2.000511

J-451 Estrada, L. C., & Gratton, E. (2011). 3D nanometer images of biological fibers by directed motion of gold nanoparticles. Nano Letters, 11(11), 4656–4660. https://doi.org/10.1021/nl2022042

J-452 Stafford, R. L., Hinde, E., Knight, M. J., Pennella, M. A., Ear, J., Digman, M. A., … Bowie, J. U. (2011). Tandem SAM domain structure of human Caskin1: A presynaptic, self-assembling scaffold for CASK. Structure, 19(12), 1826–1836. https://doi.org/10.1016/j.str.2011.09.018

J-453 Lanzano, L., Lei, T., Okamura, K., Giral, H., Caldas, Y., Masihzadeh, O., … Blaine, J. (2011). Differential modulation of the molecular dynamics of the type IIa and IIc sodium phosphate cotransporters by parathyroid hormone. American Journal of Physiology - Cell Physiology, 301(4), C850–C861. https://doi.org/10.1152/ajpcell.00412.2010

J-454 Gratton, E. (2011). Deeper tissue imaging with total detection. Science, 331(6020), 1016–1017. https://doi.org/10.1126/science.1201542

J-455 Itano, M. S., Neumann, A. K., Liu, P., Zhang, F., Gratton, E., Parak, W. J., … Jacobson, K. (2011). DC-SIGN and influenza hemagglutinin dynamics in plasma membrane microdomains are markedly different. Biophysical Journal, 100(11), 2662–2670. https://doi.org/10.1016/j.bpj.2011.04.044

J-456 Kotlarchyk, M. A., Shreim, S. G., Alvarez-Elizondo, M. B., Estrada, L. C., Singh, R., Valdevit, L., … Botvinick, E. L. (2011). Concentration independent modulation of local micromechanics in a fibrin gel. PLoS ONE, 6(5). https://doi.org/10.1371/journal.pone.0020201

J-457 Marchini, C., Pozzi, D., Montani, M., Alfonsi, C., Amici, A., Candeloro De Sanctis, S., … Caracciolo, G. (2011). Role of temperature-independent lipoplex-cell membrane interactions in the efficiency boost of multicomponent lipoplexes. Cancer Gene Therapy, 18(8), 543–552. https://doi.org/10.1038/cgt.2011.12

J-458 Cardarelli, F., Lanzano, L., & Gratton, E. (2011). Fluorescence correlation spectroscopy of intact nuclear pore complexes. Biophysical Journal, 101(4), L27-29. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-84856381681&partnerID=40&md5=7a9464cc04130eb8e6a8ec6677474c94

J-459 Digman, M. A., & Gratton, E. (2011). Lessons in fluctuation correlation spectroscopy. Annual Review of Physical Chemistry, 62, 645–668. https://doi.org/10.1146/annurev-physchem-032210-103424

J-460 Wolf, U., Toronov, V., Choi, J. H., Gupta, R., Michalos, A., Gratton, E., & Wolf, M. (2011). Correlation of functional and resting state connectivity of cerebral oxy-, deoxy-, and total hemoglobin concentration changes measured by near-infrared spectrophotometry. Journal of Biomedical Optics, 16(8). https://doi.org/10.1117/1.3615249

J-461 Blaine, J., Lanzano, L., Giral, H., Caldas, Y., Levi, M., Gratton, E., … Lei, T. (2011). Dynamic Imaging of the Sodium Phosphate Cotransporters. Advances in Chronic Kidney Disease, 18(2), 145–150. https://doi.org/10.1053/j.ackd.2011.02.003

J-462 Hinde, E., Cardarelli, F., Digman, M. A., Kershner, A., Kimble, J., & Gratton, E. (2011). The impact of mitotic versus interphase chromatin architecture on the molecular flow of EGFP by pair correlation analysis. Biophysical Journal, 100(7), 1829–1836. https://doi.org/10.1016/j.bpj.2011.02.024

J-463 Caracciolo, G., Pozzi, D., Capriotti, A. L., Marianecci, C., Carafa, M., Marchini, C., … Laganà, A. (2011). Factors determining the superior performance of lipid/DNA/protammine nanoparticles over lipoplexes. Journal of Medicinal Chemistry, 54(12), 4160–4171. https://doi.org/10.1021/jm200237p

J-464 Giral, H., Lanzano, L., Caldas, Y., Blaine, J., Verlander, J. W., Lei, T., … Levi, M. (2011). Role of PDZK1 protein in apical membrane expression of renal sodium-coupled phosphate transporters. Journal of Biological Chemistry, 286(17), 15032–15042. https://doi.org/10.1074/jbc.M110.199752

J-465 Crosignani, V., Dvornikov, A. S., & Gratton, E. (2011). Enhancement of imaging depth in turbid media using a wide area detector. Journal of Biophotonics, 4(9), 592–599. https://doi.org/10.1002/jbio.201100001

J-466 Battisti, A., Digman, M. A., Gratton, E., Storti, B., Beltram, F., & Bizzarri, R. (2012). Intracellular pH measurements made simple by fluorescent protein probes and the phasor approach to fluorescence lifetime imaging. Chemical Communications, 48(42), 5127–5129. https://doi.org/10.1039/c2cc30373f

J-467 Stringari, C., Sierra, R., Donovan, P. J., & Gratton, E. (2012). Label-free separation of human embryonic stem cells and their differentiating progenies by phasor fluorescence lifetime microscopy. Journal of Biomedical Optics, 17(4). https://doi.org/10.1117/1.JBO.17.4.046012

J-468 Crosignani, V., Dvornikov, A., Aguilar, J. S., Stringari, C., Edwards, R., Mantulin, W. W., & Gratton, E. (2012). Deep tissue fluorescence imaging and in vivo biological applications. Journal of Biomedical Optics, 17(11). https://doi.org/10.1117/1.JBO.17.11.116023

J-469 Hinde, E., Digman, M. A., Welch, C., Hahn, K. M., & Gratton, E. (2012). Biosensor Förster resonance energy transfer detection by the phasor approach to fluorescence lifetime imaging microscopy. Microscopy Research and Technique, 75(3), 271–281. https://doi.org/10.1002/jemt.21054

J-470 Adu-Gyamfi, E., Digman, M. A., Gratton, E., & Stahelin, R. V. (2012). Investigation of Ebola VP40 assembly and oligomerization in live cells using number and brightness analysis. Biophysical Journal, 102(11), 2517–2525. https://doi.org/10.1016/j.bpj.2012.04.022

J-471 Whiteside, M. D., Digman, M. A., Gratton, E., & Treseder, K. K. (2012). Organic nitrogen uptake by arbuscular mycorrhizal fungi in a boreal forest. Soil Biology and Biochemistry, 55, 7–13. https://doi.org/10.1016/j.soilbio.2012.06.001

J-472 Estrada, L. C., & Gratton, E. (2012). Spectroscopic properties of gold nanoparticles at the single-particle level in biological environments. ChemPhysChem, 13(4), 1087–1092. https://doi.org/10.1002/cphc.201100771

J-473 Wright, B. K., Andrews, L. M., Markham, J., Jones, M. R., Stringari, C., Digman, M. A., & Gratton, E. (2012). NADH distribution in live progenitor stem cells by phasor-fluorescence lifetime image microscopy. Biophysical Journal, 103(1), L7–L9. https://doi.org/10.1016/j.bpj.2012.05.038

J-474 Lanzano, L., & Gratton, E. (2012). Measurement of distance with the nanoscale precise imaging by rapid beam oscillation method. Microscopy Research and Technique, 75(9), 1253–1264. https://doi.org/10.1002/jemt.22058

J-475 Stringari, C., Donovan, P., & Gratton, E. (2012). Phasor FLIM metabolic mapping of stem cells and cancer cells in live tissues. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8226). https://doi.org/10.1117/12.909420

J-476 Cardarelli, F., Lanzano, L., & Gratton, E. (2012). Capturing directed molecular motion in the nuclear pore complex of live cells. Proceedings of the National Academy of Sciences of the United States of America, 109(25), 9863–9868. https://doi.org/10.1073/pnas.1200486109

J-477 James, N. G., Digman, M. A., Gratton, E., Barylko, B., Ding, X., Albanesi, J. P., … Jameson, D. M. (2012). Number and brightness analysis of LRRK2 oligomerization in live cells. Biophysical Journal, 102(11), L41–L43. https://doi.org/10.1016/j.bpj.2012.04.046

J-478 Stringari, C., Nourse, J. L., Flanagan, L. A., & Gratton, E. (2012). Phasor Fluorescence Lifetime Microscopy of Free and Protein-Bound NADH Reveals Neural Stem Cell Differentiation Potential. PLoS ONE, 7(11). https://doi.org/10.1371/journal.pone.0048014

J-479 Sanchez, S. A., Tricerri, M. A., & Gratton, E. (2012). Laurdan generalized polarization fluctuations measures membrane packing micro-heterogeneity in vivo. Proceedings of the National Academy of Sciences of the United States of America, 109(19), 7314–7319. https://doi.org/10.1073/pnas.1118288109

J-480 Wigal, S. B., Polzonetti, C. M., Stehli, A., & Gratton, E. (2012). Phase synchronization of oxygenation waves in the frontal areas of children with attention-deficit hyperactivity disorder detected by optical diffusion spectroscopy correlates with medication. Journal of Biomedical Optics, 17(12). https://doi.org/10.1117/1.JBO.17.12.127002

J-481 Stringari, C., Edwards, R. A., Pate, K. T., Waterman, M. L., Donovan, P. J., & Gratton, E. (2012). Metabolic trajectory of cellular differentiation in small intestine by Phasor Fluorescence Lifetime Microscopy of NADH. Scientific Reports, 2. https://doi.org/10.1038/srep00568

J-482 Arnesano, C., Santoro, Y., & Gratton, E. (2012). Digital parallel frequency-domain spectroscopy for tissue imaging. Journal of Biomedical Optics, 17(9). https://doi.org/10.1117/1.JBO.17.9.096014

J-483 Adu-Gyamfi, E., Digman, M. A., Gratton, E., & Stahelin, R. V. (2012). Single-particle tracking demonstrates that actin coordinates the movement of the Ebola virus matrix protein. Biophysical Journal, 103(9), L41–L43. https://doi.org/10.1016/j.bpj.2012.09.026

J-484 Hinde, E., Cardarelli, F., Chen, A., Khine, M., & Gratton, E. (2012). Tracking the mechanical dynamics of human embryonic stem cell chromatin. Epigenetics and Chromatin, 5(1). https://doi.org/10.1186/1756-8935-5-20

J-485 Giral, H., Cranston, D., Lanzano, L., Caldas, Y., Sutherland, E., Rachelson, J., … Levi, M. (2012). NHE3 Regulatory Factor 1 (NHERF1) modulates intestinal sodium-dependent phosphate transporter (NaPi-2b) expression in apical microvilli. Journal of Biological Chemistry, 287(42), 35047–35056. https://doi.org/10.1074/jbc.M112.392415

J-486 Zhou, S., Lo, W.-C., Suhalim, J. L., Digman, M. A., Gratton, E., Nie, Q., & Lander, A. D. (2012). Free extracellular diffusion creates the Dpp morphogen gradient of the Drosophila wing disc. Current Biology, 22(8), 668–675. https://doi.org/10.1016/j.cub.2012.02.065

J-487 Kniazeva, E., Weidling, J. W., Singh, R., Botvinick, E. L., Digman, M. A., Gratton, E., & Putnam, A. J. (2012). Quantification of local matrix deformations and mechanical properties during capillary morphogenesis in 3D. Integrative Biology, 4(4), 431–439. https://doi.org/10.1039/c2ib00120a

J-488 Cutrale, F., & Gratton, E. (2012). Inclined selective plane illumination microscopy adaptor for conventional microscopes. Microscopy Research and Technique, 75(11), 1461–1466. https://doi.org/10.1002/jemt.22089

J-489 Crosignani, V., Dvornikov, A., Aguilar, J. S., Stringari, C., Edwards, R., Mantulin, W., & Gratton, E. (2012). In vivo deep tissue fluorescence imaging of the murine small intestine and colon. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8226). https://doi.org/10.1117/12.912841

J-490 Digman, M. A., & Gratton, E. (2012). Scanning image correlation spectroscopy. BioEssays, 34(5), 377–385. https://doi.org/10.1002/bies.201100118

J-491 Hinde, E., Cardarelli, F., Digman, M. A., & Gratton, E. (2012). Changes in chromatin compaction during the cell cycle revealed by micrometer-scale measurement of molecular flow in the nucleus. Biophysical Journal, 102(3), 691–697. https://doi.org/10.1016/j.bpj.2011.11.4026

J-492 Wright, B. K., Andrews, L. M., Jones, M. R., Stringari, C., Digman, M. A., & Gratton, E. (2012). Phasor-flim analysis of NADH distribution and localization in the nucleus of live progenitor myoblast cells. Microscopy Research and Technique, 75(12), 1717–1722. https://doi.org/10.1002/jemt.22121

J-493 Coppola, S., Estrada, L. C., Digman, M. A., Pozzi, D., Cardarelli, F., Gratton, E., & Caracciolo, G. (2012). Intracellular trafficking of cationic liposome-DNA complexes in living cells. Soft Matter, 8(30), 7919–7927. https://doi.org/10.1039/c2sm25532d

J-494 Digman, M. D., & Gratton, E. (2012). Fluorescence lifetime microscopy: The phasor approach. Comprehensive Biophysics (Vol. 2). https://doi.org/10.1016/B978-0-12-374920-8.00205-8

