Enrico Gratton

Curriculum Vitae

Current Address

University of California, Irvine
Department of Biomedical Engineering
3210 Natural Sciences II
Irvine, CA 92697-2715, USA

Telephone: 949/824-2674
Laboratory: 949/824-3264
Telefax: 949/824-1727
E-Mail: egratton22@yahoo.com
with copy to lfd@uci.edu

Education

Doctorate degree: Physics, University of Rome (1969)
Thesis: "The acid denaturation of DNA" (Advisor: Professor Mario Ageno).

Employment:

            2006-present: Professor, Department of Biomedical Engineering, UCI

            2006-present: Adjunct Professor, Department of Physics, Univ. of Illinois, Urbana-Champaign (UIUC)

            1986-present: Principal Investigator and Director, Laboratory for Fluorescence Dynamics

            1989-2006: Professor, Departments of Physics and Biophysics, UIUC

            1984-1989: Associate Professor, Department of Physics, UIUC

            1978-1984: Assistant Professor, Department of Physics, UIUC

            1976-1978: Research Associate, Biochemistry Department (advisor: Gregorio Weber), UIUC

            1971-1977: Researcher, SNAM PROGETTI, Monterotondo, Italy

            1970: Fellowship, Instituto Superiore di Sanita Rome (advisor:  Prof. Mario Ageno)

 

Research Areas:

            Protein Aggregation

            Membrane interactions

            Migration of cells

            Tracking moving particles

            Analyzing collagen formation and deformation

            Noninvasive optical technology methods for studying breast cancer

 

Consulting Activities:

            2007 – 2009:  Allergan, Inc. Irvine, CA

            2006:  Pacific Biosciences, Menlo Park, CA

 

Honors and Awards:

2005: Awarded the "6th Annual MSPAC Outstanding Advisor Award" by the Medical Scholars

Program Advisory Committee of the University of Illinois at Urbana-Champaign, 8/11/2005.

            2005: Awarded the "Gregorio Weber Award for Excellence in Fluorescence Theory and Application" by the Biological Fluorescence Subgroup, Long Beach, CA.

            2003: Listed on "Incomplete List of Teachers Ranked as Excellent by their Students," for Spring Semester, Physics 101: General Physics.

            1991: American Physical Society, Fellow

            1991-1992: Associate in the Center for Advanced Study

            1987-1988: University of Illinois, Xerox Award for Faculty Research, April 1988.

 

Professional Activities

  • 2004: Program Committee Member, Optical Society of American Topical Meeting: Optical Techniques in Neuroscience, April 2004.
  • 2003: Chair, Biological Fluorescence Subgroup of the Biophysical Society Meeting, San Antonios, March 2003.
  • 2002: Chair, Biological Fluorescence Subgroup of the Biophysical Society Meeting, San Francisco, February 2002.
  • 2000: Program Committee, Optical Imaging Workshop, "From Bench to Bedside." Natcher Center, National Institutes of Health, Bethesda, MD, September 7-8, 2000.
  • 1986-present: Organizer, International Weber Symposium on Innovative Fluorescence Methodologies in Biochemistry and Medicine.
  • 1986-present: Globals Unlimited© Author of the kernel of the commercialized software package (analyzes frequency and time domain fluorescence data).

Science Advisory Committee Memberships

  • Scientific Advisory Board (Fachbeirat), the Max Planck Institute for Biophysical Chemistry, 2004-present.
  • CNR, Institute of Biology, Genoa, Italy, 2001-present.
  • Cellular and Molecular Biology Group, National Flow Cytometry Resource, Los Alamos National Laboratory, Los Alamos, NM, 1990-present.
  • The Sincrotrone Trieste, Trieste, Italy, 1990-present.
  • National Institutes of Health, Division of Research Grant Advisory Committee, Bethesda, MD, 1997.
  • Biomedical Magnetic Resonance Research and Technology Resource (NIH), Urbana, IL, 1996-2002.

Society Memberships

  • Biophysical Society
  • American Physical Society
  • Optical Society of America

Editorial Boards:

            Biophysical Journal, 2003-Present.

            Journal of Fluorescence, 1992-97

            Comments On Molecular and Cellular Biophysics, 1995-96.

Administrative Services to the University (Departmental)

  • Bobone Award Comm.
  • Ph.D. Qualifying Exam
  • Liaison to Medical Scholars Program
  • Grad. Student Academic Advisor
  • Molecular Biophysics Seminars

Service to the International Community

Scientific Journals and Manuscripts Reviews

  • Analytical Biochemistry
  • Biochemistry
  • Biochimica et Biophysica Acta
  • Biophysical Journal
  • Journal of Biochemical and Biophysical Methods
  • Journal of Physical Chemistry
  • Photochemistry and Photobiology

Grants Reviews

  • Department of Energy
  • National Institutes of Health
  • National Science Foundation
  • Petroleum Research Fund
  • The Wellcome Trust
  • University of Illinois
  • University of Missouri
  • W. M. Keck Foundation
  • etc

Courses Taught

 

University of California, Irvine

 

Winter 2006

BME 297 – PhD Dissertation Research

 

Spring 2006

BME 297 – PhD Dissertation Research

 

Fall 2006

BME 297 – PhD Dissertation Research

 

Winter 2007

BME 195/295 – Spectroscopy & Imag Bio System (undergraduate & graduate)

BME 297 – PhD Dissertation Research

BME 299 – Individual Research

 

Spring 2007

BME 170 – Biomedical Engineering Lab (undergraduate)

BME 297 – PhD Dissertation Research

 

Fall 2007

BME 195/295 – Bio-Spectroscopy (undergraduate & graduate)

BME 297 – PhD Dissertation Research

BME 299 – Individual Research

 

Winter 2008

BME 297 – PhD Dissertation Research

BME 299 – Individual Research

 

Spring 2008

BME 170 – Biomedical Engineering Lab (undergraduate)

BME 299 – Individual Research

 

Fall 2008 (In Progress)

BME 195/295 – Bio-Spectroscopy (undergraduate & graduate)

BME 299 – Individual Research

 

 

University Service

 

Departmental Committees (Biomedical Engineering

Faculty Awards Committee, Chair (2007-2009)         

Faculty Recruitment Committee, Assistant - Associate Positions, Chair (2007-2008)

Retreat Planning Committee, member (2008-2010)    

Classroom Teaching Assignments (UIUC)

  • 1996-97: Physics 450
  • 1997-98: Physics 450 (Frauenfelder Notes)
  • Spring 1998 : Physics 102
  • Fall 1999: Physics 101
  • Fall 2000: Physics 301
  • Fall 2001: Physics 101
  • Spring 2003: Physics 101; Listed on "Incomplete List of Teachers Ranked as Excellent by their Students."
  • Fall 2003: Physics 398OS
  • Spring 2004: Physics 450
  • Fall 2004: Physics 598OS
  • Fall 2005: Physics 102 Discussion
  • August 2005: Awarded the "6th Annual MSPAC Outstanding Advisor Award" by the Medical Scholars Program Advisory Committee of the University of Illinois at Urbana-Champaign

Teaching/Advising/Supervising:

 

Undergraduate Students:

1.      Ottavia Golfetto

2.      Magdee Hugais

3.      Chi-Li Chiu

 

 

Current

1.    Lingjie Weng (2008)

 

Past

4.      Francesco Cutrale (2008)

5.      Amanda Napier (2007-2008)

6.      Jaime Schmieg (2007)

7.      Cosimo Arnesano (2007)

8.      Elisa Frasnelli (2006-2007)

9.      Giulia Ossato (2006-2007)

10.  Celli (1999-2001, received Tesi di Laurea in Fisica (Master's equiv), August 2001)

11.  S. T. Gammon (1998-1999)

12.  J. D. B. Sutin (1997-2000)

 

Graduate Students:

 

Current (Expected Graduation Date):

1.      Kaveh Azartash (2010)

2.      Giulia Ossato (2010)

3.      Peter Fwu

4.      Cosimo Arnesano

5.      Ylenia Santoro

6.      Shanshan Xu

7.      Francesco Cutrale

 

Past graduate students (Year Degree was Completed), present status, if known:

 

8.      Molly Rosso (2009)

9.      Ryan Colyer (Ph.D., 2008), currently at UCLA, Los Angeles, CA

10.  Claudia Lee (Ph.D., 2007), currently at UVP Inc., Upland, CA

11.  Shwayta Kukreti (Ph.D., 2007), currently in Medical Scholars Program, University of Illinois at Urbana-Champaign

12.  Kandice Tanner (Ph.D., 2006), currently at Univ. of California, Berkeley

13.  Anna Celli (2006), currently at Veterans Affairs Medical Center, UCSF

14.  D. Eckhoff (Ph.D., 2006), currently at Webster University, St. Louis, MO

15.  Chiara Polzonetti (M.S., 2006)

16.  Abdel Tahari (2005), currently finishing Medical Scholars Program, UIUC*

17.  Natalia Machado (M.S., 2005)

18.  Jee-Hyun Choi (Ph.D., 2003), currently at Samsung Advanced Institute of Technology, South Korea

19.  John Eid (Ph.D., 2003), currently at Rowland Institute at Harvard, Cambridge, MA

20.  Osman Akcakir (Ph.D., 2002), currently at Molecular Biology Consortium, Chicago, IL

21.  L. Adelina Paunescu (Ph.D., 2001), currently at MIT, Cambridge, MA

22.  Timothy Ragan (Ph.D., 2001), currently at MIT, Cambridge, MA

23.  Claudia Casavola (2000-Italian doctorate), currently in Italy

24.  Matthia Filiaci (Ph.D., 2000), currently at Rutter Associates, NY

25.  Yan Chen (Ph.D., 1999), currently at University of Minnesota

26.  Albert Cerussi (Ph.D., 1999), currently at Beckman Institute, CA

27.  Scott Walker * (Ph.D., 1998; M.D., 2001), currently at University of Colorado Health Sciences Center

28.  Chen-Yuan Dong (Ph.D., 1997), currently at National Taiwan University, Republic of China

29.  J. Maier* (Ph.D., 1997), currently at Chemimage Corp, PA

30.  Todd French (Ph.D., 1996), currently at Molecular Devices, Inc., Sunnyvale, CA

31.  Keith Berland (Ph.D., 1995), currently at Emory University, GA

32.  Jenny Carrero (Ph.D., 1994), currently at Unilever, NY

33.  Joshua Fishkin (Ph.D., 1994), currently at Boeing, Los Angeles, CA

34.  Brett Feddersen (Ph.D., 1993), currently at Frasca, Champaign, IL

35.  Norberto Silva (Ph.D., 1993), currently at Mayo Clinic, Rochester, NY

36.  J. L. Vittitow (Ph.D., 1990)

37.  David W. Piston (Ph.D., 1989), currently at Vanderbilt University, Nashville, TN

38.  S. L. Lin (Ph.D., 1988)

39.  Jose R. Alcala (Ph.D., 1987), deceased

40.  M. K. Limkeman (Ph.D., 1984), currently at Milwaukee GE Medical Center, WI

41.  C. J. Hardy (Ph.D., 1983), currently at Medical Center Schenckdidy, NY

 

*Medical Scholars Program

 

Research Associates (Post-doctorate):

Current

1.      Luca Lanzano (2008-)

2.      Francesco Cardarelli

3.      Laura Estrada

4.      Chiara Stringari

 

Past

5.      Bo Chen (2009-2010)

6.      Kandice Tanner (2007-2008), currently at Univ. of California, Berkeley

7.      Enrico D'Amico (2002-2007), currently at Univ. of California, Irvine

8.      Michelle Digman (2003-2008), currently at Univ. of California, Irvine

9.      Christian Hellriegel (2006-2008), currently at Fundacion Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain

10.  Jay Unruh (2006-2008), currently at Stowers Institute for Medical Research, Kansas City, MO

11.  Nicholas Barry (1997-2003), currently at Univ. of Colorado, Health Sciences Ctr, Denver

12.  Joseph M. Beechem (1987-89), currently at Molecular Probes, Oregon

13.  Luis A. Bagatolli (1997-00), currently at University of Southern Denmark

14.  Christof Buehler (1996-98), currently at Paul Schrerrer Institute, Switzerland

15.  Mateo Calderon-Arnulphi (2002-05), currently at University of Illinois at Chicago

16.  Yan Chen (1998-00), currently at University of Minnesota

17.  Andrea De Oliveira (2003-2006), currently at Universida de Federal do Rio de Janeiro, Brazil

18.  Svante Eriksson (1992-93)

19.  Sergio Fantini (1993-96), currently at Tufts University, Massachusetts

20.  Mari A. Franceschini (1993-99), currently at Massachusetts General Hospital

21.  Katerina Kis-Petikova (1999-2001), currently at Institute of Biophysics & Radiation Biology, Budapest, Hungary

22.  Valeria Levi (2003-2006), currently at University of Buenos Aires, Argentina

23.  Jochen Müller (1997-00), currently at University of Minnesota

24.  Gina Perez (2002), currently at Vanderbilt University Medical Center

25.  Qiaoqiao Ruan (2003-2004), currently at Abbott Labs, Illinois

26.  Cathy A. Royer (1988-91), currently at CNRS, France

27.  Larissa P. Safonova (2000-2003), currently in Russia

28.  Parijat, Sengupta (2004-), currently at SUNY Stony Brook, NY

29.  Peter T. C. So (1992-96), currently at Massachusetts Institute of Technology

30.  Allain Sillen (1999-2002)

31.  Martin Wolf (1998-2001)

32.  Ursula Wolf (1999-2001)

33.  Weiming Yu (1997-2000), currently at Indiana University

 

Visiting Scholars (more than 6 months):

1.      Paul Wiseman (2007-2008)

2.      Andre M. O. Gomes (2003)

3.      Wooseok Ko (2004)

 

Research Technicians:

 

1.      Viera Crosignani

2.      Elizabeth Hinde

3.      Claudia Magaudda

4.      Milka Strakic

5.      Ben Pruess (2008-)

6.      Jennifer Sasaki (2007-present)

7.      Christine M. Larson (1991-1997)

8.      Ruth M. Rusch (1987-1990)

Visiting Scholars (more than 6 months)

1.      Paul Wiseman (2007-2008), currently at McGill University, Montreal, QC, Canada

 

Extramural Support:

 

Active:

 

  • PHS 2P41 RR003155 (PI: E. Gratton): Laboratory for Fluorescence Dynamics. NIH. 08/1/06-07/31/11. Direct: $644,221/year.           
  • 2 U54 GM064346 (PI:  Alan Horwitz): Cell Migration Consortium. NIGMS. 08/01/06-07/31/11. Direct: $102,796/year.
  • 1P50-GM076516-01A1 (PI: A. Lander): Systems Biology of Morphogenesis and Spatial Information Flow: Optical Biology Core. NIH/NIGMS. 07/01/07-06/30/12.         Direct: $187,382/year.            
  • FY05.266.001 (Subcontract for 5 RO1 DK066029-01A2): Regulation of Renal Phosphate Transport by Lipids. NIH/NIDDK. 02/01/06-03/31/10. Direct (subcontract): $29,921/year.                                   
  • P30 DC8369 (PI: Metherate): UC Irvine Core Center for Hearing and Communication Research. NIH/NIDCD. 1/01/2007 – 12/31/2011. Direct: $253,216 /for entire center (Gratton on as-needed basis only).

Pending:

 

  • 1U54CA105480-01 (PI: B. Tromberg): Breast Cancer Multi-Diffuse Optical Imaging. NIH.

 

Publications

 

Book Chapters:

 

Published:

B-1Gratton, E. and R. Lopez-Delgado. Remarks on a novel method for fluorescence lifetime measurements. In Time Resolved Fluorescence Spectroscopy in Biochemistry and Biology (R. B. Cundall and R. E. Dale, Eds.) NATO ASIS, Ser. A. Vol. 69A, Plenum Press, NY, pp. 109-114 (1983).

B-2Jameson, D. and E. Gratton. Analysis of heterogeneous emissions by multifrequency phase and modulation fluorometry. In New Directions in Molecular Luminescence. ASTM-STP 822 (D. Eastwood, Ed.) (American Society of Testing and Materials), pp. 67-81 (1983).

B-3Careri, G. and E. Gratton. The statistical time correlation approach to enzyme action: The role of hydration. In The Fluctuating Enzyme, Ch. X, pp. 227-262 (G. R. Welch, Ed.) Wiley & Sons, NY (1984).

B-4Gratton, E., J. R. Alcala and G. Marriott. Rotational motions of tryptophan and tyrosine residues in proteins. In Structure and Dynamics of Nucleic Acids, Proteins, and Membranes (E. Clementi and S. Chin, Eds.) 149-151 (1986).

B-5Gratton, E., N. Silva and S. Ferreira. Fluorescence of tryptophan and protein dynamics. In Biological and Artificial Intelligence Systems (E. Clementi and S. Chin, Eds.) 49-55 (1988).

B-6Lentz, B. R., S. W. Burgess and E. Gratton. Concentration dependence of DPHpPC fluorescence lifetime: Photophysics and utility for monitoring membrane fusion. In Molecular Mechanisms of Membrane Fusion (S. Ohki, D. Doyle, T. D. Flanagan, S. W. Hue and E. Mayhew, Eds.) Plenum Pub. Corp. (1988).

B-7Gratton, E., J. R. Alcala and F. G. Prendergast. Protein dynamics: Fluorescence lifetime distributions. In Fluorescent Biomolecules, pp. 17-32 (D. M. Jameson and G. Reinhart, Eds.) Plenum Press (1989).

B-8Gratton, E. and M. J. vandeVen. Laser sources for confocal microscopy. In The Handbook of Biological Confocal Microscopy (J. Pawley, Ed.) Ch. 5, pp. 53-67. Plenum Press, Proc. EMSA 47th Annual Mtg., San Antonio, TX (1990).

B-9Gratton, E., J. R. Alcala and B. Barbieri. Frequency domain fluorometry. In Handbook of Luminescence Techniques in Chemical and Biochemical Analysis (W.R.G. Baeyens, D. De Keukeleire and K. Korkidis. Eds.) Marcel Dekker, Inc., pp. 47-72 (1991).

B-10                    Beechem, J. M., E. Gratton, M. Ameloot, J. R. Knutson and L. Brand. The global analysis of fluorescence intensity and anisotropy decay data: Second generation theory and programs. In Topics in Fluorescence Spectroscopy, II "Principles." (J. R. Lakowicz, Ed.) Ch. 5, pp. 241-305 (1991).

B-11                    Parasassi, T., M. Di Stefano, G. Ravagnan, O. Sapora and E. Gratton. Membrane aging during cell growth ascertained by Laurdan generalized polarization. In Experimental Cell Research 202, Academic Press, 432-439 (1992).

B-12                    Ferreira, S. T. and E. Gratton. Enzyme activity in reverse micelles: Roles of diffusion and extent of hydration. In Biomolecules in Organic Solvents, CRC Meeting, Ch. 8, pp. 189-201 (1992).

B-13                    Reinhart, G., E. Gratton and W. Mantulin. Dissociation of large oligomeric proteins by high hydrostatic pressure: dynamic light scattering studies. NATO ASI Series Volume "High Pressure Chemistry, Biochemistry and Materials Sciences." (R. Winter, Ed.), 619-626 (1993).

B-14                    vandeVen, M. and E. Gratton. Time-resolved fluorescence lifetime imaging. In Optical Microscopy: Emerging Methods and Applications, Academic Press, Ch. 14, 373-402 (1993).

B-15                    Gratton, E. and M. J. vandeVen. Laser sources for confocal microscopy. In The Handbook of Biological Confocal Microscopy, Second Edition (J. Pawley, Ed.) Plenum Press Ch. 5 pp. 69-97 (1995).

B-16                    So, P. T. C., T. French, W. M. Yu, K. M. Berland, C. Y. Dong, and E. Gratton. Two photon microscopy: Time-resolved and intensity imaging. In Fluorescence Imaging Spectroscopy and Microscopy (Wang, X. F. and B. Herman, Eds.) Chemical Analysis Series, Vol. 137, John Wiley & Sons, Inc., Ch. 11, 351-374 (1996).

B-17                    French, T., P. T. C. So, C. Y. Dong, K. M. Berland and E. Gratton. Fluorescence lifetime imaging techniques for microscopy. In "Methods in Cell Biology." Video Microscopy. Greenfield Sluder and David Wolf, Eds., Vol. 56, pp. 227-304 (1997).

B-18                    Fantini, S., B. Barbieri, M. A. Franceschini and E. Gratton. Frequency-domain spectroscopy. In Applications of Optical Engineering to the Study of Cellular Pathology, E. Kohen, ed., (Research Signpost, Trivandum, India), pp. 57-66 (1997). [abstract]

B-19                    So, P. T. C., C. Y. Dong, K. M. Berland, T. French and E. Gratton. Time-resolved stimulated-emission and transient-absorption microscopy and spectroscopy. In Topics in Fluorescence Spectroscopy, Vol. 5: Nonlinear and Two-Photon-Induced Fluorescence, Chapter 10. Plenum Press, NY. Ed., J. R. Lakowicz, pp. 427-469 (1997).

B-20                    Fantini, S., S. A. Walker, M. A. Franceschini, K. T. Moesta, P. M. Schlag, M. Kaschke, and E. Gratton. Optical characterization of breast tumors by frequency-domain optical mammography, OSA Trends in Optics and Photonics Series 21, Eds., James G. Fujimoto and Michael S. Patterson, 143­147 (1998).

B-21                    Franceschini, M. A., A. Paunescu, S. Fantini, S. Pratesi, J. S. Maier, G. P. Donzelli, and G. Gratton, Frequency-domain optical measurements in vitro on two- and three-layered tissue-like phantoms, and in vivo on infant heads, OSA Trends in Optics and Photonics Series 21, Eds., James G. Fujimoto and Michael S. Patterson, 232-236 (1998).

B-22                    Paunescu, A., M. A. Franceschini, S. Fantini, A. Cerussi, and E. Gratton, Effective optical properties of two-layered turbid media using the frequency-domain multi-distance method, OSA Trends in Optics and Photonics Series 21, Eds., James G. Fujimoto and Michael S. Patterson, 79-83 (1998).

B-23                    Toronov, V., M. Filiaci, S. Fantini, and E. Gratton, Study of large scale fluctuations in turbid media by photon-density-wave fluctuation correlation spectroscopy, OSA Trends in Optics and Photonics Series 21, Eds., James G. Fujimoto and Michael S. Patterson, 60-62 (1998).