J-495 Golfetto, O., Hinde, E., & Gratton, E. (2013). Laurdan fluorescence lifetime discriminates cholesterol content from changes in fluidity in living cell membranes. Biophysical Journal, 104(6), 1238–1247. https://doi.org/10.1016/j.bpj.2012.12.057

J-496 Chen, H., & Gratton, E. (2013). A practical implementation of multifrequency widefield frequency-domain fluorescence lifetime imaging microscopy. Microscopy Research and Technique, 76(3), 282–289. https://doi.org/10.1002/jemt.22165

J-497 Crosignani, V., Dvornikov, A., & Gratton, E. (2013). Ultra-deep imaging of turbid samples by enhanced photon harvesting. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8588). https://doi.org/10.1117/12.2002101

J-498 Hinde, E., Digman, M. A., Hahn, K. M., & Gratton, E. (2013). Millisecond spatiotemporal dynamics of FRET biosensors by the pair correlation function and the phasor approach to FLIM. Proceedings of the National Academy of Sciences of the United States of America, 110(1), 135–140. https://doi.org/10.1073/pnas.1211882110

J-499 Cutrale, F., Salih, A., & Gratton, E. (2013). Spectral phasor approach for fingerprinting of photo-activatable fluorescent proteins Dronpa, Kaede and KikGR. Methods and Applications in Fluorescence, 1(3). https://doi.org/10.1088/2050-6120/1/3/035001

J-500 Torno, K., Wright, B. K., Jones, M. R., Digman, M. A., Gratton, E., & Phillips, M. (2013). Real-time analysis of metabolic activity within lactobacillus acidophilus by phasor fluorescence lifetime imaging microscopy of NADH. Current Microbiology, 66(4), 365–367. https://doi.org/10.1007/s00284-012-0285-2

J-501 Dobrinskikh, E., Lanzano, L., Rachelson, J., Cranston, D., Moldovan, R., Lei, T., … Doctor, R. B. (2013). Shank2 contributes to the apical retention and intracellular redistribution of NaPiIIa in OK cells. American Journal of Physiology - Cell Physiology, 304(6), C561–C573. https://doi.org/10.1152/ajpcell.00189.2012

J-502 Digman, M. A., Stakic, M., & Gratton, E. (2013). Raster image correlation spectroscopy and number and brightness analysis. Methods in Enzymology, 518, 121–144. https://doi.org/10.1016/B978-0-12-388422-0.00006-6

J-503 Chiu, C. .-L., & Gratton, E. (2013). Axial super resolution topography of focal adhesion by confocal microscopy. Microscopy Research and Technique, 76(10), 1070–1078. https://doi.org/10.1002/jemt.22267

J-504 Gratton, E., Cardarelli, F., & Lanzano, L. (2013). Super-resolution by feedback imaging: Mechanisms of translocation through the nuclear pore complex. In Optical Molecular Probes, Imaging and Drug Delivery, OMP 2013. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-84887533533&partnerID=40&md5=6043c91043e554b43b7e97ee14060d16

J-505 Li, K., Markosyan, R. M., Zheng, Y.-M., Golfetto, O., Bungart, B., Li, M., … Liu, S.-L. (2013). IFITM Proteins Restrict Viral Membrane Hemifusion. PLoS Pathogens, 9(1). https://doi.org/10.1371/journal.ppat.1003124

J-506 Coppola, S., Pozzi, D., Candeloro De Sanctis, S., Digman, M. A., Gratton, E., & Caracciolo, G. (2013). Quantitative measurement of intracellular transport of nanocarriers by spatio-temporal image correlation spectroscopy. Methods and Applications in Fluorescence, 1(1). https://doi.org/10.1088/2050-6120/1/1/015005

J-507 Andrews, L. M., Jones, M. R., Digman, M. A., & Gratton, E. (2013). Spectral phasor analysis of Pyronin Y labeled RNA microenvironments in living cells. Biomedical Optics Express, 4(1), 171–177. https://doi.org/10.1364/BOE.4.000171

J-508 Skinner, J. P., Swift, K. M., Ruan, Q., Perfetto, S., Gratton, E., & Tetin, S. Y. (2013). Simplified confocal microscope for counting particles at low concentrations. Review of Scientific Instruments, 84(7). https://doi.org/10.1063/1.4812782

J-509 Gehricke, J.-G., Polzonetti, C., Caburian, C., & Gratton, E. (2013). Prefrontal hemodynamic changes during cigarette smoking in young adult smokers with and without ADHD. Pharmacology Biochemistry and Behavior, 112, 78–81. https://doi.org/10.1016/j.pbb.2013.10.001

J-510 Altamore, I., Lanzano, L., & Gratton, E. (2013). Dual channel detection of ultra low concentration of bacteria in real time by scanning fluorescence correlation spectroscopy. Measurement Science and Technology, 24(6). https://doi.org/10.1088/0957-0233/24/6/065702

J-511 Di Rienzo, C., Gratton, E., Beltram, F., & Cardarelli, F. (2013). Fast spatiotemporal correlation spectroscopy to determine protein lateral diffusion laws in live cell membranes. Proceedings of the National Academy of Sciences of the United States of America, 110(30), 12307–12312. https://doi.org/10.1073/pnas.1222097110

J-512 Leproux, A., Durkin, A., Compton, M., Cerussi, A. E., Gratton, E., & Tromberg, B. J. (2013). Assessing tumor contrast in radiographically dense breast tissue using Diffuse Optical Spectroscopic Imaging (DOSI). Breast Cancer Research, 15(5). https://doi.org/10.1186/bcr3485

J-513 Andrews, L. M., Jones, M. R., Digman, M. A., & Gratton, E. (2013). Detecting pyronin Y labeled RNA transcripts in live cell microenvironments by phasor-FLIM analysis. Methods and Applications in Fluorescence, 1(1). https://doi.org/10.1088/2050-6120/1/1/015001

J-514 Chiu, C.-L., Digman, M. A., & Gratton, E. (2013). Measuring actin flow in 3D cell protrusions. Biophysical Journal, 105(8), 1746–1755. https://doi.org/10.1016/j.bpj.2013.07.057

J-515 Chiu, C.-L., Digman, M. A., & Gratton, E. (2013). Cell matrix remodeling ability shown by image spatial correlation. Journal of Biophysics. https://doi.org/10.1155/2013/532030

J-516 Adu-Gyamfi, E., Soni, S. P., Xue, Y., Digman, M. A., Gratton, E., & Stahelin, R. V. (2013). The ebola virus matrix protein penetrates into the plasma membrane: A key step in viral protein 40 (VP40) oligomerization and viral egress. Journal of Biological Chemistry, 288(8), 5779–5789. https://doi.org/10.1074/jbc.M112.443960

J-517 Krasieva, T. B., Stringari, C., Liu, F., Sun, C.-H., Kong, Y., Balu, M., … Tromberg, B. J. (2013). Two-photon excited fluorescence lifetime imaging and spectroscopy of melanins in vitro and in vivo. Journal of Biomedical Optics, 18(3). https://doi.org/10.1117/1.JBO.18.3.031107

J-518 Coppola, S., Cardarelli, F., Pozzi, D., Estrada, L. C., Digman, M. A., Gratton, E., … Caracciolo, G. (2013). The role of cytoskeleton networks on lipid-mediated delivery of DNA. Therapeutic Delivery, 4(2), 191–202. https://doi.org/10.4155/tde.12.151

J-519 Conway, D. E., Breckenridge, M. T., Hinde, E., Gratton, E., Chen, C. S., & Schwartz, M. A. (2013). Fluid shear stress on endothelial cells modulates mechanical tension across VE-cadherin and PECAM-1. Current Biology, 23(11), 1024–1030. https://doi.org/10.1016/j.cub.2013.04.049

J-520 De La Torre, D., Gordon, E. A., Digman, M. A., Stakic, M., Häberlein, H., Gratton, E., & Caballero-George, C. (2013). Raster image correlation spectroscopy in live cells expressing Endothelin ETA Receptor. Current Trends in Biotechnology and Pharmacy, 7(1), 499–504. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-84873573246&partnerID=40&md5=f61b23d92ff1252b42639c73fd2a560d

J-521 Ranjit, S., Dvornikov, A., Holland, D. A., Reinhart, G. D., Jameson, D. M., & Gratton, E. (2014). Application of three-photon excitation FCS to the study of protein oligomerization. Journal of Physical Chemistry B, 118(50), 14627–14631. https://doi.org/10.1021/jp511126x

J-522 Crosignani, V., Jahid, S., Dvornikov, A., & Gratton, E. (2014). Deep tissue imaging by enhanced photon collection. Journal of Innovative Optical Health Sciences, 7(5). https://doi.org/10.1142/S1793545814500345

J-523 Paladino, S., Lebreton, S., Tivodar, S., Formiggini, F., Ossato, G., Gratton, E., … Zurzolo, C. (2014). Golgi sorting regulates organization and activity of GPI proteins at apical membranes. Nature Chemical Biology, 10(5), 350–357. https://doi.org/10.1038/nchembio.1495

J-524 Adu-Gyamfi, E., Soni, S. P., Jee, C. S., Digman, M. A., Gratton, E., & Stahelin, R. V. (2014). A loop region in the N-terminal domain of ebola virus VP40 is important in viral assembly, Budding, and egress. Viruses, 6(10), 3837–3854. https://doi.org/10.3390/v6103837

J-525 Crosignani, V., Jahid, S., Dvornikov, A. S., & Gratton, E. (2014). A deep tissue fluorescence imaging system with enhanced SHG detection capabilities. Microscopy Research and Technique, 77(5), 368–373. https://doi.org/10.1002/jemt.22354

J-526 Ranjit, S., Lanzano, L., & Gratton, E. (2014). Mapping diffusion in a living cell via the phasor approach. Biophysical Journal, 107(12), 2775–2785. https://doi.org/10.1016/j.bpj.2014.08.041

J-527 Plotegher, N., Gratton, E., & Bubacco, L. (2014). Number and Brightness analysis of alpha-synuclein oligomerization and the associated mitochondrial morphology alterations in live cells. Biochimica et Biophysica Acta - General Subjects, 1840(6), 2014–2024. https://doi.org/10.1016/j.bbagen.2014.02.013

J-528 Golfetto, O., Hinde, E., & Gratton, E. (2014). The laurdan spectral phasor method to explore membrane micro-heterogeneity and lipid domains in live cells. Methods in Membrane Lipids: Second Edition. https://doi.org/10.1007/978-1-4939-1752-5_19

J-529 Kang, D.-K., Ali, M. M., Zhang, K., Huang, S. S., Peterson, E., Digman, M. A., … Zhao, W. (2014). Rapid detection of single bacteria in unprocessed blood using Integrated Comprehensive Droplet Digital Detection. Nature Communications, 5. https://doi.org/10.1038/ncomms6427

J-530 Hinde, E., Yokomori, K., Gaus, K., Hahn, K. M., & Gratton, E. (2014). Fluctuation-based imaging of nuclear Rac1 activation by protein oligomerisation. Scientific Reports, 4. https://doi.org/10.1038/srep04219

J-531 Datta, R., Sobrino, A., Hughes, C., & Gratton, E. (2014). Fluorescence lifetime imaging microscopy to study metabolism in a microfluidic device based tumor microenvironment. In Optics InfoBase Conference Papers. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-85019503853&partnerID=40&md5=bab7cb439c88e935353b03a60a8663a1

J-532 Lanzanò, L., & Gratton, E. (2014). Orbital Single Particle Tracking on a commercial confocal microscope using piezoelectric stage feedback. Methods and Applications in Fluorescence, 2(2). https://doi.org/10.1088/2050-6120/2/2/024010

J-533 Anzalone, A., Annibale, P., & Gratton, E. (2014). 3D orbital tracking in a modified two-photon microscope: An application to the tracking of intracellular vesicles. Journal of Visualized Experiments, (92). https://doi.org/10.3791/51794

J-534 Pate, K. T., Stringari, C., Sprowl-Tanio, S., Wang, K., Teslaa, T., Hoverter, N. P., … Waterman, M. L. (2014). Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer. EMBO Journal, 33(13), 1454–1473. https://doi.org/10.15252/embj.201488598

J-535 Kang, D.-K., Ali, M. M., Zhang, K., Digman, M. A., Gratton, E., Peterson, E. M., & Zhao, W. (2014). Rapid, single bacterial detection from blood using microencapsulated sensors. In 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 (pp. 306–308). Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-84941711003&partnerID=40&md5=573a11d0071f9491cc647032cc6ca3ae

J-536 James, N. G., Digman, M. A., Ross, J. A., Barylko, B., Wang, L., Li, J., … Jameson, D. M. (2014). A mutation associated with centronuclear myopathy enhances the size and stability of dynamin 2 complexes in cells. Biochimica et Biophysica Acta - General Subjects, 1840(1), 315–321. https://doi.org/10.1016/j.bbagen.2013.09.001

J-537 Sharma, H., Digman, M. A., Felsinger, N., Gratton, E.,& Khine, M. (2014). Enhanced emission of fluorophores on shrinkinduced wrinkled composite structures. Optical Materials Express, 4(4), 753–763. https://doi.org/10.1364/OME.4.000753

J-538 Bonaventura, G., Barcellona, M. L., Golfetto, O., Nourse, J. L., Flanagan, L. A., & Gratton, E. (2014). Laurdan Monitors Different Lipids Content in Eukaryotic Membrane During Embryonic Neural Development. Cell Biochemistry and Biophysics, 70(2), 785–794. https://doi.org/10.1007/s12013-014-9982-8