B-24                    So, P. T. C., B. R. Master, E. Gratton, and I. E. Kochevar, Two-photon optical biopsy of thick tissues, OSA Trends in Optics and Photonics Series 22, Eds., Eva M. Sevick-Muraca, Joseph A. Izatt, and Marwood N. Ediger, 40-42 (1998).

B-25                    Filiaci, M., V. Toronov, S. Fantini, and E. Gratton, Optical probe and frequency-domain instrumentation to study spatial and temporal correlations of fluctuations in tissues, OSA Trends in Optics and Photonics Series 22, Eds., Eva M. Sevick-Muraca and Joseph A. Izatt, 183-187 (1998).

B-26                    Masters, B. R., P. T. C. So, W. W. Mantulin, and E. Gratton, Tissue Microscopy and Spectroscopy: A Two-Photon Approach, OSA Trends in Optics and Photonics Series 22, Eds., Eva Sevick-Muraca, Joseph A. Izatt, and Marwood N. Ediger, 43-45 (1998).

B-27                    Cerussi, A., S. Fantini, and E. Gratton, Quantitative fluorescence spectroscopy in strongly scattering media containing multiple fluorophores, OSA Trends in Optics and Photonics Series 22, Eds., Eva M. Sevick-Muraca, Joseph A. Izan, and Marwood N. Ediger, pp. 70-75 (1998).

B-28                    Chen, Y., J. D. Müller, K. M. Berland, and E. Gratton. Fluorescence Fluctuation Spectroscopy, In Confocal Microscopy: Methods in Enzymology 19(2) eds. P. Michael Conn, (Academic Press),  pp. 234-252 (1999).

B-29                    Masters, B. R., P. T. C. So., K. H. Kim., C. Buehler, and E. Gratton. Multiphoton excitation microscopy, confocal microscopy, and spectroscopy of living cells and tissues; functional metabolic imaging of human skin in vivo. Confocal Microscopy (methods in Enzymology, Vol. 307). By JN Abelson, MI Simon, and PM Conn (Editors). Academic Press, pp. 513-36, 1999. ISBN: 01521822087

B-30                    Gratton, E. Laser sources for confocal and two-photon microscopy. In Confocal and Two-Photon Microscopy: Foundations, Applications and Advances. A. Diaspro, ed., Wiley & Sons, Inc. (2000).

B-31                    Yu, W., W. W. Mantulin, and E. Gratton. Fluorescence Lifetime Imaging: New Microscopy Technologies. In: Emerging Tools for Single-Cell Analysis, G. Durack and J. P.Robinson, eds. (Wiley-Liss, Inc.), pp. 139-173 (2000).

B-32                    Müller, J. D., Y. Chen, and E. Gratton. Photon counting histogram statistics. In: Fluorescence Correlation Spectroscopy. Theory and Applications, E. L. Elson and R. Rigler, eds. (Springer Publishers) Ch. 20, pp. 410-435 (2001).

B-33                    Muller, J., Y. Chen, and E. Gratton. Fluorescence Correlation Spectroscopy. In: Methods in Enzymology 361, Ch. 4, pp. 69-92, G. Marriott and I. Parker, eds. (2003).

B-34                    Dong CY, T. French, P. T. So, C. Buehler, K. M. Berland and E. Gratton.  Fluorescence-lifetime imaging techniques for microscopy. In: Methods Cell Biol., 2nd Edition, G. Sluder and D. E. Wolf, eds., Vol. 72, pp. 431-64(2003).

B-35                    Bagatolli, L. A., S. Sanchez, T. Hazlett and E. Gratton. Giant vesicles, Laurdan, and two-photon fluorescence microscopy: evidence of lipid lateral separation in bilayers. In: Methods of Enzymology 360, Ch. 20, pp 481-500, G. Marriott, ed. (2003).

B-36                    Gratton, E. and S. Fantini. Reflectance and Transmittance Spectroscopy. In Laser and Current Optical Techniques in Biology, Vol. 4, Ch. 11,  R. Pratesi and G. Palumbo, eds. pp. 211-258 (2004).

B-37                    Gratton, E., S. Breusegem, N. Barry, Q. Ruan, and J. Eid. Fluctuation correlation spectroscopy in cells: Determination of molecular aggregation. Chapter 1 in: Biophotonics-Optical Science and Engineering for the 21st Century, Kluwer Academic/Plenum Publishers. Shen, X. Van Wijk, R.;(Eds.) XVIII, pp. 1-14. ISBN: 0-387-24995-8 (2005).

B-38                    S A Sánchez, M A Tricerri, G Gunther, and E Gratton. Laurdan generalized polarization: from cuvette to microscope. In Modern Research and Educational Topics in Microscopy. Vol. 2: Applications in Physical/Chemical Sciences (Microscopy Book Series, Vol. 3). By A Méndez-Vilas and J Díaz (Editors). Formatex Research Center, Badajoz, Spain, pp. 1007-1014 (2007). ISBN: 9788461194209

B-39                    A Celli, C Y Lee, and E Gratton. Fluorescence microscopy to study pressure between lipids in giant unilamellar vesicles. In Methods in Membrane Lipids (Methods in Molecular Biology, Vol. 400). By AM Dopico (Editors). Humana Press, pp. 333-340 (2007). ISBN: 1588296628

B-40                    M A Digman and E Gratton. The RICS method: measurement of fast dynamics in cells with the laser scanning microscope. In Image Analysis in Medical Microscopy and Pathology. By HS Wu and AJ Einstein (Editors). Research Signpost, Kerala, pp. 207-224 (2007). ISBN: 8130801167

 

B-41                    V Levi and E Gratton. Three-Dimensional particle tracking in a laser scanning fluorescence microscope. In Single-particle tracking and single molecule energy transfer. By C Bräuchle, DC Lamb, and J Michaelis (Editors). Wiley VCH, pp. 3-24, 2010.  ISBN: 9783527322961

B-42                    E Gratton, V Toronov, U Wolf and M Wolf. Detection of Brain Activity by Near-Infrared Light. In Biomedical Optical Imaging. By JG Fujimoto and D Farkas (Editors). Oxford University Press, pp. 378-395, 2009. ISBN: 9780195150445

B-43                    Learmonth, R. P. and E. Gratton. Assessment of membrane fluidity in individual yeast cells by Laurden Generalized Polarization and multi-photon scanning fluorescence microscopy. In: Fluorescence Spectroscopy, Imaging and Probes. By R Kraauenof, AJWG Visser, and HC gerritsen (Editors). Springer-Verlag berlin, Heidelberg, New York, pp. 241-252, 2002. ISBN: 9783540427681

B-44                    Dong, C. Y., C. Buehler, P. T. C. So., T. French, and E Gratton. Biological applications of time-resolved, pump-probe fluorescence microscopy and spectroscopy in the frequency domain. In: Methods in Cellular Imaging (Methods in Physiology Series, Vol. IV). By A Periasamy (Editors). American Physiology Society, pp. 324-344, 2001. ISBN: 9780195139365

B-45                    Dong, C. Y., K. H. Kim, C. Buehler, L. Hsu, H. Kim, P. T. C. So., B. R. Masters, E. Gratton, and I. E. Kochevar. Probing deep-tissue structures by two-photon fluorescence microscopy. In: Emerging tools for Single-Cell Anaylsis (Advances in Optical Measurement Technologies). By G. Durack and JP Robinson (Editors). Wiley-Liss, Inc. pp. 221-237, 2000. ISBN: 9780471315759

 

 

In preparation, submitted or in press:

 

Journal Articles:

 

Published:

J-1   Gratton, E. The Acid Denaturation of DNA. Rap. 1st. Sup. San. 155, 46 pp. (1971).

J-2   Grandolfo, M., E. Gratton, F. Anfosso Somma and P. Vecchia. Exciton binding energies of layer-type semiconductors GaSe and GaTe. Phys. Stat. Sol.(b) 48, 729-735 (1971).

J-3   Gratton, E. Method for the automatic correction of scattering in absorption spectra by using the integrating sphere. Biopolymers 10, 2629-2634 (1971).

J-4   Dore, E., C. Frontali and E. Gratton. The role of ions in the acid melting of DNA. Biopolymers 11, 2033-2041 (1972).

J-5   Dore, E., C. Frontali and E. Gratton. Physico-chemical description of a condensed form of DNA. Biopolymers 11, 443-459 (1972).

J-6   Cancellieri, A., C. Frontali and E. Gratton. Dispersion effect on turbidimetric size measurements. Biopolymers 13, 735-743 (1974).

J-7   Gentile, S. and E. Gratton. Misure di Costante Dielettrica su polveri di lisozima idratato. Rap. Ist. Fis. Roma 561 (1974).

J-8   Careri, G., P. Fasella and E. Gratton. Statistical time events in enzymes: A physical assessment. Crit. Rev. Biochem. 3, 141-164 (1975).

J-9   G. Careri, A. Giansanti and E. Gratton, Eds. Studio I.R. dell'idratazione del lisozima. Rap. Ist. Fis. Roma (1977).

J-10                       Giannini, L. and E. Gratton. Hydration of globular proteins: U.V. studies. Rend. Acc. Naz. Lincei. Sci. Fis. Mat. Natl. 62, 711-715 (1977).

J-11                       Careri, G., L. De Angelis, E. Gratton and C. Messana. Magnetic susceptibility of lysozyme. Phys. Lett. 60A, 490-491 (1977).

J-12                       Careri, G. and E. Gratton. Onsager coupling in enzymes. Biosystems 8, 185-186 (1977).

J-13                       Ascoli, F., E. Gratton, F. Riva, P. Fasella and M. Brunori. Infrared stretching frequencies of CO in carbomonoxyhemoglobin from trout. Biochim. Biophys. Acta 553, 534-537 (1978).

J-14                       Gratton, E. and R. Lopez-Delgado. The harmonic content of a SR pulse: The possibility to reach subpicosecond resolution in the fluorescence decay experiment. SSRL Report No. 78/09 (1978).

J-15                       Gratton, E. and R. Lopez-Delgado. Use of synchrotron radiation for the measurement of fluorescence lifetimes with subpicosecond resolution. Rev. Sci. Inst. 50, 789-790 (1979).

J-16                       Careri, G., P. Fasella and E. Gratton. Enzyme dynamics: The statistical physics approach. Ann. Rev. Biophys. and Bioeng. 8, 69-97 (1979).

J-17                       Careri, G., A. Giansanti and E. Gratton. Lysozyme film hydration events--An IR and gravimetric study. Biopolymers 18, 1187- 1203 (1979).

J-18                       Frontali, C., E. Dore, A. Ferrauto, E. Gratton, A. Bettini, M. R. Pozzan and E. Valdevit. An absolute method for the determination of the persistence length of native DNA from electron micrographs. Biopolymers 18, 1353-1373 (1979).

J-19                       Gratton, E. Hydration induced mobility in azurin. Proc. of the III Intl. Conf. "De la Physique Theorique a la Biologie" Springer, Vienna, July (1979).

J-20                       Gratton, E. The time dimension of protein systems. Adv. Physiol. Sci. 3, 269-273 (1980).

J-21                       Gratton, E. and R. Lopez-Delgado. Measuring fluorescence decay times by phase-shift and modulation techniques using the high harmonic content of pulsed light sources. I1 Nuovo Cimento 56B, 110-124 (1980).

J-22                       Careri, G., E. Gratton, P.-H. Yang and J. A. Rupley. Correlation of IR spectroscopic, heat capacity, diamagnetic susceptibility and enzymatic measurements on lysozyme powder. Nature 284, 572-573 (1980).

J-23                       Careri, G., A. Giansanti and E. Gratton. Molecular aspects of the hydration process in a globular protein. Int. J. Quantum Chem. Vol. XIX, pp. 1133-1135 (1981).

J-24                       Gratton, E. and M. Limkeman. A continuously variable frequency cross-correlation phase fluorometer with picosecond resolution. Biophys. J. 44, 315-324 (1983).

J-25                       Careri, G., U. Buontempo, F. Carta, E. Gratton and A. Scott. Infrared absorption in acetanilide by solitons. Phys. Rev. Lett. 51(4), 304-307 (1983).

J-26                       Gavish, B., E. Gratton, C. J. Hardy and A. St. Denis. Differential sound velocity apparatus for the investigation of protein solutions. Rev. Sci. Inst. 54, 1756-1760 (1983).

J-27                       Gratton, E. and M. Limkeman. Microprocessor-controlled photon-counting spectrofluorometer. Rev. Sci. Inst. 54(3), 294-299 (1983).

J-28                       Gratton, E., N. Rosato, D. M. Jameson, F. Antonangeli, F. Bassani, F. Campolungo, U. Grassano, A. Finazzi-Agró, M. Piacentini A. Savoia, G. Weber and N. Zema. A multifrequency phase-fluorometer with picosecond resolution using synchrotron

            radiation. INFN-PULS Frascati Report, 65 pp. (1983).

J-29                       Rupley, J. A., E. Gratton and G. Careri. Water and globular proteins. Trends in Biochem. 8, 18-22 (1983).

J-30                       Gavish, B., E. Gratton and C. J. Hardy. Adiabatic compressibility of globular proteins. Proc. Natl. Acad. Sci. USA 80, pp. 750-754 (1983).

J-31                       Lakowicz, J. R., E. Gratton, H. Cherek and B. P. Maliwal. Frequency-domain phase-modulation fluorometry: Resolution of complex decays of fluorescence intensity and anisotropy. J. of Lumin. 31&32, 699-702 (1984).

J-32                       Parasassi, T., F. Conti, M. Glaser and E. Gratton. Detection of phospholipids phase separation. A multifrequency phase fluorimetry study of 1,6-diphenyl-1,3,5-hexatriene fluorescence. J. Biol. Chem. 259(22), 14011-14017 (1984).

J-33                       Lakowicz, J. R., H. Cherek, G. Laczko and E. Gratton. Time-resolved fluorescence emission spectra of labeled phospholipid vesicles, as observed using multifrequency phase fluorometry. Biochim. Biophys. Acta 777, 183-193 (1984).

J-34                       Lakowicz, J. R., E. Gratton, H. Cherek, B. P. Maliwal and G. Laczko. Determination of time-resolved fluorescence emission spectra and anisotropies of a fluorophore-protein complex using frequency- domain phase-modulation fluorometry.

            J. Biol. Chem. 259(17), 10967- 10972 (1984).

J-35                       Careri, G., U. Buontempo, F. Galluzzi, A. C. Scott, E. Gratton and E. Shyamsunder. Spectroscopic evidence for Davydov-like solitons in acetanilide. Phys. Rev. B 30 (8), 4689-4702 (1984).

J-36                       Parasassi, T., F. Conti and E. Gratton. Study of heterogeneous emission of parinaric acid isomers using multifrequency phase fluorometry. Biochemistry 23(23), 5660-5664 (1984).

J-37                       Conti, F., T. Parasassi, N. Rosato, O. Sapora and E. Gratton. Fluorescence studies using synchrotron radiation on normal and differentiated cells labeled with parinaric acids. Biochim. Biophys. Acta 805, 117-122 (1984).

J-38                       Gratton, E., M. Limkeman, J. R. Lakowicz, B. P. Maliwal, H. Cherek and G. Laczko. Resolution of mixtures of fluorophores using variable-frequency phase and modulation data. Biophys. J. 46, 479­486 (1984).

J-39                       Lakowicz, J. R., G. Laczko, H. Cherek, E. Gratton and M. Limkeman. Analysis of fluorescence decay kinetics from variable-frequency phase shift and modulation data. Biophys. J. 46, 463-477 (1984).

J-40                       Marque, J., L. Eisenstein, E. Gratton, J. M. Sturtevant and C. J. Hardy. Thermodynamic properties of purple membrane. Biophys. J. 46, 567-572 (1984).

J-41                       Gratton, E., D. M. Jameson and R. Hall. Multifrequency phase and modulation fluorometry. Ann. Rev. Biophys. Bioeng. 13, 105- 124 (1984).

J-42                       Jameson, D. M., E. Gratton and R. Hall. The measurement and analysis of heterogeneous emissions by multifrequency phase and modulation fluorometry. App. Spec. Rev. 20, 55-106 (1984).

J-43                       Jameson, D., E. Gratton, G. Weber and B. Alpert. Oxygen distribution and migration within mbdes fe and hbdes fe: multifrequency phase and modulation fluorometry study. Biophys. J. 45, 795- 803 (1984).

J-44                       Gratton, E., D. M. Jameson, N. Rosato and G. Weber. Multifrequency cross-correlation phase fluorometer using synchrotron radiation. Rev. Sci. Inst. 55, 486-494 (1984).

J-45                       Gratton, E., D. Jameson, G. Weber and B. Alpert. A model of dynamic quenching of fluorescence in globular proteins. Biophys. J. 45, 789-794 (1984).

J-46                       Alcala, R., E. Gratton and D. M. Jameson. A multifrequency phase fluorometer using the harmonic content of a mode-locked laser. Anal. Inst. 14(3&4), 225-250 (1985).

J-47                       Lakowicz, J. R., B. P. Maliwal and E. Gratton. Recent developments in frequency-domain fluorometry. Anal. Inst. 14(3&4), 193-223 (1985).

J-48                       Mugnier, J., B. Valeur and E. Gratton. Rate of intramolecular energy transfer in coumarin bichromophoric molecules. An investigation by multifrequency phase-modulation fluorometry. Chem. Phys. Lett. 119 (2&3) 217-222 (1985).

J-49                       Scott, A. C., E. Gratton, E. Shyamsunder and G. Careri. IR overtone spectrum of the vibrational soliton in crystalline acetanilide. Phys. Rev. Lett. B 32, 5551-5553 (1985).

J-50                       Frauenfelder, H. and E. Gratton. Protein dynamics and hydration. In Methods in Enzymology 127, "Biomembranes, Protons and Water: Structure and Translocation." (1985).

J-51                       Gratton, E. and D. M. Jameson. New approach to phase and modulation resolved spectra. Anal. Chem. 57, 1694-1697 (1985).

J-52                       Lakowicz, J. R., H. Cherek, B. Maliwal and E. Gratton. Time- resolved fluorescence anisotropies of diphenylhexatriene and perylene in solvents and lipid bilayers obtained by multifrequency phase-modulation fluorometry.

            Biochemistry 24, 376-383 (1985).

J-53                       Gratton, E. and J. R. Lakowicz. Ultrafast dynamics in proteins and membranes by time resolved fluorescence spectroscopy. In Structure and Motion: Membranes, Nucleic Acids, and Proteins (E. Clementi, G. Corongiu, M. H. Sarma and

            A. R. Sarma, Eds.) Adenine Press, NY, pp. 155-168 (1985).

J-54                       Gratton, E. and B. Barbieri. Multifrequency phase fluorometry using pulsed sources: Theory and applications. Spectroscopy 1 (6), 28-36 (1986).

J-55                       Gratton, E., J. R. Alcala, G. Marriott and F. G. Prendergast. Fluorescence studies of protein dynamics. In Proc. International Symposium of Computer Analysis for Life Sciences. Progress and Challenges in Biological and Synthetic Polymer

                  Research, HAYASHIBARA FORUM '85 (C. Kawabata and A. R. Bishop, Eds.) Tokyo, Japan, pp. 1-11 (1986).

J-56                       Parasassi, T., F. Conti and E. Gratton. Time-resolved fluorescence emission spectra of Laurdan in phospholipid vesicles by multifrequency phase and modulation fluorometry. Cell. and Mol. Biol. 32, 103-108 (1986).

J-57                       Parasassi, T., F. Conti and E. Gratton. Fluorophores in a polar medium: time dependence of emission spectra detected by multifrequency phase and modulation fluorometry. Cell. and Mol. Biol. 32(1), 99-102 (1986).

J-58                       Rosato, N., A. Finazzi-Agró, E. Gratton, S. Stefanini and E. Chiancone. Time-resolved fluorescence of Apoferritin and its subunits. J. Biol. Chem. 262, 14487-14491 (1987).

J-59                       Glaser, M., E. Gratton, T. Parasassi, O. Sapora and F. Conti. Spectroscopic investigation of the physical state of biological membranes using the fluorescence methodology. In Proc., 2nd Conf. on The State of Art of Research in the Chemistry

            Department, La Sapienze, Rome, pp. 293-301 (1987).

J-60                       Lentz, B. R., S. W. Burgess and E. Gratton. Concentration dependence of DPHpPC fluorescence lifetime: Photophysics and utility for monitoring membrane fusion. In Proc. of International Symp. on Mole. Mech. of Membrane Fusion, Buffalo,

            NY (1987).

J-61                       Eccleston, J., E. Gratton and D. M. Jameson. Interactions of a fluorescence analog of GDP with elongation factor Tu: steady-state and time resolved fluorescence studies. Biochemistry 26, 3902­3907 (1987).

J-62                       Jameson, D. M., E. Gratton and J. Eccleston. Intrinsic fluorescence of elongation factor Tu in its complexes with GDP and elongation factor Tu. Biochemistry 26, 3894-3901 (1987).

J-63                       Fiorini, R., M. Valentino, S. Wang, M. Glaser and E. Gratton. Fluorescence lifetime distributions of 1,6-diphenyl-1-3-5-hexatriene in phospholipid vesicles. Biochemistry 26, 3864-3870 (1987).

J-64                       Alcala, R., E. Gratton and F. G. Prendergast. Interpretation of fluorescence decays in proteins using continuous lifetime distributions. Biophys. J. 51, 925-936 (1987).

J-65                       Bismuto, E., G. Irace, G. Colonna, D. M. Jameson and E. Gratton. Dynamic aspects of the heme binding site in phylogenetically distant myoglobins. Biochim. Biophys. Acta 913, 150-154 (1987).

J-66                       Schroeder, F., Y. Barenholz, E. Gratton and T. E. Thompson. A fluorescence study of dehydroergosterol in phosphatidylcholine bilayers vesicles. Biochemistry 26, 2441-2448 (1987).

J-67                       Gratton, E. and B. Barbieri. Molecular dynamics studies using frequency-domain fluorometry. SPIE Proc., Vol. 743, 104-109 (1987).

J-68                       Parasassi, T., F. Conti, E. Gratton and 0. Sapora. Membranes modifications of differentiating proerythroblast. Variation of 1,6-diphenyl-1,3,5-hexatriene lifetime distributions by multifrequency phase and modulation fluorometry.

            Biochim. Biophys. Acta 898(2), 196-201 (1987).