J-539 Gratton, E., & Digman, M. A. (2014). Laurdan identifies different lipid membranes in eukaryotic cells. Cell Membrane Nanodomains: From Biochemistry to Nanoscopy. https://doi.org/10.1201/b17634

J-540 Hinde, E., Kong, X., Yokomori, K., & Gratton, E. (2014). Chromatin dynamics during DNA repair revealed by pair correlation analysis of molecular flow in the nucleus. Biophysical Journal, 107(1), 55–65. https://doi.org/10.1016/j.bpj.2014.05.027

J-541 Subashchandrabose, S. R., Krishnan, K., Gratton, E., Megharaj, M., & Naidu, R. (2014). Potential of fluorescence imaging techniques to monitor mutagenic PAH uptake by microalga. Environmental Science and Technology, 48(16), 9152–9160. https://doi.org/10.1021/es500387v

J-542 Pozzi, D., Marchini, C., Cardarelli, F., Salomone, F., Coppola, S., Montani, M., … Caracciolo, G. (2014). Mechanistic evaluation of the transfection barriers involved in lipid-mediated gene delivery: Interplay between nanostructure and composition. Biochimica et Biophysica Acta - Biomembranes, 1838(3), 957–967. https://doi.org/10.1016/j.bbamem.2013.11.014

J-543 Bachir, A. I., Zareno, J., Moissoglu, K., Plow, E. F., Gratton, E., & Horwitz, A. R. (2014). Integrin-associated complexes form hierarchically with variable stoichiometry in nascent adhesions. Current Biology, 24(16), 1845–1853. https://doi.org/10.1016/j.cub.2014.07.011

J-544 Nicolai, E., Garau, S., Favalli, C., D’Agostini, C., Gratton, E., Motolese, G., & Rosato, N. (2014). Evaluation of BiesseBioscreen as a new methodology for bacteriuria screening. New Microbiologica, 37(4), 495–501. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-84908505559&partnerID=40&md5=c1638069651275e39c6440188018e39b

J-545 Annibale, P., & Gratton, E. (2014). Advanced fluorescence microscopy methods for the real-time study of transcription and chromatin dynamics. Transcription, 5(MAR). https://doi.org/10.4161/trns.28425

J-546 Datta, R., Heylman, C., Tran, D., George, S. C., & Gratton, E. (2014). Label - free fluorescence lifetime imaging of microfluidic device based cardiac tissue model metabolism. In Laser Science, LS 2014. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-84919752854&partnerID=40&md5=fe9c62a810647d988401fe67609b96ba

J-547 Digman, M. A., & Gratton, E. (2014). The phasor approach to fluorescence lifetime imaging: Exploiting phasor linear properties. Fluorescence Lifetime Spectroscopy and Imaging: Principles and Applications in Biomedical Diagnostics. https://doi.org/10.1201/b17018

J-548 Di Rienzo, C., Piazza, V., Gratton, E., Beltram, F.,& Cardarelli, F. (2014). Probing short-range protein Brownian motion in the cytoplasm of living cells. Nature Communications, 5. https://doi.org/10.1038/ncomms6891

J-549 Chiu, C.-L., Aguilar, J. S., Tsai, C. Y., Wu, G., Gratton, E., & Digman, M. A. (2014). Nanoimaging of focal adhesion dynamics in 3D. PLoS ONE, 9(6). https://doi.org/10.1371/journal.pone.0099896

J-550 Kang, D.-K., Zhang, K., Ali, M. M., Liu, L., Labanieh, L., Lu, M., … Zhao, W. (2015). Digital quantification of miRNA in blood using integrated comprehensive droplet digital detection (IC3D) system. In MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 200–202). Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-84983296858&partnerID=40&md5=9118449f2457e13fb8b00f8bb931cff8

J-551 Mieruszynski, S., Briggs, C., Digman, M. A., Gratton, E., & Jones, M. R. (2015). Live cell characterization of DNA aggregation delivered through lipofection. Scientific Reports, 5. https://doi.org/10.1038/srep10528

J-552 Chen, H., Holst, G., & Gratton, E. (2015). Modulated CMOS camera for fluorescence lifetime microscopy. Microscopy Research and Technique, 78(12), 1075–1081. https://doi.org/10.1002/jemt.22587

J-553 Anzalone, A., Gabriel, M., Estrada, L. C., & Gratton, E. (2015). Spectral properties of single gold nanoparticles in close proximity to biological fluorophores excited by 2-photon excitation. PLoS ONE, 10(4). https://doi.org/10.1371/journal.pone.0124975

J-554 Hinde, E., Cardarelli, F., & Gratton, E. (2015). Spatiotemporal regulation of Heterochromatin Protein 1- alpha oligomerization and dynamics in live cells. Scientific Reports, 5. https://doi.org/10.1038/srep12001

J-555 Zhang, K., Kang, D.-K., Ali, M. M., Liu, L., Labanieh, L., Lu, M., … Zhao, W. (2015). Digital quantification of miRNA directly in plasma using integrated comprehensive droplet digital detection. Lab on a Chip, 15(21), 4217–4226. https://doi.org/10.1039/c5lc00650c

J-556 Lanzanò, L., Coto Hernández, I., Castello, M., Gratton, E., Diaspro, A., & Vicidomini, G. (2015). Encoding and decoding spatio-temporal information for super-resolution microscopy. Nature Communications, 6. https://doi.org/10.1038/ncomms7701

J-557 Hedde, P. N., Ranjit, S., & Gratton, E. (2015). 3D fluorescence anisotropy imaging using selective plane illumination microscopy. Optics Express, 23(17), 22308–22317. https://doi.org/10.1364/OE.23.022308

J-558 Golfetto, O., Hinde, E., & Gratton, E. (2015). The laurdan spectral phasor method to explore membrane micro-heterogeneity and lipid domains in live cells. Methods in Molecular Biology, 1232, 273–290. https://doi.org/10.1007/978-1-4939-1752-5_19

J-559 Rong, X., Wang, B., Dunham, M. M., Hedde, P. N., Wong, J. S., Gratton, E., … Tontonoz, P. (2015). Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion. ELife, 2015(4). https://doi.org/10.7554/eLife.06557

J-560 Ranjit, S., Dvornikov, A., Stakic, M., Hong, S.-H., Levi, M., Evans, R. M., & Gratton, E. (2015). Imaging Fibrosis and Separating Collagens using Second Harmonic Generation and Phasor Approach to Fluorescence Lifetime Imaging. Scientific Reports, 5. https://doi.org/10.1038/srep13378

J-561 Chen, H., Gratton, E., & Digman, M. A. (2015). Spectral properties and dynamics of gold nanorods revealed by EMCCD-based spectral phasor method. Microscopy Research and Technique, 78(4), 283–293. https://doi.org/10.1002/jemt.22473

J-562 Stringari, C., Wang, H., Geyfman, M., Crosignani, V., Kumar, V., Takahashi, J. S., … Gratton, E. (2015). In Vivo Single-Cell Detection of Metabolic Oscillations in Stem Cells. Cell Reports, 10(1), 1–7. https://doi.org/10.1016/j.celrep.2014.12.007

J-563 Ito, A., Hong, C., Rong, X., Zhu, X., Tarling, E. J., Hedde, P. N., … Tontonoz, P. (2015). LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling. ELife, 4(JULY 2015). https://doi.org/10.7554/eLife.08009

J-564 Moens, P. D. J., Digman, M. A., & Gratton, E. (2015). Modes of diffusion of cholera toxin bound to GM1 on live cell membrane by image mean square displacement analysis. Biophysical Journal, 108(6), 1448–1458. https://doi.org/10.1016/j.bpj.2015.02.003

J-565 Malacrida, L., Gratton, E., & Jameson, D. M. (2015). Model-free methods to study membrane environmental probes: A comparison of the spectral phasor and generalized polarization approaches. Methods and Applications in Fluorescence, 3(4). https://doi.org/10.1088/2050-6120/3/4/047001

J-566 Adu-Gyamfi, E., Johnson, E. A., Fraser, M. E., Scott, J. L., Soni, S. P., Jones, K. R., … Stahelina, R. V. (2015). Host cell plasma membrane phosphatidylserine regulates the assembly and budding of Ebola virus. Journal of Virology, 89(18), 9440–9453. https://doi.org/10.1128/JVI.01087-15

J-567 Hendrix, J., Baumgärtel, V., Schrimpf, W., Ivanchenko, S., Digman, M. A., Gratton, E., … Lamb, D. C. (2015). Live-cell observation of cytosolic HIV-1 assembly onset reveals RNA-interacting Gag oligomers. Journal of Cell Biology, 210(4), 629–646. https://doi.org/10.1083/jcb.201504006

J-568 Kang, D.-K., Labanieh, L., Phung, A., Ali, M. M., Digman, M. A., Gratton, E., & Zhao, W. (2015). Rapid detection of broad-spectrum, antibiotic-resistant bacteria by droplet digital detection. In MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 1020–1022). Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-84983341252&partnerID=40&md5=e5591d3a588e0a7b89b807ec0ad4a485

J-569 Datta, R., Alfonso-Garciá, A., Cinco, R., & Gratton, E. (2015). Fluorescence lifetime imaging of endogenous biomarker of oxidative stress. Scientific Reports, 5. https://doi.org/10.1038/srep09848

J-570 Lakhani, V. V, Hinde, E., Gratton, E., & Elston, T. C. (2015). Spatio-temporal regulation of Rac1 mobility by actin islands. PLoS ONE, 10(11). https://doi.org/10.1371/journal.pone.0143753

J-571 Hedde, P. N., Stakic, M., & Gratton, E. (2015). Rapid measurement of molecular transport and interaction inside living cells using single plane illumination. Scientific Reports, 4. https://doi.org/10.1038/srep07048

J-572 Hedde, P. N., & Gratton, E. (2015). Active focus stabilization for upright selective plane illumination microscopy. Optics Express, 23(11), 14707–14714. https://doi.org/10.1364/OE.23.014707

J-573 Annibale, P., & Gratton, E. (2015). Single cell visualization of transcription kinetics variance of highly mobile identical genes using 3D nanoimaging. Scientific Reports, 5. https://doi.org/10.1038/srep09258

J-574 Annibale, P., Dvornikov, A., & Gratton, E. (2015). Electrically tunable lens speeds up 3D orbital tracking. Biomedical Optics Express, 6(6), 2181–2190. https://doi.org/10.1364/BOE.6.002181

J-575 Mieruszynski, S., Digman, M. A., Gratton, E., & Jones, M. R. (2015). Characterization of exogenous DNA mobility in live cells through fluctuation correlation spectroscopy. Scientific Reports, 5. https://doi.org/10.1038/srep13848

J-576 Plotegher, N., Stringari, C., Jahid, S., Veronesi, M., Girotto, S., Gratton, E., & Bubacco, L. (2015). NADH fluorescence lifetime is an endogenous reporter of α-synuclein aggregation in live cells. FASEB Journal, 29(6), 2484–2494. https://doi.org/10.1096/fj.14-260281

J-577 Heylman, C., Datta, R., Sobrino, A., George, S., & Gratton, E. (2015). Supervised machine learning for classification of the electrophysiological effects of chronotropic drugs on human induced pluripotent stem cell-derived cardiomyocytes. PLoS ONE, 10(12). https://doi.org/10.1371/journal.pone.0144572

J-578 Sanchez, S. A., Gratton, E., Zanocco, A. L., Lemp, E.,& Gunther, G. (2015). Correction: Sucrose monoester micelles size determined by fluorescence correlation spectroscopy (FCS). PLoS ONE, 10(4). https://doi.org/10.1371/journal.pone.0125123

J-579 Olivera-Couto, A., Salzman, V., Mailhos, M., Digman, M. A., Gratton, E., & Aguilar, P. S. (2015). Eisosomes are dynamic plasma membrane domains showing Pil1-Lsp1 heteroligomer binding equilibrium. Biophysical Journal, 108(7), 1633–1644. https://doi.org/10.1016/j.bpj.2015.02.011

J-580 Gratton, E., & Annibale, P. (2015). 3D orbital tracking for super-resolving the dynamics of gene expression. In Novel Techniques in Microscopy, NTM 2015. Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-84930805036&partnerID=40&md5=bff81704e9c13aabdf7ad3a7a19125db

J-581 Perumal, V., Krishnan, K., Gratton, E., Dharmarajan, A. M., & Fox, S. A. (2015). Number and brightness analysis of sFRP4 domains in live cells demonstrates vesicle association signal of the NLD domain and dynamic intracellular responses to Wnt3a. International Journal of Biochemistry and Cell Biology, 64, 91–96. https://doi.org/10.1016/j.biocel.2015.03.010

J-582 Lin, S., Hedde, P. N., Venugopalan, V., Gratton, E.,& Khine, M. (2016). Multi-scale silica structures for improved HIV-1 Capsid (p24) antigen detection. Analyst, 141(13), 4181–4188. https://doi.org/10.1039/c6an00519e

J-583 Malacrida, L., Gratton, E., & Jameson, D. M. (2016). Erratum: Model-free methods to study membrane environmental probes: A comparison of the spectral phasor and generalized polarization approaches (Methods and Applications in Fluorescence (2015) 3 (047001)). Methods and Applications in Fluorescence, 4(1). https://doi.org/10.1088/2050-6120/4/1/019601

J-584 Cardarelli, F., Digiacomo, L., Marchini, C., Amici, A., Salomone, F., Fiume, G., … Caracciolo, G. (2016). The intracellular trafficking mechanism of Lipofectamine-based transfection reagents and its implication for gene delivery. Scientific Reports, 6. https://doi.org/10.1038/srep25879

J-585 Di Rienzo, C., Cardarelli, F., Di Luca, M., Beltram, F., & Gratton, E. (2016). Diffusion Tensor Analysis by Two-Dimensional Pair Correlation of Fluorescence Fluctuations in Cells. Biophysical Journal, 111(4), 841–851. https://doi.org/10.1016/j.bpj.2016.07.005

J-586 Borrego, S. L., Fahrmann, J., Datta, R., Stringari, C., Grapov, D., Zeller, M., … Kaiser, P. (2016). Metabolic changes associated with methionine stress sensitivity in MDA-MB-468 breast cancer cells. Cancer and Metabolism, 4(1). https://doi.org/10.1186/s40170-016-0148-6

J-587 Noutsi, P., Gratton, E., & Chaieb, S. (2016). Assessment of membrane fluidity fluctuations during cellular development reveals time and cell type specificity. PLoS ONE, 11(6). https://doi.org/10.1371/journal.pone.0158313

J-588 Moore, J. S., Xantheas, S. S., Grate, J. W., Wietsma, T. W., Gratton, E., & Vasdekis, A. E. (2016). Modular polymer biosensors by solvent immersion imprint lithography. Journal of Polymer Science, Part B: Polymer Physics, 54(1), 98–103. https://doi.org/10.1002/polb.23961

J-589 Di Rienzo, C., Gratton, E., Beltram, F., & Cardarelli, F. (2016). Spatiotemporal Fluctuation Analysis: A Powerful Tool for the Future Nanoscopy of Molecular Processes. Biophysical Journal, 111(4), 679–685. https://doi.org/10.1016/j.bpj.2016.07.015

J-590 Annibale, P., Dvornikov, A., & Gratton, E. (2016). Optical measurement of focal offset in tunable lenses. Optics Express, 24(2), 1031–1036. https://doi.org/10.1364/OE.24.001031

J-591 Ma, N., Digman, M. A., Malacrida, L., & Gratton, E. (2016). Measurements of absolute concentrations of NADH in cells using the phasor FLIM method. Biomedical Optics Express, 7(7), 2441–2452. https://doi.org/10.1364/BOE.7.002441

J-592 Wang, B., Rong, X., Duerr, M. A., Hermanson, D. J., Hedde, P. N., Wong, J. S., … Tontonoz, P. (2016). Intestinal phospholipid remodeling is required for dietary-lipid uptake and survival on a high-fat diet. Cell Metabolism, 23(3), 492–504. https://doi.org/10.1016/j.cmet.2016.01.001

J-593 Chen, H., Gratton, E., & Digman, M. A. (2016). Self-assisted optothermal trapping of gold nanorods under two-photon excitation. Methods and Applications in Fluorescence, 4(3). https://doi.org/10.1088/2050-6120/4/3/035003

J-594 Digiacomo, L., Digman, M. A., Gratton, E., & Caracciolo, G. (2016). Development of an image Mean Square Displacement (iMSD)-based method as a novel approach to study the intracellular trafficking of nanoparticles. Acta Biomaterialia, 42, 189–198. https://doi.org/10.1016/j.actbio.2016.07.031

J-595 Clark, N. M., Hinde, E., Winter, C. M., Fisher, A. P., Crosti, G., Blilou, I., … Sozzani, R. (2016). Tracking transcription factor mobility and interaction in arabidopsis roots with fluorescence correlation spectroscopy. ELife, 5(JUN2016). https://doi.org/10.7554/eLife.14770

J-596 Ranjit, S., Dobrinskikh, E., Montford, J., Dvornikov, A., Lehman, A., Orlicky, D. J., … Furgeson, S. (2016). Label-free fluorescence lifetime and second harmonic generation imaging microscopy improves quantification of experimental renal fibrosis. Kidney International, 90(5), 1123–1128. https://doi.org/10.1016/j.kint.2016.06.030

J-597 Porcaro, F., Miao, Y., Kota, R., Haun, J. B., Polzonetti, G., Battocchio, C., & Gratton, E. (2016). Fluctuation Spectroscopy Analysis of Glucose Capped Gold Nanoparticles. Langmuir, 32(50), 13409–13417. https://doi.org/10.1021/acs.langmuir.6b02545

J-598 Brenner, M. D., Zhou, R., Conway, D. E., Lanzano, L., Gratton, E., Schwartz, M. A., & Ha, T. (2016). Spider Silk Peptide Is a Compact, Linear Nanospring Ideal for Intracellular Tension Sensing. Nano Letters, 16(3), 2096–2102. https://doi.org/10.1021/acs.nanolett.6b00305

J-599 Aguilar-Arnal, L., Ranjit, S., Stringari, C., Orozco-Solis, R., Gratton, E., & Sassone-Corsi, P. (2016). Spatial dynamics of SIRT1 and the subnuclear distribution of NADH species. Proceedings of the National Academy of Sciences of the United States of America, 113(45), 12715–121720. https://doi.org/10.1073/pnas.1609227113

J-600 Malacrida, L., Astrada, S., Briva, A., Bollati-Fogolín, M., Gratton, E., & Bagatolli, L. A. (2016). Spectral phasor analysis of LAURDAN fluorescence in live A549 lung cells to study the hydration and time evolution of intracellular lamellar body-like structures. Biochimica et Biophysica Acta - Biomembranes, 1858(11), 2625–2635. https://doi.org/10.1016/j.bbamem.2016.07.017

J-601 Hinde, E., Pand, E., Yang, Z., Ng, I. H. W., Jans, D. A., Bogoyevitch, M. A., … Gaus, K. (2016). Quantifying the dynamics of the oligomeric transcription factor STAT3 by pair correlation of molecular brightness. Nature Communications, 7. https://doi.org/10.1038/ncomms11047

J-602 Cinco, R., Digman, M. A., Gratton, E., & Luderer, U. (2016). Spatial characterization of bioenergetics and metabolism of primordial to preovulatory follicles in whole ex vivo murine ovary. Biology of Reproduction, 95(6), 1–12. https://doi.org/10.1095/biolreprod.116.142141

J-603 Ranjit, S., Dvornikov, A., Levi, M., Furgeson, S.,& Gratton, E. (2016). Characterizing fibrosis in UUO mice model using multiparametric analysis of phasor distribution from FLIM images. Biomedical Optics Express, 7(9), 3519–3530. https://doi.org/10.1364/BOE.7.003519

J-604 Alfonso-García, A., Smith, T. D., Datta, R., Luu, T. U., Gratton, E., Potma, E. O., & Liu, W. F. (2016). Label-free identification of macrophage phenotype by fluorescence lifetime imaging microscopy. Journal of Biomedical Optics, 21(4). https://doi.org/10.1117/1.JBO.21.4.046005

J-605 Alfonso-Garcia, A., Smith, T., Datta, R., Gratton, E., Potma, E. O., & Liu, W. (2016). Visualizing cellular metabolic processes with combined nonlinear optical microscopy. In Optics InfoBase Conference Papers (p. 3). https://doi.org/10.1364/OTS.2016.OTh4C.7

J-606 Sosnik, J., Zheng, L., Rackauckas, C. V, Digman, M., Gratton, E., Nie, Q., & Schilling, T. F. (2016). Noise modulation in retinoic acid signaling sharpens segmental boundaries of gene expression in the embryonic zebrafish hindbrain. ELife, 5(APRIL2016). https://doi.org/10.7554/eLife.14034

J-607 Sobrino, A., Phan, D. T. T., Datta, R., Wang, X., Hachey, S. J., Romero-López, M., … Hughes, C. C. W. (2016). 3D microtumors in vitro supported by perfused vascular networks. Scientific Reports, 6. https://doi.org/10.1038/srep31589

J-608 Dvornikov, A., & Gratton, E. (2016). Imaging in turbid media: A transmission detector gives 2-3 order of magnitude enhanced sensitivity compared to epi-detection schemes. Biomedical Optics Express, 7(9), 3747–3755. https://doi.org/10.1364/BOE.7.003747

J-609 Datta, R., Heylman, C., George, S. C., & Gratton, E. (2016). Label-free imaging of metabolism and oxidative stress in human induced pluripotent stem cellderived cardiomyocytes. Biomedical Optics Express, 7(5), 1690–1701. https://doi.org/10.1364/BOE.7.001690

J-610 Di Rienzo, C., Gratton, E., Beltram, F., & Cardarelli, F. (2016). Super-resolution in a standard microscope: From fast fluorescence imaging to molecular diffusion laws in live cells. Food as Medicine: Functional Food Plants of Africa. https://doi.org/10.1201/9781315371627

J-611 Datta, R., Sobrino, A., Hughes, C., & Gratton, E. (2016). Fluorescence lifetime imaging microscopy to study metabolism in a microfluidic device based tumor microenvironment. In Optics InfoBase Conference Papers (p. 1). Retrieved from https://www.scopus.com/inward/record.uri?eid=2-s2.0-85016819155&partnerID=40&md5=c68c4faa2039cb770b1caf153aa902f7

J-612 Scipioni, L., Gratton, E., Diaspro, A., & Lanzanò, L. (2016). Phasor Analysis of Local ICS Detects Heterogeneity in Size and Number of Intracellular Vesicles. Biophysical Journal, 111(3), 619–629. https://doi.org/10.1016/j.bpj.2016.06.029

J-613 Serebryannyy, L. A., Parilla, M., Annibale, P., Cruz, C. M., Laster, K., Gratton, E., … de Lanerolle, P. (2016). Persistent nuclear actin filaments inhibit transcription by RNA polymerase II. Journal of Cell Science, 129(18), 3412–3425. https://doi.org/10.1242/jcs.195867

J-614 Szymanska, A. F., Heylman, C., Datta, R., Gratton, E.,& Nenadic, Z. (2016). Automated detection and analysis of depolarization events in human cardiomyocytes using MaDEC. Computers in Biology and Medicine, 75, 109–117. https://doi.org/10.1016/j.compbiomed.2016.05.011

J-615 Gach, J. S., Bouzin, M., Wong, M. P., Chromikova, V., Gorlani, A., Yu, K.-T., … Forthal, D. N. (2017). Human Immunodeficiency Virus type-1 (HIV-1) evades antibody-dependent phagocytosis. PLoS Pathogens, 13(12). https://doi.org/10.1371/journal.ppat.1006793

J-616 Bhattacharjee, A., Datta, R., Gratton, E., & Hochbaum, A. I. (2017). Metabolic fingerprinting of bacteria by fluorescence lifetime imaging microscopy. Scientific Reports, 7(1). https://doi.org/10.1038/s41598-017-04032-w

J-617 Ceccarelli, A., Di Venere, A., Nicolai, E., De Luca, A., Rosato, N., Gratton, E., … Caccuri, A. M. (2017). New insight into the interaction of TRAF2 C-terminal domain with lipid raft microdomains. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1862(9), 813–822. https://doi.org/10.1016/j.bbalip.2017.05.003

J-618 Bohórquez-Hernández, A., Gratton, E., Pacheco, J., Asanov, A., & Vaca, L. (2017). Cholesterol modulates the cellular localization of Orai1 channels and its disposition among membrane domains. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1862(12), 1481–1490. https://doi.org/10.1016/j.bbalip.2017.09.005

J-619 Hedde, P. N., Malacrida, L., Ahrar, S., Siryaporn, A.,& Gratton, E. (2017). sideSPIM - Selective plane illumination based on a conventional inverted microscope. Biomedical Optics Express, 8(9), 3918–3937. https://doi.org/10.1364/BOE.8.003918

J-620 Ranjit, S., Dvornikov, A., Dobrinskikh, E., Wang, X., Luo, Y., Levi, M., & Gratton, E. (2017). Measuring the effect of a Western diet on liver tissue architecture by FLIM autofluorescence and harmonic generation microscopy. Biomedical Optics Express, 8(7), 3143–3154. https://doi.org/10.1364/BOE.8.003143

J-621 de Vega, G., Ceballos, J. A., Anzalone, A., Digman, M. A., & Gratton, E. (2017). A laser-scanning confocal microscopy study of carrageenan in red algae from seaweed farms near the Caribbean entrance of the Panama Canal. Journal of Applied Phycology, 29(1), 495–508. https://doi.org/10.1007/s10811-016-0914-4

J-622 Stortz, M., Presman, D. M., Bruno, L., Annibale, P., Dansey, M. V, Burton, G., … Levi, V. (2017). Mapping the Dynamics of the Glucocorticoid Receptor within the Nuclear Landscape. Scientific Reports, 7(1). https://doi.org/10.1038/s41598-017-06676-0

J-623 Digiacomo, L., Cardarelli, F., Pozzi, D., Palchetti, S., Digman, M. A., Gratton, E., … Caracciolo, G. (2017). An apolipoprotein-enriched biomolecular corona switches the cellular uptake mechanism and trafficking pathway of lipid nanoparticles. Nanoscale, 9(44), 17254–17262. https://doi.org/10.1039/c7nr06437c

J-624 Malacrida, L., Jameson, D. M., & Gratton, E. (2017). A multidimensional phasor approach reveals LAURDAN photophysics in NIH-3T3 cell membranes. Scientific Reports, 7(1). https://doi.org/10.1038/s41598-017-08564-z

J-625 Herrington, K. A., Trinh, A. L., Dang, C., O’Shaughnessy, E., Hahn, K. M., Gratton, E., … Sütterlin, C. (2017). Spatial analysis of Cdc42 activity reveals a role for plasma membrane-associated Cdc42 in centrosome regulation. Molecular Biology of the Cell, 28(15), 2135–2145. https://doi.org/10.1091/mbc.E16-09-0665