J-69                       Gratton, E., J. R. Alcala and G. Marriott. Rotations of tryptophan residues in proteins. Biochem. Soc. Trans., 617th Meeting, Dundee 14, 835-838 (1987).

J-70                       Bismuto, E., D. M. Jameson and E. Gratton. Dipolar relaxations in glycerol: a dynamic fluorescence study of 4-2'-(dimethylamino)-6'-naphthoylcyclohexanecarboxylic acid (DANCA). J. Am. Chem. Soc. 109, 2354-2357 (1987).

J-71                       Alcala, J. R., E. Gratton and F. G. Prendergast. Fluorescence lifetime distributions in proteins. Biophys. J. 51, 597-604 (1987).

J-72                       Barbieri, B., E. Gratton, W. W. Mantulin, J. J. Sparrow. Continuous lifetime distributions and rotations of tryptophan residues in proteins. Thirty-eight Pittsburgh Conf. & Expo. on Analytical Chem. and Appl. Spec., Atlantic City, NJ, March 8-13,

            No. 996 (1987).

J-73                       Alcala, R., E. Gratton and F. G. Prendergast. Resolvability of fluorescence lifetime distributions using phase fluorometry. Biophys. J. 51, 587-596 (1987).

J-74                       Barbieri, B., F. DePicoli and E. Gratton. Resolution of overlapping spectra using frequency-domain fluorometry. In Proc. SPIE 909, Time-Resolved Laser Spectroscopy in Biochemistry. J. R. Lakowicz, ed., 366-369 (1988).

J-75                       Beechem, J. M. and E. Gratton. Fluorescence spectroscopy data analysis environment: A second generation Global analysis program. In Proc. SPIE 909, Time-Resolved Laser Spectroscopy in Biochemistry. J. R. Lakowicz, ed., 70-81 (1988).

J-76                       Schroeder, F., G. Nemecz, Y. Barenholz, E. Gratton and T. E. Thompson. Cholestatrienol time resolved fluorescence in phosphatidylcholine bilayers. In Proc. SPIE 909, Time-Resolved Laser Spectroscopy in Biochemistry. J. R. Lakowicz, ed.,

            457-465 (1988).

J-77                       Bismuto, E., E. Gratton and G. Irace. Effect of unfolding on the tryptophanyl fluorescence lifetime distribution in apomyoglobin. Biochemistry 27, 2132-2136 (1988).

J-78                       Careri, G., E. Gratton and E. Shyamsunder. Fine structure of the amide I band in acetanilide. Phys. Rev. A, 37(10), 4048-4051 (1988).

J-79                       Fiorini, R. M., M. Valentino, M. Glaser, E. Gratton and E. Curatola. Fluorescence lifetime distributions of 1,6-diphenyl-1,3,5-hexatriene reveal the effect of cholesterol on the microheterogeneity of erythrocyte membrane. Biochim. Biophys.

            Acta 939 , 485-492 (1988).

J-80                       Valentino, M., M. Governa, E. Gratton, R. Fiorini, G. Curatola, E. Bertoli. Increased membrane heterogeneity in stimulated human granulocytes. FEBS Letters 234(2), 451-454 (1988).

J-81                       Schroeder, F., G. Nemecz, E. Gratton, Y. Barenholz and T. E. Thompson. Fluorescence properties of cholestatrienol in phosphatidylcholine bilayer vesicles. Biophys. Chem. 32, 57-72 (1988).

J-82                       Thompson, R. B. and E. Gratton. Phase fluorometric method for determination of standard lifetimes. Anal. Chem. 60, 670- 674 (1988).

J-83                       Fiorini, R., E. Gratton and G. Curatola. Effect of cholesterol on membrane microheterogeneity: A study using 1,6-diphenyl-1,3,5- hexatriene fluorescence lifetime distributions. Biochim. Biophys. Acta 006 (2), 198-202 (1989).

J-84                       Wratten, M. L., E. Gratton, M. vandeVen and A. Sevanian. DPH lifetime distributions in vesicles containing phospholipid hydroperoxidides. BBRC 164 , 169-175 (1989).

J-85                       Barcellona, M. L. and E. Gratton. Fluorescence lifetime distributions of DNA/4'6-diamidino-2­phenylindole complex. Biochim. Biophys. Acta. 993, 174-178 (1989).

J-86                       Barbieri, B. F. DePicoli and E. Gratton. Synthesizers' phase noise in frequency-domain fluorometry. Rev. Sci. Inst. 60, 3201- 3206 (1989).

J-87                       Piston, D. W. and E. Gratton. Orientational exchange approach to fluorescence anisotropy decay. Biophys. J. 56., 1083-1091 (1989).

J-88                       Gratton, E. and M. vandeVen. A superheterodyning microwave phase fluorometer with femtosecond resolution using a microchannel plate. Rev. Sci. Inst. LFD Report 18 (1989).

J-89                       Rosato, N., E. Gratton, G. Mei, I. Savini and A. Finazzi-Agrò. Dynamic fluorescence in copper proteins: Selected examples. Proc. Satellite FEBS 1989 Symp. Biochem. and Biophys. Approaches to the Study of Copper Proteins, Camerino, Italy

            (1989).

J-90                       Cardiel, G., M. L. Barcellona and E. Gratton. Polydeoxynucleotides/DAPI interactions: A fluorescence study by multifrequency phase fluorometry. The Italian J. of Biochem. 38, 125-129 (1989).

J-91                       Parasassi, T. and E. Gratton. Detection of phospholipid bilayers microheterogeneity and domains by fluorescence spectroscopy. Proc. Serono Symposium on Membrane Technology in Clinical Pathology Biochemistry and Pharmacology. Raven

            Press, 109-117 (1989).

J-92                       Govindjee, M. vandeVen, C. Preston, M. Seibert and E. Gratton. Recombinational light emission from photosystem II reaction centers. 8th Int'l Conf. on Photosynthesis, Stockholm, Sweden (1989).

J-93                       Feddersen, B. M., D. W. Piston and E. Gratton. Digital parallel acquisition in frequency domain fluorimetry. Rev. Sci. Inst. 60(9), 2929-2936 (1989).

J-94                       Piston, D. W., G. Marriott, T. Radivoyevich, R. M. Clegg, T. M. Jovin and E. Gratton. Wide-band acousto-optic light modulator for frequency domain fluorometry and phosphorimetry. Rev. Sci. Inst. 60(8), 2596- 2600 (1989).

J-95                       Bismuto, E., G. Irace and E. Gratton. Multiple conformational states in myoglobin revealed by frequency domain fluorometry. Biochemistry 28, 1508-1512 (1989).

J-96                       Piston, D. W., T. Bilash and E. Gratton. Compartmental analysis approach to fluorescence anisotropy: Perylene in viscous solvents. J. Phys. Chem. 93, 3963-3967 (1989).

J-97                       Gratton, E., W. W. Mantulin, M. J. vandeVen, J. B. Fishkin, M. B. Maris and B. Chance. The possibility of a near-infrared optical imaging system using frequency domain methods. Proc. Third Int'l Conf. for Peace through Mind/Brain Science, pp.

            183-189, Hamamatsu City, Japan (1990).

J-98                       Rosato, N., E. Gratton, G. Mei and A. Finazzi-Agrò. Fluorescence lifetime distributions in human superoxide dismutase: Effect of temperature and denaturation. Biophys. J. 58, 817-822 (1990).

J-99                       Pin, S., C. A. Royer, E. Gratton, B. Alpert and G. Weber. Subunit interactions in hemoglobin probed by fluorescence and high-pressure techniques. Biochemistry 29, 9194-9202 (1990).

J-100                   Barcellona, M. L., G. Cardiel and E. Gratton. Time-resolved fluorescence of DAPI in solution and bound to polydeoxynucleotides. Biochem. Biophys. Res. Commun. 170(1), 270-280 (1990).

J-101                   Gratton, E., B. Feddersen and M. vandeVen. Parallel acquisition of fluorescence decay using array detectors. In: Proc. SPIE 1204, Time-Resolved Laser Spectroscopy in Biochemistry II. J. R. Lakowicz, ed. 21-25 (1990).

J-102                   Barbieri, B. F., F. de Piccoli, M. Vandeven, and E. Gratton. What determines the uncertainty of phase and modulation measurements in frequency-domain fluorometry? In: Proc. SPIE 1204, Time-Resolved Laser Spectroscopy in Biochemistry II. J.

            R. Lakowicz, ed. 158-170 (1990).

J-103                   Vander Meulen, D. L., D. G. Nealon, E. Gratton and D. M. Jameson. Excitation wave-length dependent fluorescence anisotropy of Eosin- Myosin adducts: Evidence for anisotropic rotations. Biophys. Chem. 36, 177-184 (1990).

J-104                   Parasassi, T., G. De Stasio, A. d'Ubaldo and E. Gratton. Phase fluctuation in phospholipid membranes revealed by Laurdan fluorescence. Biophys. J. 57, 1179-1186 (1990).

J-105                   Rosato, N., G. Mei, E. Gratton, J. V. Bannister, W. H. Bannister and A. Finazzi-Agrò. A time-resolved fluorescence study of human copper-zinc superoxide dismutase. Biophys. Chem. 36, 41-46 (1990).

J-106                   Parasassi, T., G. De Stasio, A. Miccheli, F. Bruno, F. Conti and E. Gratton. Abscisic acid induced microheterogeneity in phospholipid vesicles. A fluorescence study. Biophys. Chem. 35, 65-73 (1990).

J-107                   Barcellona, M. L. and E. Gratton. The fluorescence properties of a DNA probe: 4'-6-diamidino-2­phenylindole (DAPI). E. Biophys. J. 17, 315-323 (1990).

J-108                   Govindjee, M. vandeVen, C. Preston, M. Seibert and E. Gratton. Chlorophyll a fluorescence lifetime distribution functions in open and closed photosystem II reaction center preparations; analysis by multifrequency phase fluorometry. Biochim.

            Biophys. Acta 173-179 (1990).

J-109                   Ferreira, S. and E. Gratton. Hydration and protein substates: fluorescence of proteins in reverse micelles, J. Mol. Liq. Special Issue in Honor of G. Careri, 253-272 (1990).

J-110                   Parasassi, T., G. De Stasio, G. Ravagnan, R. M. Rusch and E. Gratton. Quantitation of lipid phases in phospholipid vesicles by the generalized polarization of Laurdan fluorescence. Biophysical J., 60, 179-189 (1991).

J-111                   Reinhart, G., P. Marzola, D. M. Jameson and E. Gratton. A method for on-line background subtraction in frequency domain fluorometry. J. of Fluorescence 1(3) 153-162 (1991).

J-112                   Di Iorio, E. E., U. R. Hiltpold, D. Filipovic, K. H. Winterhalter, E. Gratton, E. Vitrano, A. Cupane, M. Leone and L. Cordone. Protein dynamics: comparative investigation on heme-proteins with different physiological roles. Biophys. J., 59, 742-754

            (1991).

J-113                   Chance, B., J. S. Leigh and E. Gratton. New Image. Nature, 349 (6311), 660 (1991).

J-114                   Fishkin, J., E. Gratton, M. J. vandeVen and W. W. Mantulin. Diffusion of intensity modulated near-infrared light in turbid media. In Proc. SPIE 1431, Time- Resolved Spectroscopy and Imaging of Tissues. B. Chance and A. Katzer, eds., 122-135

            (1991).

J-115                   Fishkin, J. B., B. A. Feddersen and E. Gratton. Experimental study of the diffraction of photon density waves by an absorbing edge in highly scattering media. Proc. IEEE MTT-S International Microwave Symp., Boston, MA. (1991).

J-116                   Marzola, P. and E. Gratton. Hydration and protein dynamics: Frequency domain fluorescence spectroscopy on proteins in reverse micelles. J. Phys. Chem. 95, 9488-9495 (1991).

J-117                   Barcellona, M. L. and E. Gratton. A molecular approach to 4'-6-diamidine-2-phenylindole (DAPI) photophysical behavior at different pH values. Biophys. Chem. 40, 223-229 (1991).

J-118                   Wang, S., J. M. Beechem, E. Gratton and M. Glaser. Orientational distribution of 1,6-diphenyl-1,3,5­hexatriene in phospholipid vesicles as determined by Global analysis of frequency domain fluorimetry data. Biochemistry 30 (22), 5565-5572

            (1991).

J-119                   Parasassi, T., G. De Stasio, R. M. Rusch and E. Gratton. A photophysical model for 1,6-Diphenyl­1,3,5-Hexatriene fluorescence decay in solvents and in phospholipid vesicles. Biophys. J. 59(2), 466­475 (1991).

J-120                   Axelsen, P. H., E. Gratton and F. G. Prendergast. Experimentally verifying molecular dynamics simulations through fluorescence anisotropy measurements. Biochemistry 30, 1173-1179 (1991).

J-121                   Parasassi, T. and E. Gratton. Packing of phospholipid vesicles studied by oxygen quenching of Laurdan fluorescence. J. Fluorescence, 2 (3), 167-174 (1992).

J-122                   Parasassi, T., G. Ravagnan, O. Sapora and E. Gratton. Membrane oxidative damage induced by ionizing radiation detected by diphenylhexatriene fluorescence lifetime distributions. Int. J. Rad. Biol. 61(6), 791-796 (1992).

J-123                   Mei, G., N. Rosato, N. Silva, R. Rusch, E. Gratton, I. Savini and A. Finazzi-Agrò. Denaturation of human Cu/Zn superoxide dismutase by guanidine hydrochloride: A dynamic fluorescence study. Biochem. J. 31(32), 7224-7230 (1992).

J-124                   Gratton, E. Frequency domain fluorescence lifetime measurements using synchrotron radiation. In Synchrotron Radiation and Dynamic Phenomena (A. Beswick, Ed.) Conf. Proc. 258, Particles and Fields Series 49, 453-464 (1992).

J-125                   Gratton, E., N. Silva, G. Mei, N. Rosato, I. Savini and A. Finazzi-Agró. Fluorescence lifetime distribution of folded and unfolded proteins. Int'l J. of Quantum Chem. 2, 1479-1489 (1992).

J-126                   Bucci, E., Z. Gryczynski, E. Gratton and T. Tenenholz. Heme- tryptophan relationships in hemoglobin explored by frequency-domain time- resolved fluorescence at 10 GHz resolution. In Proc. SPIE 1640, Time-Resolved Laser Spectroscopy in

                  Biochemistry III. J. R. Lakowicz, ed., 784­791 (1992).

J-127                   Clegg, R. M., B. Feddersen, E. Gratton and T. M. Jovin. Time resolved imaging fluorescence microscopy. In Proc. SPIE 1640, Time-Resolved Laser Spectroscopy in Biochemistry III. J. R. Lakowicz, ed., 448-460 (1992).

J-128                   Berland, K., E. Gratton and M. vandeVen. A laser heterodyning detector for frequency-domain ultrafast spectroscopy. In Proc. SPIE 1640, Time-Resolved Laser Spectroscopy in Biochemistry III. J. R. Lakowicz, ed., 370-378 (1992).

J-129                   Van Der Meer, B. W., M. A. Raymer, S. L. Wagoner, R. L. Hackney, J. M. Beechem, & E. Gratton. Models for fluorescence energy transfer between moving donors and acceptors. In Proc. SPIE 1640, Time-Resolved Laser Spectroscopy in

                  Biochemistry III. J. R. Lakowicz, ed., 220-229 (1992).

J-130                   French, T., E. Gratton and J. Maier. Frequency domain imaging of thick tissues using a CCD. In Proc. SPIE 1640, Time-Resolved Laser Spectroscopy in Biochemistry III. J. R. Lakowicz, ed., 254­261 (1992).

J-131                   vandeVen, M., B. Barbieri, E. Gratton and J. Maier. Analysis of noise sources in frequency domain fluorometry. In Proc. SPIE 1640, Time-Resolved Laser Spectroscopy in Biochemistry III. J. R. Lakowicz, ed., 332-341 (1992).

J-132                   Fishkin, J. and E. Gratton. Diffraction of intensity modulated light in strongly scattering media in the presence of a "semi-infinite" absorbing or reflecting plane bounded by a straight edge. In Proc. SPIE 1640, Time-Resolved Laser Spectroscopy in

                  Biochemistry III. J. R. Lakowicz, ed., 362-367 (1992).

J-133                   Silva, N., E. Gratton, G. Mei, N. Rosato, R. Rusch and A. Finazzi-Agrò. Molten globule monomers in human superoxide dismutase. Biophys. Chem. 48, 171-182 (1993).

J-134                   Bismuto, E., E. Gratton, I. Sirangelo, and G. Irace. Structure and dynamics of the acidic compact state of apomyoglobin by frequency-domain fluorometry. Eur. J. Biochem. 218, 213-219, (1993).

J-135                   Mantulin, W. W., J. B. Fishkin, P. T. C. So, E. Gratton and J. S. Maier. Quantitative diffusive wave spectroscopy in tissues. In Proc. SPIE 1888, Photon Migration and Imagining in Random Media and Tissues. B. Chance and R. R. Alfano, eds.,

            420-427 (1993).

J-136                   Maier, J. S. and E. Gratton. Frequency-domain methods in optical tomography: detection of localized absorbers and a backscattering reconstruction scheme. Photon Migration and Imagining in Random Media and Tissues (B. Chance and R. R.

            Alfano, Ed.), SPIE Proc. 1888, 440-451 (1993).

J-137                   Govindjee, M. vandeVen, J. Cao, C. Royer and E. Gratton. Multifrequency cross-correlation phase fluorometry of chlorophyll a fluorescence in thylakoid and PSII-enriched membranes. Photochem. and Photobiol. 58 (3), 438-445 (1993).

J-138                   Mantulin, W. W., T. French and E. Gratton. Optical imaging in the frequency domain. In: Proc. SPIE 1892, Medical Laser and Systems II. D. M. Harris and C. KM. Penny, eds., 158-166 (1993).

J-139                   Zolese, G., R. Staffolani, L. Mazzanti and E. Gratton. Effect of divalent cations on Na+, K+ -ATPase obtained from human placenta. Fed. of European Biochem. Soc. 323 (1,2) 11-14 (1993).

J-140                   Van Der Meer, B. W., M. A. Raymer, S. L. Wagoner, R. L. Hackney, J. M. Beechem, and E. Gratton. Designing matrix models for fluorescence energy transfer between moving donors and acceptors. Biophys. J. 64(4), 1243-1263 (1993).

J-141                   Fiorini, R., G. Curatola, A. Kantar, P. L. Giorgi and E. Gratton. Use of Laurdan fluorescence in studying plasma membrane organization of polymorphonuclear leukocytes during the respiratory burst. Photochem. and Photobiol. 57 (3), 438-441

            (1993).

J-142                   Levi, M., P. V. Wilson, O. J. Cooper and E. Gratton. Lipid phases in renal brush border membranes revealed by Laurdan fluorescence. Photochem. and Photobiol. 57(3), 420-425 (1993).

J-143                   Parasassi, T., G. Ravagnan, R. M. Rusch and E. Gratton. Modulation and dynamics of phase properties in phospholipid mixtures detected by Laurdan fluorescence. Photochem. and Photobiol. 57(3), 403-410 (1993).

J-144                   Gratton, E., W. W. Mantulin, M. J. vandeVen, J. B. Fishkin, M. B. Maris and B. Chance. A novel approach to laser tomography. Bioimaging 40-46 (1993).

J-145                   Fishkin, J. and E. Gratton. Propagation of photon density waves in strongly scattering media containing an absorbing "semi-infinite" plane bounded by a straight edge. J. of the Optical Soc. of America A. 10(1), 127-140 (1993).

J-146                   Maris, M., E. Gratton, J. Maier, W. Mantulin and B. Chance. Functional near-infrared imaging of deoxygenated hemoglobin during exercise of the finger extensor muscles using the frequency-domain technique. Bioimaging 2, 174-183 (1994).

J-147                   Berland, K. M., So, P. T. C. and E. Gratton. Two-photon fluorescence correlation spectroscopy: method and application to the intracellular environment. Biophys. J. 68, 694-701 (1995).

J-148                   Silva, N., E. Gratton and G. Mei. Proteins fluorescence and conformational substates: The dynamics of human superoxide dismutase. Comments on Cell. and Mol. Biophys. 8 (4), 217-242 (1994).

J-149                   Maier, J. S., S. A. Walker, S. Fantini, M. A. Franceschini and E. Gratton. Possible correlation between blood glucose concentration and reduced scattering coefficient of tissues in the near-infrared. Optics Letters 19 (24), 2062-2064 (1994).

J-150                   Parasassi, T., M. Di Stefano, M. Loiero, G. Ravagnan and E. Gratton. Cholesterol modifies water concentration and dynamics in phospholipid bilayers. A fluorescence study using Laurdan probe. Biophys. J. 66, 763-766 (1994).

J-151                   Parasassi, T., M. Di Stefano, M. Loiero, G. Ravagnan and E. Gratton. Influence of cholesterol on phospholipid bilayers phase domains as detected by Laurdan fluorescence. Biophys. J. 66, 120-132 (1994).

J-152                   Parasassi, T., A. M. Giusti, E. Gratton, E. Monaco, M. Raimondi, G. Ravagnan and O. Sapporo. Evidence for an increase in water concentration in bilayers after oxidative damage of phospholipids induced by ionizing radiation. Int. J. Radiat. Biol.

            65, 329-334 (1994).

J-153                   Ferreira, S. T. and E. Gratton. Anisotropic rotational diffusion of the adenine moiety in 1,N6­ethenoadenosine triphosphate (-ATP) in viscous solvents investigated by time-resolved fluorescence spectroscopy. J. of the Amer. Chem. Soc. 116 (13),

            5791-5795 (1994).

J-154                   Fantini, S., M. A. Franceschini, J. B. Fishkin, B. Barbieri and E. Gratton. Quantitative determination of the absorption spectra of chromophores in strongly scattering media: a light-emitting-diode based technique. Appl. Opt. 33 (22), 5204-5213

           (1994).

J-155                   Gratton, E., S. Fantini, M. A. Franceschini, J. B. Fishkin and J. Maier. Near-infrared optical spectroscopy of tissues using an LED frequency domain spectrometer. Proc. Advances in Optical Imaging & Photon Migration Topical Mtg. 21 (R. R.

            Alfano, Ed., Proc. Optical Soc. of Amer.) 278­282 (1994).