J-626 Davey, R. J., Digman, M. A., Gratton, E., & Moens, P. D. J. (2018). Quantitative image mean squared displacement (iMSD) analysis of the dynamics of profilin 1 at the membrane of live cells. Methods, 140–141, 119–125. https://doi.org/10.1016/j.ymeth.2017.12.002

J-627 Pedrote, M. M., De Oliveira, G. A. P., Felix, A. L., Mota, M. F., Marques, M. D. A., Soares, I. N., … Silva, J. L. (2018). Aggregation-primed molten globule conformers of the p53 core domain provide potential tools for studying p53C aggregation in cancer. Journal of Biological Chemistry, 293(29), 11374–11387. https://doi.org/10.1074/jbc.RA118.003285

J-628 Dvornikov, A., & Gratton, E. (2018). Hyperspectral imaging in highly scattering media by the spectral phasor approach using two filters. Biomedical Optics Express, 9(8), 3503–3511. https://doi.org/10.1364/BOE.9.003503

J-629 Hellenkamp, B., Schmid, S., Doroshenko, O., Opanasyuk, O., Kühnemuth, R., Rezaei Adariani, S., … Hugel, T. (2018). Precision and accuracy of single-molecule FRET measurements—a multi-laboratory benchmark study. Nature Methods, 15(9), 669–676. https://doi.org/10.1038/s41592-018-0085-0

J-630 Scipioni, L., Lanzanó, L., Diaspro, A., & Gratton, E. (2018). Comprehensive correlation analysis for super-resolution dynamic fingerprinting of cellular compartments using the Zeiss Airyscan detector. Nature Communications, 9(1). https://doi.org/10.1038/s41467-018-07513-2

J-631 Malacrida, L., Hedde, P. N., Ranjit, S., Cardarelli, F., & Gratton, E. (2018). Visualization of barriers and obstacles to molecular diffusion in live cells by spatial pair-cross-correlation in two dimensions. Biomedical Optics Express, 9(1), 303–321. https://doi.org/10.1364/BOE.9.000303

J-632 Malacrida, L., & Gratton, E. (2018). LAURDAN fluorescence and phasor plots reveal the effects of a H<inf>2</inf>O<inf>2</inf> bolus in NIH-3T3 fibroblast membranes dynamics and hydration. Free Radical Biology and Medicine, 128, 144–156. https://doi.org/10.1016/j.freeradbiomed.2018.06.004

J-633 Hellenkamp, B., Schmid, S., Doroshenko, O., Opanasyuk, O., Kühnemuth, R., Adariani, S. R., … Hugel, T. (2018). Erratum to: Precision and accuracy of single-molecule FRET measurements—a multi-laboratory benchmark study (Nature Methods, (2018), 15, 9, (669-676), 10.1038/s41592-018-0085-0). Nature Methods, 15(11), 984. https://doi.org/10.1038/s41592-018-0193-x

J-634 Wang, X. X., Wang, D., Luo, Y., Myakala, K., Dobrinskikh, E., Rosenberg, A. Z., … Levi, M. (2018). FXR/TGR5 dual agonist prevents progression of nephropathy in diabetes and obesity. Journal of the American Society of Nephrology, 29(1), 118–137. https://doi.org/10.1681/ASN.2017020222

J-635 Staaf, E., Hedde, P. N., Singh, S. B., Piguet, J., Gratton, E., & Johansson, S. (2018). Educated natural killer cells show dynamic movement of the activating receptor NKp46 and confinement of the inhibitory receptor Ly49A. Science Signaling, 11(517). https://doi.org/10.1126/scisignal.aai9200

J-636 Ranjit, S., Malacrida, L., Jameson, D. M., & Gratton, E. (2018). Fit-free analysis of fluorescence lifetime imaging data using the phasor approach. Nature Protocols, 13(9), 1979–2004. https://doi.org/10.1038/s41596-018-0026-5

J-637 Hedde, P. N., & Gratton, E. (2018). Selective plane illumination microscopy with a light sheet of uniform thickness formed by an electrically tunable lens. Microscopy Research and Technique, 81(9), 924–928. https://doi.org/10.1002/jemt.22707

J-638 Malacrida, L., Rao, E., & Gratton, E. (2018). Comparison between iMSD and 2D-pCF analysis for molecular motion studies on in vivo cells: The case of the epidermal growth factor receptor. Methods, 140–141, 74–84. https://doi.org/10.1016/j.ymeth.2018.01.010

J-639 Ranjit, S., Malacrida, L., & Gratton, E. (2018). Differences between FLIM phasor analyses for data collected with the Becker and Hickl SPC830 card and with the FLIMbox card. Microscopy Research and Technique, 81(9), 980–989. https://doi.org/10.1002/jemt.23061

J-640 Mäntylä, E., Chacko, J. V, Aho, V., Parrish, C. R., Shahin, V., Kann, M., … Vihinen-Ranta, M. (2018). Viral highway to nucleus exposed by image correlation analyses. Scientific Reports, 8(1). https://doi.org/10.1038/s41598-018-19582-w

J-641 Hedde PN, Abram T, Vu T, Zhao W, Gratton E.Fluorescence lifetime detection with particle counting devices.Biomed Opt Express. 2019; 10(3): 1223-1233.

J-642 Begarani F, D'Autilia F, Signore G, Grosso AD, Cecchini M, Gratton E, Beltram F, Cardarelli F.Capturing metabolism-dependent solvent dynamics in the lumen of a trafficking lysosome. ACS Nano. 2019; 13(2): 1670-1682.

J-643 Ou CY, Vu T, Grunwald JT, Toledano M, Zimak J, Toosky M, Shen B, Zell JA, Gratton E, Abram TJ, Zhao W. An ultrasensitive test for profiling circulating tumor DNA using integrated comprehensive droplet digital detection.Lab Chip. 2019; [Epub ahead of print].

J-644 Levi M, Gratton E.Visualizing the regulation of SLC34 proteins at the apical membrane.Pflugers Arch. 2019; [Epub ahead of print].

J-645 Scipioni L, Lanzanò L, Diaspro A, Gratton E.Comprehensive correlation analysis for super-resolution dynamic fingerprinting of cellular compartments using the Zeiss Airyscan detector.Nat Commun. 2018; 9(1), 5120. PMCID: PMC6269422

J-646 Malacrida L, Gratton E.L AURDAN fluorescence and phasor plots reveal the effects of a H2O2 bolus in NIH-3T3 fibroblast membranes dynamics and hydration. Free Radic Biol Med. 2018; 128: 144-156. PMCID: PMC6175669

J-647 Chen H, Ma N, Kagawa K, Kawahito S, Digman M, Gratton E. Widefield multi-frequency fluorescence lifetime imaging using a two-tap CMOS camera with lateral electric field charge modulators. J Biophotonics. 2018; [Epub ahead of print], e201800223.

J-648 Ranjit S, Malacrida L, Gratton E.

J-649 Differences between FLIM phasor analyses for data collected with the Becker and Hickl SPC830 card and with the FLIMbox card. Microsc Res Tech. 2018; 81(9): 980-989. PMCID: PMC6240382

J-650 Ranjit S, Malacrida L, Jameson DM, Gratton E. Fit-free analysis of fluorescence lifetime imaging data using the phasor approach. Nat. Protoc. 2018; 13(9): 1979-2004.

J-651 Hedde PN, Gratton E. Selective plane illumination microscopy with a light sheet of uniform thickness formed by an electrically tunable lens. Microsc Res Tech. 2018; 81(9): 924-928. PMCID: PMC5479743

J-652 Hellenkamp B, Schmid S, Doroshenko O, Opanasyuk O, Kühnemuth R, Adariani SR, Ambrose B, Aznauryan M, Barth A, Birkedal V, Bowen ME, Chen H, Cordes T, Eilert T, Fijen C, Gebhardt C, Götz M, Gouridis G, Gratton E, Ha T, Hao P, Hanke CA, Hartmann A, Hendrix J, Hildebrandt LL, Hirschfeld V, Hohlbein J, Hua B, Hübner CG, Kallis E, Kapanidis AN, Kim JY, Krainer G, Lamb DC, Lee NK, Lemke EA, Levesque B, Levitus M, McCann JJ, Naredi-Rainer N, Nettels D, Ngo T, Qiu R, Robb NC, Röcker C, Sanabria H, Schlierf M, Schröder T, Schuler B, Seidel H, Streit L, Thurn J, Tinnefeld P, Tyagi S, Vandenberk N, Vera AM, Weninger KR, Wünsch B, Yanez-Orozco IS, Michaelis J, Seidel CAM, Craggs TD, Hugel T. Precision and accuracy of single-molecule FRET measurements-a multi-laboratory benchmark study. Nat Methods. 2018; 15(9): 669-676. PMCID: PMC6121742

J-653 Pedrote MM, de Oliveira GAP, Felix AL, Mota MF, de Marques MA, Soares IN, Iqbal A, Norberto DR, Gomes AMO, Gratton E, Cino EA, Silva JL. Aggregation-primed molten globule conformers of the p53 core domain provide potential tools for studying p53C aggregation in cancer. J Biol Chem. 2018; 293(29): 11374-11387. PMCID: PMC6065177

J-654 Dvornikov A, Gratton E. Hyperspectral imaging in highly scattering media by the spectral phasor approach using two filters. Biomed Opt Express. 2018; 9(8): 3503-3511. PMCID: PMC6191637

J-655 Davey RJ, Digman MA, Gratton E, Moens PDJ. Quantitative image mean squared displacement (iMSD) analysis of the dynamics of Profilin 1 at the membrane of live cells. Methods. 2018; 140-141: 119-125. PMCID: PMC5995621

J-656 Malacrida L, Rao E, Gratton E. Comparison between iMSD and 2D-pCF analysis for molecular motion studies on in vivo cells: the case of the epidermal growth factor receptor. Methods. 2018; 140-141: 74-84. PMCID: PMC5999564

J-657 Staaf E, Hedde PN, Singh SB, Piguet J, Gratton E, Johansson S. Educated natural killer cells show dynamic movement of the activating receptor NKp46 and confinement of the inhibitory receptor Ly49A. Sci Signal. 2018; 11(517), eaai9200. PMCID: PMC5925740

Patents

1. Cutrale F, Gratton E.Apparatus and method for an inclined single plane imaging microscope box (iSPIM box).Patent US9874736B2, 23 Jan 2018.
2. Gratton E, D'Amico E.System and method for digital parallel frequency fluorometry.Patent EP2529152B1, 15 Nov 2017.
3. Lanzanò L, Digman MA, Gratton E.Nanometer-scale optical imaging by the Modulation Tracking (MT) method.Patent US9110282, 18 Aug 2015.
4. Zhao W, Kang Dk, Zhang K, Ali MM, Eckert MA, Li F, Gratton E, Digman MA, Labanieh L, Lu M.Encapsulated sensors and sensing systems for bioassays and diagnostics and methods for making and using them.Patent WO2015048173, 30 Apr 2015.
5. Gratton E, Dvornikov AS, Crosignani V.Apparatus and method for light emission detection for in-depth imaging of turbid media.Patent US8692998, 08 Apr 2014.
6. Gratton E, D'Amico E.System and method for digital parallel frequency fluorometry.Patent US8330123, 11 Dec 2012.
7. Stringari C, Gratton E, Digman MA, Donovan P.Phasor method to fluorescence lifetime microscopy to discriminate metabolic state of cells in living tissue.Patent US20120276578, 01 Nov 2012.
8. Gratton E, Azartash K, Marsili L.Method and device for tear film analysis.Patent US8256898, 12 Sep 2012.
9. Gratton E, Motolese G, Tahari AK.Methods and devices for characterizing particles in clear and turbid media [continuation of US patent 7528384].Patent US20090230324, 17 Sep 2009.
10. Gratton E, Motolese G, Tahari AK. Methods and devices for characterizing particles in clear and turbid media.Patent US7528384, 05 May 2009.
11. Gatto R, D'Amico E, Mantulin WW, Gratton E, Charbel FT.Optical microprobe for blood clot detection. Patent US20080300493, 04 Dec 2008.
12. Gratton E, Kukreti S, Cerussi AE, Tromberg BJ.Method and apparatus for the determination of intrinsic spectroscopic tumor markers by broadband-frequency domain technology.Patent US20080009748, 10 Jan 2008.
13. Barbieri BB, Gratton E.Rapid high throughput spectrometer and method [Division of US patent 6603546].Patent US6794659, 21 Sep 2004.
14. Barbieri BB, Gratton E.Rapid high throughput spectrometer and method.Patent US6603546, 05 Aug 2003.
15. Franceschini MA, Fantini S, Gratton E.Method for measuring absolute saturation of time-varying and other hemoglobin compartments.Patent US6216021, 10 Apr 2001.
16. Gratton E, Fantini S, Franceschini MA, Mantulin WW, Barbieri BB.Photosensor with multiple light sources.Patent US6192261, 20 Feb 2001.
17. Dong CY, Gratton E, So PTC.
18. Pump probe cross correlation fluorescence frequency domain microscope and microscopy.Patent US5814820, 29 Sep 1998.
19. Gratton E, Fantini S, Franceschini MA, Mantulin WW, Barbieri BB.Photosensor with multiple light sources [Continuation-in-part of US patents 5497769 and 5492118].Patent US5772587, 30 Jun 1998.
20. Gratton E, Fantini S, Franceschini MA, Mantulin WW, Barbieri BB.Photosensor with multiple light sources.Patent US5497769, 12 Mar 1996.
21. Gratton E, Maier JS, Franceschini MA, Fantini S, Walker SA.Determining material concentrations in tissues.Patent US5492118, 20 Feb 1996.
22. Gratton E, VandeVen MJ, Barbieri BB.Time resolved optical array detectors and CCD cameras for frequency domain fluorometry and/or phosphorimetry.Patent US5323010, 21 Jun 1994.
23. Feddersen BA, Gratton E, Piston DW.Method and means for parallel frequency acquisition in frequency domain fluorometry.Patent US5257202, 26 Oct 1993.
24. Gratton E, Mantulin WW, VandeVen MJ.Frequency domain optical imaging using diffusion of intensity modulated radiation.Patent US5213105, 25 May 1993.
25. Gratton E, Barbieri BB.High speed cross-correlation frequency domain fluorometry-phosphorimetry.Patent US5212386, 18 May 1993.
26. Gratton E.Frequency domain cross-correlation fluorometry with phase-locked loop frequency synthesizers.Patent US4840485, 20 Jun 1989.