J-156                   So, P., T. French and E. Gratton. A frequency domain time-resolved microscope using a fast-scan CCD camera. In Proc. SPIE 2137, Time resolved Laser Spectroscopy in Biochemistry IV, J. R. Lakowicz, ed., 83-92 (1994).

J-157                   Gryczynski, Z. C.Fronticelli, E. Gratton, J. Lubkowski, E. Bucci. Effect of disordered hemes and dimerization in isolated a-subunits of hemoglobin detected by time-resolved fluorescence spectroscopy in the picosecond range.  In Proc. SPIE 2137,

                  Time resolved Laser Spectroscopy in Biochemistry IV, J. R. Lakowicz, ed., 129-134 (1994).

J-158                   Fantini, S., M. A. Franceschini and E. Gratton. Semi-infinite geometry boundary problem for light migration in highly scattering media: a frequency-domain study in the diffusion approximation. J. Optical Soc. of Amer.11(10), 2128-2138 (1994).

J-159                   Fantini, S., M. A. Franceschini, J. B. Fishkin and E. Gratton. Absolute measurement of absorption and scattering coefficients spectra of a multiply scattering medium. In: Proc. SPIE 2131, Biomedical Fiber Optic Instrumentation, A. Katzir, ed., 356-

            364 (1994).

J-160                   Fantini, S., M. A. Franceschini and E. Gratton. LED based quantitative measurement of absorption and scattering coefficient spectra of a strongly scattering medium. In Proc. SPIE 2131, Biomedical Fiber Optic Instrumentation. A. Katzir, ed., 356-

            364 (1994).

J-161                   Franceschini, M. A., S. Fantini and E. Gratton. LED's in frequency-domain spectroscopy of tissues. In Proc SPIE 2135, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases. R. R. Alfano, ed., 300-306 (1994).

J-162                   Mantulin, W. W. and E. Gratton. Spectroscopic innovations at the Laboratory for Fluorescence Dynamics. In: Proc. SPIE 2100, Cell and Biotissue Optics: Applications in Laser Diagnostics and Therapy. V. V. Tuchin, ed., 6-18 (1994).

J-163                   Fantini, S., M. A. Franceschini, J. B. Fishkin, W. W. Mantulin and E. Gratton. The absorption spectra of a chromophore in highly scattering media. In: Proc. SPIE 2100, Cell and Biotissue Optics: Applications in Laser Diagnostics and Therapy. V.

            V. Tuchin, ed., 114-123 (1994).

J-164                   Brunet, J. E., V. Vargas, E. Gratton and D. Jameson. Hydrodynamics of horseradish peroxidase revealed by global analysis of multiple fluorescence probes. Biophys. J. 66, 446-453 (1994).

J-165                   Ferreira, S. T., L. Stella and E. Gratton. Conformational dynamics of bovine Cu, Zu superoxide dismutase revealed by time-resolved fluorescence spectroscopy of the single tyrosine residue. Biophys. J. 66, (4), 1185-1196 (1994).

J-166                   Gratton, G., J. S. Maier, M. Fabiani, W. W. Mantulin and E. Gratton. Feasibility of intracranial near-infrared optical scanning. Psychophysiology 31, 211-215 (1994).

J-167                   Gratton, E. and J. Maier. Frequency-domain measurements of photon migration in highly scattering media. In Proc. SPIE Medical Optical Tomography: Functional Imaging and Monitoring.  G. Müller, B. Chance, R. Alfano, S. Arridge, J. Beuthan,

            E. Gratton, M. Kaschke, B. Masters, S. Svanberg and P. van der Zee, eds., 534-544 (1994).

J-168                   Parasassi, T., M. Loiero, M. Raimondi, G. Ravagnan and E. Gratton. Absence of lipid gel-phase domains in seven mammalian cell lines and in four primary cell types. Biochim. Biophys. Acta 1153, 143-154 (1994).

Bernsdorff, C., R. Winter, T. L. Hazlett, and E. Gratton. Influence of Cholesterol and BSitosterol on the Dynamic Behaviour of DPPC as Detected by TMA-DPH and PyrPc Fluorescence: A Fluorescence Lifetime Distribution and Time-Resolved             Anisotropy Study, Ber. Bunsenges. Phys. Chem. 99, 1479-1488 (1995).

J-169                   So, P. T. C., T. French, W. M. Yu, K. M. Berland, C. Y. Dong, and E. Gratton. Time-resolved fluorescence microscopy using two photon excitation. Bioimaging 3, 49-63 (1995).

J-170                   Giusti, A. M., E. Gratton, T. Parasassi, M. Raimondi and G. Ravagnan. Cholesterol effects on membrane structure and dynamics as detected by Laurdan fluorescence. Biochimica in Italia 3 64-72 (1995).

J-171                   Parasassi, T., A. M. Giusti, M. Raimondi, G. Ravagnan, O. Sapora and E. Gratton. Cholesterol protects the phospholipid bilayer from oxidative damage. Free Radical Biol. and Med. 19 (4), 511­516 (1995).

J-172                   Gratton, G., M. Fabiani, D. Friedman, M. A. Franceschini, S. Fantini, P. M. Corballis, and E. Gratton. Rapid changes of optical parameters in the human brain during a tapping task. J. Cognitive Neuroscience 7 (4), 446-456 (1995).

J-173                   Gratton, E. and J. B. Fishkin. Optical spectroscopy of tissue-like phantoms using photon density waves. Comments on Cell. and Mol. Biophys. 8(6), 309-359 (1995).

J-174                   Franceschini, M. A., S. Fantini, S. A. Walker, J. S. Maier, W. W. Mantulin and E. Gratton. Multi­channel optical instrument for near-infrared imaging of tissue. In Proc. SPIE 2389, Optical Tomography, Photon Migration, and Spectroscopy of Tissue

            and Model Media: Theory, Human Studies, and Instrumentation. B. Chance, R. R. Alfano, eds., 264-273 (1995).

J-175                   J. S. Maier, B. Barbieri, A. Chervu, I. Chervu, S. Fantini, M. A. Franceschini, M. Levi W. W. Mantulin, A. Rosenberg, S. A. Walker and E. Gratton. In vivo study of human tissues with a portable near-infrareD tissue spectrometer. In Proc. SPIE

            2387, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases II, R.R. Alfano, ed., 240-248 (1995).

J-176                   Ferrari, M., R. A. De Blasi, S. Fantini, M. A. Franceschini, B. Barbieri, V. Quaresima and E. Gratton. Cerebral and muscle oxygen saturation measurement by a frequency-domain near-infrared spectroscopic technique. In Proc. SPIE 2389,

            Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases II, R.R. Alfano, ed., 868-874 (1995).

J-177                   Fantini, S., M. A. Franceschini, S. A. Walker, J. S. Maier and E. Gratton. Photon path distributions in turbid media: applications for imaging. In Proc. SPIE 2389, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases II,

            R.R. Alfano, ed., 340-349 (1995).

J-178                   Walker, S. A., A. E. Cerussi and E. Gratton. Back-projection image reconstruction using photon density waves in tissues. In Proc. SPIE 2389, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases II, R.R. Alfano, ed.,

            350-357 (1995).

J-179                   Gratton, E. and T. Parasassi. Fluorescence lifetime distributions in membrane systems. J. of Fluorescence 5 (1), 51-57 (1995).

J-180                   Parasassi, T., A. M. Giusti, M. Raimondi and E. Gratton. Abrupt modification of phospholipid bilayer properties at critical cholesterol concentrations, Biophys. J. 68 (5), 1895-1902 (1995).

J-181                   Maier, J. S., S. Fantini, M. A. Franceschini-Fantini, W. W. Mantulin, S. A. Walker and E. Gratton. Application of a portable near-infrared spectrometer in the study of several human tissues. SPIE Proc. 2387 240-248 (1995).

J-182                   Mantulin, W. W., S. Fantini, M. A. Franceschini-Fantini, S. A. Walker, J. S. Maier, and E. Gratton. Tissue optical parameter map generated with frequency domain spectroscopy. In: SPIE Proc., 2396, Biomedical Optoelectronic Instrumentation.  A.

            Katzir, J. A. Harrington, D. M. Harris, eds., 323-330 (1995).

J-183                   Fantini, S., M. A. Franceschini, J. S. Maier, S. A. Walker and E. Gratton. Frequency-domain multi­source optical spectrometer and oximeter, In: Proc. SPIE 2326 Photon Transport in Highly Scattering Tissue; Biomedical Optics Europe'94, Lille,

            France. S. Avrillier, B. Chance, G. J. Mueller, A. V. P., V. V. Tuchin, eds., 108-115 (1995).

J-184                   Carrero, J., D. M. Jameson and E. Gratton. Oxygen penetration and diffusion into myoglobin revealed by quenching of Zincprotoporphyrin IX fluorescence. Biophys. Chem. 54 143-154 (1995).

J-185                   Fishkin, J. B., P. T. C. So, A. E. Cerussi, S. Fantini, M. A. Franceschini and E. Gratton. Frequency-domain method for determining spectral properties in multiple scattering media: methemoglobin absorption spectrum in a tissue-like phantom.

            Applied Optics 34 (7), 1143-1155 (1995).

J-186                   Fantini, S., M. A. Franceschini, J. S. Maier, S. A. Walker, B. Barbieri and E. Gratton. Frequency-domain multichannel optical detector for non-invasive tissue spectroscopy and oximetry. Opt. Eng. 34 (1), 32-42 (1995).

J-187                   De Blasi, R. A., S. Fantini, M. A. Franceschini, M. Ferrari and E. Gratton. Cerebral and muscle oxygen saturation measurement by a novel frequency-domain near-infrared spectrometer. Medical & Biological Engineering & Computing 33, 228-230

            (1995).

J-188                   Parasassi, T. and E. Gratton. Membrane lipid domains and dynamics as detected by Laurdan fluorescence. J. of Fluorescence. 5 (1), 59-69 (1995).

J-189                   Dong, C. Y., P. T. C. So, T. French, and E. Gratton. Fluorescence lifetime imaging by asynchronous pump-probe microscopy. Biophys. J. 69, 2234-2242 (1995).

J-190                   Gratton, E., C. Y. Dong, P. T. C. So. Fluorescence Lifetime Microscopy: A Stimulated-emission Approach. In: Proc. SPIE 2678, Optical Diagnostics of Living Cells and Biofluids. D. L. Farkas, R. C. Leif, A. V. Priezzhev, T. Asakura, B. J.

            Tromberg, eds., 98-109 (1996).

J-191                   Walker, S., S. Fantini and E. Gratton. Back-projection reconstructions of cylindrical inhomogeneities from frequency domain optical measurements in turbid media. OSA Trends in Optics and Photonics on Advances in Optical Imaging and Photon

                  Migration 2, R. R. Alfano and J. G. Fujimoto, eds., 137­141 (1996).

J-192                   Maier, J. S., A. Cerussi, S. Fantini, M. A. Franceschini and E. Gratton. Quantitative fluorescence in tissue-like media. OSA Trends in Optics and Photonics on Biomedical Optical Spectroscopy and Diagnostics 3, E. Sevick-Muraca and D. Benaron,

            eds., 206-209 (1996).

J-193                   Cerussi, A., J. Maier, S. Fantini, M. A. Franceschini and E. Gratton. The frequency-domain multi-distance method in the presence of curved boundaries. OSA Trends in Optics and Photonics on Biomedical Optical Spectroscopy and Diagnostics 3,

            E. Sevick-Muraca and D. Benaron, eds., 92-97 (1996).

J-194                   Franceschini, M. A., S. Fantini, A. Cerussi, B. Barbieri, B. Chance and E. Gratton. The effect of water in the quantitation of hemoglobin concentration in a tissue-like phantom by near-infrared spectroscopy. OSA Trends in Optics and Photonics 3,

            E. Sevick-Muraca and D. Benaron, eds., 126­130 (1996).

J-195                   Mei, G., A. Di Venere, G. Gilardi, N. Rosato, R. McKay, E. Gratton and A. Finazzi-Agró. Two classes of tryptophans in ascorbate oxidase revealed by time resolved fluorescence. OSA Trends in Optics and Photonics on Advances in Optical

                  Imaging and Photon Migration 2, R. R. Alfano and J. G. Fujimoto, Eds. (1996).

J-196                   Bismuto, E., G. Irace, E. Sirangelo and E. Gratton. Pressure-induced perturbation of ANS­apomyoglobin complex: Frequency domain fluorescence studies on native and acidic compact states. Protein Science 5(1) 121-126 (1996).

J-197                   Berland, K. M., P. T. C. So, Y. Chen, W. W. Mantulin and E. Gratton. Scanning two-photon fluctuation correlation spectroscopy: Particle counting measurements for detection of molecular aggregation. Biophys. J. 71, 410-420 (1996).

J-198                   Gratton, E., S. Fantini, M. A. Franceschini, S. Walker, and J. Maier. Spectroscopy and tomography of tissues in the frequency-domain. October 14-18, 1995, Proc. NATO ARW Workshop on Analytical Use of Fluorescent Probes in Oncology,

            Miami FL (1996).

J-199                   Parasassi, T. and E. Gratton. Comments on DPH fluorescence decrease at critical cholesterol concentration in phospholipid membranes. Biophys. J. March (1996).

J-200                   Barcellona, M. L. and E. Gratton. Torsional dynamics and orientation of DNA-DAPI complexes. Biochemistry 35, 321-333 (1996).

J-201                   Barcellona M. L. and E. Gratton. Fluorescence anisotropy of DNA/DAPI complex: Torsional dynamics and geometry of the complex. Biophys. J. 70 (5), 2341-2351 (1996).

J-202                   Yu, W., P. T. C. So, T. French, and E. Gratton. Fluorescence generalized polarization of cell membranes-a two photon scanning microscopy approach. Biophys. J. 70, 626-636 (1996).

J-203                   Gratton, E., G. Gratton, M. Fabiani and P. M. Corballis. Detection of brain activity using time-resolved interfered techniques. Proc. 5th Conference on Mind-Brain Science Hamamatsu City, Japan. (1996).

J-204                   Fishkin, J. B., S. Fantini, M. J. van de Ven, and E. Gratton. GigaHertz photon density waves in a turbid medium: Theory and experiments. Phys. Rev. E. 53, 2307-2319 (1996).

J-205                   Gratton, E., W. W. Mantulin, G. Weber, C. A. Royer, R. Reininger and R. W. C. Hansen. Fluorescence dynamics of biological systems using synchrotron radiation. Rev. Sci. Instrum. 66 (9), 1-7 (1996).

J-206                   Fantini, S., M. A. Franceschini, G. Gaida, E. Gratton, H. Jess, W. W. Mantulin, K. T. Moesta, P. M. Schlag, and M. Kaschke. Frequency-domain optical mammography: Edge effect corrections. Med. Phys. 23 (1), 149-157 (1996).

J-207                   Berberan-Santos, M. N., J. Canceill, E. Gratton, L. Jullien, J.-M. Lehn, P. So, J. Sutin and B. Valeur. Multichromophoric cyclodextrins. 3. Investigation of dynamics of energy hopping by frequency-domain fluorometry. J. Phys. Chem. 100 15-20

            (1996).

J-208                   Koenig, K., P. T. C. So, W. W. Mantulin, and E. Gratton. Cell damage in two-photon microscopes In: Proc. SPIE 2926, Optical Biopsies and Microscopic Techniques. I. J. Bigio, W. S. Grundfest, H. Schneckenburger, K. Svanberg, P. M. Viallet, eds.

            172-176 (1996).

J-209                   Koenig, K., P. T. C. So, W. W. Mantulin, B. J. Tromberg and E. Gratton. Two-photon excited lifetime imaging of autofluorescence in cells during UVA and NIR photostress. J. Microscopy 183, 197-204 (1996).

J-210                   Bismuto, E., I. Sirangelo, G. Erace, and E. Gratton. Pressure-induced perturbation of apomyoglobin structure: Fluorescence studies on native and acidic compact forms. Biochemistry 35, 1173-1178, (1996).

J-211                   Koenig, K., P. T. C. So, W. W. Mantulin, E. Gratton, T. Krasieva, M. W. Berns and B. J. Tromberg. Two-photon excited cellular autofluorescence induced by cw and femtosecond NIR microradiation. Proc. SPIE, Int. Soc. Opt. Eng., 2628 , 12-19

            (1996).

J-212                   Zolese, G., E. Giambanco, G. Curatola, R. Staffolani, E. Gratton, and R. Donato. Time-resolved fluorescence of S-100a protein: Effect of Ca2+, Mg2+ and unilamellar vesicles of egg phosphatidylcholine. Cell Calcium 20(6), 465-474 (1996).

J-213                   Fantini, S., M. A. Franceschini and E. Gratton. Effective source term in the diffusion equation for photon transport in turbid media. Appl. Opt. 36(1) , 156-163 (1996).

J-214                   Maier, J., S. Walker and E. Gratton. Frequency-domain optical spectroscopy and imaging of tissues. In Biomedical Optical Instrumentation and Laser-assisted Biotechnology. Course on Biomedical Optical Instrumentation and Laser-assisted

            Biotechnology, Erice, Italy, Nov. 10-22, 1995. A. M. Verga Scheggi, S. Martellucci, A. N. Chester and R. Pratesi, eds., Vol. 325, pp. 121-142 (1996).

J-215                   Fantini, S., M. A. Franceschini, G. Gaida, H. Jess, H. Erdl, W. W. Mantulin, E. Gratton, K. M. Moesta, P. M. Schlag and M. Kaschke. Contrast enhancement by edge effect corrections in frequency-domain optical mammography. OSA Trends in

            Optics and Photonics on Advances in Optical Imaging and Photon Migration 2, R. R. Alfano and J. G. Fujimoto, eds., 160-163 (1996).

J-216                   Jess, H., H. Erdl, K. T. Moesta, S. Fantini, M. A. Franceschini, E. Gratton, and M. Kaschke. Intensity modulated breast imaging: Technology and clinical pilot study results. OSA Trends in Optics and Photonics on Advances in Optical Imaging and

            Photon Migration 2, R. R. Alfano and J. G. Fujimoto, eds., 126-129 (1996).

Gratton, G., M. Fabiani, P. Corballis, D. C. Hood, M. Goodman, J. Hirsch, K. Kim, D. Friedman and E. Gratton. Fast and localized event-related optical signals (EROS) in the human occipital cortex: Comparisons with the visual evoked potential and fMRI. Neuroimage 6, 168-180 (1997).

J-217                   Fantini, S., M. A. Franceschini, and E. Gratton, Effective source term in the diffusion equation for photon transport in turbid media, Appl. Opt. 36, 156-163 (1997).

J-218                   Dong, C. Y., P. T. C. So, C. Buehler and E. Gratton. Spatial resolution in scanning pump-probe fluorescence microscopy. Optik, 106(1) 7-14 (1997).

J-219                   Gratton, E., S. Fantini, M. A. Franceschini, G. Gratton and M. Fabiani. Measurements of scattering and absorption changes in muscle and brain. Phil. Trans. R. Soc. London. B 352 , 727-735 (1997).

J-220                   Franceschini, M. A., S. Fantini, A. Cerussi, B. Barbieri, B. Chance and E. Gratton. Quantitative spectroscopic determination of hemoglobin concentration and saturation in turbid medium: Analysis of the effect of water absorption.

            J. of Biomedical Optics 2(2), 147-153 (1997).

J-221                   Franceschini, M. A., K. T. Moesta, S. Fantini, G. Gaida, E. Gratton, H. Jess, W. W. Mantulin, M. Seeber, P. M. Schlag, and M. Kaschke. Frequency-domain techniques enhances optical mammography: Initial clinical results.

            Proc. Natl. Acad. Sci. USA, 94, 6468-6473 (1997).

J-222                   Masters, B. R., P. T. C. So, and E. Gratton. Multi-photon excitation fluorescence and spectroscopy of in vivo human skin. Biophys. J. 72, 2405-2412 (1997).

J-223                   Barshtein. G., L. Bergelson, A. Dagan,  E. Gratton and S. Yedgar, S. Membrane lipid order of human red cells is altered by physiological levels of hydrostatic pressure. Amer. J. Physiol., Heart and Circulatory Physiology, 272, H538-H543 (1997).

J-224                   Koenig, K., P. T. C. So, W. W. Mantulin, and E. Gratton, Cell Damage in Two-Photon Femtosecond Microscopes, Applied Optics 22, 135 (1997).

J-225                   Parasassi, T., E. Gratton, W. Yu, P. Wilson, and M. Levi. Two-photon fluorescence microscopy of laurdan gp-domains in model and natural membranes. Biophys. J. 72 (5), 2413-2429 (1997).

J-226                   Cerussi, A., J. S. Maier, S. Fantini, M. A. Franceschini, W. W. Mantulin and E. Gratton. Experimental verification of a theory for the time-resolved fluorescence spectroscopy of thick tissues. Diffusing Photons in Turbid Media,

            Appl. Opt. 36(1) , 116-124 (1997).

J-227                   S. Fantini, K. T. Moesta, M. A. Franceschini, H. Jess, H. Erdl, E. Gratton, P. M. Schlag, and M. Kaschke, "Instrumentation and Clinical Applications in Frequency-Domain optical Mammography,"

            Proc. 19th Int. Conf.-IEEE/EMBS on Photon Migration Tomography (MS21), A. H. Hielscher and L. Wang, chairs, pp. 2741-2744 (1997).

French, T., P. T. C. So, D. J. Weaver, Jr., T. Coelho-Sampaio, E. Gratton, E. W. Voss, Jr., and J. Carrero. Macrophage-mediated processing of an exogenous fluorescent antigenic probe. I. Use of processing probe with two photon fluorescence microscopy with time resolved and intensity imaging. J. Microscopy, 185 339-353 (1997).

J-228                   Koenig, K., H. Liang, S. Kimel, O. Svaasand, B. J. Tromberg, T. b. Krasieva, M. W. Berns,K. J. Halbhuber, P. T. C. So, W. W. Mantulin, and E. Gratton, Cell damage in UVA and CW/Femtosecond NIR Microscopes.  In Functional Imaging and

                 Optical Manipulation of Livings Cells, SPIE Proc. 2983, 37-44 (1997).

J-229                   So, P. T. C., T Ragan, E. Gratton, J. Carrero, E, Voss. Two-photon Single Particle Tracking in 3-D. In Functional Imaging and Optical Manipulation of Livings Cells, SPIE Proc. 2983, 45-56 (1997).

J-230                   So, P. T. C., K. H. Duggar, K. M. Berland and E. Gratton. Generating an Intracellular Diffusion Map by Two-photon Fluorescence Correlation Spectroscopy, In Material Science of the Cell, Symposium Material Research Society (1997).

J-231                   Walker, S. A., S. Fantini and E. Gratton. Image reconstruction using back-projection from frequency domain optical measurements in highly scattering media. Appl. Opt. 36(1) , 170-179 (1997).

J-232                   Bernsdorff, C., A. Wolf, R. Winter, and E. Gratton. Effect of hydrostatic pressure on water penetration and rotational dynamics in phospholipid-cholesterol bilayers. Biophys. J. 72, 1264-1277 (1997).

J-233                   Cerussi, A. E., S. Fantini, J. S. Maier, W. W. Mantulin, and E. Gratton. Chromophore detection by fluorescence spectroscopy in tissue-like phantoms. SPIE Proc., Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model,

                  and Human Studies II, 2979 pp. 139-150 (1997).

J-234                   Maier, J. S., A. E. Cerussi, S. Fantini, and E. Gratton. Experimental recovery of absorption, scattering, and fluorescence parameters in highly-scattering media from a single measurement. SPIE Proc., Optical Tomography and Spectroscopy of

            Tissue: Theory, Instrumentation, Model, and Human Studies II, 2979 6-13 (1997).

J-235                   Walker, S. A., S. Fantini, and E. Gratton. The effect of index of refraction mismatch on the recovery of optical properties of cylindrical inhomogeneities in an infinite turbid medium. SPIE Proc., Optical Tomography and Spectroscopy of Tissue:

            Theory, Instrumentation, Model, and Human Studies II, 2979 219-225 (1997).

J-236                   Franceschini, M. A., D. Wallace, B. Barbieri, S. Fantini, W. W. Mantulin, S. Pratesi, G. P. Donzelli and E. Gratton. Optical study of the skeletal muscle during exercise with a second generation frequency-domain tissue oximeter. SPIE Proc., Optical

            Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II, 2979 807-814 (1997).

J-237                   Fantini, S., M. A. Franceschini, and E. Gratton. Effect of spatially distributed light sources on the frequency-domain solution to the diffusion equation. SPIE Proc., Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model,

            and Human Studies II, 2979 807-814 (1997).

J-238                   Franceschini, M. A., S. Fantini, L. A. Paunescu, J. S. Maier, and E. Gratton. Influence of a superficial layer in the quantitative spectroscopic study of strongly scattering media. Appl. Opt. 37, 7447-7458 (1998).

J-239                   Masters, B.R., P. T. So, and E. Gratton. Multiphoton Excitation Microscopy of In Vivo Human Skin: Functional and Morphological Optical Biopsy Based on Three-Dimensional Imaging, Lifetime Measurements and Fluorescence Spectroscopy.

            Annals of the New York Academy of Sciences. 838:58-67 (1998).

J-240                   Chance B., M. Cope, E. Gratton, N. Ramanujam, and B. Tromberg. Phase measurement of light absorption and scatter in human tissue. Rev. of Sci. Inst. 69 (10), 3457-3481, (1998).

J-241                   Di Venere, A., G. Mei, G. Gilardi, N. Rosato, F. De Matteis, R. McKay, E. Gratton, and S. Finazzi-Agró. Resolution of heterogeneous fluorescence in multi-tryptophan proteins: ascorbate oxidase. Eur. J. Biochem. 257, 337-343, (1998).

J-242                   Walker, S. A., D. A. Boas, and E. Gratton. Photon density waves scattered from cylindrical inhomogeneities: Theory and experiments. Appl. Opt. 37(10), 1935-1944 (1998).

J-243                   Krasnowska, E., K., E. Gratton, and T. Parasassi. Prodan as a membrane surface fluorescence probe. Partitioning between water and phospholipid phases. Biophys. J. 74: 1984-1993 (1998).

J-244                   Bagatolli, L. A., E. Gratton and G. D. Fidelio. Water dynamics in glysophingolipid aggregates studied by Laurdan fluorescence. Biophys. J. 75:331-341 (1998).

J-245                   Parasassi, T., E. K. Krasnowska, L. Bagatolli, and E. Gratton. Laurdan and prodan as polarity-sensitive fluorescent membrane probes. J. of Fluorescence 8 (4), 365-373 (1998).

J-246                   Toronov, V., M. Filiaci, S. Fantini, and E. Gratton. Photon-density wave correlation spectroscopy detects large-scale fluctuations in turbid media. Phys. Rev. E. 58, 2288-2297 (1998)

J-247                   Fantini, S., S. A. Walker, M. A. Franceschini, K. T. Moesta, P. M. Schlag, M. Kaschke, and E. Gratton. Assessment of the size, position, and optical properties of breast tumors in vivo by non­invasive optical methods, Appl. Opt. 37, 1982-1989

            (1998).

J-248                   So, P. T. C., K. Koenig, K. M. Berland, C. Y Dong, T. French, C. Buehler, T. Ragan, and E. Gratton. New Time-resolved Techniques in Two-photon Microscopy, Cell. Mol. Biol. 44, 771-773 (1998).

J-249                   Masters, B. R., P. So, E. Gratton, Optical Biopsy of In vivo human skin: Multi-photon excitation microscopy, Lasers in Medical Science 13, 197-204 (1998).

J-250                   Kim, K. H., P. T. C. So, I. E. Kochevar, B. R. Masters, and E. Gratton, Two-photon fluorescence and confocal reflected light imaging of thick tissue structures, SPIE Proc. 3260, Eds., D. L. Farkas, R. C. Leif, and B. J. Tromberg, 46-57 (1998).

J-251                   Franceschini, M. A., S. Fantini, R. Palumbo, L. Pasqualini, G. Vaudo, E. Franceschini, E. Gratton, B. Palumbo, S. Innocente and E. Mannarino. Quantitative near-infrared spectroscopy on patients with peripheral vascular disease. In: Proc. SPIE

            3194 (BIOS Europe '97, San Remo, Italy, Sept. 4-8) 112-115 (1998).

J-252                   Quaresima, V., M. A. Franceschini, S. Fantini, E. Gratton and M. Ferrari. Difference in leg muscles oxygenation during treadmill exercise by a new near infrared frequency-domain oximeter. In: Proc. SPIE 3194 (BIOS Europe '97, San Remo, Italy,

            Sept. 4-8) 116-120 (1998).

J-253                   Toronov, V., M. Filiaci, M. Franceschini, S. Fantini, and E. Gratton. Exploring tissue dynamics by photon-density-wave fluctuation correlation spectroscopy, Proc. SPIE 3726, Eds., Tuchin, Ryabukho, Zimnyakov, pp. 555-559 (1999).

J-254                   Cerussi, A. E., E. Gratton, and S. Fantini, Fluorescence lifetime spectroscopy in multiple-scattering environments: An application to biotechnology, SPIE Proc. 3600, Eds., Bornhop, Contag, and Sevick, pp. 171-181, (1999)

J-255                   Casavola, C., L. A. Paunescu, S. Fantini, M. A. Franceschini, P. M. Lugara, and E. Gratton. Application of near-infrared tissue oximeter to the diagnosis of peripheral vascular disease. Clinical Hemorheology and Microcirculation 21, 389-393

            (1999).

J-256                   Nayfeh, M., O. Akcakir, J. Theiren, Z. Yamani, N. Barry, W. Yu and E. Gratton. Highly nonlinear photoluminescence threshold in porous silicon, Appl. Phys. Lett. 75 4112 (1999).

J-257                   Bagatolli, L. A., T. Parasassi, G.D. Fidelio, and E. Gratton. A model for the interaction of 6-Lauroyl­2-(N,N-dimethylamino)naphthalene with lipid environments: Implications for spectral properties. Photochem. and Photobiol. 70 (4), 557-564

            (1999).

J-258                   Bagatolli, L. A. and E. Gratton. Two-photon fluorescence microscopy observation of shape changes at the phase transition in phospholipid's giant unilamellar vesicles. Biophys. J. 77, 2090-2101 (1999).

Stankovic, M. R., D. Maulik, W. Rosenfeld, P. G. Stubblefield, A. D. Kofinas, S. Drexler, R. Nair, M. A. Franceschini, D. Hueber, E. Gratton, and S. Fantini, Real-Time Optical Imaging of Experimental Brain Ischemia and Hemorrhage in Neonatal Piglets, J. Perinat. Med. 27 (4) 279-286 (1999).

J-259                   Fantini, S., D. Hueber, M. A. Franceschini, E. Gratton, W. Rosenfeld, P. G. Stubblefield, D. Maulik, and M. R. Stankovic. Noninvasive optical monitoring of the newborn piglet brain using continuous-wave and frequency-domain spectroscopy.

            Physics in Med. and Biol. 44(6), 1543-63 (1999).

J-260                   Franceschini, M. A., E. Gratton, and S. Fantini. Noninvasive optical method of measuring tissue and arterial saturation: an application to absolute pulse oximetry of the brain. Opt. Lett. 24 (12), 829-831, (1999).

J-261                   Chen, Y., J. D. Müller, P. T. C. So, and E. Gratton, The Photon Counting Histogram in Fluorescence Fluctuation Spectroscopy, Biophys. J. 77: 553-567 (1999).

J-262                   Buehler, C., K. H. Kim, B. R. Masters, P. T. C. So, I. E. Kochevar, and E. Gratton, Two-photon Deep Tissue Imaging, IEEE Engineering in Medicine and Biology 18, 23-30 (1999).

J-263                   Masters, B. R., P. T. C. So, and E. Gratton, Multiphoton excitation microscopy and confocal microscopy of human skin in vivo, Comments on Cell. and Mol. Biophys. 9(6), 379-405 (1999).

J-264                   Masters, B. R., P. T. C. So, K. H. Kim, C. Buehler, and E. Gratton. Multiphoton Excitation microscopy, Confocal Microscopy, and Spectroscopy of Living Cells and Tissues; Functional Metabolic Imaging of Human Skin In Vivo, Methods Enzymol,

            307, 513-536 (1999).

J-265                   Masters, B. R., P. T. C. So, E. Gratton, G. Gonnord, P. Corcuff, Microscopy of Human Skin In Vivo: Multi-photon Excitation and Confocal Microscopy, Microscopy and Microanalysis 5, 282-289 (1999).

J-266                   Parasassi, T., E. Gratton, H. Zajicek, M. Levi, and W. Yu. Detecting membrane lipid microdomains by two-photon fluorescence microscopy. IEEE Engineering in Medicine and Biology 18 (5), 92-99, (1999).

J-267                   Fantini, S., M. A. Franceschini, E. Gratton, D. Hueber, W. Rosenfeld, D. Maulik, P. G. Stubblefield, and M. R. Stankovic. Non-invasive optical mapping of the piglet brain in real time.  Opt. Express 4 (8), 308-314 (1999).

J-268                   Franceschini, M. A., E. Gratton, D. Hueber, and S. Fantini. Near-Infrared Absorption and Scattering Spectra of Tissues in Vivo. SPIE Biomedical Optics '99, San Jose (CA) Vol. 3597, 526-531 (1999).

J-269                   Filiaci, M., M. A. Franceschini, S. Fantini, and E. Gratton. Photon density waves in tissues: a study of the optical properties during changes in the oxygenation level. SPIE Biomedical Optics '99, San Jose (CA) Vol. 3597 (1999).

J-270                   Stankovic, M. R., , D. M. Hueber, D. Maulik, P, G. Stubblefield, W. Rosenfeld, E. Gratton, M. A. Franceschini, and S. Fantini. Real-Time Optical Imaging and Spectroscopy of Brain Ischemia and Hemorrhage. SPIE Biomedical Optics '99,

            San Jose (CA) Vol. 3597 (1999).

J-271                   Toronov, V., M. Filiaci, M. A. Franceschini, S. Fantini, and E. Gratton. Photon-density-wave fluctuation-correlation-spectroscopy: study of coherence in the brain and muscles. SPIE Biomedical Optics '99, San Jose (CA) Vol. 3597 (1999).

J-272                   Lasagna, M., E. Gratton, D. M. Jameson, and J. E. Brunet. Apohorseradish peroxidase unfolding and refolding: Intrinsic tryptophan fluorescence studies. Biophys. J. 76: 443-450 (1999).

J-273                   Paunescu, L. A., C. Casavola, M. A. Franceschini, S. Fantini, L. Winter, J. Kim, D. Wood and E. Gratton. Calf muscle blood flow and oxygen consumption measured with near-infrared spectroscopy during venous occlusion. SPIE Proc. 3597,

            Eds., B. Chance, R. R. Alfano, B. J. Tromberg, pp. 317­323 (1999).

J-274                   Casavola, C., L. A. Paunescu, M. A. Franceschini, S. Fantini, L. Winter, J. Kim, D. Wood, and E. Gratton. Near-infrared spectroscopy and the tilting table protocol: a novel method to study the blood flow and the oxygen consumption in tissues.

            SPIE Proc. 3597, Eds., Britton Chance, Robert R. Alfano, and Bruce J. Tromberg, pp. 685-692 (1999).

J-275                   Buehler, C., C. Y. Dong, P. T. C. So, T. E. French, and E. Gratton. Frequency-domain pump-probe microscopic imaging using intensity-modulated laser diodes In: Proc. SPIE 3603, Systems and Technologies for Clinical Diagnostics and Drug

            Discovery II. G. E. Cohn, J. C. Owicki, eds., 262­271 (1999).

J-276                   Franceschini, M. A., S. Fantini, V. Toronov, M. E. Filiaci, and E. Gratton. Cerebral hemodynamics measured by near-infrared spectroscopy at rest and during motor activation. In Proc. Inter-Institute Workshop on In Vivo Optical Imaging at the

                  NIH, OSA pp. 73-80 (2000).

J-277                   Bettati, S., S. Benci, B. Campanini, S. Raboni, G. Chirico, S. Beretta, K. D. Schnackerz, T. L. Hazlett, E. Gratton, and A. Mozzarelli.  Role of pyridoxal 5'-phosphate in the structural stabilization of 0-acetylserine sulfhydrylase.

            J. Biolog. Chem. 275(51), 40244-40251 (2000).

J-278                   Arcangeli, C., W. Yu, S. Cannistraro, and E. Gratton. Two-photon autofluorescence microscopy and spectroscopy of an Antarctic fungus: a new approach for studying the effect of UV-B irradiation, Biospectroscopy 57(4) 218-225 (2000).

Zolese, G., G. Falcioni, E. Bertoli, R. Galeazzi, M. Wozniak, Z. Wypych, E. Gratton, and A. Ambrosini. Steady-state and time resolved fluorescence of albumins interacting with n­oleylethanolamine, a component of the endogenous n-acylethanolamines. Proteins: Structure, Function, and Genetics 40, 39-40 (2000).

J-279                   Stankovic M. R., D. Maulik, W. Rosenfeld, P. G. Stubblefield, A. D. Kofinas, E. Gratton, M. A. Franceschini, S. Fantini, D. Hueber. 

            The role of frequency domain optical spectroscopy in the detection of neonatal brain hemorrhage - a newborn     piglet study. J Maternal Fetal Medicine 9(2), 142-149 (2000).

J-280                   Chen, Y., J. D. Müller, S. Y Tetin, J. D. Tyner and E. Gratton. Probing ligand protein binding equilibria with fluorescence fluctuation spectroscopy. Biophys. J. 79(2), 1074-1084 (2000).

J-281                   Casavola, C,. L. A. Paunescu, S. Fantini, M. A. and E. Gratton. Blood flow and oxygen consumption with near-infrared spectroscopy and venous occlusion: Spatial maps and the effect of time and pressure of inflation.

            J. of Biomedical Optics 5(3), 269-276 (2000).

J-282                   Parasassi, T., W. Yu, D. Durbin, L. Kuriashkina, E. Gratton, N. Maeda and F. Ursini.  Two-photon microscopy of aorta fibers shows proteolysis induced by LDL hydroperoxides.  Free Radical Biology and Medicine 28(11), 1589-1597 (2000).

J-283                   Bagatolli, L. A., and E. Gratton, A correlation between lipid domain shape and binary phospholipid mixture composition in free standing bilayers. A two-photon fluorescence microscopy study, Biophys. J. 79, 434-447 (2000).

J-284                   Bagatolli, L., E. Gratton, T. K. Khan, and P. L-G. Chong. Two-photon fluorescence microscopy studies of bipolar tetraether giant liposomes from thermoacidophilic archaebacteria sulfolobus acidocaldarius, Biophys. J. 79(1), 416-425 (2000).

J-285                   Buehler, C., C. Y. Dong, P. T. So., T. French, and E. Gratton. Time-resolved polarization imaging by pump-probe (stimulated emission) fluorescence microscopy. Biophys. J. 79, 536-549 (2000).

J-286                   Sukhishvili, S A., Y. Chen, J.D.. Muller, E. Gratton, K.S. Schweizer, S. Granick. Materials science: Diffusion of a polymer 'pancake'. Nature. 406(6792):146 (2000).

J-287                   Eid, J., J. D. Müller, and E. Gratton. Data acquisition card for FCS allowing full access to the detected photon sequence. Rev. of Sci. Inst. 71(2), 361-368 (2000).

J-288                   Bagatolli, L. A., T. Parasassi, and E. Gratton. Giant phospholipid vesicles: comparison among the whole lipid samples characteristics using different preparation methods. A two-photon fluorescence microscopy study, Chemistry and Physics of

            Lipids 105, 135-147 (2000).

J-289                   Fantini, S. and E. Gratton. Fluorescence photon-density waves in optically diffusive media. Optics Communications 173, 73-79 (2000).

J-290                   Franceschini, M. A., V. Toronov, M. Filiaci, E. Gratton, and S. Fantini. On-line optical imaging of the human brain with 160-ms temporal resolution, Optics Express 6(3), 49-57 (2000).

J-291                   Frolov, A., A. Petrescu, B. P. Atshaves, P. T. C. So, E. Gratton, G. Serrero and F. Schroeder.

            High Density Lipoprotein-mediated Cholesterol Uptake and Targeting to Lipid Droplets in Intact L-cell Fibroblasts. A Single- and Multiphoton Fluorescence Approach. J. Biol. Chem. 275, 12769-12780 (2000).

J-292                   Müller, J. D., Y. Chen, and E. Gratton. Resolving heterogeneity on the single molecular level with the photon counting histogram. Biophys. J. 78(1) 474-486 (2000).

J-293                   Bagatolli, L. A. and E. Gratton. Two photon fluorescence microscopy of coexisting lipid domains in giant unilamellar vesicles of binary phospholipid mixtures. Biophys. J., 78 290-305 (2000).

J-294                   Michalos, A., L. A. Paunescu, M. Wolf, U. Wolf, V. Toronov, M. A. Franceschini, S. Fantini, and E. Gratton. Assessment of cerebral oxygenation and hemodynamics in obstructive sleep apnea syndrome. SuH16, Proc. OSA Technical Digest,

            Biomedical Topical Meeting (2000)

J-295                   Toronov, V., M. A. Franceschini, M. Filiaci, S. Fantini, M. Wolf, A. Michalos, and E. Gratton. Near-infrared study of fluctuations in cerebral hemodynamics during rest and motor stimulation: Temporal analysis and spatial mapping,

            Med. Phys. 27(4), 801-815 (2000).

J-296                   Franceschini, M. A., S. Fantini, V. Toronov, M. E. Filiaci, M. P. Wolf, A. Michalos, and E. Gratton. Real-time video of brain activation in human subjects using a non-invasive near-infrared technique. ME6, Proc. OSA Technical Digest,

            Biomedical Topical Meeting (2000).

J-297                   Paunescu, L. A., U. Wolf, M. Wolf, A. Michalos, and E. Gratton. Scattering coefficient-hemoglobin concentration relation determined by frequency-domain spectroscopy during venous occlusion. TuD2. Proc. OSA Technical Digest,

            Biomedical Topical Meeting (2000).

J-298                   Wolf, M., V. Toronov, U. Wolf, L. A. Paunescu, A. Michalos, and E. Gratton. Maps of cerebral hemoglobin concentration changes obtained by near-infrared spectroscopy, Characterization of phase shifts among locations. TuF6, Proc.

            OSA Technical Digest, Biomedical Topical Meeting, pp. 416­418 (2000).

J-299                   Wolf, U., M. Wolf, V. Toronov, A. Michalos, L. A. Paunescu, and E. Gratton. Detecting cerebral functional slow and fast signals by frequency-domain near-infrared spectroscopy using two different sensors. TuF10, Proc. OSA Technical Digest,

            Biomedical Topical Meeting, pp. 427-429 (2000).

J-300                   Toronov, V., M. Wolf, A. Michalos, and E. Gratton. Analysis of cerebral hemodynamic fluctuations measured simultaneously by magnetic resonance imaging and near-infrared spectroscopy. WA5, Proc. OSA Technical Digest, Biomedical Topical

            Meeting (2000).

J-301                   Akcakir, O., J. Theiren, N. Barry, M. Nayfeh and E. Gratton. Detection of luminescent single ultra small silicon nanoparticles using fluctuation correlation spectroscopy, Appl. Phys. Lett. 76, 14 (2000).

J-302                   Toronov V, Fantini S, Franceschini MA, Filiaci M, Wolf M, Gratton E. Temporal analysis of fluctuations in cerebral hemodynamics revealed by near-infrared spectroscopy. In: Proc. SPIE 4001, Saratov Fall Meeting '99: Optical Technologies in

            Biophysics and Medicine. V. V. Tuchin, D. A. Zimnyakov, A. B. Pravdin, eds., 224-227 (2000).

J-303                   Huang, H. C. Y. Dong, J. D. Sutin, H. S. Kwon, G. Cragg, R. Gilbert, R. T. Lee, E. Gratton, R. D. Kamm, D. Lauffenburger, and P. T. So. Magnetic tweezers microscope for cellular manipulation In: Proc. SPIE 3921, Optical Diagnostics of Living

                  Cells III. D. L. Farkas, R. C. Leif, eds., 176-185 (2000).

J-304                   Wolf, M., M. A. Franceschini, L. A. Paunescu, V. Toronov, A. Michalos, U. Wolf, E. Gratton, and S. Fantini. Absolute frequency-domain pulse oxymetry of the brain: Methodology and measurements. In: Proc. ISOTT Oxygen Transport to Tissue

                  XXII. 27th Annual Meeting of ISOTT, J. F. Dunn, H. M. Swartz, eds. (2000).

J-305                   Toronov, V., A. Webb, J-H. Choi, M. Wolf, and E. Gratton. Simultaneous assessment of human brain functional hemodynamics by magnetic resonance and near-infrared imaging. In: Proc. SPIE 4320, Medical Imaging 2001: Physics of Medical

            Imaging. L. E. Antonuk, M. J. Yaffe, eds., 861-867 (2001).