Proceedings

1. M A Digman and E Gratton. Multicolor fluctuation spectroscopy in cells. BIOS 2009. Part of SPIE Photonics west. San Jose, California, January 24-29, 2009. Multiphoton Microscopy in the Biomedical Sciences IX (Proceedings of SPIE, Vol. 7183). By A Periasamy and PTC So (Editors). 718303,2009. ISBN: 9780819474292
2. V R Caiolfa, E Gratton, and M Zamai. Phasor-FLIM analysis of FRET for homotypic and heterotypic non-covalent iteractions: stimulated membrane receptors in live cells. EMC 2008 14^th European Microscopy Congress 1-5 September 2008, Aachen, Germany. EMC 2008: Life Sciences (Vol. 3). By A Aretz, B Hermanns-Sachweh, and J Mayer (Editors). Springer Berlin Heidelberg, pp. 157-158, 805-Pos/B650, 2008. ISBN: 9783540852278
3. E Gratton. Digital frequency-domain FLIM. Frontiers in Optics (FiO), Rochester, New York, October 19, 2008. Frontiers in Optics (Technical Digest). Optical Society of America, FWP1, 2008.
4. S Kukreti, A E Cerussi, B J Tromberg, and E Gratton. Intrinsic near-infrared spectroscopic markers of breast tumors. SPIE Photonics West, San Jose California, 2007. Biomedical Applications of Light Scattering (Proceedings of SPIE, Vol. 6446). By A Wax and V Backman (Editors). 6435-52, 2007. ISBN: 9780819465597
5. K Tanner, R Ma, J G malpeli, W W Mantulin, and E Gratton. Evidence for optical determination of the fast neuronal signal as a scattering change using a broad-band spectral method. SPIE Photonics West, San Jose, California, 2007. Biomedical Applications of Light Scattering (proceedings of SPIE, Vol. 6446). By A Wax and V Backman
6. E D’Amico, E Frasnelli, G Ossato, S Perfetto, W W mantulin, and E Gratton. Development of a non-contact optical scanning system for frequency domain and broadband spectroscopy of breast tissue. SPIE Photonics West, San Jose, California, 2007.  Biomedical Applications of Light Scattering (Proceedings of SPIE, Vol. 6446). By A Wax and V Backman (Editors). 6434-44, 2007. ISBN: 9780819465597
7. Ko, W. S., N. Darwish, E. Gratton and S. H. Kim. Development of the scanning system to detect the concentration of oxy- and deoxy-hemoglobin by tracking the head. In: Proc. SPIE, Photonic Therapeutics and Diagnostics. K. E. Bartels, L. S. Bass, W. T. W. de Riese, K. W. Gregory, H. Hirschberg, A. Katzir, N. Kollias, S. J. Madsen, R. S. Malek, K. M. McNally-Heintzelman, L. P. Tate, Jr., E. A. Trowers, B. Jet-Fei Wong, Eds. Vol. 5686, pp. 588-595 (2005).
8. Toronov, V. Y., E. D'Amico, D. Hueber, E. Gratton, A. G. Webb, B. B. Barbieri.Optimization of the frequency-domain instrument for the near-infrared spectro-imaging of the human brain. In: Proc. SPIE, Lasers in Surgery: Advanced Characterization, Therapeutics and Systems XIV, K. E. Bartels, L. S. Bass, W. T. DeRiese, K. W. Gregory, H. Hirschberg, A. Katzir, N. Kollias, S. J. Madsen, R. S. Malek, K. M. McNally-Heintzelman, K. D. Paulsen, D. S. Robinson, L. P. Tate, Jr., E. A. Trowers and B. J. Wong, eds., Vol. 5312, 378-383 (2004).
9. Michalos, A., M. Calderon, L. P. Safonova, R. Gupta, W. W. Mantulin, E. Gratton. Changes in oxygenation and hemodynamics in the human head assessed by frequency-domain multidistance NIRS. In: Proc. Optical Society of America , Biomedical Topical Meeting,FE7, 17-19 (2004).
10. Toronov, V. Y., E. D'Amico, D. M. Hueber, E. Gratton, B. B. Barbieri and A. G. Webb. Optimization of the phase and modulation depth signal-to-noise for near-infrared spectroscopy of the biological tissue. In: Proc. SPIE, Saratov Fall Meeting 2003: Optical Technologies in Biophysics and Medicine, V. V. V. Tuchin, ed., Vol. 5474 281-284 (2004).
11. Toronov, V., A. Webb, S. Walker, R. Gupta, J. H. Choi, E. Gratton, and D. M. Hueber. Study of the FMRI blood oxygen level dependent effect by near-infrared spectroscopy. In: Proc. SPIE Int. Soc. Opt. Eng. 5068, 222 (2003).
12. Gratton, E., Scanning FCS: measuring spatio-temporal correlations in the millisecond range. In: Proc. SPIE, Vol. #4963, San Jose, CA(2003).
13. Barry, N. P., K. M. Hanson, E. Gratton, R. M. Clegg, M. J. Behne, and T. Mauro. Applications of ultrafast lasers to two-photon fluorescence and lifetime imaging. In: Proc. SPIE 4633, Commercial and Biomedical Applications of Ultrafast and Free-Electron Lasers. G. S. Edwards, J. Neev, A. Ostendorf, J. C. Sutherland, eds., 50-61 (2002).
14. Morren, G., M. Wolf, P. Lemmerling, U. Wolf, J. H. Choi, E. Gratton, L. De Lathauwer, S. Van Huffel. Extraction of fast neuronal changes from multichannel functional near-infrared spectroscopy signals using independent component analysis. In: Proc. SPIE 4623 , Functional Monitoring and Drug-Tissue Interaction. M. D. Kessler, G. J. Mueller; eds., 68-76 (2002).
15. Toronov, V., A. Webb, J-H. Choi, M. Wolf, and E. Gratton. Simultaneous assessment of human brain functional hemodynamics by magnetic resonance and near-infrared imaging. In: Proc. SPIE 4320, Medical Imaging 2001: Physics of Medical Imaging. L. E. Antonuk, M. J. Yaffe, eds., 861-867 (2001).
16. Toronov, V. Y., A. G. Webb, J. H. Choi, M. Wolf, L. P. Safonova, U. Wolf, E. Gratton. Functional cerebral activation detected by frequency-domain near-infrared spectroscopy. In: Proc. SPIE, Optical Technologies in Biophysics and Medicine III; Saratov Fall Meeting, V. V. Tuchin; ed., Vol. 4707, 92-96 (2001)
17. Nayfeh, M. H., J. Therrien, G. Belomoin, A. Akcakir, N. Barry, and E. Gratton. Stimulated blue emission and second harmonic generation from films of ultrasmall Si nanoparticles. In: Proc. Materials Research Society Symposium, V. 638, F951-F9512 (2001).
18. Ragan, T., P. T. C. So, H-S.Kwon, and E. Gratton. 3D particle tracking on the two-photon microscope In: Proc. SPIE 4262, Multiphoton Microscopy in the Biomedical Sciences. A. Periasamy, P. T. So, eds., 247-258 (2001).
19. Toronov, V., A. Webb, J. H. Choi, M. Wolf, E. Gratton, and D. M. Hueber. Simultaneous functional magnetic resonance and near-infrared imaging of adult human brain. In: Proc. SPIE: Optical Tomography and Spectroscopy of Tissue IV. B. Chance, R. R. Alfano, B. J. Tromberg, M. Tamura, E. M. Sevick-Muraca, eds., Vol. 4250, pp. 380-382 (2001).
20. Paunescu, L. A., A. Michalos, J. H. Choi, U. Wolf, M. Wolf, and E. Gratton. In vitro correlation between reduced scattering coefficient and hemoglobin concentration of human blood determined by near-infrared spectroscopy. In: Proc. SPIE Proc. BIOS 2001; International Biomedical Optics Symposium. Optical Tomography and Spectroscopy of Tissue IV. B.Chance, R.R. Alfano, B.J. Tromberg, M. Tamura, E.M. Sevick-Muraca, eds., Vol. 4250, pp. 319-326 (2001).
21. Toronov V, Fantini S, Franceschini MA, Filiaci M, Wolf M, Gratton E. Temporal analysis of fluctuations in cerebral hemodynamics revealed by near-infrared spectroscopy. In: Proc. SPIE 4001, Saratov Fall Meeting '99: Optical Technologies in Biophysics and Medicine. V. V. Tuchin, D. A. Zimnyakov, A. B. Pravdin, eds., 224-227 (2000).
22. Michalos, A., L. A. Paunescu, M. Wolf, U. Wolf, V. Toronov, M. A. Franceschini, S. Fantini, and E. Gratton. Assessment of cerebral oxygenation and hemodynamics in obstructive sleep apnea syndrome. SuH16, Proc. OSA Technical Digest, Biomedical Topical Meeting (2000)
23. Franceschini, M. A., S. Fantini, V. Toronov, M. E. Filiaci, M. P. Wolf, A. Michalos, and E. Gratton. Real-time video of brain activation in human subjects using a non-invasive near-infrared technique. ME6, Proc. OSA Technical Digest, Biomedical Topical Meeting (2000).
24. Paunescu, L. A., U. Wolf, M. Wolf, A. Michalos, and E. Gratton. Scattering coefficient-hemoglobin concentration relation determined by frequency-domain spectroscopy during venous occlusion. TuD2. Proc. OSA Technical Digest, Biomedical Topical Meeting (2000).
25. Dong, C-Y., H. Huang, J. D. Sutin, H. S. Kwon, G. Cragg, R. Gilbert, R. T. Lee, E. Gratton, R. D. Kamm, D. Lauffenburger, and P. T. So. Magnetic tweezers microscope for cellular manipulation In: Proc. SPIE 3921, Optical Diagnostics of Living Cells III. D. L. Farkas, R. C. Leif, eds., 176-185 (2000).
26. Wolf, M., V. Toronov, U. Wolf, L. A. Paunescu, A. Michalos, and E. Gratton. Maps of cerebral hemoglobin concentration changes obtained by near-infrared spectroscopy, Characterization of phase shifts among locations. TuF6, Proc. OSA Technical Digest, Biomedical Topical Meeting, pp. 416-418 (2000).
27. Wolf, U., M. Wolf, V. Toronov, A. Michalos, L. A. Paunescu, and E. Gratton. Detecting cerebral functional slow and fast signals by frequency-domain near-infrared spectroscopy using two different sensors. TuF10, Proc. OSA Technical Digest, Biomedical Topical Meeting, pp. 427-429 (2000).
28. Toronov, V., M. Wolf, A. Michalos, and E. Gratton. Analysis of cerebral hemodynamic fluctuations measured simultaneously by magnetic resonance imaging and near-infrared spectroscopy. WA5, Proc. OSA Technical Digest, Biomedical Topical Meeting (2000).
29. Wolf, M., M. A. Franceschini, L. A. Paunescu, V. Toronov, A. Michalos, U. Wolf, E. Gratton, and S. Fantini. Absolute frequency-domain pulse oxymetry of the brain: Methodology and measurements. In: Proc. ISOTT Oxygen Transport to Tissue XXII. 27th Annual Meeting of ISOTT, J. F. Dunn, H. M. Swartz, eds. (2000).
30. Franceschini, M. A., S. Fantini, V. Toronov, M. E. Filiaci, and E. Gratton. Cerebral hemodynamics measured by near-infrared spectroscopy at rest and during motor activation. In Proc. Inter-Institute Workshop on In Vivo Optical Imaging at the NIH, OSA pp. 73-80 (2000).
31. Toronov, V., M. Filiaci, M. Franceschini, S. Fantini, and E. Gratton. Exploring tissue dynamics by photon-density-wave fluctuation correlation spectroscopy, Proc. SPIE 3726, Eds., Tuchin, Ryabukho, Zimnyakov, pp. 555-559 (1999).
32. Cerussi, A. E., E. Gratton, and S. Fantini, Fluorescence lifetime spectroscopy in multiple-scattering environments: An application to biotechnology, SPIE Proc. 3600, Eds., Bornhop, Contag, and Sevick, pp. 171-181 (1999)
33. Franceschini, M. A., E. Gratton, D. Hueber, and S. Fantini. Near-infrared absorption and scattering spectra of Tissues in vivo. SPIE Biomedical Optics '99, San Jose (CA)Vol. 3597, 526-531 (1999).
34. Filiaci, M., M. A. Franceschini, S. Fantini, and E. Gratton. Photon density waves in tissues: a study of the optical properties during changes in the oxygenation level. SPIE Biomedical Optics '99, San Jose (CA)Vol. 3597 (1999).
35. Stankovic, M. R., , D. M. Hueber, D. Maulik, P, G. Stubblefield, W. Rosenfeld, E. Gratton, M. A. Franceschini, and S. Fantini. Real-Time Optical Imaging and Spectroscopy of Brain Ischemia and Hemorrhage. SPIE Biomedical Optics '99, San Jose (CA)Vol. 3597 (1999).
36. Toronov, V., M. Filiaci, M. A. Franceschini, S. Fantini, and E. Gratton. Photon-density-wave fluctuation-correlation-spectroscopy: study of coherence in the brain and muscles. SPIE Biomedical Optics '99, San Jose (CA) Vol. 3597 (1999).
37. Paunescu, L. A., C. Casavola, M. A. Franceschini, S. Fantini, L. Winter, J. Kim, D. Wood and E. Gratton. Calf muscle blood flow and oxygen consumption measured with near-infrared spectroscopy during venous occlusion. SPIE Proc. 3597, Eds., B. Chance, R. R. Alfano, B. J. Tromberg, pp. 317-323 (1999).