J-306                   Toronov, V. Y., A. G. Webb, J. H. Choi, M. Wolf, L. P. Safonova, U. Wolf, E. Gratton. Functional cerebral activation detected by frequency-domain near-infrared spectroscopy. In: Proc. SPIE, Optical Technologies in Biophysics and Medicine III;

            Saratov Fall Meeting, V. V. Tuchin; ed., Vol. 4707, 92-96 (2001).

J-307                   Sanchez, S. A., Y. Chen, J. D. Mueller, E. Gratton, T. L. Hazlett. Solution and interface aggregation states of C. atrox venom phospholipase A2 by 2-photon excitation fluorescence correlation spectroscopy. Biochemistry 40, 6903-6911 (2001).

J-308                   Bagatolli, L. A., and E. Gratton. Direct observation of lipid domains in free standing bilayers using two-photon excitation fluorescence microscopy. J. of Fluorescence 11(3), 141-160 (2001).

J-309                   Bismuto, E., E. Gratton, and D. C. Lamb. Dynamics of ANS Binding to Tuna Apomyoglobin Measured with Fluorescence Correlation Spectroscopy. Biophys. J. 81, 3510-3521 (2001).

J-310                   Gratton, E., N. P. Barry, S. Beretta and A. Celli. Multiphoton Fluorescence Microscopy. Methods 25(1), 103-110 (2001).

J-311                   Toronov, V., A. Webb, J-H. Choi, M. Wolf, L. Safonova, U. Wolf and E. Gratton.

            Study of local cerebral hemodynamics by frequency-domain near-infrared spectroscopy and correlation with simultaneously acquired functional magnetic resonance imaging. Optics Express 9(8), 417-427 (2001).

J-312                   Krasnowska, E. K., L. A. Bagatolli, E. Gratton and T. Parasassi. Surface properties of cholesterol-containing membranes detected by Prodan fluorescence. BBA - Biomembranes 1511(2) 330-340 (2001).

J-313                   Van Rompaey, E., Y. Chen, J. D. Mueller, E. Gratton, E. Van Craenenbroeck, Y. Engelborghs, S. De Smedt and J. Demeester.  Fluorescence fluctuation analysis for the study of interactions between oligonucleotides and polycationic polymers.

            Biological Chem. 382, 379-386 (2001).

J-314                   Margeat, E., N. Poujol, A. Boulahtouf, Y. Chen, J. D. Muller, E. Gratton, V. Cavailles, and C. Royer. The Human estrogen receptor a dimer binds a single SRC-1 coactivator molecule with an affinity dictated by agonist structure. 

            J. Mol. Biol. 306 (3), 433-442 (2001).

J-315                   Toronov, V., A. Webb, J. H. Choi, M. Wolf, A. Michalos, E. Gratton and D. Hueber.  Investigation of human brain hemodynamics by simultaneous near-infrared spectroscopy and functional magnetic resonance imaging. Medical Physics 28(4)

            521-527 (2001).

J-316                   Chirico, G., S.Bettati, A. Mozzarelli, Y. Chen, J. D.Müller, and E. Gratton. Molecular Heterogeneity of O-Acetylserine Sulfhydrylase by Two-Photon Excited Fluorescence Fluctuation Spectroscopy. Biophys J. 80(4), 1973-1985 (2001).

J-317                   Dietrich, C., L. A. Bagatolli, Z. N. Volovyk, N. L. Thompson, M. Levi, K. Jacobson, and E. Gratton. Lipid Rafts Reconstituted in Model Membranes. Biophys. J. 80(3), 1417-1428 (2001).

J-318                   Dong, C-Y, C. Buehler, P. T. C. So, T. French, and E. Gratton. Implementation of intensity-modulated laser diodes in time-resolved, pump-probe fluorescence microscopy. Appl. Opt. 40, 1109-1115 (2001).

J-319                   Barcellona, M. L., Y. Chen, J. D. Müller, and E. Gratton. 4',6-diamidino-2-phenylindole (DAPI) interacts with rare structures of GC polymers.  Eur. Biophys. J. 30 (2), 98-109 (2001).

J-320                   Nayfeh, M. H., J. Therrien, G. Belomoin, A. Akcakir, N. Barry, and E. Gratton. Stimulated blue emission and second harmonic generation from films of ultrasmall Si nanoparticles.  In: Proc. Materials Research Society Symposium, V. 638 F951-

            F9512 (2001).

J-321                   Ragan, T., P. T. C. So, H-S.Kwon, and E. Gratton. 3D particle tracking on the two-photon microscope In: Proc. SPIE 4262, Multiphoton Microscopy in the Biomedical Sciences. A. Periasamy, P. T. So, eds., 247-258 (2001).

J-322                   Toronov, V., A. Webb, J. H. Choi, M. Wolf, E. Gratton, and D. M. Hueber. Simultaneous functional magnetic resonance and near-infrared imaging of adult human brain. In: Proc. SPIE 4250, Optical Tomography and Spectroscopy of Tissue IV.

            B. Chance, R. R. Alfano, B. J. Tromberg, M. Tamura, E. M. Sevick-Muraca, eds. 380-382 (2001).

J-323                   Paunescu, L. A., A. Michalos, J. H. Choi, U. Wolf, M. Wolf, and E. Gratton. In vitro correlation between reduced scattering coefficient and hemoglobin concentration of human blood determined by near-infrared spectroscopy.

            In: Proc. SPIE Proc. 4250, BIOS 2001; Internatonal Biomedical Optics Symposium. Optical Tomography and Spectroscopy of Tissue IV. B.Chance, R.R. Alfano, B.J. Tromberg, M. Tamura, E.M. Sevick-Muraca, eds., 319-326 (2001).

J-324                   Ruan, Q., Y. Chen, E. Gratton, M. Glaser and W. W. Mantulin. Cellular characterization of adenylate kinase and its isoform; Two-photon excitation fluorescence imaging and fluorescence correlation spectroscopy. Biophys. J. 83 (6), 3177-3187

            (2002).

J-325                   Hanson, K.M., M. J. Behne, N. P. Barry, T. M. Mauro, E. Gratton, and R. M. Clegg. Two-photon fluorescence lifetime imaging of the skin stratum corneum pH gradient. Biophys J. 83(3), 1682-1690 (2002).

J-326                   Wolf, M., U. Wolf, J.H. Choi, R. Gupta, L. P. Safonova, L. A. Paunescu, A. Michalos and E. Gratton. Functional Frequency-Domain Near-Infrared Spectroscopy Detects Fast Neuronal Signal in the Motor Cortex,

            NeuroImage 17(4), 1868-1875 (2002).

J-327                   Wolf, M., U. Wolf, V. Toronov, A. Michalos, L. A. Paunescu, J-H. Choi and E. Gratton.

            Different time evolution of oxyhemoglobin and deoxyhemoglobin concentration changes in the visual and motor cortices during functional stimulation: A near-infrared spectroscopy study. NeuroImage 16, 704-712 (2002).

J-328                   Bettati, S., B.Campanini, S. Vaccari, A. Mozzarelli, G. Schianchi, T. L. Hazlett, and E. Gratton. Unfolding of pyridoxal 5'-phosphate-dependent O-acetylserine sulfhydrylase probed by time-resolved tryptophan fluorescence. Biochim. Biophys. Acta

            1596(1), 47-54 (2002).

J-329                   Tricerri, M A., S. A. Sanchez, C. Arnulphi, D. M. Durbin, E. Gratton, A. Jonas. Interaction of apolipoprotein A-I in three different conformations with palmitoyl oleoyl phosphatidylcholine vesicles, J. of Lipid Research 43(2), 187-197 (2002).

J-330                   Patel, R. C; U. Kumar, D. C. Lamb, J. S. Eid, M. Rocheville, M. Grant, A. Rani, T. Hazlett, S. C. Patel, E. Gratton, Y. C. Patel. Ligand binding to somatostatin receptors induces receptor-specific oligomer formation in live cells. Proc. of the National

            Academy of Sciences of the USA 99(5), 3294­3299 (2002).

J-331                   Fahsel, S., E.-M. Pospiech, M. Zein, T. L. Hazlet, E. Gratton, and R. Winter. Modulation of Concentration Fluctuations in Phase-Separated Lipid Membranes by Polypeptide Insertion. Biophys. J. 83, 334-344 (2002).

J-332                   Behne, M.J., J. W. Meyer, K. M. Hanson, N. P. Barry, S. Murata, D. Crumrine, R. W. Clegg, E. Gratton, W. M. Holleran, P. M. Elias, and T. M. Mauro.

            NHE1 regulates the stratum corneum permeability barrier homeostasis. Microenvironment acidification assessed with fluorescence lifetime imaging. J Biol Chem. 277(49):47399-47406 (2002).

J-333                   Sanchez, S.A., L. A. Bagatolli, E. Gratton, and T. L. Hazlett. A Two-Photon View of an Enzyme at Work: Crotalus atrox Venom PLA2 Interaction with Single-Lipid and Mixed-Lipid Giant Unilamellar Vesicles. Biophys. J. 82, 2232-2243 (2002).

J-334                   Chen, Y., J. D. Müller, Q.Q. Ruan, and E. Gratton. Molecular Brightness Characterization of EGFP in Vivo by Fluorescence Fluctuation Spectroscopy. Biophys. J. 82, 133-144 (2002).

J-335                   Sukhishvili, S. A., Y. Chen, J.D. Muller, E. Gratton, K. S. Schweizer, S. Granick. Surface Diffusion of Poly(ethylene glycol). Macromolecules 35(5), 1776-1784 (2002).

J-336                   Barry, N. P., K. M. Hanson, E. Gratton, R. M. Clegg, M. J. Behne, and T. Mauro. Applications of ultrafast lasers to two-photon fluorescence and lifetime imaging. In: Proc. SPIE 4633, Commercial and Biomedical Applications of Ultrafast and Free-

            Electron Lasers. G. S. Edwards, J. Neev, A. Ostendorf, J. C. Sutherland, eds., 50-61 (2002).

J-337                   Morren, G., M. Wolf, P. Lemmerling, U. Wolf, J. H. Choi, E. Gratton, L. De Lathauwer, and S. Van Huffel.

            Extraction of fast neuronal changes from multichannel functional near-infrared spectroscopy signals using independent component analysis. In: Proc. SPIE 4623 , Functional Monitoring and Drug-Tissue Interaction. M. D. Kessler, G. J. Mueller;

            eds., 68-76 (2002).

J-338                   Toronov, V., E. D'Amico, D. Hueber, E. Gratton, B. Barbieri, A.Webb. Optimization of the signal-to-noise ratio of frequency-domain instrumentation for near-infrared spectro-imaging of the human brain. Optics Express 11(21), 2717-2729 (2003).

J-339                   Levi, V., Q. Ruan, K. Kis-Petikova and E. Gratton. Scanning FCS, a novel method for three-dimensional particle tracking. Biochem. Soc. Transactions 31(5), 997-1000 (2003).

J-340                   Toronov, V., A. Webb, S. Walker, R. Gupta, J. H. Choi, E. Gratton, and D. M. Hueber. Study of the FMRI blood oxygen level dependent effect by near-infrared spectroscopy.  In: Proc. SPIE Int. Soc. Opt. Eng. 5068, 222 (2003).

J-341                   Gratton, E., Scanning FCS: measuring spatio-temporal correlations in the millisecond range. In: Proc. SPIE, Vol. #4963, San Jose, CA (2003).

J-342                   Gaus, K., E. Gratton, E. P. W. Kable, A. S. Jones, I. Gelissen, L. Kritharides, and W. Jessup. Visualizing lipid structure and raft domains in living cells with two-photon microscopy. Proc. Nat. Acad. Sci. 100, 15554-15559 (2003).

J-343                   Muller, J. D. and E. Gratton. High-pressure fluorescence correlation spectroscopy. Biophys. J. 85, 2711-2719 (2003).

J-344                   Wolf, U., M. Wolf, J. H. Choi, M. Levi, D. Choudhury, S. Hull, D. Coussirat, L. A. Paunescu, L. P. Safonova, A. Michalos, W. W. Mantulin and E. Gratton.

            Localized irregularities in hemoglobin flow and oxygenation in the calf muscle in patients with peripheral vascular disease detected by near-infrared spectrophotometry. J. Vasc. Surgery 37, 1017-1026 (2003).

J-345                   Toronov. V. S. Walker, R. Gupta, J. H. Choi, E. Gratton, D. Hueber and A. Webb.  The roles of changes in deoxyhemoglobin concentration and regional cerebral blood volume in the fMRI BOLD signal. NeuroImage 19 (4), 1521-1531(2003).

J-346                   Gratton, E., S. Breusegem, J. Sutin, Q. Ruan and N. Barry. Fluorescence lifetime imaging for the two-photon microscope: Time-domain and frequency-domain methods. J. of Biomedical Optics 8(3), 381-390 (2003).

J-347                   Wolf, M., M.A.  Franceschini, L.A. Paunescu, V. Toronov, A. Michalos, U. Wolf, E. Gratton and S. Fantini. Absolute frequency-domain pulse oximetry of the brain: Methodology and measurements. Adv Exp Med Biol. 530: 61-73 ( 2003).

J-348                   Behne, M. J. N.P. Barry, K. M. Hanson, I. Aronchik, R. W. Clegg, E. Gratton, K. Feingold, W. M. Holleran, P.M. Elias, T.M. Mauro.

            Neonatal development of the Stratum Corneum pH gradient: localization and mechanisms leading to emergence of optimal barrier function. J of Invest. Dermatology. 120(6), 998-1006, 2003.

J-349                   Wolf, M., U. Wolf J.H. Choi, V. Toronov, L. A. Paunescu, A. Michalos, and E. Gratton. Fast cerebral functional signal in the 100ms range detected in the visual cortex by frequency-domain near-infrared spectroscopy.

            Psychophysiology 40, 521-528 (2003).

J-350                   Wolf, M., U. Wolf, J. H. Choi, R. Gupta, L. P. Safonova, L. A. Paunescu, A. Michalos and E. Gratton. Detection of the fast neuronal signal on the motor cortex using functional frequency domain near infrared spectroscopy.

            Adv. Exp. Med. Biol. 510, D. F. Wilson, S. M. Evans, J. Biaglow, A. Pastuszko, eds., 193-197 (2003).

J-351                   Wolf, U., M. Wolf, J. H. Choi, L. A. Paunescu, A. Michalos, L. Safonova and E. Gratton. Mapping of hemodynamics with near infrared spectroscopy of the human calf tissue and the influence of the adipose tissue thickness.

            Adv. Exp. Med. Biol. D. F. Wilson, S. M. Evans, J. Biaglow, A. Pastuszko, eds., 225-230 (2003).

J-352                   Best, K. B., A. J. Ohran, A. C. Hawes, T. L. Hazlett, E. Gratton, A. M. Judd, and J. D. Bell. Relationship between erythrocyte membrane phase properties and susceptibility to secretory phospholipase A2. Biochemistry 41(47), 13982-13988 (2003).

J-353                   Zamai, M., M. VandeVen, M. Farao, E. Gratton, A. Ghiglieri, M. G. Castelli, E. Fontana, R. D'Argy, A. Fiorino, E. Pesenti, A. Suarato, V. R. Caiolfa.

            Camptothecin poly[n-(2-hydroxypropyl) methacrylamide] copolymers in antitopoisomerase-I tumor therapy: intratumor release and antitumor efficacy. Mol Cancer Ther. 2(1), 29-40 (2003).

J-354                   Safonova L.P., A. Michalos, U. Wolf, M. Wolf, W.W. Mantulin, D.M. Hueber and E. Gratton. Diminished cerebral circulatory autoregulation in obstructive sleep apnea investigated by near-infrared spectroscopy. Sleep Research On-line 5(4), 126-

            132 (2003).

J-355                   Barcellona, M. L., S. Gammon, T. Hazlett, M. Digman and E. Gratton. Polarized fluorescence correlation spectroscopy of DNA-DAPI complexes. Microscopy Res. and Tech. 65(4-5), 205-217 (2004).

J-1   Inoue, M., M. A. Digman, M. Cheng, S. Y. Breusegem, N. Halaihel, V. Sorribas, W. W. Mantulin, E. Gratton, N. P. Barry and M. Levi.

            Partitioning of NaPi cotransporter in cholesterol, sphingomyelin and glycosphingolipid enriched membrane domains modulates NaPi protein diffusion, clustering and activity. J Biol. Chem. 279 (47) 49160–49171 (2004).

J-2   Czeslik, C., G. Jackler, T. Hazlett, E. Gratton, R. Steitz, A. Wittemann and M. Ballauff. Salt-induced protein resistance of polyelectrolyte brushes studied using fluorescence correlation spectroscopy and neutron reflectometry. Phys . Chem. Chem.

            Phys. 6, 5557–5563 (2004).

J-3   Janosch, S., C. Nicolini, B. Ludolf, C. Peters, M. Volkert, T.L. Hazlett, E. Gratton, H. Waldmann and R. Winter. Partitioning of dual-lipidated peptides into membrane microdomains - lipid sorting vs. peptide aggregation. J. Amer. Chem. Soc.

            126(24), 7496-7503 (2004).

J-4   Rao, S., J. Sutin, R. Clegg, E. Gratton, M. H. Nayfeh, S. Habbal, A. Tsolakidis and R. M. Martin. Excited states of tetrahedral single-core Si29 nanoparticles. Phys. Rev. B 69, 205319 (2004).

J-5   Safonova L.P., A. Michalos, U. Wolf, M. Wolf, D.M. Hueber, J.H. Choi, R. Gupta, C. Polzonetti, W.W. Mantulin and E. Gratton. Age-correlated changes in cerebral hemodynamics assessed by near-infrared spectroscopy. Archives of Gerontology

            and Geriatrics 39(3), 207-225 (2004).

J-6   Ruan, Q., M. A. Cheng, M. Levi, E. Gratton and W. W. Mantulin. Spatial-temporal studies of membrane dynamics: scanning fluorescence correlation spectroscopy (SFCS).  Biophys J 87, 1260­1267 (2004).

J-7   Czeslik, C., R. Jansen, M. Ballauff, A. Wittmann, C. A. Royer, E. Gratton and T. Hazlett. Mechanism of protein binding to spherical polyelectrolyte brushes studied in situ using two-photon excitation fluorescence fluctuation spectroscopy. Phys.

            Rev. E 69, 021401-021409 (2004).

J-8   Morren, G., U. Wolf, P. Lemmerling, M. Wolf, J.H. Choi, E. Gratton, L. De Lathauwer and S. Van Huffel.

            Detection of fast neuronal signals in the motor cortex from functional near infrared spectroscopy measurements using independent component analysis. Med. Biol. Eng. Comp. 42(1), 92-99 (2004).

J-9   Kis-Petekova, K. and E. Gratton. Distance Measurement by Circular Scanning of the Excitation Beam in the Two-Photon Microscope. Microsc Res Tech 63 (1), 34-49 (2004).

J-10                       Choi, J.H., W. Wolf, V. Toronov, U. Wolf, C. Polzonetti, L.P. Safonova, A. Michalos, W.W. Mantulin and E. Gratton, Noninvasive determination of the optical properties of the adult brain: Near infrared spectroscopy approach J. Biomed. Optics,

            9(1) 221-229 (2004).

J-11                       Tanner, K. and E. D’Amico, A. Kaczmarowski, S. Kukreti, J. Malpeli, W. W. Mantulin and E. Gratton. Spectrally resolved neurophotonics: A case report of hemodynamics and vascular components in the mammalian brain. J. of Biomed. Optics 10,

            064009-1-9 (2005).

J-12                       Levi, V., Q. Ruan, M. Plutz, A. S. Belmont, and E. Gratton. Chromatin dynamics in interphase cells revealed by tracking in a two-photon excitation microscope. Biophys. J. 89, 4275–4285 (2005).

J-13                       Gokhale, N. A., A. Abraham, M. A. Digman, E. Gratton, and W. Cho. Phosphoinositide specificity of and mechanism of lipid domain formation by annexin A2-p11 heterotetramer. J. Biol. Chem. 280(52), 42831-42840 (2005).

J-14                       Eckhoff, D. A., J. D. B. Sutin, R. M. Clegg, E. Gratton, E. V. Rogozhina, P. V. Braun. Optical Characterization of Ultrasmall Si Nanoparticles Prepared through Electrochemical Dispersion of Bulk Si. J. Phys. Chem. B , 109(42), 19786-19797

            (2005).

J-15                       Digman, M. A., C. M. Brown, P. Sengupta, P. W. Wiseman, A. R. Horwitz and E. Gratton. Measuring Fast Dynamics in Solutions and Cells with a Laser Scanning Microscope. Biophys. J. 89, 1317-1327 (2005).

J-16                       Digman, M. A., P. Sengupta, P. W. Wiseman, C. M. Brown, A. R. Horwitz, and E. Gratton. Fluctuation Correlation Spectroscopy with a Laser-Scanning Microscope: Exploiting the Hidden Time Structure. Biophys. J. Biophysical Letters: 88: L33-

            36L (2005).

J-17                       Arnulphi, C., S. A. Sánchez, M. A.Tricerri, E. Gratton and A. Jonas. Interaction of Human Apolipoprotein A-I with Model Membranes Exhibiting Lipid Domains. Biophys. J. 89, 285-295 (2005).

J-18                       Sanchez, S. A. and E. Gratton. Lipid-protein interactions revealed by two-photon microscopy and fluorescence correlation spectroscopy. Acc. Chemical Research 38, 469-477 (2005).

J-19                       Levi, V., Q. Ruan, and E. Gratton. 3-D Particle Tracking in a Two-Photon Microscope: Application to the Study of Molecular Dynamics in Cells. Biophys. J. 88, 2919-2928 (2005).

J-20                       Gratton, E., V. Y. Toronov, U. Wolf, M. Wolf, A. G. Webb. Measurement of brain activity by near-infrared light. J. Biomedical Optics 10(01), 1-13 (2005).

J-21                       Tricerri M.A., J. D. Toledo, S. A. Sanchez, T. L. Hazlett, E. Gratton, A. Jonas and H. A. Garda. Visualization and analysis of apolipoprotein A-I interaction with binary phospholipid bilayers. J. Lipid Res. 46(4), 669-678 (2005).