38. Casavola, C., L. A. Paunescu, M. A. Franceschini, S. Fantini, L. Winter, J. Kim, D. Wood, and E. Gratton. Near-infrared spectroscopy and the tilting table protocol: a novel method to study the blood flow and the oxygen consumption in tissues. SPIE Proc. 3597, Eds., Britton Chance, Robert R. Alfano, and Bruce J. Tromberg, pp. 685-692 (1999).
39. Buehler, C., C. Y. Dong, P. T. C. So, T. E. French, and E. Gratton. Frequency-domain pump-probe microscopic imaging using intensity-modulated laser diodes In: Proc. SPIE 3603, Systems and Technologies for Clinical Diagnostics and Drug Discovery II. G. E. Cohn, J. C. Owicki, eds., 262-271 (1999).
40. Masters, B. R., P. T. C. So, E. Gratton, G. Gonnord, P. Corcuff. Microscopy of Human Skin In Vivo: Multi-photon Excitation and Confocal Microscopy. Microscopy and Microanalysis 5, 282-289 (1999).
41. Fantini, S., S. A. Walker, M. A. Franceschini, K. T. Moesta, P. M. Schlag, M. Kaschke, and E. Gratton. Optical characterization of breast tumors by frequency-domain optical mammography. OSA Trends in Optics and Photonics Series 21, Eds., James G. Fujimoto and Michael S. Patterson, 143-147 (1998).
42. Franceschini, M. A., A. Paunescu, S. Fantini, S. Pratesi, J. S. Maier, G. P. Donzelli, and G. Gratton, Frequency-domain optical measurements in vitro on two- and three-layered tissue-like phantoms, and in vivo on infant heads. OSA Trends in Optics and Photonics Series 21, Eds., James G. Fujimoto and Michael S. Patterson, 232-236 (1998).
43. Paunescu, A., M. A. Franceschini, S. Fantini, A. Cerussi, and E. Gratton. Effective optical properties of two-layered turbid media using the frequency-domain multi-distance method. OSA Trends in Optics and Photonics Series 21, Eds., James G. Fujimoto and Michael S. Patterson, 79-83 (1998).
44. Toronov, V., M. Filiaci, S. Fantini, and E. Gratton Study of large scale fluctuations in turbid media by photon-density-wave fluctuation correlation spectroscopy. OSA Trends in Optics and Photonics Series 21, Eds., James G. Fujimoto and Michael S. Patterson, 60-62 (1998).
45. So, P. T. C., B. R. Masters, E. Gratton, and I. E. Kochevar. Two-photon optical biopsy of thick tissues. OSA Trends in Optics and Photonics Series 22, Eds., Eva M. Sevick-Muraca, Joseph A. Izatt, and Marwood N. Ediger, 40-42 (1998).
46. Cerussi, A., S. Fantini, and E. Gratton. Quantitative fluorescence spectroscopy in strongly scattering media containing multiple fluorophores. OSA Trends in Optics and Photonics Series 22, Eds., Eva M. Sevick-Muraca, Joseph A. Izan, and Marwood N. Ediger, pp. 70-75 (1998).
47. Filiaci, M., V. Toronov, S. Fantini, and E. Gratton, Optical probe and frequency-domain instrumentation to study spatial and temporal correlations of fluctuations in tissues, OSA Trends in Optics and Photonics Series 22, Eds., Eva M. Sevick-Muraca and Joseph A. Izatt, 183-187 (1998).
48. Masters, B. R., P. T. C. So, W. W. Mantulin, and E. Gratton, Tissue Microscopy and Spectroscopy: A Two-Photon Approach, OSA Trends in Optics and Photonics Series 22, Eds., Eva Sevick-Muraca, Joseph A. Izatt, and Marwood N. Ediger, 43-45 (1998).
49. Kim, K. H., P. T. C. So, I. E. Kochevar, B. R. Masters, and E. Gratton, Two-photon fluorescence and confocal reflected light imaging of thick tissue structures, SPIE Proc. 3260, Eds., D. L. Farkas, R. C. Leif, and B. J. Tromberg, 46-57 (1998).
50. Franceschini, M. A., S. Fantini, R. Palumbo, L. Pasqualini, G. Vaudo, E. Franceschini, E. Gratton, B. Palumbo, S. Innocente and E. Mannarino. Quantitative near-infrared spectroscopy on patients with peripheral vascular disease. In: Proc. SPIE 3194 (BIOS Europe '97, San Remo, Italy , Sept. 4-8) 112-115 (1998).
51. Quaresima, V., M. A. Franceschini, S. Fantini, E. Gratton and M. Ferrari. Difference in leg muscles oxygenation during treadmill exercise by a new near infrared frequency-domain oximeter. In: Proc. SPIE 3194 (BIOS Europe '97, San Remo, Italy , Sept. 4-8) 116-120 (1998).
52. Cerussi, A. E., S. Fantini, J. S. Maier, W. W. Mantulin, and E. Gratton. Chromophore detection by fluorescence spectroscopy in tissue-like phantoms. SPIE Proc., Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II, 2979 pp. 139-150 (1997).
53. Maier, J. S., A. E. Cerussi, S. Fantini, and E. Gratton. Experimental recovery of absorption, scattering, and fluorescence parameters in highly-scattering media from a single measurement. SPIE Proc., Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II, 2979 6-13 (1997).
54. Walker, S. A., S. Fantini, and E. Gratton. The effect of index of refraction mismatch on the recovery of optical properties of cylindrical inhomogeneities in an infinite turbid medium. SPIE Proc., Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II, 2979 219-225 (1997).
55. Franceschini, M. A., D. Wallace, B. Barbieri, S. Fantini, W. W. Mantulin, S. Pratesi, G. P. Donzelli and E. Gratton. Optical study of the skeletal muscle during exercise with a second generation frequency-domain tissue oximeter. SPIE Proc., Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II, 2979 807-814 (1997).
56. Fantini, S., M. A. Franceschini, and E. Gratton. Effect of spatially distributed light sources on the frequency-domain solution to the diffusion equation. SPIE Proc., Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II, 2979 807-814 (1997).
57. Fantini, A., K. T. Moesta, M. A. Franceschini, H. Jess, H. Erdl, E. Gratton, P. M. Schlag, and M. Kaschke, "Instrumentation and Clinical Applications in Frequency-Domain optical Mammography," Proc. 19^th Int. Conf.-IEEE/EMBS on Photon Migration Tomography (MS21), A. H. Hielscher and L. Wang, chairs, pp. 2741-2744 (1997).
58. Koenig, K., H. Liang, S. Kimel, O. Svaasand, B. J. Tromberg, T. b. Krasieva, M. W. Berns,K. J. Halbhuber, P. T. C. So, W. W. Mantulin, and E. Gratton, Cell damage in UVA and CW/Femtosecond NIR Microscopes. In Functional Imaging and Optical Manipulation of Livings Cells, SPIE Proc. 2983, 37-44 (1997).
59. So, P. T. C., T Ragan, E. Gratton, J. Carrero, E, Voss. Two-photon Single Particle Tracking in 3-D. In Functional Imaging and Optical Manipulation of Livings Cells, SPIE Proc. 2983, 45-56 (1997).
60. So, P. T. C., K. H. Duggar, K. M. Berland and E. Gratton. Generating an Intracellular Diffusion Map by Two-photon Fluorescence Correlation Spectroscopy, In Material Science of the Cell, Symposium Material Research Society (1997).
61. Koenig, K., P. T. C. So, W. W. Mantulin, and E. Gratton. Cell damage in two-photon microscopes In: Proc. SPIE 2926, Optical Biopsies and Microscopic Techniques. I. J. Bigio, W. S. Grundfest, H. Schneckenburger, K. Svanberg, P. M. Viallet, eds. 172-176 (1996).
62. Koenig, K., P. T. C. So, W. W. Mantulin, E. Gratton, T. Krasieva, M. W. Berns and B. J. Tromberg. Two-photon excited cellular autofluorescence induced by cw and femtosecond NIR microradiation. Proc. SPIE, Int. Soc. Opt. Eng., 2628 , 12-19 (1996).
63. Gratton, E., C. Y. Dong, P. T. C. So. Fluorescence Lifetime Microscopy: A Stimulated-emission Approach. In: Proc. SPIE 2678, Optical Diagnostics of Living Cells and Biofluids. D. L. Farkas, R. C. Leif, A. V. Priezzhev, T. Asakura, B. J. Tromberg, eds., 98-109 (1996).
64. Fantini, S., M. A. Franceschini, G. Gaida, H. Jess, H. Erdl, W. W. Mantulin, E. Gratton, K. M. Moesta, P. M. Schlag and M. Kaschke. Contrast enhancement by edge effect corrections in frequency-domain optical mammography. OSA Trends in Optics and Photonics on Advances in Optical Imaging and Photon Migration 2, R. R. Alfano and J. G. Fujimoto, eds., 160-163 (1996).
65. Walker, S., S. Fantini and E. Gratton. Back-projection reconstructions of cylindrical inhomogeneities from frequency domain optical measurements in turbid media. OSA Trends in Optics and Photonics on Advances in Optical Imaging and Photon Migration 2, R. R. Alfano and J. G. Fujimoto, eds., 137-141 (1996).
66. Jess, H., H. Erdl, K. T. Moesta, S. Fantini, M. A. Franceschini, E. Gratton, and M. Kaschke. Intensity modulated breast imaging: Technology and clinical pilot study results. OSA Trends in Optics and Photonics on Advances in Optical Imaging and Photon Migration 2, R. R. Alfano and J. G. Fujimoto, eds., 126-129 (1996).
67. Mei, G., A. Di Venere, G. Gilardi, N. Rosato, R. McKay, E. Gratton and A. Finazzi-Agró. Two classes of tryptophans in ascorbate oxidase revealed by time resolved fluorescence. OSA Trends in Optics and Photonics on Advances in Optical Imaging and Photon Migration 2, R. R. Alfano and J. G. Fujimoto, Eds. (1996).
68. Cerussi, A., J. Maier, S. Fantini, M. A. Franceschini and E. Gratton. The frequency-domain multi-distance method in the presence of curved boundaries. OSA Trends in Optics and Photonics on Biomedical Optical Spectroscopy and Diagnostics 3, E. Sevick-Muraca and D. Benaron, eds., 92-97 (1996).
69. Maier, J. S., A. Cerussi, S. Fantini, M. A. Franceschini and E. Gratton. Quantitative fluorescence in tissue-like media. OSA Trends in Optics and Photonics on Biomedical Optical Spectroscopy and Diagnostics 3, E. Sevick-Muraca and D. Benaron, eds., 206-209 (1996).
70. Franceschini, M. A., S. Fantini, A. Cerussi, B. Barbieri, B. Chance and E. Gratton. The effect of water in the quantitation of hemoglobin concentration in a tissue-like phantom by near-infrared spectroscopy. OSA Trends in Optics and Photonics 3, E. Sevick-Muraca and D. Benaron, eds., 126-130 (1996).
71. Gratton, E., G. Gratton, M. Fabiani and P. M. Corballis. Detection of brain activity using time-resolved interfered techniques. Proc. 5th Conference on Mind-Brain Science Hamamatsu City, Japan . (1996).
72. Franceschini, M. A., S. Fantini, S. A. Walker, J. S. Maier, W. W. Mantulin and E. Gratton. Multi-channel optical instrument for near-infrared imaging of tissue. In Proc. SPIE 2389, Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation. B. Chance, R. R. Alfano, eds., 264-273 (1995).
73. Maier, J.S., B. Barbieri, A. Chervu, I. Chervu, S. Fantini, M. A. Franceschini, M. Levi W. W. Mantulin, A. Rosenberg, S. A. Walker and E. Gratton. In vivo study of human tissues with a portable near-infrared [C tissue spectrometer. In Proc. SPIE 2389, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases II, R.R. Alfano, ed., 240-248 (1995).
74. Ferrari, M., R. A. De Blasi, S. Fantini, M. A. Franceschini, B. Barbieri, V. Quaresima and E. Gratton. Cerebral and muscle oxygen saturation measurement by a frequency-domain near-infrared spectroscopic technique. In Proc. SPIE 2389, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases II, R.R. Alfano, ed., 868-874 (1995).
75. Fantini, S., M. A. Franceschini, S. A. Walker, J. S. Maier and E. Gratton. Photon path distributions in turbid media: applications for imaging. In Proc. SPIE 2389, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases II, R.R. Alfano, ed., 340-349 (1995).
76. Walker, S. A., A. E. Cerussi and E. Gratton. Back-projection image reconstruction using photon density waves in tissues. In Proc. SPIE 2389, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases II, R.R. Alfano, ed., 350-357 (1995).
77. Maier, J. S., S. Fantini, M. A. Franceschini-Fantini, W. W. Mantulin, S. A. Walker and E. Gratton. Application of a portable near-infrared spectrometer in the study of several human tissues. SPIE Proc. 2387 240-248 (1995).
78. Mantulin, W. W., S. Fantini, M. A. Franceschini-Fantini, S. A. Walker, J. S. Maier, and E. Gratton. Tissue optical parameter map generated with frequency domain spectroscopy. In: SPIE Proc., 2396, Biomedical Optoelectronic Instrumentation. A. Katzir, J. A. Harrington, D. M. Harris, eds., 323-330 (1995).
79. Fantini, S., M. A. Franceschini, J. S. Maier, S. A. Walker and E. Gratton. Frequency-domain multi-source optical spectrometer and oximeter, In: Proc. SPIE 2326 Photon Transport in Highly Scattering Tissue; Biomedical Optics Europe'94, Lille, France . S. Avrillier, B. Chance, G. J. Mueller, A. V. P., V. V. Tuchin, eds., 108-115 (1995).
80. Gratton, E., S. Fantini, M. A. Franceschini, J. B. Fishkin and J. Maier. Near-infrared optical spectroscopy of tissues using an LED frequency domain spectrometer. Proc. Advances in Optical Imaging & Photon Migration Topical Mtg. 21 (R. R. Alfano, Ed., Proc. Optical Soc. of Amer.) 278-282 (1994).
81. So, P., T. French and E. Gratton. A frequency domain time-resolved microscope using a fast-scan CCD camera. In Proc. SPIE 2137, Time resolved Laser Spectroscopy in Biochemistry IV, J. R. Lakowicz, ed., 83-92 (1994).
82. Gryczynski, Z. C.Fronticelli, E. Gratton, J. Lubkowski, E. Bucci. Effect of disordered hemes and dimerization in isolated a-subunits of hemoglobin detected by time-resolved fluorescence spectroscopy in the picosecond range. In Proc. SPIE 2137, Time resolved Laser Spectroscopy in Biochemistry IV, J. R. Lakowicz, ed., 129-134 (1994).
83. Fantini, S., M. A. Franceschini, J. B. Fishkin and E. Gratton. Absolute measurement of absorption and scattering coefficients spectra of a multiply scattering medium. In: Proc. SPIE 2131, Biomedical Fiber Optic Instrumentation, A. Katzir, ed., 356-364 (1994).
84. Fantini, S., M. A. Franceschini and E. Gratton. LED based quantitative measurement of absorption and scattering coefficient spectra of a strongly scattering medium. In Proc. SPIE 2131, Biomedical Fiber Optic Instrumentation. A. Katzir, ed., 356-364 (1994).
85. Franceschini, M. A., S. Fantini and E. Gratton. LED's in frequency-domain spectroscopy of tissues. In Proc SPIE 2135, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases. R. R. Alfano, ed., 300-306 (1994).
86. Mantulin, W. W. and E. Gratton. Spectroscopic innovations at the Laboratory for Fluorescence Dynamics. In: Proc. SPIE 2100, Cell and Biotissue Optics: Applications in Laser Diagnostics and Therapy. V. V. Tuchin, ed., 6-18 (1994).
87. Fantini, S., M. A. Franceschini, J. B. Fishkin, W. W. Mantulin and E. Gratton. The absorption spectra of a chromophore in highly scattering media. In: Proc. SPIE 2100, Cell and Biotissue Optics: Applications in Laser Diagnostics and Therapy. V. V. Tuchin, ed., 114-123 (1994).
88. Gratton, E. and J. Maier. Frequency-domain measurements of photon migration in highly scattering media. In Proc. SPIE Medical Optical Tomography: Functional Imaging and Monitoring. G. Müller, B. Chance, R. Alfano, S. Arridge, J. Beuthan, E. Gratton, M. Kaschke, B. Masters, S. Svanberg and P. van der Zee, eds., 534-544 (1994).
89. Mantulin, W. W., J. B. Fishkin, P. T. C. So, E. Gratton and J. S. Maier. Quantitative diffusive wave spectroscopy in tissues. In Proc. SPIE 1888, Photon Migration and Imagining in Random Media and Tissues. B. Chance and R. R. Alfano, eds., 420-427 (1993).
90. Maier, J. S. and E. Gratton. Frequency-domain methods in optical tomography: detection of localized absorbers and a backscattering reconstruction scheme. Photon Migration and Imagining in Random Media and Tissues (B. Chance and R. R. Alfano, Ed.), SPIE Proc. 1888, 440-451 (1993).
91. Mantulin, W. W., T. French and E. Gratton. Optical imaging in the frequency domain. In: Proc. SPIE 1892, Medical Laser and Systems II. D. M. Harris and C. KM. Penny, eds., 158-166 (1993).
92. Gratton, E. Frequency domain fluorescence lifetime measurements using synchrotron radiation. In Synchrotron Radiation and Dynamic Phenomena (A. Beswick, Ed.) Conf. Proc. 258, Particles and Fields Series 49, 453-464 (1992).
93. Bucci, E., Z. Gryczynski, E. Gratton and T. Tenenholz. Heme- tryptophan relationships in hemoglobin explored by frequency-domain time- resolved fluorescence at 10 GHz resolution. In Proc. SPIE 1640, Time-Resolved Laser Spectroscopy in Biochemistry III. J. R. Lakowicz, ed., 784-791 (1992).
94. Clegg, R. M., B. Feddersen, E. Gratton and T. M. Jovin. Time resolved imaging fluorescence microscopy. In Proc. SPIE 1640, Time-Resolved Laser Spectroscopy in Biochemistry III. J. R. Lakowicz, ed., 448-460 (1992).
95. Berland, K., E. Gratton and M. vandeVen. A laser heterodyning detector for frequency-domain ultrafast spectroscopy. In Proc. SPIE 1640, Time-Resolved Laser Spectroscopy in Biochemistry III. J. R. Lakowicz, ed., 370-378 (1992).
96. Van Der Meer, B. W., M. A. Raymer, S. L. Wagoner, R. L. Hackney, J. M. Beechem, & E. Gratton. Models for fluorescence energy transfer between moving donors and acceptors. In Proc. SPIE 1640, Time-Resolved Laser Spectroscopy in Biochemistry III. J. R. Lakowicz, ed., 220-229 (1992).
97. French, T., E. Gratton and J. Maier. Frequency domain imaging of thick tissues using a CCD. In Proc. SPIE 1640, Time-Resolved Laser Spectroscopy in Biochemistry III. J. R. Lakowicz, ed., 254-261 (1992).
98. vandeVen, M., B. Barbieri, E. Gratton and J. Maier. Analysis of noise sources in frequency domain fluorometry. In Proc. SPIE 1640, Time-Resolved Laser Spectroscopy in Biochemistry III. J. R. Lakowicz, ed., 332-341 (1992).
99. Fishkin, J. and E. Gratton. Diffraction of intensity modulated light in strongly scattering media in the presence of a "semi-infinite" absorbing or reflecting plane bounded by a straight edge. In Proc. SPIE 1640, Time-Resolved Laser Spectroscopy in Biochemistry III. J. R. Lakowicz, ed., 362-367 (1992).
100. Ferreira, S. T. and E. Gratton. Enzyme activity in reverse micelles: Roles of diffusion and extent of hydration. In Biomolecules in Organic Solvents, CRC Meeting, Ch. 8, pp. 189-201 (1992).
101. Fishkin, J., E. Gratton, M. J. vandeVen and W. W. Mantulin. Diffusion of intensity modulated near-infrared light in turbid media. In Proc. SPIE 1431, Time- Resolved Spectroscopy and Imaging of Tissues. B. Chance and A. Katzer, eds., 122-135 (1991).
102. Fishkin, J. B., B. A. Feddersen and E. Gratton. Experimental study of the diffraction of photon density waves by an absorbing edge in highly scattering media. Proc. IEEE MTT-S International Microwave Symp., Boston, MA. (1991).
103. Gratton, E. and M. J. vandeVen. Laser sources for confocal microscopy. In The Handbook of Biological Confocal Microscopy (J. Pawley, Ed.) Ch. 5, pp. 53-67. Plenum Press, Proc. EMSA 47th Annual Mtg., San Antonio, TX (1990).
104. Gratton, E., W. W. Mantulin, M. J. vandeVen, J. B. Fishkin, M. B. Maris and B. Chance. The possibility of a near-infrared optical imaging system using frequency domain methods. Proc. Third Int'l Conf. for Peace through Mind/Brain Science, pp. 183-189, Hamamatsu City, Japan (1990).
105. Gratton, E., B. Feddersen and M. vandeVen. Parallel acquisition of fluorescence decay using array detectors. In: Proc. SPIE 1204, Time-Resolved Laser Spectroscopy in Biochemistry II. J. R. Lakowicz, ed. 21-25 (1990).
106. Barbieri, B. F., F. de Piccoli, M. Vandeven, and E. Gratton. What determines the uncertainty of phase and modulation measurements in frequency-domain fluorometry? In: Proc. SPIE 1204, Time-Resolved Laser Spectroscopy in Biochemistry II. J. R. Lakowicz, ed. 158-170 (1990).
107. Rosato, N., E. Gratton, G. Mei, I. Savini and A. Finazzi-Agrò. Dynamic fluorescence in copper proteins: Selected examples. Proc. Satellite FEBS 1989 Symp. Biochem. and Biophys. Approaches to the Study of Copper Proteins, Camerino, Italy (1989).
108. Parasassi, T. and E. Gratton. Detection of phospholipid bilayers microheterogeneity and domains by fluorescence spectroscopy. Proc. Serono Symposium on Membrane Technology in Clinical Pathology Biochemistry and Pharmacology. Raven Press, 109-117 (1989).
109. Govindjee, M. vandeVen, C. Preston, M. Seibert and E. Gratton. Recombinational light emission from photosystem II reaction centers. 8th Int'l Conf. on Photosynthesis, Stockholm, Sweden (1989).
110. Barbieri, B., F. DePicoli and E. Gratton. Resolution of overlapping spectra using frequency-domain fluorometry. In Proc. SPIE 909, Time-Resolved Laser Spectroscopy in Biochemistry. J. R. Lakowicz, ed., 366-369 (1988).
111. Beechem, J. M. and E. Gratton. Fluorescence spectroscopy data analysis environment: A second generation Global analysis program. In Proc. SPIE 909, Time-Resolved Laser Spectroscopy in Biochemistry. J. R. Lakowicz, ed., 70-81 (1988).
112. Schroeder, F., G. Nemecz, Y. Barenholz, E. Gratton and T. E. Thompson. Cholestatrienol time resolved fluorescence in phosphatidylcholine bilayers. In Proc. SPIE 909, Time-Resolved Laser Spectroscopy in Biochemistry. J. R. Lakowicz, ed., 457-465 (1988).
113. Glaser, M., E. Gratton, T. Parasassi, O. Sapora and F. Conti. Spectroscopic investigation of the physical state of biological membranes using the fluorescence methodology. In Proc., 2nd Conf. on The State of Art of Research in the Chemistry Department, La Sapienze, Rome, pp. 293-301 (1987).
114. Lentz, B. R., S. W. Burgess and E. Gratton. Concentration dependence of DPHpPC fluorescence lifetime: Photophysics and utility for monitoring membrane fusion. In Proc. of International Symp. on Mole. Mech. of Membrane Fusion, Buffalo, NY (1987).
115. Barbieri, B., E. Gratton, W. W. Mantulin, J. J. Sparrow. Continuous lifetime distributions and rotations of tryptophan residues in proteins. Thirty-eight Pittsburgh Conf. & Expo. on Analytical Chem. and Appl. Spec., Atlantic City, NJ, March 8-13, No. 996 (1987).
116. Gratton, E. and B. Barbieri. Molecular dynamics studies using frequency-domain fluorometry. SPIE Proc., Vol. 743, 104-109 (1987).
117. Gratton, E., J. R. Alcala, G. Marriott and F. G. Prendergast. Fluorescence studies of protein dynamics. In Proc. International Symposium of Computer Analysis for Life Sciences. Progress and Challenges in Biological and Synthetic Polymer Research, HAYASHIBARA FORUM '85 (C. Kawabata and A. R. Bishop, Eds.) Tokyo, Japan , pp. 1-11 (1986).
118. Gratton, E., N. Rosato, D. M. Jameson, F. Antonangeli, F. Bassani, F. Campolungo, U. Grassano, A. Finazzi-Agró, M. Piacentini A. Savoia, G. Weber and N. Zema. A multifrequency phase-fluorometer with picosecond resolution using synchrotron radiation. INFN-PULS Frascati Report, 65 pp. (1983).
119. Gratton, E. Hydration induced mobility in azurin. Proc. of the III Intl. Conf. "De la Physique Theorique a la Biologie" Springer, Vienna, July (1979).
120. Gratton, E. and R. Lopez-Delgado. The harmonic content of a SR pulse: The possibility to reach subpicosecond resolution in the fluorescence decay experiment. SSRL Report No. 78/09 (1978).
121. Careri, G., A. Giansanti and E. Gratton, Eds. Studio I.R. dell'idratazione del lisozima. Rap. Ist. Fis. Roma (1977).
122. Giannini, L. and E. Gratton. Hydration of globular proteins: U.V. studies. Rend. Acc. Naz. Lincei. Sci. Fis. Mat. Natl. 62, 711-715 (1977).

Invited talks

During the last year I counted about 20 talks in the US and international

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