J-22                       Hanson, K., E. Gratton, and C. J. Bardeen. Sunscreen enhancement of UV-induced reactive oxygen species in the skin. Free Radic Biol Med 41(8):1205-12 (2006).

J-23                       Nicolini, C., A. Celli, E. Gratton, and R. Winter. Pressure tuning of the morphology of heterogeneous lipid vesicles: a two-photon-excitation fluorescence microscopy study. Biophys J 91(8):2936-42 (2006).

J-24                       Eckhoff, D.A., J. N. Stuart, J. D. B. Sutin, J. V. Sweedler, and E. Gratton. Capillary electrophoresis of ultrasmall carboxylate functionalized silicon nanoparticles. J Chem Phys 125(8):081103 (2006).

J-25                       Rogozhina, E. V., D. A. Eckhoff, E. Gratton and P. V. Braun. Carboxyl functionalization of ultrasmall luminescent silicon nanoparticles through thermal hydrosilylation. J. Materials Chemistry 16, 1421-1430 (2006).

J-26                       Nicolini, C., J. Baranski, S. Schlummer, J. Palomo, M. Lumbierres-Burgues, M. Kahms, J. Kuhlmann, S. Sanchez, E. Gratton, H. Waldmann and R. Winter.

            Visualizing association of N-Ras in lipid microdomains: Influence of domain structure and interfacial adsorption. JACS, 192-201 (2006).

J-27                       Simonson, P., E. D’Amico and E. Gratton. Modulation of an optical needle’s reflectivity alters the average photon path through scattering media. J. Biomedical Optics, 11(1) 014023-1-9 (2006).

J-28                       Ragan, T., H. Huang, P. So and E. Gratton. 3D particle tracking on a two-photon microscope. J. Fluorescence (2006).

J-29                       Levi, V., V. I. Gelfand, A. S. Serpinskaya and E. Gratton. Melanosomes Transported by Myosin V in Xenopus Melanophores Perform Slow 35 nm Steps. Biophys. J. (2006).

J-30                       Levi, V., A. S Serpinskaya, E. Gratton, and V. Gelfand. Organelle transport along microtubules in Xenopus melanophores: evidence for cooperation between multiple motors. Biophys. J. 90, 318-327 (2006).

J-31                       V R Caiolfa, M Zamai, G Malengo, A Andolfo, C D Madsen, J D B Sutin, M A Digman, E Gratton, F Blasi, and N Sidenius. Monomer–dimer dynamics and distribution of GPI-anchored uPAR are determined by cell surface protein assemblies. J

            Cell Biol 2007; 179(5): 1067-1082.

J-32                       C O Olopade, E Mensah, R Gupta, D Huo, D L Picchiett, E Gratton, and A Michalos. Noninvasive determination of brain tissue oxygenation during sleep in obstructive sleep apnea: a near-infrared spectroscopic approach. Sleep 2007; 30(12):

            1747-1755.

J-33                       U Wolf, M Wolf, J-H Choi, L A Paunescu, A Michalos, and E Gratton. Regional differences of hemodynamics and oxygenation in the human calf muscle detected with near-infrared spectrophotometry. J Vasc Interv Radiol 2007; 18(9): 1094-

            1101.

J-34                       R Gatto, W Hoffman, C Paisansathan, W W Mantulin, E Gratton, and F T Charbel. Effect of age on brain oxygenation regulation during changes in position. J Neurosci Methods 2007; 164(2): 308-311.

J-35                       S A Sánchez, M A Tricerri, and E Gratton. Interaction of high density lipoprotein particles with membranes containing cholesterol. J Lipid Res 2007; 48(8): 1689-1700.

J-36                       V Levi and E Gratton. Exploring dynamics in living cells by tracking single particles. Cell Biochem Biophys 2007; 48(1): 1-15. 

J-37                       S Kukreti, A Cerussi, B Tromberg, and E Gratton. Intrinsic tumor biomarkers revealed by novel double-differential spectroscopic analysis of near-infrared spectra. J Biomed Opt 2007; 12(2): 020509.

J-38                       N Boens, W Qin, N Basari, J Hofkens, M Ameloot, J Pouget, J-P Lefèvre, B Valeur, E Gratton, M vandeVen, N D Silva, Jr, Y Engelborghs, K Willaert, A Sillen, G Rumbles, D Phillips, A J W G Visser, A van Hoek, J R Lakowicz, H Malak, I

            Gryczynski, A G Szabo, D T Krajcarski, N Tamai, and A Miura. Fluorescence lifetime standards for time and frequency domain fluorescence spectroscopy. Anal Chem 2007; 79(5): 2137-49.

J-39                       M Calderon-Arnulphi, A Alaraj, S Amin-Hanjani, W W Mantulin, C M Polzonetti, E Gratton, and F T Charbel. Detection of cerebral ischemia in neurovascular surgery using quantitative frequency-domain near-infrared spectroscopy. J Neurosurg

            2007; 106(2): 283-290.

J-40                       K Tanner, E Beitel, E D'Amico, W W Mantulin, and E Gratton. Effects of vasodilation on intrinsic optical signals in the mammalian brain: a phantom study. J Biomed Opt 2007; 11(6): 064020.

J-41                       O Barreiro, M Zamai, M Yanez-Mo, E Tejera, P Lopez-Romero, P N Monk, E Gratton, V R Caiolfa, and F Sanchez-Madrid. Endothelial adhesion receptors are recruited to adherent leukocytes by inclusion in preformed tetraspanin nanoplatforms.

            J Cell Biol. 2008; 183(3): 527-542. PMCID: PMC2575792

J-42                       G Malengo, A Andolfo, N Sidenius, E Gratton, M Zamai, and V R Caiolfa.

            Fluorescence correlation spectroscopy and photon counting histogram on membrane proteins: functional dynamics of the glycosylphosphatidylinositol-anchored urokinase plasminogen activator receptor. J Biomed Opt 2008; 13(3): 031215.

J-43                       V Levi and E Gratton. Chromatin dynamics during interphase explored by single-particle tracking. Chromosome Res 2008; 16(3): 439-449.

J-44                       S Kwok, C Y Lee, S A Sánchez, T L Hazlett, E Gratton, and Y Hayashi. Genetically encoded probe for fluorescence lifetime imaging of CaMKII activity. Biochem Biophys Res Commun 2008; 369(2): 519-525. PMCID: PMC2396457

J-45                       M A Digman, C M Brown, A R Horwitz, W W Mantulin, and E Gratton. Paxillin dynamics measured during adhesion assembly and disassembly by correlation spectroscopy. Biophys J 2008; 94(7): 2819-2831.

J-46                       A Garcia-Marcos, S A Sánchez, P Parada, J S Eid, D M Jameson, M Remacha, E Gratton, and J P G Ballesta. Yeast ribosomal stalk heterogeneity in vivo shown by two-photon FCS and molecular brightness analysis.

            Biophys J 2008; 94(7): 2884-2890.

J-47                       M A Digman, R Dalal, A R Horwitz, and E Gratton. Mapping the number of molecules and brightness in the laser scanning microscope. Biophys J 2008; 94(6): 2320-2332.

J-48                       C B Raub, J R Unruh, V Suresh, T Krasieva, T Lindmo, E Gratton, B J Tromberg, and S C George. Image correlation spectroscopy of multiphoton images correlates with collagen mechanical properties. Biophys J 2008; 94(6): 2361-2373.

J-49                       R A Colyer, C Y Lee, and E Gratton. A novel fluorescence lifetime imaging system that optimizes photon efficiency. Microsc Res Tech 2008; 71(3): 201-213.

J-50                       S A Sánchez, M A Tricerri, and E Gratton. Detecting cholesterol changes in lipid bilayers. BioWorld Europe 2008; 1: 8-11.

J-51                       M A Digman, V R Caiolfa, M Zamai, and E Gratton. The Phasor approach to fluorescence lifetime imaging analysis. Biophys J 2008; 94(2): L14-16.

J-52                       R Fiorini, L Ragni, S Ambrosi, G P Littarru, E Gratton, and T Hazlett. Fluorescence studies of the interactions of ubiquinol-10 with liposomes. Photochem Photobiol 2008; 84(1): 209-214.

J-53                       R B Dalal, M A Digman, A R Horwitz, V Vetri, and E Gratton. Determination of particle number and brightness using a laser scanning confocal microscope operating in the analog mode. Microsc Res Tech 2008; 71(1): 69-81.

J-54                       A Celli, S Beretta, and E Gratton. Phase fluctuation on the micron-submicron scale in GUVs composed of a binary lipid mixture. Biophys J 2008; 94(1): 104-116.

J-55                       C M Brown, R B Dalal, B Hebert, M A Digman, A R Horwitz, and E Gratton. Raster image correlation spectroscopy (RICS) for measuring fast protein dynamics and concentrations with a commercial laser scanning confocal microscope. J Microsc

            2008; 229(1): 78-91.

J-56                       H Sanabria, M A Digman, E Gratton, and M N Waxham. Spatial Diffusivity and availability of intracellular Calmodulin. Biophys J 2008; 95(12): 6002-6015. PMCID: PMC2599858

J-57                       J R Unruh and E Gratton. Analysis of molecular concentration and brightness from fluorescence fluctuation data with an electron multiplied CCD camera. Biophys J 2008; 95(11): 5385-5398. PMCID: PMC2586556

J-58                       C Hellriegel and E Gratton. Real-time multi-parameter spectroscopy and localization in three-dimensional single-particle tracking. Theodor Forster Lecture Series on Quantitative Fluorescence Microscopy, University of Cambridge, UK 2007. J R

            Soc Interface. 2009; 6 (Suppl 1):S3-S14. PMCID: PMC2706464

J-59                       M A Digman, P W Wiseman, A R Horwitz, and E Gratton. Detecting protein complexes in living cells from laser scanning confocal image sequences by the cross correlation raster image spectroscopy method. Biophys J 2009; 96(2): 707-716.

            PMCID:PMC2716688     

J-60                       M A Digman, E Gratton. Analysis of diffusion and binding in cells using the RICS approach. Microsc Res Tech. 2009; 72(4): 323-332.

J-61                       S Kukreti, A Cerussi, B Tromberg, and E Gratton. Intrinsic near-infrared spectroscopic markers of breast tumors. Disease Markers (IOS Press), 2008; 25(6): 281-290. PMCID: PMC2732199

J-62                       M Digman and E Gratton. Fluorescence Correlation Spectroscopy and Fluorescence Cross-Correlation Spectroscopy.  Wiley Interdisciplinary Reviews: Systems Biology and Medicine 2009; 1(2): 273-282.

J-63                       M A Digman, P W Wiseman, C K Choi, A R Horwitz, and E Gratton. Stoichiometry of molecular complexes at adhesions in living cells. Proc Natl Acad Sci USA. 2009; 106(7): 2170-2175. PMCID: PMC2630200

J-64                       K Tanner, D R Ferris, L Lanzano, B Mandefro, W W Mantulin, D M Gardiner, E Rugg, and E Gratton. Coherent movement of cell layers during wound healing by image correlation spectroscopy. Biophys J. 2009; 97(7) : 20-98-2106. PMCID:

            PMC2756390

J-65                       Ellen Gielen, Nick Smisdom, Martin J vandeVen, Ben De Clercq, Enrico Gratton, Michelle A Digman, Jean-Michel Rigo, Johan Hofkens, Yves Engelborghs, and Marcel Ameloot.

            Measuring diffusion of lipid-like probes in artificial and natural    membranes by raster image correlation spectroscopy (RICS): Use of a commercial laser-scanning microscope with analog detection. Langmuir. 2009; 25(9): 5209-5218.

                        PMCID: PMC2728053

J-66                       C A Toro, S A Sanchez, A Zanocco, E Lemp, E Gratton, and G Gunther. Solubilization of lipid bilayers by myristyl sucrose ester: effect of cholesterol and phospholipid head group size. Chem. Phys Lipids. 2009; 157(2): 104-112.

J-67                       E Gratton and M Digman. One photon up, one photon down.  Nat Biotechnol. 2009; 27(2): 147-148.

J-68                       M J Rossow, W W Mantulin, and E Gratton. Spatiotemporal image correlation spectroscopy measurements of flow demonstrated in micrfluidic channels. J Biomed Opt. 2009; 14(2): 024014. PMCID: PMC2702990.

J-69                       G Caracciolo, M Digman, E Gratton, S A Sanchez, and R Caminiti. Efficient escape from endosomes determines the superior efficiency of multicomponent lipoplexes. J phys Chem B. 2009; 113(15): 4995-4997. PMCID: PMC2673460.

J-70                       K Krishnan, o Holub, E Gratton, A H A Clayton, S cody, and P D J Moens. Profilin interaction with phosphatidylinositol (4,5)-bisphosphate destabilizes the membrane of giant unilamellar vesicles.  Biophys J. 2009; 96(12): 5112-5121. PMCID:

            PMC2712054

J-71                       M A Digman and E Gratton. Imaging barriers to diffusion by pair correlation functions. Biophys J.2009; 97(2): 665-673. PMCID: PMC2711318

J-72                       Y Katayama, O Burkacky, M Myer, C Brauchle, E Gratton, and D C Lamb. Real-time nanomicroscopy via three-dimensional single particle tracking. ChemPhysChem. 2009; 10(14): 2458-2464.

J-73                       A Celli and E Gratton. Dynamics of lipid domain formation: fluctuation analysis. Biochim Biophys Acta. 2009; [epub ahead of print].

J-74                       E Gratton, V Toronov, U Wolf and M Wolf. Detection of brain activity by near-infrared light. Biomedical Optical Imaging. By JG Fujimoto and D Farkas (Editors). Oxford University Press, pp. 378-395, 2009. ISBN: 9780195150445

J-75                       M Digman and E Gratton. Multicolor fluctuation spectroscopy in cells.  BiOS 2009. Part of SPIE Photonics West. San Jose, California, January 24-29, 2009. Multiphoton Microscopy in the Biomedical Sciences IX (Proceedings of SPIE, Vol. 7183).

            By A periasamy and PTC So (Editors). 718303, 2009. ISBN: 978081947429

J-76                       S Kukreti, A E Cerussi, W Tanamai, D Hsiang, B J Tromberg, and E Gratton. Characterization of metabolic differences between benign and malignant tumors: high-spectral-resolution diffuse optical spectroscopy. Radiology .2010; 254(1): 277-284.

            PMCID: PMC2797652

J-77                       Y Yoon, J Tong, P J Lee, A Albanese, N Bhardawaj, M Kallberg, M A Digman, H Lu, E Gratton, Y-K Shin, and W Cho. Molecular basis of the potent membrane remodeling activity of the epsin1 ENTH domain. J Biol Chem. 2010; 285(1): 531-

            540. PMCID: PMC2804201

J-78                       A Celli, S A Sanchez, M J Behne, T L Hazlett, E Gratton, and T M Mauro. The epidermal Ca(2+) gradient: measurement using the phasor representation of fluorescent lifetime imaging. Biophys J. 2010; 98(5): 911-921. PMCID: PMC2830439.

J-79                       S A Sanchez, M A Tricerri, G Ossato, and E Gratton. Lipid packing determines protein-membrane interactions: Challenges for apoliprotein A-I and High Density Lipoproteins. Biochim Biophys Acta. 2010; [epub ahead of print].

J-80                       F Cardarelli and E Gratton. In vivo imaging of single-molecule translocation through nuclear pore complexes by pair correlation functions. PLoS ONE. 2010; 5(5): e10475.

J-81                       M Rossow, W Mantulin and E Gratton. Scanning laser image correlation for measurement of flow. J Biomed Opt. 2010; 15(2): 026003

J-82                       G Ossato, M Digman, C Aiken, T Lukacsovich, J Marsh, and E Gratton. A two-step path to inclusion formation of huntingtin peptides revealed by number and brightness analysis. Biophys J. 2010: 98(12): 3078-3085

J-83                       E Hinde, F Cardarelli, M Digman, and E Gratton.In vivo pair correlation analysis of EGFP intranuclear diffusion reveals DNA-dependant molecular flow. Proc Natl Acad Sci USA. 2010; 107(38): 16560-16565

J-84                       K Azertash, C Nein Shy, K Flynn, J Jester, and E Gratton. Non-invasive in vivo measurement of the tear film using spatial autocorrelation in a live mammal model.Biomed Opt Express. 2010; 1(4): 1127-1137

J-85                       M Rossow, J Sasaki, M Digman, and E Gratton.  Raster Image Correlation spectroscopy in live cells. Nat Protoc. 2010; 5(11): 1761-1774

J-86                       C Fu, G Ossato, M Long, M Digman, A Gopinathan, L Lee, E Gratton and M Khine.  Bimetallic nanopetals for thousand-fold dluoresence enhancements. Appl Phys let.  2010; 97(20): 203101

J-87                       S Kim, H Sanabria, M Digman, E Gratton, P Schwille, W Zipfel, and  M N Waxham. Quantifying translational mobility in neurons: comparison between current optical techniques. J Neurosci.  2010; 30(49): 16409-16416

J-88                       M Behne, S Sanchez, N Barry, N Kirschner, W Meyer, T Mauro, I Moll and E Gratton.  Major translocation of calcium upon epidermal barrier insult: imaging and quantification via FLIM/Fourier vector analysis. Arch Dermatol Res.  2010; [Epub

            ahead of print]

J-89                       M Digman and E Gratton Lessons in Fluctuation Correlation Spectroscopy.  Ann Rev Phys Chem. 2011; [Epub ahead of print]

 

 

 

 

(Journals) In preparation, submitted or in press:

 

 

 

Conference Presentations

 

CP-1                    Gratton, E., Invited Speaker: 2nd Annual Workshop on Advanced Optical Methods: Molecular Machines to Cells, Molecular Imaging Center, University of California, Berkeley. January 20-21, 2005.

CP-2                    Ko, W. S., N. Darwish, E. Gratton, S. H. Kim, Development of the scanning system to detect the concentration of the oxy- and deoxy-hemoglobin by tracking the head. Poster 5686-119. SPIE Meeting, San Jose, California, January, 22-27, 2005.

CP-3                    Gratton, E., "NIRS measures brain vasoreactivity." Invited Seminar, Cognitive Imaging Laboratory, Beckman Institute, February 2005.

Biophysical Society Meeting, California, February, 2005

CP-4        Digman, Michelle A., Makoto Inoue, Melanie Cheng, Sophia Y. Breusegem, Nabil Halaihel, Victor Sorribas, William W. Mantulin, Enrico Gratton, Nicholas P. Barry, Moshe Levi. Partitioning of NaPi Cotransporter in Cholesterol, Sphingomyelin and Glycosphingolipid Enriched Membrane Domains Modulates NaPi Protein Diffusion, Clustering and Activity.

CP-5        Sengupta, Parijat, Michelle Digman, Enrico Gratton. Scanning Image Correlation Spectroscopy Reveals Fast Molecular Dynamics.

CP-6        Colyer, Ryan A., Jason D. B. Sutin, Bryant B. Chhun, Enrico Gratton. Spatial Resolution Enhancement using Non-Linear Temporal Cross-Correlation Techniques in Pump-Probe Confocal Microscopy.

CP-7        Celli, Anna, Claudia Lee, Enrico Gratton. High hydrostatic pressure induced shape and lipid phase changes on Giant Unilamellar Vesicles studied with two-photon excitation microscopy.

CP-8        Digman, Michelle A., Claire M. Brown, Alan R. Horwitz, Parijat Sengupta, William W. Mantulin, Enrico Gratton. Spatio-temporal fluorescence fluctuation analysis of paxillin-EGFP in cellular adhesions using scanning FCS, ICS and PCH.

CP-9        Czeslik, Claus ,Theodore Hazlett, Enrico Gratton, Roland Steitz, Hans-Hennig von Grünberg, Matthias Ballauff. Effect of salt on the immobilization of proteins at polyelectrolyte brushes

CP-10    Gomes, Andre M. O., Andrea C. Oliveira, Valeria Levi, Rafael B. Goncalves, Umesh Katpally, Thomas J. Smith, Enrico Gratton. Real Time 3D Tracking of Virus Particles in Live Cell

CP-11    Levi, Valeria, Andrew Belmont, Matthew Plutz, Enrico Gratton. Dynamics of a DNA Sequence in Interphase Cells Revealed by Fast-tracking in a Two-photon Microscope

CP-12    Malengo, Gabriele, Annapaola Andolfo, Parijat Sengupta, Shih Chu Liao, Beniamino Barbieri, Giuseppe Chirico, Enrico Gratton, Francesco Blasi, Nicolai Sidenius, Valeria R. Caiolfa. The GPI-anchored Urokinase Receptor (uPAR) dynamics on the cells surface followed by fluorescence fluctuation spectroscopy.

CP-13    Tahari, Abdel K. Guido Motolese, Enrico Gratton. Fluorescence correlation spectroscopy in turbid media: Ultrasensitive detection of bacteria, viruses, and protein aggregates.

CP-14    Hazlett, Theodore L., Marisa Barcellona, Michelle Digman, Enrico Gratton, Polarized FCS: detection of rotational motions of macromolecules

CP-15                Gratton, E., "FCS," Hamamatsu Special Seminar, Rockville, MD, March 16, 2005.

CP-16                Gratton, E., "FCS," Hamamatsu Special Seminar, Bridgewater, NJ, March 17, 2005.

CP-17                Sutin, J., S. Awtar, J. Hart, A.H. Slocum, E. Gratton. "Improving the performance of the optical microscope via modern opto and optomechanical design." Focus on Microscopy, Jena, Germany , March 20-23, 2005.

CP-18                Lera, M., J. Sutin, J.F. Aguilar, E. Gratton. "Confocal profiling of spherical cavities." Focus on Microscopy, Jena, Germany , March 20-23, 2005.

CP-19                Gratton, E., "Tracking Molecules in Cells using a Two-photon Microscope." Chemical Biophysics Mini-Symposium, University of Pennsylvania, April 21, 2005.

CP-20                Gratton, E., "Brain vasoreactivity by near-ir optical spectroscopy." 2005 Industry Research Symposium, Irvine, CA, May, 2005.

CP-21                Gratton, E. and K. Tanner: Second Annual Breast Cancer Imaging Network Retreat and Workshop, Newport Beach, California, June 2-4, 2005.

CP-22                Gratton E., and S. Sanchez,  FCS, Generalized Polarization and other techniques to probe the membrane organization. INSERM workshop on "Dynamic and functional imaging of live cells: from the detection of singles molecules to the visualization of tissues" June, 2005.

CP-23                Gratton, E., INSERM and the French Society of Cell Biology, Marseille, France , June 29-July 2, 2005.

CP-24                Gratton, E., Steering Committee, 9th International Conference on Methodsand Applications ofFluorescence Spectroscopy, Imaging and Probes. Libson, Portugal , September 4-7, 2005.

CP-25                Gratton, E., Instructor, Principles of Fluorescence Techniques, Laboratory for Advanced Microscopy, Bioimaging and Spectroscopy, Genova, Italy , September 13-14, 2005.

CP-26                Gratton, E., "Fluctuation dynamics of the cell interior." First European Conference on Chemistry for Life Sciences. Rimini, Italy , October 4-8, 2005.

CP-27                Gratton, E., "Looking into the Brain with Lasers." Saturday Physics Honors Program Seminar, University of Illinois at Urbana-Champaign, October 15, 2005.

CP-28                Barry, N. M. Digman, C. Lee, S. Y. Breusegem, W. W. Mantulin, E. Gratton, M. Levi, "The Heterogeneity of NaPi Protein Dynamics and NaPi Cotransport Activity in Rat Brush Border Membranes" Meeting of American Society of Nephrology, Pennsylvania Convention Center, Philadelphia, Pennsylvania, November 8-13, 2005.

CP-29                Gratton, E., "Probing Single Molecule Diffusion and Clustering with Fluorescence Correlation Spectroscopy (FCS) and Photon Counting Histogram (PCH)," Invited Speaker, American Society of Nephrology, Renal Week 2005, Pennsylvania Convention Center, Philadelphia, PA, November 8–13, 2005.

CP-30                Gratton, E., Invited Speaker,  Department of Biology Seminar Series, December 1, 2005

CP-31                Gratton, E., A New Approach to FLIM Analysis. Advanced Optical Methods Workshop 2006, Berkeley, CA, January 19-20, 2006.

CP-32                Gratton, E., Department of Biology Seminar Series, John Hopkins University, February 16, 2006.

Biophysical Society, February 18-22, 2006.

CP-33    Gratton, E., 3-D particle tracking using a two-photon excitation microscope, Invited Speaker, Analyzing Submicrometer Structure and Motion in Light Microscopy Workshop.

CP-34    Toro, C. A.,  A. Zanocco, G. Gunther, E. Gratton, S. A. Sanchez.  Detergent solubilization of lipid bilayers followed by 2-photon microscopy. (276-Pos/B142)

CP-35    Levi, V., A. S. Serpinskaya, V. Gelfand, E. Gratton.  Single particle tracking study of organelles transport in Xenopus Melanophores. (647-Pos/B513)

CP-36    Gratton, E., M. A. Digman.   Ultrafast analysis of fluorescence lifetime images using the phasor approach: application to FRET analysis. (681-Pos/B547)

CP-37    Colyer, R. A., C. Y. C. Lee, E. Gratton.   Frequency-Domain Fluorescence Lifetime Imaging Microscopy in the Photon-Counting Regime with Field-Programmable Gate Arrays. (684-Pos/B550)

CP-38    Lee, C. Y. C., E. Gratton.  Fluctuation Correlation Spectroscopy with Colloidal Gold Particles. (685-Pos/B551)

CP-39    Hazlett,  T. L., E. Gratton. Characterization of Particle Angular Fluctuations by Intensity and Polarization Trajectory Plots. (691-Pos/B557)

CP-40    Digman, M. A., C. M. Brown, A. F. Horwitz, W. W. Mantulin, E. Gratton.  Fast dynamics in the cell interior revealed by RICS. (699-Pos/B565)

CP-41    Gomes, A. O., A. C. Oliveira, V. Levi, R. B. Goncalves, U. Katpally, T. J. Smith, E. Gratton.  New insights on transport and particle dynamics obtained from real-time 3D tracking of viral particles in live cells. (1483-Pos/B604)

CP-42    Brown, C. M., M. A. Digman, E. Gratton, A. R. Horwitz.  Measuring protein binding kinetics at submicron resolution from high speed Total Internal Reflection Fluorescence Microscopy Images. (2314-Platform Talk)

CP-43    Sanchez, S. A., M. A. Tricerri, A. Gomes, V. Levi, A. C. de Oliveira, E. Gratton.  Reconstituted HDL particles as an alternative acceptor to remove cholesterol in vitro and in vivo. (2439-Pos/B106)

CP-44    Celli, A., E. Gratton.  Lipid organization fluctuations in model membranes studied by two photon fluorescence microscopy. (2464-Pos/B131)

CP-45                Gratton, E.,  Tracking Protein-coated Particles in 3D.  Invited Speaker. American Physical Society, Baltimore, MD, March 13-17, 2006.

Optical Society of America, March 18-23, 2006

CP-46    Tanner, K., E. D’Amico, A. Kaczmarowski, S. Kukreti, J. Malpeli, W. W. Mantulin, E. Gratton.  Spectrally Resolved Neurophotonics: The Optical BOLD Effect and Vascular Components in the Mammalian Brain.

CP-47    Gratton, E., K. Tanner, E. Beitel, E. D’Amico, W. W. Mantulin.  Effects of Vasodilation on Intrinsic Optical Signals.

CP-48    Simonson, P. D., E. D’Amico, E. Gratton. Proposal and Proof of Principle for a Novel Optical Biopsy Needle: Modulating an Optical Needles Reflectivity Alters the Average Photon Path in Scattering Media.

CP-49    Machado, N. G., A. Perlman, E. Gratton.  Near-Infrared Spectroscopy and the Swallowing Event.

CP-50    Gatto, R. G., E. D’Amico, W. Mantulin, E. Gratton, F. Charbel.  Optical Microprobe for Blood Clot Detection.

CP-51    Rossow, M., E. Gratton, E. D’Amico, W. W. Mantulin, R. Gatto. Blood Flow Measurements and Clot Detection with Near-Infrared Spectroscopy.

CP-52                Gratton, E., M. Digman.  Lipid Rafts and Cell Function (D2).  Keystone Symposium, March 23-28, 2006.

CP-53                Tahari, A. K., and E. Gratton.  Fluorescence correlation spectroscopy in turbid media:  Application to the detection and analysis of oligomeric complexes of Alzheimer’s beta-peptide in CSF.  ASCI/AAP 2006 Joint Meeting, Chicago, IL, April 28–30, 2006.

CP-54                Gratton, E., Kavli Institute for Theoretical Physics. May 8, 2006.

CP-55                Gratton, E.,  "B5" Advanced Microscopy course and the Bioimaging Symposium Biochemistry and Molecular Biology Department, University of Southern Denmark on June 2006.

CP-56                Gratton, E.,  S. Sanchez. EMBO Advanced Microscopy Course, University of Buenos Aires, Argentina , August 6-18, 2006.

CP-57                Gratton, E., Program Committee, Fifth Inter-Institute Workshop on Optical Diagnostic Imaging from Bench to Bedside at the National Institutes of Health, Bethesda, Maryland, August 27-30, 2006.

CP-58                Gratton, E., Tracking protein-coated particles in 3D. XVIII Congresso Nazionale della Societa' Italiana di Biofisica Pura e Applicata (SIBPA), Palermo, Sicily, Italy, September 17-21, 2006.

CP-59                Gratton, E., Particle Tracking in 3-D: Chromatin Structure and Dynamics. CeNS Workshop, Venice International University, Italy , September 25-29, 2006.

CP-60                Gratton, E., Fluorescence Correlation Spectroscopy. Fluoro 2006, National Marine Science Center, University of New England, Coffs Harbour, NSW, Australia, October 2-6, 2006.

CP-61                Gratton, E., Dynamic Cell Imaging with the Conforcor Microscope. Distinguished Lecture Series at Fox Chase Cancer Center, Philadelphia, PA, November 9, 2006.

CP-62                Gratton, E., Raster Image Correlation Spectroscopy. Advanced Optical Imaging Workshop, University of Melbourne, Australia, November 20-21, 2006.

51st Annual Meeting of the Biophysical Society, Baltimore, Maryland, 2007

CP-63    Gratton, E., Number Fluctuations and Aggregation in Live Cells. Advanced Optical Methods Workshop 2006, Berkeley, CA, January 17-19, 2007.

CP-64    Jee-Hyun Choi, Martin Wolf, Vladislav Toronov, Ursula Wolf, Antonios Michalos, and Enrico Gratton. Spatio-temporal analysis of the cerebral spontaneous oscillations. 37th Annual Meeting of the Society for Neuroscience, San Diego, California.Abstract

CP-65    Shwayta Kukreti, Albert E Cerussi, V W Tanamai, Bruce Tromberg, and Enrico Gratton. Intrinsic markers of breast tumors. P41 Principal Investigator Meeting Bethesda, Maryland. 19-20 June 2007.Abstract

CP-66    Kaveh Azartash and Enrico Gratton. Measuring the deformation of collagen matrix in response to cell migration detected with digital holographic microscopy. 2nd Frontiers in Biomedical Devices Conference, Irvine, California, 2007.

CP-67    Kandice Tanner, Shuo Tang, and Enrico Gratton. Dynamics of cell migration for cells embedded in collagen using a multimodal platform of optical coherence tomography, multi-photon excitation and second harmonic generation. 2007 APS March Meeting, Denver, Colorado, 2007.

CP-68    Molly J Rossow, William W Mantulin, and Enrico Gratton. An optical technique for fluid velocity measurement applicable to intra-operative blood flow. 51st Annual Meeting of the Biophysical Society, Baltimore, Maryland, 2007. Biophys J Supplement: 332a, 1565-Pos/B618, 2007.

CP-69    Kandice Tanner, Shuo Tang, and Enrico Gratton. Dynamics of cell migration for cells embedded in collagen using a multimodal platform of optical coherence tomography, multi-photon excitation and second harmonic generation. 51st Annual Meeting of the Biophysical Society, Baltimore, Maryland, 2007. Biophys J Supplement: 517a, 2467-Pos/B682, 2007.

CP-70    Susana A Sanchez, Claudia Toro, M Alejandra Tricerri, Enrico Gratton, and German Gunther. Interaction of rHDL particles with membranes containing cholesterol in different lipid packing. 51st Annual Meeting of the Biophysical Society, Baltimore, Maryland, 2007. Biophys J Supplement: 428a, 2052-Pos/B270, 2007.

CP-71    Jay R Unruh, Michelle A Digman, Hideaki Takahashi, Judith Blaine, Sophia Y Breusegem, Nicholas P Barry, Moshe Levi, and Enrico Gratton. Lipid dynamics in native rat renal brush border membranes as measured by scanning fluorescence correlation spectroscopy. 51st Annual Meeting of the Biophysical Society, Baltimore, Maryland, 2007. Biophys J Supplement: 155a, 722-Pos/B566, 2007.

CP-72    Ryan A Colyer, Claudia Y Lee, and Enrico Gratton. Time-resolved frequency-domain fluorescence lifetime imaging microscopy in the photon-counting regime. 51st Annual Meeting of the Biophysical Society, Baltimore, Maryland, 2007. Biophys J Supplement: 321a, 1511-Pos/B564, 2007.

CP-73    Michelle A Digman, Rooshin Dalal, Claire M Brown, Allen R Horwitz, and Enrico Gratton. Determination of aggregates size and number of proteins from TIRF, LSM, and two photon microscopy. 51st Annual Meeting of the Biophysical Society, Baltimore, Maryland, 2007. Biophys J Supplement: 322a, 517-Pos/B570, 2007.

CP-74    Enrico Gratton, Claire M Brown, Allan R Horwitz, and Michelle Digman. Velocity maps of protein aggregates near adhesion sites form from TIRF data obtained with a fast electron multiplier camera. 51st Annual Meeting of the Biophysical Society, Baltimore, Maryland, 2007. Biophys J Supplement: 517a (2466-Pos/B681), 2007.

CP-75    Kaveh Azartash, Michelle Digman, Oliver Holub, and Enrico Gratton. Deformation of collagen matrix detected by digital holographic microscopy. 51st Annual Meeting of the Biophysical Society, Baltimore, Maryland, 2007. Biophys J Supplement, 2007.

CP-76                Kandice Tanner, Shuo Tang, and Enrico Gratton. Dynamics of cell migration for cells embedded in collagen using a multimodal platform of optical coherence tomography, multi-photon excitation and second harmonic generation. 2007 APS March Meeting, Denver, Colorado, 2007.

CP-77                Shwayta Kukreti, Albert E Cerussi, Bruce Tromberg, and Enrico Gratton. Near-infrared tumor spectral signature enhances optical mammography. ASCI/AAP Joint Meeting, Chicago, Illinois, April 2007.

CP-78                Kaveh Azartash and Enrico Gratton. Measuring the deformation of collagen matrix in response to cell migration detected with digital holographic microscopy. 2nd Frontiers in Biomedical Devices Conference, Irvine, California, 2007.

CP-79                Shwayta Kukreti, Albert E Cerussi, V W Tanamai, Bruce Tromberg, and Enrico Gratton. Intrinsic markers of breast tumors. P41 Principal Investigator Meeting Bethesda, Maryland. 19-20 June 2007.

CP-80                Jee-Hyun Choi, Martin Wolf, Vladislav Toronov, Ursula Wolf, Antonios Michalos, and Enrico Gratton. Spatio-temporal analysis of the cerebral spontaneous oscillations. 37th Annual Meeting of the Society for Neuroscience, San Diego, California.

CP-81                Shwayta Kukreti, Albert E Cerussi, V W Tanamai, Bruce J Tromberg, M Rita, H David, and Enrico Gratton. Intrinsic near-infrared spectroscopic biomarkers applied for evaluation of final pathological response to neaoadjuvant chemotherapy. 30th Annual San Antonio Breast Cancer Symposium, San Antonio, Texas, 2007.

52nd Annual Meeting of the Biophysical Society, Long Beach, California, 2008.

CP-82    Michelle A Digman, Alan F Horwitz, and Enrico Gratton. N&B fluctuation analysis of paxillin reveals mechanisms of adhesion assembly and disassembly. 52nd Annual Meeting of the Biophysical Society, Long Beach, California, 2008. Biophys J Supplement, 1588-Pos/B564, 2008.

CP-83    Enrico Gratton, Michelle A Digman, and Angelika Rück. Simultaneous FLIM measurement of the decay of the donor and acceptor in a FRET pair. 52nd Annual Meeting of the Biophysical Society, Long Beach, California, 2008. Biophys J Supplement, 1601-Pos/B577, 2008.

CP-84    Claudia Toro, Susana A Sánchez, Enrico Gratton, A Zanocco, E Lemp, and German Gunther. Effect of cholesterol in the solubilization process by b-D-Fructofuranosyl-6-O-myristyl-a-D-Glucopyranoside (MMS). 52nd Annual Meeting of the Biophysical Society, Long Beach, California, 2008. Biophys J Supplement, 2008.

CP-85    Travis I Moore, Theodore L Hazlett, Enrico Gratton, and Tau-Mu Yi. Membrane diffusion measured using fluorescence correlation spectroscopy in polarized S. cerevisiae. 52nd Annual Meeting of the Biophysical Society, Long Beach, California, 2008. Biophys J Supplement, 2008.

CP-86    Molly Rossow, William Mantulin, and Enrico Gratton. Blood flow mapping through spatial temporal image correlation. 52nd Annual Meeting of the Biophysical Society, Long Beach, California, 2008. Biophys J Supplement, 1691-Pos/B667, 2008.

CP-87    Susana A Sánchez, M Alejandra Tricerri, Andre Gomes, Andrea De Oliveira, Valeria Levi, and Enrico Gratton. Changes in membrane water content after Cholesterol removal revealed by Laurdan generalized polarization microscopy. 52nd Annual Meeting of the Biophysical Society, Long Beach, California, 2008. Biophys J Supplement, 2008.

CP-88    Kandice Tanner, Luca Lanzano, and Enrico Gratton. Cell migration in collagen matrices: assessment of local stiffness by fluctuation spectroscopy. 52nd Annual Meeting of the Biophysical Society, Long Beach, California, 2008. Biophys J Supplement, 1595-Pos/B571, 2008.

CP-89    Sergio Perfetto, Marcela Redigolo, and Enrico Gratton. Development of an instrument for measuring extremely low concentrations of particles. 52nd Annual Meeting of the Biophysical Society, Long Beach, California, 2008. Biophys J Supplement, 1617-Pos/B593, 2008.

CP-90    Kaveh Azartash and Enrico Gatton. Quantitative analysis of the dynamics of cell and the extracellular matrix with digital holographic microscopy. 52nd Annual Meeting of the Biophysical Society, Long Beach, California, 2008. Biophys J Supplement, 797-Pos/B640, 2008.

CP-91    Ryan A Colyer, Claudia Y Lee, and Enrico Gratton. A novel fluorescence lifetime imaging system that optimizes photon efficiency. 52nd Annual Meeting of the Biophysical Society, Long Beach, California, 2008. Biophys J Supplement, 807-Pos/B650, 2008.

CP-92    Christian Hellriegel and Enrico Gratton.  3D particle tracking in 2-photon microscopy using orbital scanning expanded. 52nd Annual Meeting of the Biophysical Society, Long Beach, California, 2008. Biophys J Supplement, 809-Pos/B652, 2008.

CP-93    Giulia Ossato, Elisa Frasnelli, Luca Lanzano, Michelle A Digman, J Lawrence Marsh, and Enrico Gratton. Imaging HTT protein aggregation in cells by fluctuation analysis. 52nd Annual Meeting of the Biophysical Society, Long Beach, California, 2008. Biophys J Supplement, 233-Pos/B65, 2008.

CP-94    Jay R Unruh and Enrico Gratton. Number and brightness analysis for EMCCD cameras. 52nd Annual Meeting of the Biophysical Society, Long Beach, California, 2008. Biophys J Supplement, 788-Pos/B631, 2008.

7th International Weber Symposium, Kauai, Hawaii, June 6-12, 2008

CP-95    Enrico Gratton. The SimFCS environment: from simulation to data acquisition and analysis. 7th International Weber Symposium, Kauai, Hawaii, June 6-12, 2008.

CP-96    German Gunther, Claudia A Toro, Antonio Zanocco, M Rifo, Enrico Gratton, and Susana A Sánchez. Interaction of human erythrocyte with MMS detergent: changes in membrane fluidity reported by Laurdan. 7th International Weber Symposium, Kauai, Hawaii, June 6-12, 2008.

CP-97    C K Choi, M Vicente-Manzanares, J Zareno, Claire M Brown, A Mogilner, Michelle A Digman, D Kolin, Paul W Wiseman, Enrico Gratton, and Alan R Horwitz. The assembly, maturation, and disassembly of adhesions in migrating cells. 7th International Weber Symposium, Kauai, Hawaii, June 6-12, 2008.

CP-98    Susana A Sánchez and Enrico Gratton. Laurdan GP fluctuations in biological membranes. 7th International Weber Symposium, Kauai, Hawaii, June 6-12, 2008.

CP-99    Yoshihiko Katayama, Ondrej Burkacky, Susanne Lange, Christoph Bräuchle, Ralf-Peter Jansen, Enrico Gratton, and Don C Lamb. On the trail of single particles: 3D single particle tracking in live cells. 7th International Weber Symposium, Kauai, Hawaii, June 6-12, 2008.

CP-100                        Giulia Ossato, Elisa Frasnelli, Luca Lanzano, Michelle A Digman, J Lawrence Marsh, and Enrico Gratton. Imaging Htt protein aggregation in cells by fluctuation analysis. 7th International Weber Symposium, Kauai, Hawaii, June 6-12, 2008.

CP-101                        Michelle Digman, Giulia Ossato, Elisa Frasnelli, Gabriele Buonaventura, Charity Aiken, J Lawrence Marsh, and Enrico Gratton. Huntingtin (Htt) oligomer formation in live cells. 7th International Weber Symposium, Kauai, Hawaii, June 6-12, 2008.

CP-102                        Enrico Gratton. Exploiting fluctuations to determine protein aggregation and stoichiometry in cells. 7th International Weber Symposium, Kauai, Hawaii, June 6-12, 2008.

CP-103                        Christian Hellriegel and Enrico Gratton. Latest data from 3D single particle tracking. 7th International Weber Symposium, Kauai, Hawaii, June 6-12, 2008.Abstract

CP-104                        Molly J Rossow, William Mantulin, and Enrico Gratton. Line scanning flow measurements. 53rd Annual Meeting of the Biophysical Society, Boston Massachusetts, 2009. Biophys J. 2009; 96(3, Suppl 1): 314a, 1601-PosB445

CP-105                        Susana Sanchez and Enrico Gratton. Laurdan GP fluctuations in membranes of intact erythrocytes. 53rd Annual Meeting of the Biophysical Society, Boston Massachusetts, 2009. Biophys J. 2009; 96(3, Suppl 1): 151a, 779-PosB658

CP-106                        Kaveh Azartash and Enrico Gratton. Obtaining quantitative information on the cell-induced deformation of collagen with digital holographic microscopy. 53rd Annual Meeting of the Biophysical Society, Boston Massachusetts, 2009.

                  Biophys J. 2009:96(3, Suppl 1): 297a, 1512-PosB356

CP-107                        Michelle Digman, Enrico Gratton, Paul Wiseman, and Alan Horowitz. Multicolor fluctuation scpectroscopy in cells: obtaining the stoichiometry of molecular complexes. 53rd Annual Meeting of the Biophysical Society, Boston

                  Massachusetts, 2009. Biophys J. 2009; 96(3, Suppl 1): 208a, 1076-Plat

CP-108                        Francesco Cutrale, Michelle Digman and Enrico Gratton. Paxillin focal adhesions, localization and implication: insight from photo-activated localization microscopy. 53rd Annual Meeting of the Biophysical Society, Boston Massachusette,

                  2009. Biophys J 2009;96(3, Suppl 1): 637a, 3284-PosB331

CP-109                        Valeria Vetri, Giulia Ossato, Valerie Militello, Michelle Digman, Maurizio Leone, and Enrico Gratton. Detecting protein aggregation on cells surface: Concanavalin A oligomers formation. 53rd Annual Meeting of the Biophysical Society,

                  Boston, Massachusetts, 2009. Biophys J. 2009; 96(3, Suppl 1): 88a, 454-PosB333

CP-110                        Giulia Ossato, Michelle Digman, Charity aiken